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Zezhou Wang
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Journal Articles

Preclinical Characterization of TTI-281, a Novel, Orally Bioavailable BET Inhibitor: Predictive Biomarker Identification and Combination Treatment Analysis

Free
Jaehyun Choi, PhD, Chunlei Wang, Zezhou Wang, PhD, Aaron D. Schimmer, MD PhD, Penka S. Petrova, PhD, Malik Slassi, PhD, Robert A. Uger, PhD
Journal: Blood
Blood (2016) 128 (22): 4719.
https://doi.org/10.1182/blood.V128.22.4719.4719
Published: 2016
Journal Articles

TTI-281, an Orally Bioavailable Bromodomain and Extraterminal Domain (BET) Inhibitor, Is a Promising Candidate for the Treatment of Multiple Myeloma

Free
Zezhou Wang, PhD, Jaehyun Choi, PhD, Peter Dove, Chunlei Wang, Aaron D. Schimmer, MD PhD, Penka S. Petrova, PhD, Robert A. Uger, PhD, Malik Slassi, PhD
Journal: Blood
Blood (2016) 128 (22): 2095.
https://doi.org/10.1182/blood.V128.22.2095.2095
Published: 2016
Journal Articles

The Highly Potent Bromodomain (BRD) Inhibitor FV-281 Displays Preclinical Efficacy in Acute Myeloid Leukemia (AML)

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Zezhou Wang, PhD, Peter Dove, Aisha Shamas-Din, PhD, Rose Hurren, Xiaoming Wang, Neil MacLean, Marcela Gronda, Feng Bo, Janessa Li, Clarissa Skorupski, Wissam Hadri, David O'Neill, PhD, Ahmed Aman, PhD, Rima Al-awar, PhD, Mark D. Minden, MD PhD, Malik Slassi, PhD, Aaron D. Schimmer, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1364.
https://doi.org/10.1182/blood.V126.23.1364.1364
Published: 2015
Journal Articles

Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia

Free
Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Etienne Coyaud, PhD, Rose Hurren, Marcela Gronda, MSc, Fengshu Lin, PhD, Neil Maclean, BSc, Elisa Leung, BSc, Yihua Qiu, MD, Nianxiang Zhang, PhD, Kevin R. Coombes, PhD, Mark D. Minden, MD PhD, Walid A. Houry, PhD, Zenyaho Hao, PhD, Steven M. Kornblau, MD, Brian Raught, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 3937.
https://doi.org/10.1182/blood.V122.21.3937.3937
Published: 2013
Journal Articles

FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo

Free
Zezhou Wang, PhD, Peter Dove, Xiaoming Wang, Carolyn A. Goard, PhD, Zhihua Li, Alex Nachman, Yoonsun Jenny Oh, Rose Hurren, Amy Ruschak, PhD, Shane Climie, PhD, David O'Neill, PhD, Barry Press, PhD, Carly Griffin, PhD, Elijus Undzys, Ahmed Aman, PhD, Rima Al-awar, PhD, Lewis Kay, PhD, Suzanne Trudel, MD, MSC, FRCPC, Malik Slassi, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 1988.
https://doi.org/10.1182/blood.V122.21.1988.1988
Published: 2013
Journal Articles

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Free
Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Rose Hurren, BSc, Fengshu Lin, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Methvin Isaac, PhD, Elisa Leung, BSc., Mohan Babu, PhD, Mahadeo A. Sukhai, PhD, Walid A. Houry, PhD, Aaron D. Schimmer, MD
Journal: Blood
Blood (2012) 120 (21): 3603.
https://doi.org/10.1182/blood.V120.21.3603.3603
Published: 2012
Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Free
Marko Skrtic, BSc, Shrivani Sriskanthadevan, PhD, Bozhena Livak, BSc, Marinella Gebbia, PhD, Xiaoming Wang, Zezhou Wang, PhD, Rose Hurren, BSc, Yulia Jitkova, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Courteney Lai, BSc, Yanina Eberhard, BSc, PhD, Justyna Bartoszko, BSc, Paul A. Spagnuolo, PhD, Angela Rutledge, PhD, Alessandro Datti, PhD, Troy Ketela, Jason Moffat, Brian H Robinson, PhD, Jessie M Cameron, PhD, Jeff L. Wrana, PhD, Connie J. Eaves, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, R. Keith Humphries, MD, PhD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 233.
https://doi.org/10.1182/blood.V118.21.233.233
Published: 2011