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Journal Articles

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Naoyuki Tange, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Hideyuki Yamamoto, MD, Daiki Hirano, MD, PhD, Shinobu Tsuzuki, MD,PhD, Hitoshi Kiyoi, MD PhD

Blood (2019) 134 (Supplement_1): 1349.

https://doi.org/10.1182/blood-2019-123602

Published: 2019

Journal Articles

Excretion and Distribution of the 60-kDa PEG Moiety Used in BAY 94-9027 in Male Wistar Rats

Andreas Baumann, Thomas Schwarz, Frank Hucke, Isabel Piel, Steffen Sandmann

Blood (2017) 130 (Supplement 1): 3674.

https://doi.org/10.1182/blood.V130.Suppl_1.3674.3674

Published: 2017

Journal Articles

Extravascular Distribution of Conventional and Ehl FIX Products Using In Vivo SPECT Imaging Analysis in Hemophilia B Mice

Joe Salas, PhD, Arjan Van Der Flier, PhD, Vu P. Hong, PhD, Jennifer Dumont, PhD, Kelly D Orcutt, PhD, Apollina Goel, PhD, Robert Peters, PhD

Blood (2017) 130 (Supplement 1): 1061.

https://doi.org/10.1182/blood.V130.Suppl_1.1061.1061

Published: 2017

Journal Articles

Preclinical Modeling of ACVR1-Dependent Hepcidin Production and Anemia By Momelotinib

Matthew Warr, Malte Asshoff, Jim Zheng, Shringi Sharma, Pat Maciejewski, Guenter Weiss, Igor Theurl, J. Andrew Whitney

Blood (2016) 128 (22): 1967.

https://doi.org/10.1182/blood.V128.22.1967.1967

Published: 2016

Journal Articles

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Athiwat Hutchaleelaha, PhD, Mira Patel, PhD, Abel Silva, Donna Oksenberg, PhD, Brian Metcalf, PhD

Blood (2015) 126 (23): 2172.

https://doi.org/10.1182/blood.V126.23.2172.2172

Published: 2015

Journal Articles

Novel Approach to Study Biodistribution and Accumulation of Pegylated Recombinant Factor VIII in Haemophilia A Mice

Vu P. Hong, PhD, Ayman Ismail, PhD, Nancy Moore, Robert Peters, PhD, Joe Salas, PhD

Blood (2015) 126 (23): 3517.

https://doi.org/10.1182/blood.V126.23.3517.3517

Published: 2015

Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD

Blood (2014) 124 (21): 3630.

https://doi.org/10.1182/blood.V124.21.3630.3630

Published: 2014

Journal Articles

Quantitative Whole Body Autoradiography (QWBA) Analysis Reveals That CPX-351 Shifts the Exposure of Cytarabine (Cyt) and Daunorubicin (Daun) Away from Many Tissues While Providing Prolonged Exposure to Cytotoxic Drug Concentrations in the Bone Marrow Compared to Conventional Free Drug Administration

Lawrence D Mayer, PhD, Nicole Sadowski, Paul Tardi, PhD, Xiaowei Xie, PhD, Donna Cabral-Lilly, PhD, Dennis Heller, PhD

Blood (2014) 124 (21): 3740.

https://doi.org/10.1182/blood.V124.21.3740.3740

Published: 2014

Journal Articles

Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 ( 211 At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Sofia H.L. Frost, PhD, Erlinda B. Santos, BS, Brian W. Miller, PhD, Tom A. Bäck, PhD, Donald K. Hamlin, BS, D. Scott Wilbur, PhD, Aimee L. Kenoyer, BS, Shani L. Frayo, BS, Oliver W. Press, MD, PhD, Rainer Storb, MD, Brenda M. Sandmaier, MD, John M. Pagel, MD, PhD

Blood (2013) 122 (21): 5139.

https://doi.org/10.1182/blood.V122.21.5139.5139

Published: 2013

Journal Articles

Cellular Uptake of rFVIIIFc in Liver Is Primarily Contributed by Sinusoidal Endothelial Cells.

Siyuan Tan, PhD, Kai Chen, Arjan van der Flier, PhD, Zhan Liu, David R. Light, PhD, Haiyan Jiang, PhD

Blood (2012) 120 (21): 2219.

https://doi.org/10.1182/blood.V120.21.2219.2219

Published: 2012

Journal Articles

Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc

Arjan van der Flier, PhD, Zhan Liu, Douglas Drager, Sebastien Vallee, PhD, Kai Chen, Siyuan Tan, PhD, Keith Wharton, MD, PhD, David R. Light, PhD, Haiyan Jiang, PhD

Blood (2012) 120 (21): 1103.

https://doi.org/10.1182/blood.V120.21.1103.1103

Published: 2012

Journal Articles

Biodistribution of the Recombinant Fusion Protein Linking the Human Factor IX to Human Albumin (rIX-FP) in Rats

Eva Herzog, Stephen Harris, Andrew McEwen, Ingo Pragst, Gerhard Dickneite, Stefan Schulte, PhD, Sabine Zollner

Blood (2012) 120 (21): 1117.

https://doi.org/10.1182/blood.V120.21.1117.1117

Published: 2012

Journal Articles

Absorption, Metabolism, Distribution, and Excretion of Longer Acting rFVIII (BAX 855) Following Intravenous Administration to Rats

Reinhard Stidl, PhD, Juergen Siekmann, PhD, Sean M Culbertson, Tony Vinson, Antoni Kozlowski, Xiaoming Shen, Mary J Bossard, Hanspeter Rottensteiner, PhD, Barbara Dietrich, DVM, Chyung Cook, Peter L Turecek, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4358.

https://doi.org/10.1182/blood.V118.21.4358.4358

Published: 2011

Journal Articles

Identification and Characterization of a Human Platelet Glycoprotein VI Peptidomimetic Permitting Molecular Imaging of Fibrosis.

Martine Jandrot-Perrus, Julien Muzard, Laure Sarda-Mantel, Stéphane Loyau, Alain Meulemans, Liliane Louedec, Florence Hervatin, Jean-Baptiste Michel, Dominique Le Guludec, Philippe Billiald

Blood (2008) 112 (11): 1830.

https://doi.org/10.1182/blood.V112.11.1830.1830

Published: 2008

Journal Articles

Analysis of Differentially Activated Signaling Pathways in Myeloproliferative Disease Using Kinomics Chip Profiling

Daniel B Lipka, MD, Marie-Christine Blum, MSc, Florian H Heidel, MD, Thomas Kindler, M.D., Thomas Fischer, MD

Blood (2008) 112 (11): 3723.

https://doi.org/10.1182/blood.V112.11.3723.3723

Published: 2008

Journal Articles

3,4-Diarylmaleimides Effectively Inhibit Proliferation of FLT3-ITD-Positive Leukemic Cells, Induce Apoptosis and Show Additive Effects in Combination with Chemotherapeutic Drugs.

Florian H. Heidel, MD, Daniel B. Lipka, MD, Fian K. Mirea, Boyka Markova, PhD, Christian Peifer, PhD, Jan-Peter Kramp, PhD, Stanislav Plutizki, Christoph Huber, MD, Gerd Dannhardt, PhD, Thomas Fischer, MD

Blood (2007) 110 (11): 1605.

https://doi.org/10.1182/blood.V110.11.1605.1605

Published: 2007

Journal Articles

Reaction of Factor VIIa (VIIa) with Plasma Inhibitors Ex Vivo and In Vivo .

Lars C. Petersen, Carsten L. Christoffersen, Thomas N. Krogh, Torben Elm

Blood (2006) 108 (11): 1750.

https://doi.org/10.1182/blood.V108.11.1750.1750

Published: 2006

Journal Articles

Risk Factors for Recurrence of Thrombotic Thrombocytopenic Purpura.

Flora Peyvandi, MD, PhD, Silvia Lavoretano, Roberta Palla, Hendrik B. Feys, Tullia Battaglioli, MD, PhD, Carla Valsecchi, Maria T. Canciani, Fabrizio Fabris, MD, Pier M. Mannucci, MD

Blood (2006) 108 (11): 1060.

https://doi.org/10.1182/blood.V108.11.1060.1060

Published: 2006

Journal Articles

Protein Palmitoylation Participates in PAR1-Mediated Platelet Activation.

Derek S. Sim, PhD, Blake R. Peterson, PhD, Steffen P. Creaser, PhD, Robert Flaumenhaft, MD PhD

Blood (2004) 104 (11): 1560.

https://doi.org/10.1182/blood.V104.11.1560.1560

Published: 2004

Journal Articles

Tissue Uptake of Circulating Thrombopoietin Is Increased in Immune-Mediated Compared With Irradiated Thrombocytopenic Mice: Presented in part at the Annual Meeting of the American Society of Hematology, December 1996, Orlando, FL, and December 1997, San Diego, CA.

Mei Chang, John X. Qian, Sun min Lee, John Joubran, George Fernandez, Jacqueline Nichols, Annika Knoppel, Jeffrey S. Buzby

Blood (1999) 93 (8): 2515–2524.

https://doi.org/10.1182/blood.V93.8.2515

Published: 1999

NARROW

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Excretion and Distribution of the 60-kDa PEG Moiety Used in BAY 94-9027 in Male Wistar Rats

Extravascular Distribution of Conventional and Ehl FIX Products Using In Vivo SPECT Imaging Analysis in Hemophilia B Mice

Preclinical Modeling of ACVR1-Dependent Hepcidin Production and Anemia By Momelotinib

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Novel Approach to Study Biodistribution and Accumulation of Pegylated Recombinant Factor VIII in Haemophilia A Mice

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Quantitative Whole Body Autoradiography (QWBA) Analysis Reveals That CPX-351 Shifts the Exposure of Cytarabine (Cyt) and Daunorubicin (Daun) Away from Many Tissues While Providing Prolonged Exposure to Cytotoxic Drug Concentrations in the Bone Marrow Compared to Conventional Free Drug Administration

Anti-CD45 Monoclonal Antibody (MAb) Dose Optimization For Astatine-211 ( 211 At)-Radioimmunotherapy (RIT) Of Relapsed Non-Hodgkin Lymphoma (NHL) In a Canine Model

Cellular Uptake of rFVIIIFc in Liver Is Primarily Contributed by Sinusoidal Endothelial Cells.

Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc

Biodistribution of the Recombinant Fusion Protein Linking the Human Factor IX to Human Albumin (rIX-FP) in Rats

Absorption, Metabolism, Distribution, and Excretion of Longer Acting rFVIII (BAX 855) Following Intravenous Administration to Rats

Identification and Characterization of a Human Platelet Glycoprotein VI Peptidomimetic Permitting Molecular Imaging of Fibrosis.

Analysis of Differentially Activated Signaling Pathways in Myeloproliferative Disease Using Kinomics Chip Profiling

3,4-Diarylmaleimides Effectively Inhibit Proliferation of FLT3-ITD-Positive Leukemic Cells, Induce Apoptosis and Show Additive Effects in Combination with Chemotherapeutic Drugs.

Reaction of Factor VIIa (VIIa) with Plasma Inhibitors Ex Vivo and In Vivo .

Risk Factors for Recurrence of Thrombotic Thrombocytopenic Purpura.

Protein Palmitoylation Participates in PAR1-Mediated Platelet Activation.

Tissue Uptake of Circulating Thrombopoietin Is Increased in Immune-Mediated Compared With Irradiated Thrombocytopenic Mice: Presented in part at the Annual Meeting of the American Society of Hematology, December 1996, Orlando, FL, and December 1997, San Diego, CA.

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American Society of Hematology

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American Society of Hematology

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