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Journal Articles

The Exosomal Transfer of Acid Sphingomyelinase Contributes to Drug Resistance in Multiple Myeloma

Inge Oudaert, MSc, Sylvia Faict, MSc, Ludovic D'Auria, PhD, Jonas Dehairs, PhD, Ken Maes, Philip Vlummens, MD, Lotte Jacobs, BSc, Kim De Veirman, Elke De Bruyne, PhD, Karel Fostier, MD, Isabelle Vande Broek, MD PhD, Rik Schots, Karin Vanderkerken, PhD, Johannes V. Swinnen, PhD, Eline Menu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3058.
https://doi.org/10.1182/blood-2019-122857
Published: 2019
Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2661.
https://doi.org/10.1182/blood-2019-125455
Published: 2019
Journal Articles

Separate Roles of Asparagine and Glutamine in Cytostatic Effect of L-Asparaginase - Stable Isotope Tracing Approach

Katerina Hlozkova, PhD, Alpesh Thakker, PhD, Natividad Alquézar-Artieda, Marketa Zaliova, MD PhD, Jan Trka, Prof., MD PhD, Daniel A Tennant, PhD, Julia Starkova, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2575.
https://doi.org/10.1182/blood-2019-127911
Published: 2019
Journal Articles

Linking Microenvironmental Signals to Metabolic Switches and Drug Responses in Chronic Lymphocytic Leukemia

Zhenghao Chen, Gaspard Cretenet, Hanneke ter Burg, Gabriela Andrejeva, Jeffrey C Rathmell, Francesco Forconi, MD DM, PhD FRCPath, Gerritje J. W. van der Windt, Arnon P. Kater, Eric Eldering
Journal: Blood
Blood (2019) 134 (Supplement_1): 479.
https://doi.org/10.1182/blood-2019-123005
Published: 2019
Journal Articles

Mitochondrial Complex II in Intestinal Epithelial Cells Is a Critical Metabolic Checkpoint That Regulates Severity of Gastrointestinal Graft-Versus-Host Disease

Hideaki Fujiwara, Anna V Mathew, Ilya Kovalenko, Pal Anupama, Dan Peltier, Stephanie Kim, Austin Taylor, BA, Katherine Oravecz-Wilson, Yaping Sun, Costas Lyssiotis, Alnawaz Rehemtulla, Subramanian Pennarthur, Pavan Reddy
Journal: Blood
Blood (2019) 134 (Supplement_1): 584.
https://doi.org/10.1182/blood-2019-126775
Published: 2019
Journal Articles

A Phase II Clinical Trial of Cpi-613 (devimistat) in Patients with Relapsed or Refractory Burkitt Lymphoma/Leukemia or High-Grade B-Cell Lymphoma with Rearrangements of MYC and BCL2 and/or BCL6

Ariela Noy, MD, Timothy S. Pardee, MD PhD, Liana Nikolaenko, MD, Raphael Eric Steiner, MD, Jeremy S. Abramson, MD MMSc, Kieron Dunleavy, MD, Sanjeev Luther, MBA
Journal: Blood
Blood (2019) 134 (Supplement_1): 4087.
https://doi.org/10.1182/blood-2019-131563
Published: 2019
Journal Articles

Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death

Matthew Tcheng, BSc, Alessia Roma, BSc, Nawaz Ahmed, MSc, Richard Smith, PhD, Preethi Jayanth, PhD, Mark D. Minden, MD PhD, Rose Hurren, BSc, Aaron D Schimmer, MD PhD, Gale Bozzo, PhD, David Hess, PhD, Kristin Hope, PhD, Kevin Rea, MSc, Tariq A. Akhtar, PhD, Al-Walid Mohsen, PhD, Jerry Vockley, MD PhD, Paul A. Spagnuolo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3922.
https://doi.org/10.1182/blood-2019-122262
Published: 2019
Journal Articles

New Insights into Heme Utilization Pathways

Emanuela Tolosano, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-25.
https://doi.org/10.1182/blood-2019-121068
Published: 2019
Journal Articles

Trial in Progress: Phase I Dose-Escalation and Dose-Expansion Trial of a Novel Glutaminase Inhibitor (CB-839 HCl) in Combination with Carfilzomib and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma

Wilson I Gonsalves, MD, Srinivas Devarakonda, MD, Rachid Baz, MD, Natalia Neparidze, MD, Alex A Adjei, MD PhD, Charles Kunos, MD, Shaji K. Kumar, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3160.
https://doi.org/10.1182/blood-2019-123399
Published: 2019
Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1506.
https://doi.org/10.1182/blood-2019-126738
Published: 2019
Journal Articles

Mitochondrial Dysfunction in Normal and Malignant Hematopoiesis

Aaron Schimmer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): SCI-11.
https://doi.org/10.1182/blood-2018-99-109470
Published: 2018
Journal Articles

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Yusuke Saito, MD PhD, Daisuke Sawa, MD, Mariko Kinoshita, MD, Ai Yamada, MD, Sachiyo Kamimura, MD, Kazuhiro Morishita, MD PhD, Tomoyoshi Soga, PhD, Hiroshi Moritake, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2601.
https://doi.org/10.1182/blood-2018-99-111581
Published: 2018
Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1311.
https://doi.org/10.1182/blood-2018-99-112529
Published: 2018
Journal Articles

High Glutathione and NAD(P)H Levels, and Increased Protein Folding Capacity Are Involved in Mediating Proteasome Inhibitor-Resistance in Multiple Myeloma

Lenka Besse, Andrej Besse, Marianne Kraus, Jürgen Bader, Christoph Driessen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1258.
https://doi.org/10.1182/blood.V130.Suppl_1.1258.1258
Published: 2017
Journal Articles

Inhibition of Oxphos with Iacs-010759 Depletes AML Leukemia Initiating Cells (LIC) in Vitro and Improves Survival in Pre-Clinical AML Models

Natalia Baran, PhD MD, Lina Han, PhD, Shannon Renee Sweeney, MS, Alessia Lodi, PhD, Shelley Herbrich, MS, Antonio Cavazos, MSc, Helen Ma, MS, Jason P Gay, MS, Ningping Feng, PhD, Hsiang-Chun Chen, PhD, Marcin Kaminski, PhD, Kenneth Dunner, Jr., AS, BS, Guilin Tang, MD, Gheath Alatrash, DO, PhD, Jennifer Molina, PhD, Monica L. Guzman, PhD, Jing Ning, PhD, Stefano Tiziani, PhD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1350.
https://doi.org/10.1182/blood.V130.Suppl_1.1350.1350
Published: 2017
Journal Articles

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Meng Li, PhD, Ying-Ling Chiang, PhD, Costas Lyssiotis, PhD, Matthew Teater, PhD, Hao Shen, MD, Ling Wang, MS, Jun Young Hong, BS, Hui Jin, PhD, Cihangir Duy, PhD, Sucharita Mistry, PhD, Leandro Cerchietti, MD, Justin Cross, PhD, Lewis Cantley, MD, Hening Lin, PhD, Ari Melnick, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 643.
https://doi.org/10.1182/blood.V130.Suppl_1.643.643
Published: 2017
Journal Articles

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

Zongdong Li, PhD, Wadie F. Bahou, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3763.
https://doi.org/10.1182/blood.V130.Suppl_1.3763.3763
Published: 2017
Journal Articles

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Simon Raffel, MD, Mattia Falcone, Niclas Kneisel, Jenny Hansson, Wei Wang, Christoph Lutz, MD, Gernot Poschet, Yannic Nonnenmacher, Patrizia Jensen, Claudia Scholl, MD, Stefan Fröhling, MD, Sibylle Cocciardi, MSc, Patrick Wuchter, MD, Christian Thiede, MD, Anne Floercken, Joerg Westermann, MD, Gerhard Ehninger, Karsten Hiller, Rüdiger Hell, Carl Herrmann, Anthony D. Ho, Jeroen Krijgsveld, Bernhard Radlwimmer, Andreas Trumpp, Prof, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 472.
https://doi.org/10.1182/blood.V130.Suppl_1.472.472
Published: 2017
Journal Articles

Small Molecule Activators of Protein Phosphatase 2A (SMAPs) Cause c-Myc Degradation and Tumor Growth Suppression in Preclinical Models of Lymphoid Malignancies

Molly M Gallogly, MDPhD, Eric Yuan, MPhil, Sahar Mazhar, BA, Caroline Farrington, BA, Goutham Narla, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2819.
https://doi.org/10.1182/blood.V130.Suppl_1.2819.2819
Published: 2017
Journal Articles

Glutamine Catabolism Maintains MCL-1 Expression in Glucose-Deprived Multiple Myeloma

Changyong Wei, PhD BS, Richa Bajpai, PhD, Alisha D Hunter, MS, Darius Mahboubi, MS, Mala Shanmugam, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3076.
https://doi.org/10.1182/blood.V130.Suppl_1.3076.3076
Published: 2017