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Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis

Marcelo A. S. Toledo, Malrun Gatz, Stephanie Sontag, Karoline V. Gleixner, Gregor Eisenwort, Kristina Feldberg, Ahmed E. I. Hamouda, Frederick Kluge, Riccardo Guareschi, Giulia Rossetti, Antonio S. Sechi, Olli M. J. Dufva, Satu M. Mustjoki, Angela Maurer, Herdit M. Schüler, Roman Goetzke, Till Braunschweig, Anne Kaiser, Jens Panse, Mohamad Jawhar, Andreas Reiter, Frank Hilberg, Peter Ettmayer, Wolfgang Wagner, Steffen Koschmieder, Tim H. Brümmendorf, Peter Valent, Nicolas Chatain, Martin Zenke
Journal: Blood
Blood (2021) 137 (15): 2070–2084.
https://doi.org/10.1182/blood.2019004509
Published: 2021
Includes: Supplemental data
Journal Articles

New developments in diagnosis, prognostication, and treatment of advanced systemic mastocytosis

Andreas Reiter, Tracy I. George, Jason Gotlib
Journal: Blood
Blood (2020) 135 (16): 1365–1376.
https://doi.org/10.1182/blood.2019000932
Published: 2020
Journal Articles

BCL-2 Is Expressed in Advanced Mastocytosis and Midaustorin Induces Venetoclax Sensitivity of Mast Leukemia Cell Lines

Danielle Canioni, MD, Josquin Moraly, MD, Ludovic Lhermitte, MD PhD, Laura Polivka, MD, Mélanie Féroul, Julien Rossignol, MD PhD, Laurent Frenzel, MD PhD, Michel Arock, pharmD, PhD, Patrice Dubreuil, PhD, Leila maouche-Chretien, PhD, Olivier Hermine, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1683.
https://doi.org/10.1182/blood-2019-131256
Published: 2019
Journal Articles

Ruxolitinib Reverses Checkpoint Inhibition By Downregulating PD-L1 and PD-L2 Expression on Both Tumor and Stromal Cells in Multiple Myeloma

Haiming Chen, MD PhD, Mingjie Li, BS, Eric Sanchez, BA, Nicole Ng, BS, Erin Yu, BS, Sean Bujarski, BA, Zhengyi Yin, Tara Hekmati, Dylan Field, Jasper Wang, Isabella Nassir, Janna Yu, Justin Huang, David Daniely, Cathy S. Wang, BS, Ning Xu, PhD, James R. Berenson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4402.
https://doi.org/10.1182/blood-2019-130888
Published: 2019
Journal Articles

Safety and Utilization of Midline Catheters in the Management of Acute Myeloid Leukemia: A Single Center Experience

Jose Miguel Torregrosa Diaz, Helene Gardeney, Maria Pilar Gallego Hernanz, Deborah Desmier, Xavier Leleu, MD PhD, Blandine Rammaert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5840.
https://doi.org/10.1182/blood-2019-130884
Published: 2019
Journal Articles

Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease

Yankai Zhang, PhD, Celeste K. Kanne, BA, Jennifer N. Tran, DO, Michael J. Lacagnina, PhD, Peter M. Grace, PhD, Vivien A. Sheehan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3575.
https://doi.org/10.1182/blood-2019-128921
Published: 2019
Journal Articles

Peripheral serotonin causes dengue virus–induced thrombocytopenia through 5HT 2 receptors

Mohamad Fadhli Bin Masri, Chinmay Kumar Mantri, Abhay P. S. Rathore, Ashley L. St. John
Journal: Blood
Blood (2019) 133 (21): 2325–2337.
https://doi.org/10.1182/blood-2018-08-869156
Published: 2019
Includes: Supplemental data
Journal Articles

A Retrospective Case Series Describing the Efficacy of Omalizumab in Systemic Mastocytosis

Calum Anthony Slapnicar, Conrad Scullion Smeenk, Lisa K. Hicks, MD MSc, Jessica Petrucci, MSc, Peter Vadas, MD, Martina Trinkaus, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5470.
https://doi.org/10.1182/blood-2018-99-118415
Published: 2018
Journal Articles

A Retrospective Case Series Describing the Efficacy of Ketotifen in Systemic Mastocytosis

Calum Anthony Slapnicar, Conrad Scullion Smeenk, Lisa K. Hicks, MD MSc, Jessica Petrucci, MSc, Peter Vadas, MD, Martina Trinkaus, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5474.
https://doi.org/10.1182/blood-2018-99-120112
Published: 2018
Journal Articles

Mast Cells Contribute to Brain Microvascular Permeability in Sickle Cell Disease

Aditya M Mittal, Huy Tran, BSMedTech, Varun Sagi, BS, Aithanh Nguyen, Kathryn Luk, Julia Nguyen, BS, Jianxun Lei, PhD, Kalpna Gupta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 269.
https://doi.org/10.1182/blood-2018-99-117246
Published: 2018
Journal Articles

Idelalisib for Treatment of Follicular Lymphoma and Chronic Lymphocytic Leukemia in Clinical Trials Versus the Real World: Treatment Duration and Survival Are Associated with Pretreatment Modified Charlson Score

Steven T Bird, PhD PharmD, Natasha Flowers, BA, Fang Tian, PhD MHS, MPH, Donna Przepiorka, MD PhD, Tae Hyun Jung, PhD, Rongrong Wang, MPH, Zebulin Kessler, BS, Corinne Woods, RPh, MPH, Bo Kim, BA, Barry W. Miller, MS, CNP, Michael Wernecke, BA, Stephen McKean, PhD, Clara Kim, PhD, Kate Gelperin, MD MPH, Jeffrey A Kelman, MD MMSc, David J Graham, MD MPH
Journal: Blood
Blood (2018) 132 (Supplement 1): 2889.
https://doi.org/10.1182/blood-2018-99-116498
Published: 2018
Journal Articles

CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis

Niklas Mueller, Daniel Wicklein, Gregor Eisenwort, Mohamad Jawhar, Daniela Berger, Gabriele Stefanzl, Georg Greiner, Alexandra Boehm, Christoph Kornauth, Leonhard Muellauer, Susanne Sehner, Gregor Hoermann, Wolfgang R. Sperr, Philipp B. Staber, Ulrich Jaeger, Johannes Zuber, Michel Arock, Udo Schumacher, Andreas Reiter, Peter Valent
Journal: Blood
Blood (2018) 132 (18): 1936–1950.
https://doi.org/10.1182/blood-2018-02-833582
Published: 2018
Includes: Supplemental data
Journal Articles

Selection and Efficacy of Cytoreductive Agents in Patients with Mastocytosis Included in the Registry of the European Competence Network on Mastocytosis (ECNM)

Chiara Elena, Serena Merante, MD, Virginia Valeria Ferretti, Lambertus CM Span, MD PhD, Aleksandra Górska, MD, Massimiliano Bonifacio, MD, Cecelia Perkins, Olivier Hermine, MD PhD, Anja Illerhaus, PhD, Sabine Mueller, Roberta Parente, MD, Mohamad Jawhar, MD, Elena Fontana, Alexander Zink, Alex Kilbertus, MD, Akif Selim Yavuz, Michael Doubek, MD PhD, Hans Hagglund, MD PhD, Jens P. Panse, MD, Vito Sabato, Haifa Kathrin Al Ali, Elisabeth Aberer, MD, Marie Anne Morren, Magdalena Lange, MD, David Fuchs, MD, Knut Brockow, MD, Anna Belloni Fortina, Andreas Reiter, MD, Massimo Triggiani, MD, Nikolas von Bubnoff, MD, Karin Hartmann, MD, Jason Gotlib, MD, Luigi Scaffidi, Marek Niedoszytko, MD, Hanneke Kluin-Nelemans, MD PhD, Luca Malcovati, MD, Wolfgang R. Sperr, MD, Peter Valent, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1650.
https://doi.org/10.1182/blood.V130.Suppl_1.1650.1650
Published: 2017
Journal Articles

Effects of the Gamma Secretase Inhibitors (GSI) Dapt (GSI-IX) and LSN424354 on Gene Expression and Shedding of Bcma from Multiple Myeloma and Chronic Lymphocytic Leukemia Tumor Cells

Haiming Chen, MD PhD, Mingjie Li, BS, Eric Sanchez, BA, Camilia Soof, BS, Saurabh Patil, BS, Kyle Udd, BA, Mizi Zhou, MS, Tara Hekmati, BS, Emily Y Wang, Edward J Tanenbaum, BS, Remy Schlossberg, Moryel A Yashar, BS, Cathy S Wang, BS, George Y Tang, PhD, James R Berenson, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5390.
https://doi.org/10.1182/blood.V130.Suppl_1.5390.5390
Published: 2017
Journal Articles

Cytokine Profiling of Human Umbilical Cord Plasma and Human Umbilical Cord Blood Mononuclear Cells

Ekaterina E. Garanina, PhD, Dilara Gatina, Ekaterina V. Martynova, MD PhD, Albert Rizvanov, DSc, PhD, Svetlana Khaiboullina, DrSci, MD, Ilnur Salafutdinov, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4814.
https://doi.org/10.1182/blood.V130.Suppl_1.4814.4814
Published: 2017
Journal Articles

Phase 2 Study of Brentuximab Vedotin in Patients with Advanced Systemic Mastocytosis

John H. Baird, Srdan Verstovsek, MD PhD, Tracy I. George, Isabel Reyes, Justin Abuel, Cecelia Perkins, Cheryl Langford, Kurt Schroeder, Jason Gotlib, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2909.
https://doi.org/10.1182/blood.V130.Suppl_1.2909.2909
Published: 2017
Journal Articles

Enolase 2-Mediated Glucose Metabolism Promotes Cell Proliferation and Survival in Acute Lymphoblastic Leukemia

Liu Chengcheng, Wang Hua, Wang Weida, Liu Wenjian, Lu Yue
Journal: Blood
Blood (2017) 130 (Supplement 1): 5124.
https://doi.org/10.1182/blood.V130.Suppl_1.5124.5124
Published: 2017
Journal Articles

Polo-like Kinase-1 and Aurora Kinase A As Novel Therapeutic Targets in Neoplastic Mast Cells

Manuela Mancini, PhD, Cecilia Monaldi, Sara De Santis, Cristina Papayannidis, MD, Michela Rondoni, MD, Maria Chiara Abbenante, MD, Luana Bavaro, Margherita Martelli, Roberta Zanotti, MD, Livio Pagano, MD, Michele Cavo, MD, Peter Valent, MD, Giovanni Martinelli, MD, Simona Soverini, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5290.
https://doi.org/10.1182/blood.V130.Suppl_1.5290.5290
Published: 2017
Journal Articles

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

Clinical Trials & Observations
Peter Valent, Cem Akin, Dean D. Metcalfe
Journal: Blood
Blood (2017) 129 (11): 1420–1427.
https://doi.org/10.1182/blood-2016-09-731893
Published: 2017
Includes: Supplemental data
Journal Articles

Preliminary Safety and Clinical Activity in a Phase 1 Study of Blu-285, a Potent, Highly-Selective Inhibitor of KIT D816V in Advanced Systemic Mastocytosis (SM)

Mark W. Drummond, PhD MD, Daniel J. DeAngelo, MD PhD, Michael W. Deininger, MD PhD, Deepti Radia, MBBS, MRCPI, FRCPath MSc, MD, Albert Thomas Quiery, MD, Elizabeth O Hexner, MD, Hongliang Shi, MS, Terri Alvarez-Diez, PhD, Erica K. Evans, PhD, Mary Ellen Healy, MS, Beni B. Wolf, MD PhD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2016) 128 (22): 477.
https://doi.org/10.1182/blood.V128.22.477.477
Published: 2016