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Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Blood (2020) 136 (11): 1303–1316.

https://doi.org/10.1182/blood.2019001808

Published: 2020

Includes: Supplemental data

Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD

Blood (2019) 134 (Supplement_1): 2260.

https://doi.org/10.1182/blood-2019-128727

Published: 2019

Journal Articles

A Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, Triggers Intravascular Coagulation and Inflammation through Generation of Tissue Factor-Positive Microvesicles

Shabbir Ansari, PhD, Shiva Keshava Gaddam Bala Krishna, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 2383.

https://doi.org/10.1182/blood-2019-124498

Published: 2019

Journal Articles

Pharmacologic Activation of Aldehyde Metabolism to Protect Hematopoietic Stem Cells (HSC) in Murine Models of Fanconi Anemia (FA)

Jennifer Tsai, MD, Kelsey R. Logas, MS, Lauren D. Van Wassenhove, PhD, Beruh Dejene, BS, Che-Hong Chen, PhD, Daria Mochly-Rosen, PhD, Kenneth I. Weinberg, MD

Blood (2019) 134 (Supplement_1): 105.

https://doi.org/10.1182/blood-2019-124439

Published: 2019

Journal Articles

A Novel Source of Endogenous DNA Damage That Requires Repair By the Fanconi Anemia Pathway

Moonjung Jung, MD, Sunandini Sridhar, PhD, Audrey Goldfarb, BA, Ryan White, PhD, Danielle Keahi, BA, Raymond Noonan, BA, Tom Wiley, BS, Francis P. Lach, BS, Agata Smogorzewska, MD PhD

Blood (2019) 134 (Supplement_1): 106.

https://doi.org/10.1182/blood-2019-127686

Published: 2019

Journal Articles

Replication Stress Response and CDKN1A Engagement Constrain Fetal Hematopoietic Stem Cell Pool Size in Fanconi Anemia

Makiko Mochizuki-Kashio, PhD, Young Me Yoon, Theresa N Menna, BS, Markus Grompe, MD, Peter Kurre, MD

Blood (2019) 134 (Supplement_1): 107.

https://doi.org/10.1182/blood-2019-125669

Published: 2019

Journal Articles

A Novel Non-Covalent Modulator of Hemoglobin Improves Anemia and Reduces Sickling in a Mouse Model of Sickle Cell Disease

Kelly M. Knee, PhD, Reema Jasuja, PhD, Amey Barakat, MS, Dharani Rao, Zane Wenzel, MS, Parag Sahasrabudhe, Jatin Narula, PhD, Jay Jasti, Jeanne S. Chang, Kevin Beaumont, David W. Piotrowski, Jay M. Janz, PhD

Blood (2019) 134 (Supplement_1): 207.

https://doi.org/10.1182/blood-2019-128270

Published: 2019

Journal Articles

Fanconi Anemia: A Paradigm for Understanding DNA Repair During Replication.

Agata Smogorzewska, MD PhD

Blood (2019) 134 (Supplement_1): SCI-32.

https://doi.org/10.1182/blood-2019-121229

Published: 2019

Journal Articles

Dual Targeting of ALDH1 and ALDH3: A Promising Therapeutic Approach in Acute Myeloid Leukemia

Mileidys Perez-Alea, Sr., PhD, Julien Colle, Jr., MD, Muhube Yazir, Jr., MSc, Céline Baier, Jr., PhD, Yasmine Labiad, PhD, Isabelle Arnoux, Sr., Hematologist, Geoffroy Venton, Jr., PhD MD, Guillaume Guillaume, MSc, Ismail Ceylan, MSc, Regis T. Costello, Sr., MD PhD

Blood (2019) 134 (Supplement_1): 3364.

https://doi.org/10.1182/blood-2019-126484

Published: 2019

Journal Articles

Characterization of Pathogenic Variants and Clinical Phenotypes in 117 Japanese Fanconi Anemia Patients

Minako Mori, MD, Asuka Hira, MD PhD, Kenichi Yoshida, MD PhD, Hideki Muramatsu, MD PhD, Yusuke Okuno, MD PhD, Michiko Anmae, MS, Kazuo Tamura, MD PhD, Jun Yasuda, MD PhD, Tomoo Osumi, MD, Yasushi Noguchi, MD, Souichi Adachi, MD PhD, Hiroshi Kawabata, MD PhD, Akifumi Takaori-Kondo, MD PhD, Seiji Kojima, MD PhD, Seishi Ogawa, MD PhD, Hiromasa Yabe, MD, PhD, Miharu Yabe, MD PhD, Minoru Takata, MD PhD

Blood (2018) 132 (Supplement 1): 3860.

https://doi.org/10.1182/blood-2018-99-110362

Published: 2018

Journal Articles

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 428.

https://doi.org/10.1182/blood-2018-99-118745

Published: 2018

Journal Articles

LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

Benjamin Vieira, Vu P. Hong, Kunal Desai, Martin K. Safo, David R. Light

Blood (2018) 132 (Supplement 1): 1074.

https://doi.org/10.1182/blood-2018-99-116319

Published: 2018

Journal Articles

The Novel Small Molecule Inhibitor KS99 Targets AML and Inhibits Stemness Markers STAT3 and ALDH

Charyguly Annageldiyev, Krishne Gowda, Dhimant Desai, Viola Devine, Daniel Brosius, Chandrika Gowda, MBBS, Sinisa Dovat, MD PhD, Shantu Amin, David F. Claxton, MD, Arati Sharma, PhD

Blood (2018) 132 (Supplement 1): 1440.

https://doi.org/10.1182/blood-2018-99-117376

Published: 2018

Journal Articles

Trph-222, a Novel Anti-CD22 Antibody Drug Conjugate (ADC), Has Signficant Anti-Tumor Activity in NHL Xenografts and Is Well Tolerated in Non-Human Primates

Ann Maclaren, PhD BS, Nancy Levin, PhD, Henry Lowman, PhD, Mohit Trikha, PhD

Blood (2017) 130 (Supplement 1): 4105.

https://doi.org/10.1182/blood.V130.Suppl_1.4105.4105

Published: 2017

Journal Articles

4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption By Two Independent Mechanisms

Shabbir Ansari, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 1382.

https://doi.org/10.1182/blood.V128.22.1382.1382

Published: 2016

Journal Articles

Alda-1 Constrains TLR-Induced Cytokine Overproduction By Fanconi Anemia Macrophages By Enhancing ALDH1A1 Activity

Michael Garbati, PhD BS, Winifred Keeble, BS, Wenjin Yang, PhD, Grover C. Bagby, Jr., MD MACP

Blood (2015) 126 (23): 1000.

https://doi.org/10.1182/blood.V126.23.1000.1000

Published: 2015

Journal Articles

Impaired Spindle Assembly Checkpoint In Vivo Promotes MDS/AML in a Novel Mouse Model of Fanconi Anemia

Donna Cerabona, Zahi Abdul Sater, Elizabeth Sierra Potchanant, PhD, Ying He, Zejin Sun, MD PhD, Grzegorz Nalepa, MDPhD

Blood (2015) 126 (23): 1211.

https://doi.org/10.1182/blood.V126.23.1211.1211

Published: 2015

Journal Articles

Tissue Factor Decryption By Oxidative Stress-Induced Lipid Peroxidation: Potential Mechanisms

Shabbir Ansari, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2015) 126 (23): 125.

https://doi.org/10.1182/blood.V126.23.125.125

Published: 2015

Journal Articles

Replication Associated Stress in the Fetal Stem Cell Pool of FA Mice Can be Rescued By Pharmacologic Inhibition of Constitutively Activated P38 MAPK

Youngme Yoon, B.S., Ashley N. Kamimae-Lanning, PhD, Kelsie Storm, MD, Natalya A Goloviznina, B.S., Peter Kurre, MD

Blood (2015) 126 (23): 2411.

https://doi.org/10.1182/blood.V126.23.2411.2411

Published: 2015

Journal Articles

NEOD001 Specifically Binds Aggregated Light Chain Infiltrates in Multiple Organs from Patients with AL Amyloidosis and Promotes Phagocytic Clearance of AL Aggregates in Vitro

Wagner Zago, Mark Renz, Ronald Torres, Philip J. Dolan, Robin M. Barbour, Joshua R. Salmans, Paul J. Shughrue, Dale Schenk, Gene G. Kinney

Blood (2015) 126 (23): 3016.

https://doi.org/10.1182/blood.V126.23.3016.3016

Published: 2015

NARROW

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

A Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, Triggers Intravascular Coagulation and Inflammation through Generation of Tissue Factor-Positive Microvesicles

Pharmacologic Activation of Aldehyde Metabolism to Protect Hematopoietic Stem Cells (HSC) in Murine Models of Fanconi Anemia (FA)

A Novel Source of Endogenous DNA Damage That Requires Repair By the Fanconi Anemia Pathway

Replication Stress Response and CDKN1A Engagement Constrain Fetal Hematopoietic Stem Cell Pool Size in Fanconi Anemia

A Novel Non-Covalent Modulator of Hemoglobin Improves Anemia and Reduces Sickling in a Mouse Model of Sickle Cell Disease

Fanconi Anemia: A Paradigm for Understanding DNA Repair During Replication.

Dual Targeting of ALDH1 and ALDH3: A Promising Therapeutic Approach in Acute Myeloid Leukemia

Characterization of Pathogenic Variants and Clinical Phenotypes in 117 Japanese Fanconi Anemia Patients

Small-Molecule Targeting of Musashi RNA-Binding Activity in Acute Myeloid Leukemia

LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences

The Novel Small Molecule Inhibitor KS99 Targets AML and Inhibits Stemness Markers STAT3 and ALDH

Trph-222, a Novel Anti-CD22 Antibody Drug Conjugate (ADC), Has Signficant Anti-Tumor Activity in NHL Xenografts and Is Well Tolerated in Non-Human Primates

4-Hydroxy-2-Nonenal (HNE), a Product of Lipid Peroxidation, Induces Tissue Factor Decryption By Two Independent Mechanisms

Alda-1 Constrains TLR-Induced Cytokine Overproduction By Fanconi Anemia Macrophages By Enhancing ALDH1A1 Activity

Impaired Spindle Assembly Checkpoint In Vivo Promotes MDS/AML in a Novel Mouse Model of Fanconi Anemia

Tissue Factor Decryption By Oxidative Stress-Induced Lipid Peroxidation: Potential Mechanisms

Replication Associated Stress in the Fetal Stem Cell Pool of FA Mice Can be Rescued By Pharmacologic Inhibition of Constitutively Activated P38 MAPK

NEOD001 Specifically Binds Aggregated Light Chain Infiltrates in Multiple Organs from Patients with AL Amyloidosis and Promotes Phagocytic Clearance of AL Aggregates in Vitro

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American Society of Hematology

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ASH Publications

American Society of Hematology

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