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Journal Articles

Transcription Factor Induction of Ectopic Vascular Blood Stem Cell Niches In Vivo

Elliott J. Hagedorn, PhD, Julie R. Perlin, PhD, Rebecca J. Freeman, BS, Clara Mao, BS, Inés Fernández-Maestre, BS, Madeleine L. Daily, B.S., Christopher R. D'Amato, B.S., Samuel J. Wattrus, B.S., Tianxiao Han, BS, Michael J. Fairchild, PhD, Raquel Riquelme, Brian Li, B.S., Shelby E. Redfield, B.S., Samantha H. Collins, B.S., Asher Lichtig, BS, Song Yang, PhD, Yi Zhou, Balvir Kunar, Jesus M Gomez-Salinero, PhD, Theresa T. Dinh, PhD, Junliang Pan, MD PhD, Karoline Holler, B.S., Eugene Butcher, Alexander Van Oudenaarden, Shahin Rafii, MD, Jan Philipp Junker, PhD, Leonard I Zon, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 525.
https://doi.org/10.1182/blood-2019-127219
Published: 2019
Journal Articles

The Influence of FLT3-ITD Mutation on Baseline Levels of Selected Cytokines and Soluble Adhesion Molecules in Acute Myeloid Leukemia with Mutated NPM-1

Tomas Kupsa, MD PhD, Jan M Horacek, MD PhD, Ladislav Jebavy, MD PhD, Pavel Zak, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5111.
https://doi.org/10.1182/blood-2019-126433
Published: 2019
Journal Articles

Prothrombotic State, Platelet Activation and Netosis in Systemic Lupus Erythematosus

Elena Monzón Manzano, Ihosvany Fernandez-Bello, Raul Justo Sanz, Larissa Valor, Francisco Javier López-Longo, Angel Robles, Teresa Álvarez Roman, Miguel A Canales, MD PhD, Victor Jimenez-Yuste, Nora Butta, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1141.
https://doi.org/10.1182/blood-2019-127991
Published: 2019
Journal Articles

Reveal the Neutrophil: Elucidating the Role of a Neutrophil-Specific JAK2-V617F Mutation

Tobias Ronny Haage, MD, Andreas Johann Müller, Priyadharshini Arunachalam, Thomas Fischer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2965.
https://doi.org/10.1182/blood-2019-122660
Published: 2019
Journal Articles

Synergistic Targeting of BTK and E-Selectin/CXCR4 in the Microenvironment of Mantle Cell Lymphomas

Mahesh Basyal, Weiguo Zhang, MD PhD, Nalini B Patel, Sujan Piya, PhD, Hongying Zhang, MD PhD, William E. Fogler, PhD, William G Rice, PhD, John L. Magnani, PhD, Gautam M. Borthakur, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3802.
https://doi.org/10.1182/blood-2019-126030
Published: 2019
Journal Articles

Transcriptome Profiling of Glycosylation Genes Defines Correlation with E-Selectin Ligand Expression and Clinical Outcome in AML

Amanda R. Leonti, MS, Laura Pardo, Todd A. Alonzo, PhD, Robert B. Gerbing, Lisa Eidenschink Brodersen, PhD, Rhonda E. Ries, MA, Jenny L. Smith, MSc, MD, Quy Le, PhD, Richard Aplenc, MD PhD, E. Anders Kolb, MD, John L. Magnani, PhD, William E. Fogler, PhD, Michael R. Loken, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3772.
https://doi.org/10.1182/blood-2019-124525
Published: 2019
Journal Articles

A Pilot Study on Biomarkers of Vascular Injury in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura

Camila Masias, MDMPH, Rawan Tarawneh, MD, Haiwa Wu, Krista Carter, Shangbin Yang, PhD, Alcinda Flowers, MD, Marie Scully, Spero Cataland, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2377.
https://doi.org/10.1182/blood-2019-130369
Published: 2019
Journal Articles

Dysregulation of Hemostatic Biomarkers, Inflammatory Biomarkers, and Alteration of Cellular Indices As Predictors of Adverse Outcomes in Pulmonary Embolism Patients

Iman Darwish, Yevgeniy Brailovsky, DO, Amir Darki, MD MSc, Debra Hoppensteadt, PhD, Brett Slajus, Emily Bontekoe, Frank De Stefano, Jawed Fareed, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2408.
https://doi.org/10.1182/blood-2019-126876
Published: 2019
Journal Articles

Effects of Targeting the Interleukin-1 Receptor in a Murine Model of Sickle Cell Disease

Jessica Venugopal, PhD, Jintao Wang, PhD, Chiao Guo, Daniel Eitzman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2259.
https://doi.org/10.1182/blood-2019-128980
Published: 2019
Journal Articles

High E-Selectin Ligand Expression Contributes to Chemotherapy-Resistance in Poor Risk Relapsed and Refractory (R/R) Acute Myeloid Leukemia (AML) Patients and Can be Overcome with the Addition of Uproleselan

Daniel J. DeAngelo, MD PhD, Brian A Jonas, MD PhD, Jane L. Liesveld, MD, Dale L. Bixby, MD, Anjali S. Advani, MD, Paula Marlton, MBBS (Hons), FRACP, FRCPA, Michael E O'Dwyer, MD, William E. Fogler, PhD, John L. Magnani, PhD, Mary M Chen, MD PhD, Eric J. Feldman, MD, Helen M Thackray, MD, Pamela S. Becker, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2690.
https://doi.org/10.1182/blood-2019-123744
Published: 2019
Journal Articles

A Double-Blind, Placebo-Controlled, Phase 3 Registration Trial to Evaluate the Efficacy of Uproleselan (GMI-1271) with Standard Salvage Chemotherapy in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia

Daniel J. DeAngelo, MD PhD, Harry P. Erba, MD PhD, Brian A Jonas, MD PhD, Michael E O'Dwyer, MD, Paula Marlton, MBBS (Hons), FRACP, FRCPA, Gerwin Huls, MD PhD, Jane L. Liesveld, MD, Brenda Cooper, MD, Bhavana Bhatnagar, DO, Geoffrey L. Uy, MD, Gavin Cull, MB, BS, FRACP, FRCPA, Michael B. Armstrong, MD PhD, William E. Fogler, PhD, Mary M Chen, MD PhD, John L. Magnani, PhD, Helen M Thackray, MD, Eric J. Feldman, MD, Anjali S. Advani, MD, Pamela S. Becker, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2650.
https://doi.org/10.1182/blood-2019-123816
Published: 2019
Journal Articles

Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways

Ingrid G Winkler, PhD, Valerie Barbier, Masters, Joshua Tay, PhD, Jean-Pierre Levesque, PhD, John L. Magnani, PhD, Corrine E Fiveash, BSc(Hons), Johanna D Erbani
Journal: Blood
Blood (2019) 134 (Supplement_1): 2657.
https://doi.org/10.1182/blood-2019-132212
Published: 2019
Journal Articles

JAK2V617F-Mediated Endothelial Dysfunction Promotes Congestive Heart Failure in a Murine Model of Myeloproliferative Neoplasm

Melissa Castiglione, BS, Christopher Mazzeo, BS, Ya-Ping Jiang, Juei-Suei Chen, Wei Yin, Richard Lin, Huichun Zhan, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 7.
https://doi.org/10.1182/blood-2019-131372
Published: 2019
Journal Articles

CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche

Johanna D Erbani, Joshua Tay, PhD, Valerie Barbier, Masters, Jean-Pierre Levesque, PhD, John L. Magnani, PhD, Ingrid G Winkler, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 907.
https://doi.org/10.1182/blood-2019-132233
Published: 2019
Journal Articles

The Pro-Adhesive and Reduced Angiogenic Properties of Endothelial Colony Forming Cells (ECFC) from JAK2 V617F MPN Patients Are Not Related to the Expression of the JAK2 mutation in These Cells: A Potential Role of ADAM17

Bruno Kosa Lino Duarte, Stephanie Ospina-Prieto, PhD, Lucia Helena Siqueira, Jessica O F Guanaes, MSc, Fernando Ferreira Costa, MD PhD, Margareth C Ozelo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3618.
https://doi.org/10.1182/blood-2019-131488
Published: 2019
Journal Articles

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Christina Caruso, MD, Xiao Zhang, BS, Yumiko Sakurai, MSc, Wei Li, MD, Meredith E. Fay, BS, Marcus A. Carden, MD, David R. Myers, PhD, Robert G. Mannino, PhD, Clinton H. Joiner, MD PhD, Michael D. Graham, PhD, Wilbur A. Lam, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3560.
https://doi.org/10.1182/blood-2019-125408
Published: 2019
Journal Articles

Improved Bone Marrow Homing of NK Cells through PM21 Particle Stimulated Enhancement of Fucosylation of E-Selectin Ligand

Jeremiah Oyer, BSc, Nitin Chakravarti, PhD, Robert Igarashi, PhD, Deborah Altamore, PhD, Dean Anthony Lee, MD PhD, Alicja Joanna Copik, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3598.
https://doi.org/10.1182/blood-2019-131137
Published: 2019
Journal Articles

Alliance A041701 - a Randomized Phase 2/3 Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia (AML) Receiving Intensive Induction Chemotherapy

Geoffrey L. Uy, MD, Jun Yin, PhD, Heidi D. Klepin, MD, Shira Dinner, MD, Anthony J. Jaslowski, MD, Stephen A. Strickland, MD, Jane L. Liesveld, MD, John C. Byrd, MD, Richard M. Stone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1366.
https://doi.org/10.1182/blood-2019-127142
Published: 2019
Journal Articles

Vascular E-Selectin Acts As a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature

Ingrid G Winkler, PhD, Valerie Barbier, Masters, Jessica Lowe, BSc(Hons), Joshua Tay, PhD, John L Magnani, PhD, Paula Marlton, Anthony K Mills, FRACP, FRCPA, MBBS, Andrew Perkins, MBBS, PhD FRCPA, FRACP, Corrine E Fiveash, BSc(Hons), Johanna M Erbani, PhDstudent, Jean-Pierre Levesque, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4552.
https://doi.org/10.1182/blood-2018-99-120376
Published: 2018
Journal Articles

A Novel Role for Bst2 and E-Selectin in IFNg-Stimulated HSC Niche Relocalization

Katie A Matatall, PhD, Hamilton Wang, PhD, Roman Jaksik, PhD, Marek Kimmel, PhD DSc, Dongsu Park, PhD, Katherine Y. King, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 874.
https://doi.org/10.1182/blood-2018-99-116547
Published: 2018