1-20 of 1437
caspases
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Preclinical Validation of Ubiquitin Receptor PSMD4 As Therapeutic Target in Multiple Myeloma

Yan Song, PhD, Ting DU, PhD, Arghya Ray, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4403.
https://doi.org/10.1182/blood-2019-122952
Published: 2019
Journal Articles

Pharmacological Inhibition of MAP2K7 Induces Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia

Taylor J Chen, BS, Ye Shen, PhD, Cory Seth Bridges, BS, Chun Shik Park, PhD, Jacob J. Junco, PhD, Karen R. Rabin, MD PhD, H. Daniel Lacorazza, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3889.
https://doi.org/10.1182/blood-2019-129127
Published: 2019
Journal Articles

Ironomycin Induces Diffuse Large B-Cell Lymphoma Cell Death By Targeting Iron Metabolism Addiction

Julie Devin, PharmD, Tatiana Cañeque, Yea-Lih Lin, PhD, Guillaume Cartron, Philippe Pasero, PhD, Caroline Bret, PhD PharmD, Raphael Rodriguez, Jerome Moreaux, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3960.
https://doi.org/10.1182/blood-2019-129954
Published: 2019
Journal Articles

Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Can be Therapeutically Targeted Inducing Apoptotic Cell Death in a Caspase-Dependent Way

Manuela Mancini, PhD, Sara De Santis, Dr, Cecilia Monaldi, Dr, Luana Bavaro, Dr, Margherita Martelli, Dr, Gabriele Gugliotta, MD PhD, Fausto Castagnetti, MD PhD, Gianantonio Rosti, MD, Maria Chiara Fontana, PhD, Samantha Bruno, Dr, Elisa Dan, PhD, Barbara Sinigaglia, Dr, Alessandra Iurlo, MD PhD, Nicola Orofino, MD, Elisabetta Abruzzese, MD, Marzia Salvucci, MD, Patrizia Pregno, Antonella Gozzini, MD, Monica Crugnola, MD, Francesco Albano, MD, Massimiliano Bonifacio, MD, Elisabetta Calistri, MD, Mario Tiribelli, Gianni Binotto, MD, Annalisa Imovilli, Elena Trabacchi, MD, Sara Galimberti, MD PhD, Claudia Baratè, Elena Tenti, Michele Baccarani, MD, Giovanni Martinelli, MD, Michele Cavo, Simona Soverini, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4142.
https://doi.org/10.1182/blood-2019-126500
Published: 2019
Journal Articles

Pivotal Role of OCL-Derived IGF1 in Drug Resistance and Bone Destruction in MM

Jumpei Teramachi, Kazuaki Miyagawa, DDS, PhD, Delgado-Calle Jesus, PhD, Jolene Windle, PhD, Noriyoshi Kurihara, DDS, PhD, G David Roodman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4336.
https://doi.org/10.1182/blood-2019-126959
Published: 2019
Journal Articles

Single-Cell RNA-Seq to Assess Differential Responses to Tnfα in Human Hematopoietic Stem and Progenitor Cells in Myeloproliferative Neoplasm

Brianna Craver, MS, Quy Nguyen, Gajalakshmi Ramanathan, PhD, Angela G. Fleischman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2518.
https://doi.org/10.1182/blood-2019-123480
Published: 2019
Journal Articles

CD3xCD19 Dart Treatment Is Efficient in Venetoclax Resistant CLL and Reverses T Cell Dysfunction

Anne W. J. Martens, MSc, Susanne R. Janssen, MSc, Ingrid A.M. Derks, Sanne Tonino, MD PhD, Eric Eldering, Gerritje J. W. van der Windt, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3043.
https://doi.org/10.1182/blood-2019-123350
Published: 2019
Journal Articles

Proteomic Analysis Identifies Mechanism(s) of Overcoming Bortezomib-Resistance Via Targeting Ubiquitin Receptor Rpn13

Ting Du, PhD, Yan Song, PhD, Arghya Ray, PhD, Dharminder Chauhan, PhD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3074.
https://doi.org/10.1182/blood-2019-130236
Published: 2019
Journal Articles

In Vitro and in Vivo Activity of Melflufen in Amyloidosis

Ken Flanagan, PhD, Muntasir M Majumder, MSc, BPharm, Romika Kumari, PhD, Juho Miettinen, PhD, Ana Slipicevic, PhD, Sarah A. Holstein, MD PhD, Michelle L. Varney, MS, Minna Suvela, MSC, Fredrik Lehmann, PhD, Nina N. Nupponen, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3100.
https://doi.org/10.1182/blood-2019-125952
Published: 2019
Journal Articles

Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma

Antonio Sacco, RN, Cinzia Federico, PhD, Katia Todoerti, PhD, Bachisio Ziccheddu, PhD, Arianna Giacomini, PhD, Cosetta Ravelli, PhD, Federica Maccarinelli, PhD, Giada Bianchi, MD, Angelo Belotti, Rossella Ribolla, MD, Vanessa Favasuli, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brandon Willis, PhD, Hongoo Cai, PhD, Joana Hauser, RN, Claire Rooney, PhD, Helen Ambrose, PhD, Anna Staniszewska, PhD, Lyndsey Hanson, PhD, Giuseppe Rossi, Roberto Ronca, PhD, Antonino Neri, MD, Stefania Mitola, PhD, Niccolò Bolli, MD PhD, Marco Presta, PhD, Michele Moschetta, MD PhD, Sarah Ross, PhD, Aldo M. Roccaro, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3104.
https://doi.org/10.1182/blood-2019-124391
Published: 2019
Journal Articles

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

Michael Weickert, John Dillberger, John R. Mackey, Paul Wyatt, David Gray, Kevin Read, Christian Li, Audrey Parenteau, Luc G. Berthiaume
Journal: Blood
Blood (2019) 134 (Supplement_1): 3362.
https://doi.org/10.1182/blood-2019-124934
Published: 2019
Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Yurie Nagai, MD, Naoya Mimura, MD PhD, Ola Rizq, MD PhD, Yusuke Isshiki, MD PhD, Motohiko Oshima, PhD, Mohamed Rizk, BSc, MSc, Atsunori Saraya, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Makiko Miyota, Nagisa Oshima-Hasegawa, MD PhD, Shokichi Tsukamoto, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Chikako Ohwada, MD PhD, Masahiro Takeuchi, MD PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD PhD, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4414.
https://doi.org/10.1182/blood-2019-122350
Published: 2019
Journal Articles

Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors

Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Edward Simpson, PhD, Judith L Anderson, BS, Xiang-Qun Xie, PhDMD,MBA, Yunlong Liu, PhD, John Chirgwin, PhD, G. David Roodman, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4391.
https://doi.org/10.1182/blood-2019-131865
Published: 2019
Journal Articles

Geranylgeranyl Diphosphate Synthase Inhibitor and Proteasome Inhibitor Combination Therapy in Multiple Myeloma

Staci L. Haney, PhD, Michelle L. Varney, MS, Lynette M. Smith, PhD, Sarah A. Holstein, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4417.
https://doi.org/10.1182/blood-2019-129244
Published: 2019
Journal Articles

Downregulation of MDM2 Leads to Anti-Proliferative Effects through Activation of p53-Associated Pathway Mediated By Both Dual Inhibitor MX69 and Mir-548c-3p in Multiple Myeloma

Faruq Faruq, PhD, Davidson Zhao, Jian Wu, MD, Jonahunnatha Nesson George William, PhD, Min Zhang, MD, Hong Chang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4419.
https://doi.org/10.1182/blood-2019-129430
Published: 2019
Journal Articles

R-2HG/KDM2B/RIPK1 Signaling Mediates Necroptosis in Myelodysplastic Syndromes

Shuanghong Zhu, Chen Mei, Hongyan Tong, Jie Jin, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5049.
https://doi.org/10.1182/blood-2019-125482
Published: 2019
Journal Articles

Manufacture of an Allogeneic CAR-T Stem Cell Memory Product Candidate for Multiple Myeloma, P-Bcma-ALLO1, Is Robust, Reproducible and Highly Scalable

Stacey A Cranert, PhD, Maximilian Richter, PhD, Min Tong, MS, Leslie Weiss, MS, Yening Tan, MS, Eric M. Ostertag, MD PhD, Julia Coronella, PhD, Devon J Shedlock, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4445.
https://doi.org/10.1182/blood-2019-131839
Published: 2019
Journal Articles

CUDC-101 Overcomes Arsenic Trioxide Resistance Via Caspase-Dependent PML-Rarα Degradation in Acute Promyelocytic Leukemia

Tianzhuo Zhang, Jishi Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5054.
https://doi.org/10.1182/blood-2019-131618
Published: 2019
Journal Articles

This Is a Title in Title Case: A Combination of Low-Dose Decitabine and Chidamide Resulted in Synergistic Effects on the Proliferation and Apoptosis of Human Myeloid Leukemia Cell Lines

Fangfang Xu, PhD, Honggang Guo, MD, Mingyue Shi, MD, Siwei Liu, MD, Min Wei, MD, Kai Sun, MD, Yuqing Chen, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5160.
https://doi.org/10.1182/blood-2019-128663
Published: 2019
Journal Articles

Identification of Potential Chemical Compounds Able to Trigger Enucleation of Immortalized Human Erythroid Cell Lines

Svetlana Soboleva, Ryo Kurita, PhD, Fredrik Ek, PhD, Rita Alves, Roger Olsson, PhD, Yukio Nakamura, MD PhD, Kenichi Miharada, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 951.
https://doi.org/10.1182/blood-2019-128427
Published: 2019