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Journal Articles

Inhibition of De Novo Pyrimidine Nucleotide Synthesis By the Novel DHODH Inhibitor PTC299 Induces Differentiation and/or Death of AML Cells

Marla Weetall, PhD, Kensuke Kojima, MD PhD, Sujan Piya, PhD, Christopher Trotta, PhD, John Baird, PhD, Kylie O'Keefe, Bansri Furia, Gautam M. Borthakur, MD, Robert Spiegel, MD

Blood (2019) 134 (Supplement_1): 5152.

https://doi.org/10.1182/blood-2019-124569

Published: 2019

Journal Articles

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

Satoshi Kitazawa, PhD, Yukiko Ishii, PhD, Keiko Makita-Suzuki, Koichi Saito, PhD, Kensuke Takayanagi, Hiromi Sugihara, Shun Matsuda, PhD, Takayuki Yamakawa, PhD, Yasuhiro Tsutsui, Tadashi Tanaka, Tomohisa Hatta, PhD, Tohru Natsume, PhD, Toru Kondo, PhD, Yuichi Ishikawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD

Blood (2019) 134 (Supplement_1): 2663.

https://doi.org/10.1182/blood-2019-121869

Published: 2019

Journal Articles

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

Amy N Sexauer, MD PhD, Brian Do, David B Sykes, MD PhD

Blood (2019) 134 (Supplement_1): 2712.

https://doi.org/10.1182/blood-2019-128910

Published: 2019

Journal Articles

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

Zongdong Li, PhD, Wadie F. Bahou, MD

Blood (2017) 130 (Supplement 1): 3763.

https://doi.org/10.1182/blood.V130.Suppl_1.3763.3763

Published: 2017

Journal Articles

Splitting the Functions of a Mitochondrial Iron/Pyrimidine Carrier

Simon A.B. Knight, PhD, Heeyong Yoon, PhD, Emmanuel Lesuisse, PhD, Debkumar Pain, PhD, Andrew Dancis, MD

Blood (2017) 130 (Supplement 1): 2213.

https://doi.org/10.1182/blood.V130.Suppl_1.2213.2213

Published: 2017

Journal Articles

PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells

Liangxian Cao, MD, Arthur Branstrom, PhD, John Baird, PhD, Christopher Trotta, PhD, Joseph Colacino, PhD, Marianne T. Santaguida, BSc, PhD, Diane Heiser, PhD BA, Mark Ma, PhD, Kensuke Kojima, MD PhD, Stuart Peltz, PhD, Edward O'Mara, MD, Robert Spiegel, MD, Marla Weetall, PhD

Blood (2017) 130 (Supplement 1): 1371.

https://doi.org/10.1182/blood.V130.Suppl_1.1371.1371

Published: 2017

Journal Articles

Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5′-Nucleotidase Causing Hereditary Hemolytic Anemia.

Laurent R. Chiarelli, Simone M. Morera, Paola Rognoni, Paola Bianchi, Elisa Fermo, Alessandro Galizzi, Alberto Zanella, Giovanna Valentini

Blood (2007) 110 (11): 1730.

https://doi.org/10.1182/blood.V110.11.1730.1730

Published: 2007

Journal Articles

A Case of Acute Lymphoblastic Leukemia with Eosinophilia.

Zhen Cai, MD, PhD, Gao Feng Zheng, MD, Ji Min Shi, MD, Xiao Yan Han, MD

Blood (2006) 108 (11): 4537.

https://doi.org/10.1182/blood.V108.11.4537.4537

Published: 2006

Journal Articles

Pyrimidine 5′ Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients.

Elisa Fermo, PhD, Anna Marcello, PhD, Paola Bianchi, PhD, Simona Viglio, Laurent R. Chiarelli, Giovanna Valentini, Alberto Zanella, MD

Blood (2005) 106 (11): 3711.

https://doi.org/10.1182/blood.V106.11.3711.3711

Published: 2005

Journal Articles

Functional Analysis of Two Mutants of Pyrimidine 5′ Nucleotidase Causing Nonspherocytic Hemolytic Anemia.

Laurent Chiarelli, Andrea Mattevi, Alessandro Galizzi, Elisa Fermo, Paola Bianchi, Alberto Zanella, Giovanna Valentini

Blood (2004) 104 (11): 1592.

https://doi.org/10.1182/blood.V104.11.1592.1592

Published: 2004

Journal Articles

Molecular characterization of Turkish patients with pyrimidine 5′ nucleotidase-I deficiency

Gunay Balta, Fatma Gumruk, Nurten Akarsu, Aytemiz Gurgey, Cigdem Altay

Blood (2003) 102 (5): 1900–1903.

https://doi.org/10.1182/blood-2003-02-0628

Published: 2003

Journal Articles

Genetic basis of hemolytic anemia caused by pyrimidine 5′ nucleotidase deficiency

Anthony M. Marinaki, Emilia Escuredo, John A. Duley, H. Anne Simmonds, Adolfo Amici, Valeria Naponelli, Giulio Magni, Martin Seip, Isaac Ben-Bassat, Eric H. Harley, Swee Lay Thein, David C. Rees

Blood (2001) 97 (11): 3327–3332.

https://doi.org/10.1182/blood.V97.11.3327

Published: 2001

NARROW

Inhibition of De Novo Pyrimidine Nucleotide Synthesis By the Novel DHODH Inhibitor PTC299 Induces Differentiation and/or Death of AML Cells

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

Splitting the Functions of a Mitochondrial Iron/Pyrimidine Carrier

PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells

Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5′-Nucleotidase Causing Hereditary Hemolytic Anemia.

A Case of Acute Lymphoblastic Leukemia with Eosinophilia.

Pyrimidine 5′ Nucleotidase Deficiency: Clinical and Molecular Characterization of Two New Italian Patients.

Functional Analysis of Two Mutants of Pyrimidine 5′ Nucleotidase Causing Nonspherocytic Hemolytic Anemia.

Molecular characterization of Turkish patients with pyrimidine 5′ nucleotidase-I deficiency

Genetic basis of hemolytic anemia caused by pyrimidine 5′ nucleotidase deficiency

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American Society of Hematology

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American Society of Hematology

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