1-20 of 20
functional genomics
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL

Lorena Fontan, Rebecca Goldstein, Gabriella Casalena, Matthew Durant, Matthew R. Teater, Jimmy Wilson, Jude Phillip, Min Xia, Shivem Shah, Ilkay Us, Himaly Shinglot, Ankur Singh, Giorgio Inghirami, Ari Melnick
Journal: Blood
Blood (2021) 137 (6): 788–800.
https://doi.org/10.1182/blood.2019004713
Published: 2021
Includes: Supplemental data
Journal Articles

CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Dennis Buckley, Olga Dashevsky, PhD, Sondra L. Downey-Kopyscinski, PhD, Huihui Tang, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Brian Glassner, PhD, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Johanna B Bruggenthies, Quinlan Sievers, BA, Haley Poarch, Nicholas P Kwiatkowski, PhD, Tinghu Zhang, PhD, Jacob Laubach, MD, Robert L. Schlossman, MD, Paul Richardson, Aedin Culhane, PhD, Richard WJ Groen, PhD, Eric S. Fischer, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, Daniel Auclair, PhD, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, Benjamin L. Ebert, MDPhD, James Bradner, MD, Nathanae Gray, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1367.
https://doi.org/10.1182/blood-2018-99-116232
Published: 2018
Journal Articles

Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics

Poornima Ramkumar, PhD, Jaime Leong, B.S., Meghan Seyler, B.S., Stratton J Georgoulis, Axel Hyrenius Wittsten, PhD, Priya Choudhry, PhD, Kole Roybal, PhD, Arun P Wiita, MD PhD, Martin Kampmann, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1926.
https://doi.org/10.1182/blood-2018-99-115368
Published: 2018
Journal Articles

CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior

Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Olga Dashevsky, PhD, Brian Glassner, PhD, Olivia Bare, John G Doench, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1915.
https://doi.org/10.1182/blood-2018-99-114986
Published: 2018
Journal Articles

Integration of Functional Dependencies and Molecular Alterations of Myeloma Cells

Ricardo De Matos Simoes, PhD, Geoffrey Matthews, PhD, Ryosuke Shirasaki, MD PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Paul Hengeveld, Johanna Bruggenthies, Eugen Dhimolea, PhD, Huihui Tang, PhD, Megan Bariteau, Andrew Aguirre, MD PhD, Quinlan Sievers, BA, Benjamin L. Ebert, MD PhD, Brian Glassner, PhD, Christopher J. Ott, PhD, Dennis Buckley, Nicholas P Kwiatkowski, PhD, Jonathan D. Licht, MD, Nathanael Gray, PhD, Joshua Dempster, PhD, Richard WJ Groen, PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Aedin Culhane, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1212.
https://doi.org/10.1182/blood.V130.Suppl_1.1212.1212
Published: 2017
Journal Articles

Gene-Drug Interactions in AML Patients Identified By RNA Sequencing and Comprehensive Ex Vivo Drug Sensitivity and Resistance Testing

Ashwini Kumar, MRes, Dishaben Rameshbhai Malani, MSc, Bhagwan Yadav, PhD, Matti Kankainen, PhD, Swapnil Potdar, MSc, Mika Kontro, MD, Kimmo Porkka, MD PhD, Olli Kallioniemi, MD PhD, Simon Anders, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1398.
https://doi.org/10.1182/blood.V130.Suppl_1.1398.1398
Published: 2017
Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
https://doi.org/10.1182/blood.V130.Suppl_1.286.286
Published: 2017
Journal Articles

Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology

Ricardo De Matos Simoes, PhD, Geoffrey M. Matthews, PhD, Yiguo Hu, MD PhD, Brian Glassner, PhD, Megan A. Bariteau, BSc, Michal Sheffer, PhD, Ryosuke Shirasaki, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 486.
https://doi.org/10.1182/blood.V128.22.486.486
Published: 2016
Journal Articles

Functional Genomics and Computational Approaches Identify Novel Small Molecules Targeting Quiescent Leukemia Stem Cells

Costakis Frangou, PhD, Jason Den Haese, PhD, Jordan Warunek, Scott Portwood, MS, MBA, Norma J Nowak, PhD, Andrei V Gudkov, PhD, Katerina Gurova, PhD, Meir Wetzler, MD, Eunice S. Wang, MD
Journal: Blood
Blood (2015) 126 (23): 1391.
https://doi.org/10.1182/blood.V126.23.1391.1391
Published: 2015
Journal Articles

A New Model for Studying the Dissemination of Myeloma Cells throughout the Bone Marrow Using Embryonic Zebrafish

Aldo M Roccaro, MD PhD, Antonio Sacco, BS, Dongdong Ma, MD PhD, Jiantao Shi, Yuji Mishima, PhD, Michele Moschetta, MD, Robert I. Handin, MD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2015) 126 (23): 915.
https://doi.org/10.1182/blood.V126.23.915.915
Published: 2015
Journal Articles

Phenotypic, Genotypic, and Functional Characterization Of AML-Derived Endothelial Cells

Russell J Pizzo, Myra Coppage, PhD, Karen Rosell, BS, Kimberly Morse, MS, Jane L. Liesveld, MD
Journal: Blood
Blood (2013) 122 (21): 1411.
https://doi.org/10.1182/blood.V122.21.1411.1411
Published: 2013
Journal Articles

GATA-1-Dependent and -Independent Modes of Establishing the Erythroid Cell Genetic Network.

Nathaniel James Pope, Emery H Bresnick, PhD
Journal: Blood
Blood (2012) 120 (21): 2083.
https://doi.org/10.1182/blood.V120.21.2083.2083
Published: 2012
Journal Articles

Are Gene Expression Signatures Treatment Specific?

Parantu K Shah, PhD, Stephane Minvielle, PhD, Hervé Avet-Loiseau, MD, PhD, Cheng Li, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2011) 118 (21): 807.
https://doi.org/10.1182/blood.V118.21.807.807
Published: 2011
Journal Articles

Functional Genomics Approaches to Platelet Signaling

Willem Hendrik Ouwehand, MD, PhD, Nicole Soranzo
Journal: Blood
Blood (2010) 116 (21): SCI-37.
https://doi.org/10.1182/blood.V116.21.SCI-37.SCI-37
Published: 2010
Journal Articles

Functional Genomics in Zebrafish Permits Rapid Characterization of Novel Platelet Membrane Proteins

Isabelle I Salles, Marie N O’Connor, Nicholas A. Watkins, Adam Walker, Stephen F Garner, Chris I Jones, Iain Macauley, Michael Steward, Jaap Jan Zwaginga, Sarah L Bray, Ana Cvejic, Frank Dudbridge, Bernard de Bono, Hans Deckmyn, Derek L. Stemple, Willem Ouwehand, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2860.
https://doi.org/10.1182/blood.V112.11.2860.2860
Published: 2008
Journal Articles

RNAi-Based Functional Genomics Screening of the Human Kinome Identifies Major Growth Regulating Kinases in Acute Myeloid Leukemia Cells

Raoul Tibes, MD, PhD, Ashish Choudhary, PhD, Amanda Henrichs, BS, Sadia Guled, BS, Irma Monzon, BS, Lourdes Peralta, BS, Jeff Kiefer, PhD, David Azorsa, PhD
Journal: Blood
Blood (2008) 112 (11): 2951.
https://doi.org/10.1182/blood.V112.11.2951.2951
Published: 2008
Journal Articles

Identification of Sensitizing Targets to the Hypomethylating Agent 5-Azacytidine in Acute Myeloid Leukemia Cells Using RNAi-Based Functional Genomics Screening

Raoul Tibes, MD, PhD, Ashish Choudhary, PhD, Amanda Henrichs, BS, Sadia Guled, BS, Irma Monzon, BS, Lourdes Peralta, BS, Spyro Mousses, PhD, David Azorsa, PhD
Journal: Blood
Blood (2008) 112 (11): 2665.
https://doi.org/10.1182/blood.V112.11.2665.2665
Published: 2008
Journal Articles

Functional Genomics of the Platelet ADP and Collagen Signalling Pathways.

Stephen F Garner, Chris I Jones, Jonathan Stephens, Sarah L Bray, Will Angenent, Philippa Burns, Richard W Farndale, Catherine Rice, Frank Dudbridge, Nick Watkins, Bernard de Bono, Panos Deloukas, Alison H Goodall, Willem Ouwehand
Journal: Blood
Blood (2008) 112 (11): 1844.
https://doi.org/10.1182/blood.V112.11.1844.1844
Published: 2008
Journal Articles

Differential Sensitivity of Normal and CML-Derived CD34+ Cells to Inhibition of SHP-2 Gene Expression by RNA Interference (RNAi).

Michaela Scherr, PhD, Karin Battmer, Anuhar Chaturvedi, Beate Schultheis, MD, Arnold Ganser, MD, Matthias Eder, MD
Journal: Blood
Blood (2004) 104 (11): 2778.
https://doi.org/10.1182/blood.V104.11.2778.2778
Published: 2004
Journal Articles

Functional Analysis of the Differential Gene Expression Profile of Human HSC Using a Functional Genomics Screen in the Zebrafish.

Craig E. Eckfeldt, Eric M. Mendenhall, Stephen C. Ekker, Catherine M. Verfaillie
Journal: Blood
Blood (2004) 104 (11): 136.
https://doi.org/10.1182/blood.V104.11.136.136
Published: 2004