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Journal Articles

Regulatory T Cells Control PF4/Heparin Antibody Production in Mice

Yongwei Zheng, Wen Zhu, Dipica Haribhai, PhD, Calvin B. Williams, PhD, Richard H. Aster, MD, Renren Wen, PhD, Demin Wang, PhD

Blood (2018) 132 (Supplement 1): 2542.

https://doi.org/10.1182/blood-2018-99-113049

Published: 2018

Journal Articles

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Deepti M. Warad, MD, Bethany T Samuelson Bannow, MD, Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhD, Daniel W. Bougie, PhD, Parisa R Khalighi, BS, Diane E. Grill, MS, Rachel Leger, BAE, Ruchika Sharma, MD, Dong Chen, MD PhD, Richard H. Aster, MD, David A. Garcia, MD, Anand Padmanabhan, MD PhD

Blood (2018) 132 (Supplement 1): 416.

https://doi.org/10.1182/blood-2018-99-112475

Published: 2018

Journal Articles

Use of Intravenous Immunoglobulin G in HIT: Impact on Thrombosis and Mortality in a Population-Based Study

Binod Dhakal, MBBS, Rein Lisa, Aniko Szabo, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2018) 132 (Supplement 1): 2512.

https://doi.org/10.1182/blood-2018-99-117190

Published: 2018

Journal Articles

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Blood (2017) 130 (Supplement 1): 109.

https://doi.org/10.1182/blood.V130.Suppl_1.109.109

Published: 2017

Journal Articles

Drug-Induced Immune Thrombocytopenia (DITP) Caused By Multiple Drug-Dependent Platelet-Reactive Antibodies (DDAbs) in Patients Undergoing Oxaliplatin-Containing Combination Chemotherapy for Metastatic Colon Cancer

Brian R. Curtis, PhDMT(ASCP), Yen-Michael S. Hsu, MD PhD, Nikolai A. Podoltsev, MD PhD, Jill Lacy, MD, Susanna A Curtis, MD, Robert Andrew Desimone, MD, Michael Samuel, MD, Kristin Zutavern, BS, Daniel Bougie, PhD, Richard H. Aster, MD

Blood (2017) 130 (Supplement 1): 3625.

https://doi.org/10.1182/blood.V130.Suppl_1.3625.3625

Published: 2017

Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 Targets Both NOTCH1-MYC Regulatory Circuit and Leukemia-Microenvironment in T-ALL

Sujan Piya, PhD, Hong Mu, MD PhD, Seemana Bhattacharya, PhD, Teresa McQueen, MS, Richard E Davis, BSPharm, MS, Vivian Ruvolo, PhD, Natalia Baran, PhD MD, Yimin Qian, PhD, Kanak Raina, PhD, Craig M Crews, PhD, M. James You, MD PhD, Patrick Zweider McKay, MDPhD, Marina Konopleva, MD PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2017) 130 (Supplement 1): 716.

https://doi.org/10.1182/blood.V130.Suppl_1.716.716

Published: 2017

Journal Articles

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Shannon Pechauer, Curtis Jones, BS, Daniel W. Bougie, PhD, Brian R. Curtis, PhDMT(ASCP), Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2017) 130 (Supplement 1): 458.

https://doi.org/10.1182/blood.V130.Suppl_1.458.458

Published: 2017

Journal Articles

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhDMT(ASCP), Daniel W. Bougie, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2017) 130 (Supplement 1): 2402.

https://doi.org/10.1182/blood.V130.Suppl_1.2402.2402

Published: 2017

Journal Articles

Systematic KIT Sequencing Identifies Unsuspected Systemic Mastocytosis with Associated Hematological Neoplasm

Elizabeth A Morgan, MD, Jeffrey W. Craig, MD PhD, Annette S. Kim, MDPhD, Geraldine S. Pinkus, Jon C. Aster, MD PhD, Frank C Kuo, MBBS, PhD, David P. Steensma, MD, R. Coleman Lindsley, MD PhD, Daniel J. DeAngelo, MD

Blood (2017) 130 (Supplement 1): 2923.

https://doi.org/10.1182/blood.V130.Suppl_1.2923.2923

Published: 2017

Journal Articles

Microenvironment-Specific Activation of Notch2 in Splenic Marginal Zone Lymphoma

Vignesh Shanmugam, MD, Scott B Lovitch, MD, PhD, Karim A. Benhadji, Gerald J. Oakley, MD, Jon C. Aster, MD PhD

Blood (2017) 130 (Supplement 1): 1485.

https://doi.org/10.1182/blood.V130.Suppl_1.1485.1485

Published: 2017

Journal Articles

Autoimmune Thrombocytopenia in Mice Immunized with Allogeneic Platelets: A Model for Post-Transfusion Purpura (PTP)?

Daniel W. Bougie, PhD, Jessica Sutton, Richard H. Aster, MD

Blood (2016) 128 (22): 168.

https://doi.org/10.1182/blood.V128.22.168.168

Published: 2016

Journal Articles

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Lisa M. Baumann Kreuziger, MD MS, Brenda M. Pierce, MD, Richard H. Aster, MD

Blood (2016) 128 (22): 2599.

https://doi.org/10.1182/blood.V128.22.2599.2599

Published: 2016

Journal Articles

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Barbara J. Bryant, MD, Jack B. Alperin, MD, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Renren Wen, PhD, Demin Wang, PhD, Richard H. Aster, MD

Blood (2016) 128 (22): 2600.

https://doi.org/10.1182/blood.V128.22.2600.2600

Published: 2016

Journal Articles

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Jianghai Zhu, PhD, Jieqing Zhu, PhD, Daniel W. Bougie, PhD, Richard H. Aster, MD, Timothy A. Springer, PhD

Blood (2015) 126 (23): 1063.

https://doi.org/10.1182/blood.V126.23.1063.1063

Published: 2015

Journal Articles

Binding of Quinine-Dependent Monoclonal Antibodies to Gpiib/Iiia Appears to Involve Drug-Induced Modulation of Antibody Affinity

Daniel W. Bougie, PhD, Julie A. Peterson, PhD, Mark Rasmussen, Richard H. Aster, MD

Blood (2015) 126 (23): 2246.

https://doi.org/10.1182/blood.V126.23.2246.2246

Published: 2015

Journal Articles

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

Anand Padmanabhan, MBBS, MA, PhD, Curtis Jones, Brian R Curtis, MS, MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia Sullivan, Namrata Peswani, MD MBBS, Janice McFarland, MD, Daniel Eastwood, Demin Wang, PhD, Richard H. Aster, MD

Blood (2015) 126 (23): 764.

https://doi.org/10.1182/blood.V126.23.764.764

Published: 2015

Journal Articles

RUNX1 Is Required For Maintenance Of Established T-ALL Blasts

Christopher R Jenkins, Olena O Shevchuk, Hongfang Wang, Ph.D., Vincenzo Giambra, PhD, Samuel D Gusscott, Jon C. Aster, MD, PhD, Andrew P Weng, MD, PhD

Blood (2013) 122 (21): 3742.

https://doi.org/10.1182/blood.V122.21.3742.3742

Published: 2013

Journal Articles

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Monique Dail, PhD, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, PhD., Shann-Ching Chen, PhD, Keiko Akagi, Leslie Lee, Jon C. Aster, MD, PhD, Warren S. Pear, MD, PhD, Deepak Sampath, PhD, James R. Downing, MD, Kevin Shannon, MD

Blood (2013) 122 (21): 2677.

https://doi.org/10.1182/blood.V122.21.2677.2677

Published: 2013

Journal Articles

Angiopoietin-Like Proteins Stimulate HSC Development Through Direct Interaction With Notch

Michelle I Lin, PhD, Emily Price, Sonja Boatman, Eirini Trompouki, PhD, Sruthi Satishchandran, Charles W Carspecken, MD, Audrey Uong, Anthony DiBiase, Jon C. Aster, MD, PhD, Richard M. White, MD, PhD, Leonard I. Zon, M.D.

Blood (2013) 122 (21): 463.

https://doi.org/10.1182/blood.V122.21.463.463

Published: 2013

Journal Articles

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

Adrian Schwarzer, MD, Johann Meyer, PhD, Martijn Brugman, PhD, Axel Schambach, MD PhD, Martin Stanulla, MD, MSc, Martin Schrappe, MD, Doris Steinemann, PhD, Brigitte Schlegelberger, M.D., Christopher Baum, MD, Zhixiong Li, MD

Blood (2011) 118 (21): 1381.

https://doi.org/10.1182/blood.V118.21.1381.1381

Published: 2011

NARROW

Regulatory T Cells Control PF4/Heparin Antibody Production in Mice

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Use of Intravenous Immunoglobulin G in HIT: Impact on Thrombosis and Mortality in a Population-Based Study

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Drug-Induced Immune Thrombocytopenia (DITP) Caused By Multiple Drug-Dependent Platelet-Reactive Antibodies (DDAbs) in Patients Undergoing Oxaliplatin-Containing Combination Chemotherapy for Metastatic Colon Cancer

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 Targets Both NOTCH1-MYC Regulatory Circuit and Leukemia-Microenvironment in T-ALL

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

Systematic KIT Sequencing Identifies Unsuspected Systemic Mastocytosis with Associated Hematological Neoplasm

Microenvironment-Specific Activation of Notch2 in Splenic Marginal Zone Lymphoma

Autoimmune Thrombocytopenia in Mice Immunized with Allogeneic Platelets: A Model for Post-Transfusion Purpura (PTP)?

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Binding of Quinine-Dependent Monoclonal Antibodies to Gpiib/Iiia Appears to Involve Drug-Induced Modulation of Antibody Affinity

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

RUNX1 Is Required For Maintenance Of Established T-ALL Blasts

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Angiopoietin-Like Proteins Stimulate HSC Development Through Direct Interaction With Notch

Evidence for Cooperation of Receptor Tyrosine Kinases and Activating NOTCH Mutations to Hyperactivate mTOR in T-Cell Leukemia: A Rationale Basis for Targeted Therapy

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American Society of Hematology

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American Society of Hematology

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