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Journal Articles

RGL2 Deficiency Impairs Human Erythropoiesis By Altering Terminal Erythroid Differentiation and Apoptosis

Harry Lesmana, MD, Georgios E Christakopoulos, MD, Mary Risinger, Haripriya Sakthivel, Omar Niss, MD, Theodosia A. Kalfa, MD PhD

Blood (2017) 130 (Supplement 1): 8.

https://doi.org/10.1182/blood.V130.Suppl_1.8.8

Published: 2017

Journal Articles

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Acute Myeloid Leukemia

Hui Yang, MD PhD, Zachary S. Bohannan, MA, Zhihong Fang, Irene Gañán-Gómez, PhD, Yue Wei, PhD, Linda J. Paradiso, DVM, MBA, Hiroyuki Iwamura, Dphil, Guillermo Garcia-Manero, MD

Blood (2016) 128 (22): 2756.

https://doi.org/10.1182/blood.V128.22.2756.2756

Published: 2016

Journal Articles

Phase 1 Results of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures

Blood (2016) 128 (22): 1640.

https://doi.org/10.1182/blood.V128.22.1640.1640

Published: 2016

Journal Articles

The Atypical Gtpase Rhou Lies Downstream IL6/STAT3 and Regulates Myeloma Plasma Cells Adhesion/Motility

Sara Nunes Canovas, PhDstudent, Marilena Carrino, PhDstudent, Sabrina Manni, PhD, Laura Quotti Tubi, PhD, Martina Manzoni, PhD, Gregorio Barilà, MD, Livio Trentin, MD, Renato Zambello, MD, Antonino Neri, Pr, MD, Gianpietro Semenzato, Francesco Piazza, MD

Blood (2016) 128 (22): 5661.

https://doi.org/10.1182/blood.V128.22.5661.5661

Published: 2016

Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD

Blood (2016) 128 (22): 750.

https://doi.org/10.1182/blood.V128.22.750.750

Published: 2016

Journal Articles

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures

Guillermo Garcia-Manero, MD, Hui Yang, MD PhD, Zhihong Fang, Courtney DiNardo, MD, Elias Jabbour, MD, Naveen Pemmaraju, MD, Ricardo Delumpa, RN, Christopher Loiselle, RN, Susan Denton, RN, Whitney Smith, Hiroyuki Iwamura, PhD, Teletha Gipson, PhD, Michele Rosner, MS, Timothy Madden, PharmD, Thomas J. Myers, MD, Linda J. Paradiso, DVM, MBA

Blood (2015) 126 (23): 3800.

https://doi.org/10.1182/blood.V126.23.3800.3800

Published: 2015

Journal Articles

Hsp90 at the Hub of Metabolic Homeostasis in Malignant B Cells

Nieves Calvo-Vidal, PhD, Jayeshkumar Patel, MS, Jan Krumsiek, PhD, Thibault Dupont, Rebecca Goldstein, BA, Shao Ning Yang, MS, Ari Melnick, MD, Gabriela Chiosis, PhD, Leandro Cerchietti, MD

Blood (2014) 124 (21): 1764.

https://doi.org/10.1182/blood.V124.21.1764.1764

Published: 2014

Journal Articles

T Cells Engineered For Resistance To Mycophenolate Mofetil Demonstrate Enhanced Expansion and Improved Tumour Control In Immunosuppressed Hosts

James Edward Griffin, MD, Shoa-An Xue, Benjamin J Carpenter, Pedro Velica, PhD, Angelika Holler, Sara Ghorashian, MD, Emma Nicholson, MD, Martin Pule, MD, Ronjon Chakraverty, MD, PhD

Blood (2013) 122 (21): 4486.

https://doi.org/10.1182/blood.V122.21.4486.4486

Published: 2013

Journal Articles

Perturbation Of Gpsm2/Lgn Enhances Haematopoietic Stem Cell Function

Stephen Ting, MB BS, FRACP, FRCPA, PhD, Nicole Lee, PhD, Ming Li, PhD, Sarah Russell, PhD, Nathan Godde, PhD, Patrick Humbert, PhD, Fumio Matsuzaki, PhD, Eric Deneault, PhD, Guy Sauvageau, MD, PhD

Blood (2013) 122 (21): 1176.

https://doi.org/10.1182/blood.V122.21.1176.1176

Published: 2013

Journal Articles

In Vivo Selection of Mycophenolate Mofetil-Resistant T Cells for Adoptive Immunotherapy.

James Edward Griffin, MD, Ben Carpenter, MD, Emma Nicholson, MD, Shao-an Xue, PhD, Martin Pule, MD, Hans Stauss, MD, PhD, Ronjon Chakraverty, MD, PhD

Blood (2012) 120 (21): 3008.

https://doi.org/10.1182/blood.V120.21.3008.3008

Published: 2012

Journal Articles

Overexpression of Rasgrf1, a Guanine Nucleotide Exchange Factor in Chronic Lymphocytic Leukemia.

Sanjai Sharma, MD, MB, BS

Blood (2009) 114 (22): 1253.

https://doi.org/10.1182/blood.V114.22.1253.1253

Published: 2009

Journal Articles

Mycophenolic Acid Inhibits the Proliferation and Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Guanosine Depletion.

Weijie Cao, Lizhen Liu, Xiaoyu Lai, Xiaohong Yu, He Huang, MD, PhD

Blood (2009) 114 (22): 1454.

https://doi.org/10.1182/blood.V114.22.1454.1454

Published: 2009

Journal Articles

P-REX1: A Novel RAC Activing Guanine-Nucleotide Exchange Factor in Human Platelets.

Alex Morgan-Spencer, B.A., Daniel Greenberg, MD

Blood (2007) 110 (11): 3639.

https://doi.org/10.1182/blood.V110.11.3639.3639

Published: 2007

Journal Articles

Clinical-Biomarker Correlations in Adult AML Patients in a Phase I Trial of AVN944 Support Observations of Clinical Effect and Provide Hypotheses for Patient Selection Criteria for Further Clinical Trials.

Rebecca B. Klisovic, MD, Steven Coutre, MD, Tibor J. Kovacsovics, MD, Hagop M. Kantarjiam, MD, Guido J. Tricot, MD, Jeffrey W. Strovel, PhD, Thomas Genna, RhP, David K. Bol, PhD, Michael Hamilton, MD, Beverly S. Mitchell, MD

Blood (2007) 110 (11): 896.

https://doi.org/10.1182/blood.V110.11.896.896

Published: 2007

Journal Articles

Genetic and Biochemical Biomarkers of IMPDH Inhibition in Phase I Dose Escalation of AVN-944 for Hematologic Malignancies.

Jeffrey W. Strovel, PhD, Marion Chakiath, M.S, Pachai Natarajan, M.S., Tammy Lawrence, M.S., Karina M. Zuck, Ph.D., Lenore Urbani, Ph.D., Beverly S. Mitchell, M.D., David K. Bol, Ph.D.

Blood (2006) 108 (11): 2590.

https://doi.org/10.1182/blood.V108.11.2590.2590

Published: 2006

Journal Articles

Molecular Cloning of DOCK10/Zizimin3, a Novel Cdc42/Rac-Interacting Protein Specifically Induced by IL4 in B Lymphocytes.

Estefania Yelo, MSc, Lourdes Gimeno, PhD, Maria Victoria Bernardo, PhD, Maria Juliana Majado, MD, PhD, Maria Rocio Alvarez, PhD, Antonio Parrado, PhD

Blood (2006) 108 (11): 939.

https://doi.org/10.1182/blood.V108.11.939.939

Published: 2006

Journal Articles

The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model.

Jugnu Jain, PhD, Jianguo Ma, PhD, Brinley Furey, BS, Christian Recher, MS, Cecile Demur, PhD, Srinivasu Poondru, PhD, Jianbo Zhang, PhD, Shaolan Li, MD, Brant Firestone, BS, Karen Olson, PhD, Maura Murphy, PhD, Jennifer Taylor, PhD, Greg Henkel, PhD, Edward Ball, MD, Yung-Mae Yao, PhD, Susan Almquist, MS, Russell Hoover, PhD

Blood (2004) 104 (11): 2530.

https://doi.org/10.1182/blood.V104.11.2530.2530

Published: 2004

Journal Articles

A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment.

Kenji Ishitsuka, M.D., Ph.D, Teru Hideshima, M.D., Ph.D, Makoto Hamasaki, M.D., Ph.D, Raje Noopur, M.D., Ph.D, Kumar Shaji, M.D., Ph.D, Hiroshi Yasui, M.D., Ph.D, Aldo M. Roccaro, M.D., Dharminder Chauhan, Ph.D, Klaus Podar, M.D., Ph.D, Yu-Zu Tai, Ph.D, Jugnu Jain, Ph.D, Kenneth C. Anderson, M.D., Ph.D

Blood (2004) 104 (11): 2468.

https://doi.org/10.1182/blood.V104.11.2468.2468

Published: 2004

Journal Articles

Rhogtpase RAC2 Is Required for In Vivo Transformation Activity by P210 Bcr-Abl Fusion Oncogene.

Nithya Krishnan, PhD, Jeff R. Bailey, Victoria Summey-Harner, Claudio Brunstein, PhD, Catherine M. Verfaillie, MD, David A. Williams, MD

Blood (2004) 104 (11): 717.

https://doi.org/10.1182/blood.V104.11.717.717

Published: 2004

Journal Articles

Induction of apoptosis in IL-3–dependent hematopoietic cell lines by guanine nucleotide depletion

Jing Jin Gu, Karen Gathy, Lalaine Santiago, Eric Chen, Min Huang, Lee M. Graves, Beverly S. Mitchell

Blood (2003) 101 (12): 4958–4965.

https://doi.org/10.1182/blood-2002-08-2547

Published: 2003

NARROW

RGL2 Deficiency Impairs Human Erythropoiesis By Altering Terminal Erythroid Differentiation and Apoptosis

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Acute Myeloid Leukemia

Phase 1 Results of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures

The Atypical Gtpase Rhou Lies Downstream IL6/STAT3 and Regulates Myeloma Plasma Cells Adhesion/Motility

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Anti-Leukemia Effect of FF-10501-01, a Novel Inosine 5'-Monophosphate Dehydrogenase Inhibitor, in Advanced Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS), Including Hypomethylating Agent (HMA) Failures

Hsp90 at the Hub of Metabolic Homeostasis in Malignant B Cells

T Cells Engineered For Resistance To Mycophenolate Mofetil Demonstrate Enhanced Expansion and Improved Tumour Control In Immunosuppressed Hosts

Perturbation Of Gpsm2/Lgn Enhances Haematopoietic Stem Cell Function

In Vivo Selection of Mycophenolate Mofetil-Resistant T Cells for Adoptive Immunotherapy.

Overexpression of Rasgrf1, a Guanine Nucleotide Exchange Factor in Chronic Lymphocytic Leukemia.

Mycophenolic Acid Inhibits the Proliferation and Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Guanosine Depletion.

P-REX1: A Novel RAC Activing Guanine-Nucleotide Exchange Factor in Human Platelets.

Clinical-Biomarker Correlations in Adult AML Patients in a Phase I Trial of AVN944 Support Observations of Clinical Effect and Provide Hypotheses for Patient Selection Criteria for Further Clinical Trials.

Genetic and Biochemical Biomarkers of IMPDH Inhibition in Phase I Dose Escalation of AVN-944 for Hematologic Malignancies.

Molecular Cloning of DOCK10/Zizimin3, a Novel Cdc42/Rac-Interacting Protein Specifically Induced by IL4 in B Lymphocytes.

The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model.

A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment.

Rhogtpase RAC2 Is Required for In Vivo Transformation Activity by P210 Bcr-Abl Fusion Oncogene.

Induction of apoptosis in IL-3–dependent hematopoietic cell lines by guanine nucleotide depletion

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American Society of Hematology

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American Society of Hematology

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