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Journal Articles

A Patient-Specific Ex Vivo Screening Platform for Personalized Acute Myeloid Leukemia (AML) Therapy

Diana Azzam, PhD, Claude-Henry Volmar, PhD, Al-Ali Hassan, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Francisco Vega, MD PhD, Arthur Zelent, PhD, Christopher R. Cogle, MD, Claes Wahlestedt, PhD, Ronan T. Swords, MDPhDFRCPI FRCPath
Journal: Blood
Blood (2015) 126 (23): 1352.
https://doi.org/10.1182/blood.V126.23.1352.1352
Published: 2015
Journal Articles

Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia

Ronan T. Swords, MDPhDFRCPI FRCPath, Tino Schenk, PhD, Sven Stengel, PhD, Veronica Sylvina Gil, PhD, Kevin R. Petrie, PhD, Aymee Perez, PhD, Rodriguez Ana, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 1363.
https://doi.org/10.1182/blood.V126.23.1363.1363
Published: 2015
Journal Articles

The BET Bromodomain Inhibitors EP11313 and EP11336 Have Potent Anti-Leukemic Activity in Acute Myeloid Leukemia (AML) and Augment the Effects of All-Trans-Retinoic Acid (AtRA) in Vitro

Ronan T. Swords, MDPhDFRCPI FRCPath, Shaun Brothers, PhD, Nagi Ayad, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Ana Rodriguez, Shawn Johnstone, PhD, Jeffrey Albert, Joseph Collard, Arthur Zelent, PhD, Claes Wahlestedt, PhD
Journal: Blood
Blood (2015) 126 (23): 2552.
https://doi.org/10.1182/blood.V126.23.2552.2552
Published: 2015
Journal Articles

The Small Molecule Img-98, a Potent and Selective Inhibitor of the Lysine Demethylase Lsd-1, Effectively Augments the Pro-Differentiation Effects of ATRA in a Pre-Clinical Model of AML

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Hugh Y. Rienhoff, Jr., MD, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 460.
https://doi.org/10.1182/blood.V126.23.460.460
Published: 2015
Journal Articles

In Acute Myeloid Leukemia (AML), Targeting the Histone Methyltransferase EZH2 Promotes Differentiation, Impairs Clonogenic Survival and Augments the Anti-Leukemic Effects of the Retinoid, All-Trans-Retinoic Acid (ATRA)

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Tino Schenk, PhD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 3786.
https://doi.org/10.1182/blood.V126.23.3786.3786
Published: 2015