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Journal Articles

A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

Lei Guo, PhD, Jia Li, PhD, Hongxiang Zeng, PhD, Anna Guzman, Tingting Li, MD, Minjung Lee, MS, Yubin Zhou, PhD, Clifford Stephan, Peter J.A Davies, Margaret Goodell, PhD, Deqiang Sun, PhD, Mark A. Dawson, PhD MBBS, Yun Huang, PhD

Blood (2019) 134 (Supplement_1): 5053.

https://doi.org/10.1182/blood-2019-130586

Published: 2019

Journal Articles

Acceleration of AML Progression By Cigarette Smoke Exposure or Condensate Exposure and Associated DNA Methylation Alterations

Mary Figueroa, BS, Mansour Alfayez, MD, Yue Lu, PhD, Marcos Estecio, PhD, Seyed Javad Moghaddam, MD, Marina Y Konopleva, MD PhD, Elias Jabbour, MD, Courtney D. DiNardo, MDMSc, Joya Chandra, PhD

Blood (2019) 134 (Supplement_1): 2554.

https://doi.org/10.1182/blood-2019-127216

Published: 2019

Journal Articles

The Histone Demethylase KDM4A Is Required to Sustain H3K9me3/H3K27me3 Epigenetic States and Oncogenesis in MLL-AF9 Acute Myeloid Leukemia

Matthew E Massett, BSc, Niamh Mannion, BSc,PhD, Laura Monaghan, BSc, Joana Bittencourt-Silvestre, BSc, MSc, Sandra Marmiroli, BSc,PhD, Robert M J Liskamp, BSc, PhD, Alison M Michie, BSc, PhD, David Vetrie, BSc, PhD, Xu Huang, BSc, PhD

Blood (2018) 132 (Supplement 1): 3879.

https://doi.org/10.1182/blood-2018-99-111256

Published: 2018

Journal Articles

The BET Inhibitor INCB054329 Primes AML Cells for Venetoclax-Induced Apoptosis

Haley Ramsey, PhD MSc, Susu Zhang, Yue Zhao, PhD, Melissa Ann Fischer, PhD, Agnieszka Ewa Gorska, MSc, Maria Arrate, MSc, Londa Fuller, Dalton Greenwood, Matthew C. Stubbs, PhD, Phillip Liu, PhD, Jeffrey C Rathmell, PhD, Scott Hiebert, PhD, Michael R. Savona, MD

Blood (2018) 132 (Supplement 1): 4074.

https://doi.org/10.1182/blood-2018-99-111393

Published: 2018

Journal Articles

Hematopoietic Stem and Progenitor Cell Proliferation and Differentiation Requires the Trithorax Protein Ash2l In Vivo

Nicolas Chatain, PhD, Juliane Lüscher-Firzlaff, Chao-Chung Kuo, Agnieszka Bochyńska, Andrea Ullius, Bernd Denecke, Ivan Costa, Steffen Koschmieder, MD, Bernhard Lüscher

Blood (2018) 132 (Supplement 1): 2566.

https://doi.org/10.1182/blood-2018-99-115950

Published: 2018

Journal Articles

Differentially Expressed Trfs in Relapsed & Refractory Diffuse Large B Cell Lymphoma and the Bioinformatic Analysis for Their Potential Clinical Use

Qingyuan Qu, Yujie Jiang, MD, Ying Li, MD, Yiqing Cai, Ya Zhang, MD, Xin Wang, MD PhD

Blood (2018) 132 (Supplement 1): 5121.

https://doi.org/10.1182/blood-2018-99-118134

Published: 2018

Journal Articles

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Margaret Shatara, MD, Tingting Wang, Xinyu Li, Holly Edwards, BS, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD

Blood (2018) 132 (Supplement 1): 5224.

https://doi.org/10.1182/blood-2018-99-113937

Published: 2018

Journal Articles

Founding Precision Therapy in 1q-Amplified Multiple Myeloma

Romanos Sklavenitis-Pistofidis, MD, Mairead Reidy, PhD, Daisy Huynh, MS, Karma Ziad Salem, MD, Jihye Park, PhD, Siobhan Glavey, MD PhD, Xavier Leleu, MD PhD, David Root, PhD, Irene M. Ghobrial, MD, Salomon Manier, MD PhD

Blood (2018) 132 (Supplement 1): 1007.

https://doi.org/10.1182/blood-2018-99-112673

Published: 2018

Journal Articles

Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Kylee H Maclachlan, BSc, MBChB, FRACP, FRCPA, Andrew Cuddihy, PhD, Nadine Hein, PhD, Carleen Cullinane, PhD, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD, Ross Hannan, PhD, Gretchen Poortinga, PhD

Blood (2018) 132 (Supplement 1): 1945.

https://doi.org/10.1182/blood-2018-99-113765

Published: 2018

Journal Articles

A Long Noncoding RNA from the HBS1L-MYB Intergenic Region on Chr6q23 Regulates Human Fetal Hemoglobin Expression

Tasha A. Morrison, MPH,BA, Ibifiri Wilcox, BS, Hong-Yuan Luo, PhD, John Farrell, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, George J Murphy, PhD, Shuaiying Cui, PhD, Martin H. Steinberg, MD, David H.K. Chui, MD

Blood (2017) 130 (Supplement 1): 288.

https://doi.org/10.1182/blood.V130.Suppl_1.288.288

Published: 2017

Journal Articles

Histone Deacetylase Inhibitors Mimic BET Inhibitors and Cause RNA Polymerase Pausing at MYC, KIT, and Other Oncogenes in t(8;21) AML

Pankaj Acharya, PhD, Shilpa Sampathi, PhD, Yue Zhao, PhD, Jing Wang, PhD, Qi Liu, PhD, Kristy Stengel, PhD, Scott Hiebert, PhD

Blood (2017) 130 (Supplement 1): 2470.

https://doi.org/10.1182/blood.V130.Suppl_1.2470.2470

Published: 2017

Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD

Blood (2017) 130 (Supplement 1): 3835.

https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835

Published: 2017

Journal Articles

Molecular Pathogenesis of Progressive Refractoriness in MLL -Rearranged AML

Shinichi Kotani, Keisuke Kataoka, MD PhD, June Takeda, MD, Hiroo Ueno, MD, Yusuke Shiozawa, MD , PhD, Tetsuichi Yoshizato, MD,PhD, Ayana Kon, MD PhD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Akinori Yoda, PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Akifumi Takaori-Kondo, MD PhD, Hideki Makishima, MD PhD, Seishi Ogawa, MD PhD

Blood (2017) 130 (Supplement 1): 474.

https://doi.org/10.1182/blood.V130.Suppl_1.474.474

Published: 2017

Journal Articles

The CDK7 Inhibitor THZ1 Alters RNA Polymerase Dynamics at the 5' and 3' Ends of Genes

Shilpa Sampathi, PhD, Pankaj Acharya, PhD, Yue Zhao, PhD, Jing Wang, PhD, Kristy Stengel, PhD, Qi Liu, PhD, Michael R. Savona, MD, Scott Hiebert, PhD

Blood (2017) 130 (Supplement 1): 1195.

https://doi.org/10.1182/blood.V130.Suppl_1.1195.1195

Published: 2017

Journal Articles

Selective Targeting Cyclin-Dependent Kinase-9 (CDK9) Downmodulates c-MYC and Induces Apoptosis in Diffuse Large B-Cell Lymphoma (DLBCL) Cells

Taylor Rowland, Cody Paiva, BS, Joelle Rowley, Andy Chen, MD PhD, Lisa Drew, PhD, Peter Hurlin, Bill H. Chang, MD PhD, Alexey V Danilov, MD PhD

Blood (2016) 128 (22): 289.

https://doi.org/10.1182/blood.V128.22.289.289

Published: 2016

Journal Articles

Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

Cody Paiva, BS, Claire Godbersen, Stephen E Spurgeon, MD, Sreesha Srinivasa, Jennifer R Brown, MD PhD, Alexey V Danilov, MD PhD

Blood (2015) 126 (23): 1752.

https://doi.org/10.1182/blood.V126.23.1752.1752

Published: 2015

Journal Articles

Network-Based Analysis of Exome Sequencing Mutations Identifies Molecular Subtypes of Myelodysplastic Syndromes

Aziz Nazha, MD, Bartlomiej Przychodzen, MSc, Hideki Makishima, MD PhD, Hetty E. Carraway, MD MBA, Bhumika J. Patel, Cassandra M Hirsch, Michael Clemente, MS, Srinivasa R. Sanikommu, MBBS, Aaron T. Gerds, MD MS, Jennifer S. Carew, PhD, Satoru Miyano, MD PhD, Matt Kalaycio, MD, Seishi Ogawa, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS

Blood (2015) 126 (23): 611.

https://doi.org/10.1182/blood.V126.23.611.611

Published: 2015

Journal Articles

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

Elisabeth Höring, German Ott, MD, Christine Bayha, Kleih Markus, Matthias C. Voehringer, MD, Heiko van Der Kuip, Walter E. Aulitzky, MD

Blood (2015) 126 (23): 2757.

https://doi.org/10.1182/blood.V126.23.2757.2757

Published: 2015

Journal Articles

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Hans Lee, MD, Hua Wang, PhD, Heather Lin, M.S., Veera Baladandayuthapani, PhD, Jin He, Richard Julian Jones, PhD, Isere Kuiatse, PhD, Dongmin Gu, MD, PhD, Zhiqiang Wang, PhD, Sean O'Brien, PhD, Jonathan J Keats, PhD, Jing Yang, PhD, Richard Eric Davis, MD, Robert Z. Orlowski, PhD, MD

Blood (2015) 126 (23): 3010.

https://doi.org/10.1182/blood.V126.23.3010.3010

Published: 2015

Journal Articles

High Resolution Mapping of Active RNA Polymerases Identifies KIT As a Target of BET Inhibitors in t(8;21) AML

Yue Zhao, PhD, Phillip Liu, PhD, Peggy Scherle, PhD, Reid Huber, PhD, Michael R. Savona, MD, Scott Hiebert, PhD

Blood (2015) 126 (23): 1225.

https://doi.org/10.1182/blood.V126.23.1225.1225

Published: 2015

NARROW

A Combination Strategy Targeting Enhancer Plasticity Exerts Synergistic Lethality Against Beti-Resistant Leukemia Cells

Acceleration of AML Progression By Cigarette Smoke Exposure or Condensate Exposure and Associated DNA Methylation Alterations

The Histone Demethylase KDM4A Is Required to Sustain H3K9me3/H3K27me3 Epigenetic States and Oncogenesis in MLL-AF9 Acute Myeloid Leukemia

The BET Inhibitor INCB054329 Primes AML Cells for Venetoclax-Induced Apoptosis

Hematopoietic Stem and Progenitor Cell Proliferation and Differentiation Requires the Trithorax Protein Ash2l In Vivo

Differentially Expressed Trfs in Relapsed & Refractory Diffuse Large B Cell Lymphoma and the Bioinformatic Analysis for Their Potential Clinical Use

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Founding Precision Therapy in 1q-Amplified Multiple Myeloma

Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

A Long Noncoding RNA from the HBS1L-MYB Intergenic Region on Chr6q23 Regulates Human Fetal Hemoglobin Expression

Histone Deacetylase Inhibitors Mimic BET Inhibitors and Cause RNA Polymerase Pausing at MYC, KIT, and Other Oncogenes in t(8;21) AML

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Molecular Pathogenesis of Progressive Refractoriness in MLL -Rearranged AML

The CDK7 Inhibitor THZ1 Alters RNA Polymerase Dynamics at the 5' and 3' Ends of Genes

Selective Targeting Cyclin-Dependent Kinase-9 (CDK9) Downmodulates c-MYC and Induces Apoptosis in Diffuse Large B-Cell Lymphoma (DLBCL) Cells

Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

Network-Based Analysis of Exome Sequencing Mutations Identifies Molecular Subtypes of Myelodysplastic Syndromes

Dual Targeting of NOXA/MCL-1 Synergistically Induces Cell Death in Mantle Cell Lymphoma (MCL) Cells

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

High Resolution Mapping of Active RNA Polymerases Identifies KIT As a Target of BET Inhibitors in t(8;21) AML

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American Society of Hematology

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American Society of Hematology

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