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Journal Articles

IL-9 in CLL: sensing home and settling down!

Ingo Ringshausen

Blood (2021) 137 (16): 2130–2131.

https://doi.org/10.1182/blood.2020009464

Published: 2021

Journal Articles

Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape of the stromal microenvironment

Laura Patrussi, Noemi Manganaro, Nagaja Capitani, Cristina Ulivieri, Vanessa Tatangelo, Francesca Libonati, Francesca Finetti, Federica Frezzato, Andrea Visentin, Mario Milco D’Elios, Livio Trentin, Gianpietro Semenzato, Cosima T. Baldari

Blood (2021) 137 (16): 2182–2195.

https://doi.org/10.1182/blood.2020005785

Published: 2021

Includes: Supplemental data

Journal Articles

IL-33 Therapy Prevents Acute Lung Injury after Transplantation Via IL-9-Producing Type 2 Innate Lymphoid Cells Induction

Hua Jiang, PhD, Abdulraouf Ramadan, PhD, Becquet Laurine, MS, Tu Szu-Wei, Hong Liu, MS, Courtney Rowan, MD, Xiaowen Liu, PhD, Huanmei Wu, PhD, Jun Wan, PhD, Sophie Paczesny, MD PhD

Blood (2019) 134 (Supplement_1): 583.

https://doi.org/10.1182/blood-2019-123821

Published: 2019

Journal Articles

Abnormal Cytokine Production By Mast Cell Cultures from Sickle Cell Anemia Patients in Response to Inflammatory Stimuli and to Co-Culture with Eosinophils

Myriam Salazar-Terreros, PhDMSc, Kleber Yotsumoto Fertrin, MD PhD, Nicolas Moreno Reyes, PhD, Fernando Ferreira Costa, MD PhD, Carla F. Franco-Penteado, BSc, PhD

Blood (2019) 134 (Supplement_1): 3566.

https://doi.org/10.1182/blood-2019-129509

Published: 2019

Journal Articles

Bnz-1, a Selective γ-Chain Cytokine Inhibitor Has Clinical Activity in Patients with Cutaneous T Cell Lymphoma By Selectively Blocking IL-2, IL-15 and IL-9 Signaling: Results of a Multicenter, Open-Label Phase 1 Trial

Christiane Querfeld, MD PhD, Basem M. William, MRCP,MD, Jonathan E. Brammer, MD, Lubomir Sokol, MD PhD, Yutaka Tagaya, MD PhD, Paul Frohna, MD PhD PharmD, Nazli Azimi, PhD PharmD, Jasmine M. Zain, MD

Blood (2019) 134 (Supplement_1): 1557.

https://doi.org/10.1182/blood-2019-129201

Published: 2019

Journal Articles

Elevated Levels of Interleukin-9 in Obese Microenvironments Promote Leukemia Progression and Chemoresistance in B-Cell Acute Lymphoblastic Leukemia Cells

Jamie A.G. Hamilton, BS, Miyoung Lee, PhD, Ganesh R Talekar, PhD, Curtis J. Henry, PhD

Blood (2019) 134 (Supplement_1): 1468.

https://doi.org/10.1182/blood-2019-126139

Published: 2019

Journal Articles

Blockade of IL-15 Utilizing Bnz-1, a Selective γ-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemia (T-LGLL): Results of a Phase I/II Multi-Center Clinical Trial

Jonathan E. Brammer, MD, Lubomir Sokol, MD PhD, Yutaka Tagaya, MD PhD, Kerry Rogers, Anjali Mishra, PhD, Thomas A. Waldmann, MD, Nazli Azimi, PhD PharmD, Paul Frohna, MD PhD PharmD, Anoshie Ratnayake, MD, Thomas P Loughran, Jr., MD, Karen Ballen, MD

Blood (2019) 134 (Supplement_1): 2835.

https://doi.org/10.1182/blood-2019-129291

Published: 2019

Journal Articles

Syndecan-1 Is Critical in ARF6-Dependent Macropinocytosis Driven By KRAS Mutation in the Pathophysiology of Multiple Myeloma

Tengteng Yu, MD PhD, Liang Lin, PhD, Kenneth Wen, Lijie Xing, MD, Jiye Liu, PhD, Shih-Feng Cho, MD PhD, Phillip Hsieh, Ola Rizq, MD PhD, Yuyin Li, PhD, Liang Yu, Xiang Wu, Eugenio Morelli, MD, Yan Xu, MD, Gang An, MD, Nikhil C. Munshi, MD, Lugui Qiu, MD PhD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD

Blood (2019) 134 (Supplement_1): 4371.

https://doi.org/10.1182/blood-2019-127454

Published: 2019

Journal Articles

Evaluation of the Functional Landscape of Systemic Immunity in Classical Hodgkin Using a Novel Single Cell Platform (Isolight)

Catherine Diefenbach, MD, Linda Lam, PhD, Bruce G. Raphael, MD, Kenneth B. Hymes, MD, Michael L. Grossbard, MD, Tibor Moskovits, MD, Peter Martin, FRCPC, MD MS, Jia Ruan, MD PhD, John P. Leonard, MD, Pratip Chattopadhyay, PhD

Blood (2019) 134 (Supplement_1): 3980.

https://doi.org/10.1182/blood-2019-128366

Published: 2019

Journal Articles

Endothelial JAK3 Expression Enhances Pro-Hematopoietic Angiocrine Function of Sinusoidal Endothelial Cells

José Gabriel Barcia Durán, BS

Blood (2019) 134 (Supplement_1): 2488.

https://doi.org/10.1182/blood-2019-122449

Published: 2019

Journal Articles

FOXM1 and the NPM-ALK/STAT3 Axis Form a Novel Positive Feedback Loop in Promoting the Oncogenesis of ALK-Positive Anaplastic Large Cell Lymphoma

Peng Wang, MD PhD, Moinul Haque, Jing Li, Yung-Hsing Huang, Meaad Almowaled, Carter Bargar, Adam Karpf, Will Chen, Suzanne Turner, Raymond Lai, PhD MD

Blood (2018) 132 (Supplement 1): 3921.

https://doi.org/10.1182/blood-2018-99-115743

Published: 2018

Journal Articles

JAK2 V617F Dimerizes Homodimeric Cytokine Receptors Cytosolic Domains By Requiring Pseudokinase Domain Residues That Promote JAK2 Dimerization and Oncogenic Activity

Emilie Leroy, Thomas Balligand, MD, Stefan N Constantinescu, MD

Blood (2018) 132 (Supplement 1): 50.

https://doi.org/10.1182/blood-2018-99-111336

Published: 2018

Journal Articles

Low Expression of T/NK-Cell Signature Predicts Poor Survival in Patients with Primary Testicular and Diffuse Large B-Cell Lymphoma

Suvi-Katri Leivonen, PhD, Marjukka Pollari, MD, Oscar Brück, Teijo Pellinen, PhD, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, MD PhD, Pirkko-Liisa Kellokumpu-Lehtinen, MD prof, Satu Mustjoki, MDPhD, Sirpa Leppa, MD

Blood (2017) 130 (Supplement 1): 4027.

https://doi.org/10.1182/blood.V130.Suppl_1.4027.4027

Published: 2017

Journal Articles

Results from a First-in-Human Study with Bnz-1: A Novel Peptide Inhibitor of IL-2, IL-9 and IL-15 for the Treatment of T-Cell Malignancies That Safely and Selectively Decreases Regulatory T-Cells, Natural Killer Cells, and CD8 + Central Memory T-Cells

Paul Frohna, MD PhD PharmD, Yutaka Tagaya, MD PhD, Anoshie Ratnayake, MD, Nick Doerr, PhD, Asjad Basheer, PhD, Laith Al-Mawsawi, Woo Jae Kim, PhD, Juan Zapata, PhD, Xisorong Wu, BS, Nazli Azimi, PhD PharmD

Blood (2017) 130 (Supplement 1): 695.

https://doi.org/10.1182/blood.V130.Suppl_1.695.695

Published: 2017

Journal Articles

Post Transplant Cyclophosphamide (PTCy) with Anti-Thymocyte Globulin (ATG) As Gvhd Prophylaxis Is Effective in Haploidentical Peripheral Stem Cell Transplantation and without Increasing Risk of Relapse

Ching Chan Lin, MD, Tzu Ting Chen, MD, Wen Jyi Lo, Ming Yu Lein, MD, Ching Yun Hiseh, MD, Chen Yuan Lin, MD, Li-Yuan Bai, PhD, Chang-Fang Chiu, PhD, Che Hung Lin, MD, Su-Peng Yeh, PhD

Blood (2017) 130 (Supplement 1): 1978.

https://doi.org/10.1182/blood.V130.Suppl_1.1978.1978

Published: 2017

Journal Articles

Single-Cell Multiplex Proteomics Reveals Synergistic Impact of Antigen and Rimiducid-Dependent Stimulatory Signals on Promoting Polyfunctional GoCAR-T Cells Targeting Prostate Stem Cell Antigen (PSCA)

Sean Mackay, Brianna Flynn, Kevin Morse, Colin Ng, Kyle Gallatin, Patrick Paczkowski, Aruna Mahendravada, Nicholas Shinners, David M. Spencer, Aaron Foster, Jing Zhou

Blood (2017) 130 (Supplement 1): 2281.

https://doi.org/10.1182/blood.V130.Suppl_1.2281.2281

Published: 2017

Journal Articles

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Tracy Tiffany Wang, BS, Jun Yang, MD, Yong Zhang, PhD, Meili Zhang, PhD, Kevin C Conlon, MD, Yutaka Tagaya, B.M., PhD, Thomas L Olson, PhD, David J Feith, PhD, Nazli Azimi, Pharm.D., PhD, Thomas A. Waldmann, MD, Thomas P Loughran, Jr., MD

Blood (2017) 130 (Supplement 1): 3585.

https://doi.org/10.1182/blood.V130.Suppl_1.3585.3585

Published: 2017

Journal Articles

Transient Inhibition of the JAK1/3-STAT5 Pathway By Ruxolitinib Is Insufficient to Produce Clinical Benefit in Patients with Indolent Adult T-Cell Leukemia

Sigrid Dubois, PhD, Milos D. Miljkovic, MD, Thomas Fleisher, Jennifer Hsu, RN, Thomas A Waldmann, MD, Kevin C Conlon, MD

Blood (2017) 130 (Supplement 1): 3840.

https://doi.org/10.1182/blood.V130.Suppl_1.3840.3840

Published: 2017

Journal Articles

Cytokine Profiling of Human Umbilical Cord Plasma and Human Umbilical Cord Blood Mononuclear Cells

Ekaterina E. Garanina, PhD, Dilara Gatina, Ekaterina V. Martynova, MD PhD, Albert Rizvanov, DSc, PhD, Svetlana Khaiboullina, DrSci, MD, Ilnur Salafutdinov, PhD

Blood (2017) 130 (Supplement 1): 4814.

https://doi.org/10.1182/blood.V130.Suppl_1.4814.4814

Published: 2017

Journal Articles

JAK3 Variants in Adults with Myeloid Malignancies and Potential for Response to JAK3 Inhibition

Rita Assi, MD, Christopher B Benton, MD, Ahmed Al Rawi, Kamal Chamoun, MD, Feng Wang, PhD, Sherry Pierce, BSN, BA, Keyur P. Patel, MBBS, PhD, Betty K. Hamilton, MD, Courtney D. DiNardo, MDMSc, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Tapan Kadia, MD, Srdan Verstovsek, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 1381.

https://doi.org/10.1182/blood.V130.Suppl_1.1381.1381

Published: 2017

NARROW

IL-9 in CLL: sensing home and settling down!

Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape of the stromal microenvironment

IL-33 Therapy Prevents Acute Lung Injury after Transplantation Via IL-9-Producing Type 2 Innate Lymphoid Cells Induction

Abnormal Cytokine Production By Mast Cell Cultures from Sickle Cell Anemia Patients in Response to Inflammatory Stimuli and to Co-Culture with Eosinophils

Bnz-1, a Selective γ-Chain Cytokine Inhibitor Has Clinical Activity in Patients with Cutaneous T Cell Lymphoma By Selectively Blocking IL-2, IL-15 and IL-9 Signaling: Results of a Multicenter, Open-Label Phase 1 Trial

Elevated Levels of Interleukin-9 in Obese Microenvironments Promote Leukemia Progression and Chemoresistance in B-Cell Acute Lymphoblastic Leukemia Cells

Blockade of IL-15 Utilizing Bnz-1, a Selective γ-Chain Inhibiting Peptide, Is Safe and Has Clinical Activity in Patients with T-Cell Large Granular Lymphocytic Leukemia (T-LGLL): Results of a Phase I/II Multi-Center Clinical Trial

Syndecan-1 Is Critical in ARF6-Dependent Macropinocytosis Driven By KRAS Mutation in the Pathophysiology of Multiple Myeloma

Evaluation of the Functional Landscape of Systemic Immunity in Classical Hodgkin Using a Novel Single Cell Platform (Isolight)

Endothelial JAK3 Expression Enhances Pro-Hematopoietic Angiocrine Function of Sinusoidal Endothelial Cells

FOXM1 and the NPM-ALK/STAT3 Axis Form a Novel Positive Feedback Loop in Promoting the Oncogenesis of ALK-Positive Anaplastic Large Cell Lymphoma

JAK2 V617F Dimerizes Homodimeric Cytokine Receptors Cytosolic Domains By Requiring Pseudokinase Domain Residues That Promote JAK2 Dimerization and Oncogenic Activity

Low Expression of T/NK-Cell Signature Predicts Poor Survival in Patients with Primary Testicular and Diffuse Large B-Cell Lymphoma

Results from a First-in-Human Study with Bnz-1: A Novel Peptide Inhibitor of IL-2, IL-9 and IL-15 for the Treatment of T-Cell Malignancies That Safely and Selectively Decreases Regulatory T-Cells, Natural Killer Cells, and CD8 + Central Memory T-Cells

Post Transplant Cyclophosphamide (PTCy) with Anti-Thymocyte Globulin (ATG) As Gvhd Prophylaxis Is Effective in Haploidentical Peripheral Stem Cell Transplantation and without Increasing Risk of Relapse

Single-Cell Multiplex Proteomics Reveals Synergistic Impact of Antigen and Rimiducid-Dependent Stimulatory Signals on Promoting Polyfunctional GoCAR-T Cells Targeting Prostate Stem Cell Antigen (PSCA)

Blockade of IL-2 and IL-15 Gamma Chain Receptor Signaling Decreases Leukemic Cell Viability in T-Cell Large Granular Lymphocyte Leukemia and Adult T-Cell Leukemia

Transient Inhibition of the JAK1/3-STAT5 Pathway By Ruxolitinib Is Insufficient to Produce Clinical Benefit in Patients with Indolent Adult T-Cell Leukemia

Cytokine Profiling of Human Umbilical Cord Plasma and Human Umbilical Cord Blood Mononuclear Cells

JAK3 Variants in Adults with Myeloid Malignancies and Potential for Response to JAK3 Inhibition

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