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Journal Articles

RAS-MPAK Pathway Signaling in Health and Disease

Qing Li, MD PhD

Blood (2018) 132 (Supplement 1): SCI-40.

https://doi.org/10.1182/blood-2018-99-109378

Published: 2018

Journal Articles

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

Noemi A. Zambetti, PhD, Ari J. Firestone, PhD, Jasmine C. Wong, PhD, Amanda Long, BA, Anagha Inguva, BA, Radu M. Suciu, B.Sc., Benjamin F. Cravatt, PhD, Kevin M. Haigis, PhD, Kevin M. Shannon, MD

Blood (2017) 130 (Supplement 1): 1221.

https://doi.org/10.1182/blood.V130.Suppl_1.1221.1221

Published: 2017

Journal Articles

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

Justin M Watts, MD, Aymee Perez, PhD, Fernando Vargas, MD, Yao-Shan Fan, MD PhD, Alejandra Weisman, Ana Rodriguez, Omar Lopez, Francisco Vega, MD PhD, Ronan T Swords, MD PhD FRCPI, FRCPath, Arthur Zelent, PhD

Blood (2016) 128 (22): 1526.

https://doi.org/10.1182/blood.V128.22.1526.1526

Published: 2016

Journal Articles

Loss of Sos1 Inhibits Oncogenic Kras-Induced Hyperactivation of Wild-Type Ras during Leukemogenesis

Xiaona You, PhD, Guangyao Kong, PhD, Erik A. Ranheim, MD, Yun Zhou, Jing Zhang

Blood (2016) 128 (22): 1543.

https://doi.org/10.1182/blood.V128.22.1543.1543

Published: 2016

Journal Articles

RAS Association Domain Family Member 4 (RASSF4): A New Potent Tumor Suppressor in Multiple Myeloma

Eva De Smedt, Ken Maes, PhD, Stefan Verhulst, Hui Lui, Alboukadel Kassambara, PhD, Anke Maes, Dirk Hose, MD, Karine Breckpot, Jerome Moreaux, PhD, Elke De Bruyne, PhD

Blood (2016) 128 (22): 2057.

https://doi.org/10.1182/blood.V128.22.2057.2057

Published: 2016

Journal Articles

Characterization and Isolation of Splenic Littoral Cells, a Possible Cellular Niche for Extramedullary Hematopoiesis in Myelofibrosis

Jiajing Qiu, PhD, Xiaoli Wang, MD, Mohamed E Salama, MD, Ronald Hoffman, MD

Blood (2015) 126 (23): 3594.

https://doi.org/10.1182/blood.V126.23.3594.3594

Published: 2015

Journal Articles

Proteomics Profiling of Leukemia Derived Exosomes: A Potential Role in Leukemic Transformation

Bijender Kumar, PhD, Lei Zhang, PhD, Yunan Miao, Gerald Wuenschell, Allen Lin, Vinod Pullarkat, MD, Guido Marcucci, MD, Robert Hickey, PhD, Ching-Cheng Chen, PhD

Blood (2015) 126 (23): 3857.

https://doi.org/10.1182/blood.V126.23.3857.3857

Published: 2015

Journal Articles

Roles of Palmitoylation and the KIKK Membrane-Targeting Motif in Leukemogenesis By Oncogenic KRAS4A

Huanbin Zhao, PhDcandidate, Ping Liu, MD, Ruihong Zhang, BS, Min Wu, MD, Donghe Li, BS, Xuemei Zhao, BS, Chun Zhang, MS, Bo Jiao, PhD, Zhu Chen, MD PhD, Ruibao Ren, MD PhD

Blood (2015) 126 (23): 1242.

https://doi.org/10.1182/blood.V126.23.1242.1242

Published: 2015

Journal Articles

Wild-Type Kras Inhibits Nras Q61R/+ -Induced Leukemias

Zhi Wen, PhD MD, Jing Zhang, PhD

Blood (2015) 126 (23): 1249.

https://doi.org/10.1182/blood.V126.23.1249.1249

Published: 2015

Journal Articles

An Open-Label, Dose Escalation, Multi-Center Phase 1 Study of PRLX 93936, an Agent Synthetically Active Against the Activated Ras Pathway, in the Treatment of Relapsed or Relapsed and Refractory Multiple Myeloma

Peter M Voorhees, MD, Robert L. Schlossman, MD, Cristina J Gasparetto, MD, Jesus G. Berdeja, MD, John Morris, MD, Douglas A Jacobstein, MD, Kenneth C. Anderson, MD, Constantine S Mitsiades, MD PhD, Jacob P. Laubach, MD, Paul G. Richardson

Blood (2014) 124 (21): 2140.

https://doi.org/10.1182/blood.V124.21.2140.2140

Published: 2014

Journal Articles

The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine Suppresses the Plasma Membrane Translocation and Neoplastic Transforming Activity of NRAS and KRAS4A

Min Wu, PhDcandidate, Bo Jiao, PhD, Ruibao Ren, MD/PhD

Blood (2014) 124 (21): 434.

https://doi.org/10.1182/blood.V124.21.434.434

Published: 2014

Journal Articles

Palmitoyl Acyltransferase DHHC9 Is Required for Efficient Induction of Leukemia By Oncogenic NRAS

Ping Liu, MD/PhD, Bo Jiao, PhD, Ruihong Zhang, B.S., Huanbin Zhao, M.S., Chun Zhang, M.S., Min Wu, M.S., Qingsong Qiu, M.S., Donghe Li, B.S., Xuemei Zhao, B.S., Ruibao Ren, MD/PhD

Blood (2014) 124 (21): 893.

https://doi.org/10.1182/blood.V124.21.893.893

Published: 2014

Journal Articles

Another path to ERK activation

Paul A. Ney

Blood (2013) 121 (16): 3064–3065.

https://doi.org/10.1182/blood-2013-02-480459

Published: 2013

Journal Articles

Preclinical Evaluation of Oncolytic Reovirus in Targeted Therapeutics for High-Risk Pediatric Leukemia

Matthew F. Clarkson, Aru Narendran, MD, PhD, Randal N. Johnston, PhD

Blood (2012) 120 (21): 3571.

https://doi.org/10.1182/blood.V120.21.3571.3571

Published: 2012

Journal Articles

Novel Recurrent Mutations in the Ras -Like GTP-Binding Gene Rit1 in Myeloid Malignancies

Inées Góomez-Seguíi, MD., Hideki Makishima, MD, PhD, Andres Jerez, MD, PhD, Kenichi Yoshida, MD, Bartlomiej P Przychodzen, Satoru Miyano, PhD, Yuichi Shiraishi, Holleh D Husseinzadeh, MD, Edward P Evans, Kathryn M Guinta, Naoko Hosono, MD., PhD., Michael A McDevitt, MD, PhD, Alison R. Moliterno, MD, Mikkael A. Sekeres, MD, MS, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD

Blood (2012) 120 (21): 558.

https://doi.org/10.1182/blood.V120.21.558.558

Published: 2012

Journal Articles

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Liu Qingsong, PhD, Jianming Zhang, PhD, Guillaume Adelmant, PhD, Jarrod A Marto, PhD, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S Gray, PhD, James D. Griffin, MD

Blood (2012) 120 (21): 2455.

https://doi.org/10.1182/blood.V120.21.2455.2455

Published: 2012

Journal Articles

Targeting oncogenic Ras signaling in hematologic malignancies

Ashley F. Ward, Benjamin S. Braun, Kevin M. Shannon

Blood (2012) 120 (17): 3397–3406.

https://doi.org/10.1182/blood-2012-05-378596

Published: 2012

Includes: Supplemental data

Journal Articles

Evolution of Sub-Clones with KRAS Mutations In Pediatric Patients with MLL-AF4 Rearrangements

Silvia Bresolin, Emanuela Giarin, Luca Trentin, PhD, Lueder Hinrich Meyer, MD, Giuseppe Basso, MD PhD, Geertruy Kronnie, PhD

Blood (2011) 118 (21): 2454.

https://doi.org/10.1182/blood.V118.21.2454.2454

Published: 2011

Journal Articles

Mutational Analysis of N-Ras Proto-Oncogene in Acute Myeloid Leukemia: A Study of 70 Adult Korean Patients

Jihun Jeong, Jeong Yeal Ahn, Jae Hoon Lee, MD

Blood (2011) 118 (21): 4883.

https://doi.org/10.1182/blood.V118.21.4883.4883

Published: 2011

Journal Articles

Dominant Negative Effect of Palmitoylation-Deficient NRAS In Suppression of BCR/ABL Leukemogenesis

Benjamin Cuiffo, Ph.D., Ruibao Ren, M.D./Ph.D

Blood (2010) 116 (21): 3157.

https://doi.org/10.1182/blood.V116.21.3157.3157

Published: 2010

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RAS-MPAK Pathway Signaling in Health and Disease

Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

Loss of Sos1 Inhibits Oncogenic Kras-Induced Hyperactivation of Wild-Type Ras during Leukemogenesis

RAS Association Domain Family Member 4 (RASSF4): A New Potent Tumor Suppressor in Multiple Myeloma

Characterization and Isolation of Splenic Littoral Cells, a Possible Cellular Niche for Extramedullary Hematopoiesis in Myelofibrosis

Proteomics Profiling of Leukemia Derived Exosomes: A Potential Role in Leukemic Transformation

Roles of Palmitoylation and the KIKK Membrane-Targeting Motif in Leukemogenesis By Oncogenic KRAS4A

Wild-Type Kras Inhibits Nras Q61R/+ -Induced Leukemias

An Open-Label, Dose Escalation, Multi-Center Phase 1 Study of PRLX 93936, an Agent Synthetically Active Against the Activated Ras Pathway, in the Treatment of Relapsed or Relapsed and Refractory Multiple Myeloma

The Endocannabinoid/Endovanilloid N-Arachidonoyl Dopamine Suppresses the Plasma Membrane Translocation and Neoplastic Transforming Activity of NRAS and KRAS4A

Palmitoyl Acyltransferase DHHC9 Is Required for Efficient Induction of Leukemia By Oncogenic NRAS

Another path to ERK activation

Preclinical Evaluation of Oncolytic Reovirus in Targeted Therapeutics for High-Risk Pediatric Leukemia

Novel Recurrent Mutations in the Ras -Like GTP-Binding Gene Rit1 in Myeloid Malignancies

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

Targeting oncogenic Ras signaling in hematologic malignancies

Evolution of Sub-Clones with KRAS Mutations In Pediatric Patients with MLL-AF4 Rearrangements

Mutational Analysis of N-Ras Proto-Oncogene in Acute Myeloid Leukemia: A Study of 70 Adult Korean Patients

Dominant Negative Effect of Palmitoylation-Deficient NRAS In Suppression of BCR/ABL Leukemogenesis

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