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Journal Articles

Reprogramming T Cell EZH2 to Counteract CAR T Cell Dysfunction during Tumor Control

Mimi Chen, Wenbin Mo, Gennaro Clando, Yuanyuan Tian, Ciril Abraham, Qingrong Huang, Ying WANG, Morgan Chaunzwa, Yan Zhou, Andrew Ip, Andre Goy, Jaroslav Jelinek, Jozef Madzo, Jean-Pierre Issa, Yi Zhang

Blood (2024) 144 (Supplement 1): 2039.

https://doi.org/10.1182/blood-2024-207438

Published: 2024

Journal Articles

Cytokine Release Syndrome in HSCT May Affect Dendritic Cell Recovery and Early Development of aGVHD

Xin Liu, Bohan Li, Shengqin Cheng, Jinlan Zhao, Peifang Xiao, Jun Lu, Jie Li, Yuanyuan Tian, Shaoyan Hu

Blood (2024) 144 (Supplement 1): 7373.

https://doi.org/10.1182/blood-2024-210154

Published: 2024

Journal Articles

Ezh2 and Intracellular Ca2 + Signals Interdependently Coordinate Gvhd and CAR T Cell Responses

Ying WANG, Qingrong Huang, Ruqayyah sanders-Braggs, Yan Zhou, Robert Hooper, Yuanyuan Tian, Tatiana Kent, Richard Pomerantz, Gennaro Clando, Jean-Pierre Issa, Jonathan Soboloff, Yi Zhang

Blood (2024) 144 (Supplement 1): 4769.

https://doi.org/10.1182/blood-2024-212207

Published: 2024

Journal Articles

Human IFN-α2- and PD-L1-Modified T Cells (αp-T cells) Inhibit Graft-Versus-Host Disease but Retain Anti-Leukemia Activity

Yuanyuan Tian, Bei Jia, Che Young Lee, Qingrong Huang, Chenchen Zhao, Ciril Abraham, Wenbin Mo, Mimi Chen, Ying WANG, Hong Zheng, Yi Zhang

Blood (2024) 144 (Supplement 1): 87.

https://doi.org/10.1182/blood-2024-203954

Published: 2024

Journal Articles

Inhibiting Tumor Cell CDK9 Reprograms Cell Death Pathways to Enhance Efficacy of CAR T Cell Therapy

Ciril Abraham, Wenbin Mo, Tien Bui, Mimi Chen, Yuanyuan Tian, Gennaro Clando, Morgan Chaunzwa, Ying WANG, Jozef Madzo, Jean-Pierre Issa, Yi Zhang

Blood (2024) 144 (Supplement 1): 3430.

https://doi.org/10.1182/blood-2024-211530

Published: 2024

Journal Articles

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1–mediated immune suppression during GVHD

Ying Wang, Shan He, Gennaro Calendo, Tien Bui, Yuanyuan Tian, Che Young Lee, Yan Zhou, Xin Zhao, Ciril Abraham, Wenbin Mo, Mimi Chen, Ruqayyah Sanders-Braggs, Jozef Madzo, Jean-Pierre Issa, Elizabeth O. Hexner, David L. Wiest, Ran Reshef, Hai-Hui Xue, Yi Zhang

Blood (2024) 143 (2): 166–177.

https://doi.org/10.1182/blood.2023021126

Published: 2024

Includes: Supplemental data

Journal Articles

PGK1 Represents a Therapeutic Target for Pediatric Acute Myeloid Leukemia Via Regulating c-Myc/SLC7A5/mTOR Pathway

Junyan Gao, Yijun Wu, Yuanyuan Tian, De-Pei Wu, Shaoyan Hu

Blood (2023) 142 (Supplement 1): 1373.

https://doi.org/10.1182/blood-2023-185303

Published: 2023

Journal Articles

Phosphodiesterase 3A Acts As a Tumor Activator and Its Inhibitor Anagrelide Combined with Idarubicin Represents a Potential Therapeutic Approach for PDE3A High Expressed Acute Myeloid Leukemia through Pyroptosis By Triggering Cleavage of Gasdermin E

Chenwei Yang, Zhiheng Li, Jing Ling, Li Gao, Ran Zhuo, Yayun Du, Hu Liu, Yongping Zhang, Qi Ji, Minyuan Liu, Shaoyan Hu, Yuanyuan Tian

Blood (2023) 142 (Supplement 1): 5703.

https://doi.org/10.1182/blood-2023-185410

Published: 2023

Journal Articles

The Influence of Methotrexate-Related Transporter and Metabolizing Enzyme Gene Polymorphisms on Peri-Engraftment Syndrome and Graft-Versus-Host Disease after Haplo-Hematopoietic Stem Cell Transplantation in Pediatric Patients with Malignant Hematological Diseases

Qi Ji, Yongping Zhang, Yixin Hu, Lixia Liu, Shanbo Cao, Li Gao, Bohan Li, Yuanyuan Tian, Lingjun Kong, Shuiyan Wu, Jing Ling, Peifang Xiao, Jun Lu, Jie Li, Yanhua Yao, Jiayue Qin, Shaoyan Hu

Blood (2023) 142 (Supplement 1): 6960.

https://doi.org/10.1182/blood-2023-185431

Published: 2023

Journal Articles

Dysregulation of Immune Regulators in AML Bone Marrow Promotes Dysfunction of CD8 + T Cells

Yongping Zhang, Yuanyuan Tian, Lijun Meng, Qi Ji, Yijun Wu, Chenwei Yang, Li Gao, Yixin Hu, Yanhua Yao, Peifang Xiao, Jun Lu, Hailong He, Yi Zhang, Shaoyan Hu

Blood (2023) 142 (Supplement 1): 5616.

https://doi.org/10.1182/blood-2023-187900

Published: 2023

Journal Articles

A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis

Blood (2023) 141 (9): 1070–1086.

https://doi.org/10.1182/blood.2022017262

Published: 2023

Includes: Supplemental data

Journal Articles

Improved Grfs Observed in a Multicenter Prospective Study of Tcrαβ- and CD45RA-Depleted Haploidentical Transplant in Children with Acute Leukemia

Chengjuan Luo, Shaoyan Hu, Xiaoqin Feng, Jun Lu, Hua Zhu, Yongsheng Ruan, Jing Ling, Changying Luo, Jianmin Wang, Yuanyuan Tian, Bohan Li, Wing H. Leung, Jing Chen

Blood (2022) 140 (Supplement 1): 10458–10459.

https://doi.org/10.1182/blood-2022-165009

Published: 2022

Journal Articles

The Association of pDC Dose in Graft with CMV and EBV Infection after Allo-HSCT in Pediatric Patients: A Single-Center Experience

Di Yao, Bohan Li, Lu Liu, Lijun Meng, Shaoyan Hu, Yuanyuan Tian

Blood (2022) 140 (Supplement 1): 10527.

https://doi.org/10.1182/blood-2022-170635

Published: 2022

Journal Articles

Association between Haploidentical Hematopoietic Stem Cell Transplantation Combined with an Umbilical Cord Blood Unit and Graft-Versus-Host Disease in Pediatric Patients with Acquired Severe Aplastic Anemia

Di Yao, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Peifang Xiao, Lijun Meng, Shaoyan Hu, Yuanyuan Tian

Blood (2022) 140 (Supplement 1): 7634–7635.

https://doi.org/10.1182/blood-2022-170554

Published: 2022

Journal Articles

Anagrelide Represents a Potential Therapeutic Therapy for Acute Myeloid Leukemia Cells Based on Phosphodiesterase 3A Expression

Chenwei Yang, Li Gao, Jing Ling, Hu Liu, Qi Ji, Minyuan Liu, Yongping Zhang, Shaoyan Hu, Yuanyuan Tian

Blood (2022) 140 (Supplement 1): 8738–8739.

https://doi.org/10.1182/blood-2022-168553

Published: 2022

Journal Articles

Graft-Versus-Host Disease Causes the Failure of Donor Hematopoietic Progenitor Cells to Reconstitute Plasmacytoid Dendritic Cells That Promote Tolerance of Donor T Cells Against the Host

Yuanyuan Tian, Lijun Meng, PhD, Hongshuang Yu, Ying Wang, PhD, Tien Bui, Shin Mineishi, MD, Hong Zheng, MD PhD, Stefania Gallucci, MD, Yanyun Zhang, Shaoyan Hu, MD PhD, Yi Zhang, MD PhD

Blood (2019) 134 (Supplement_1): 193.

https://doi.org/10.1182/blood-2019-128721

Published: 2019

Journal Articles

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

Ying Wang, PhD, Shan He, PhD, Yongnian Liu, Robert Hooper, PhD, Hongshuang Yu, Yuanyuan Tian, Bui Tien, Bryant M Schultz, John W Elrod, PhD, Jonathan Soboloff, Yi Zhang, MD PhD

Blood (2019) 134 (Supplement_1): 4432.

https://doi.org/10.1182/blood-2019-131115

Published: 2019

Journal Articles

Stim1 Deletion Synthetically Rescues Ezh2-Null Effector T Cells and Alloimmunity

Ying Wang, PhD, Shan He, PhD, Yongnian Liu, Robert Hooper, PhD, Hongshuang Yu, Yuanyuan Tian, Hongxing Sun, PhD, Ran Reshef, MD MSc, Elizabeth O. Hexner, MD MS, Jonathan Soboloff, Yi Zhang, MD

Blood (2018) 132 (Supplement 1): 4533.

https://doi.org/10.1182/blood-2018-99-118720

Published: 2018

Journal Articles

Graft-Versus-Host Disease Impairs the Histone Methyltransferase Dot1l-Regulated Reconstitution of Plasmacytoid Dendritic Cells in Mice Undergoing Allo-HSCT

Yuanyuan Tian, Lijun Meng, PhD, Hongshuang Yu, Elizabeth O. Hexner, MDMS, Leizhen Zheng, MD, Shaoyan Hu, MD PhD, Yanyun Zhang, Yi Zhang, MD

Blood (2018) 132 (Supplement 1): 477.

https://doi.org/10.1182/blood-2018-99-118751

Published: 2018

Journal Articles

Id3 Is Essential for Mediating Ezh2-Regulated Persistence of Alloreactive T Cells in Gvhd Target Tissues in Mice

Shan He, PhD, Yuanyuan Tian, Yongnian Liu, Ying Wang, Bruce Blazar, MD, Ximi K Wang, Ran Reshef, MD, Yi Zhang, MD

Blood (2017) 130 (Supplement 1): 210.

https://doi.org/10.1182/blood.V130.Suppl_1.210.210

Published: 2017

NARROW

Reprogramming T Cell EZH2 to Counteract CAR T Cell Dysfunction during Tumor Control

Cytokine Release Syndrome in HSCT May Affect Dendritic Cell Recovery and Early Development of aGVHD

Ezh2 and Intracellular Ca2 + Signals Interdependently Coordinate Gvhd and CAR T Cell Responses

Human IFN-α2- and PD-L1-Modified T Cells (αp-T cells) Inhibit Graft-Versus-Host Disease but Retain Anti-Leukemia Activity

Inhibiting Tumor Cell CDK9 Reprograms Cell Death Pathways to Enhance Efficacy of CAR T Cell Therapy

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1–mediated immune suppression during GVHD

PGK1 Represents a Therapeutic Target for Pediatric Acute Myeloid Leukemia Via Regulating c-Myc/SLC7A5/mTOR Pathway

Phosphodiesterase 3A Acts As a Tumor Activator and Its Inhibitor Anagrelide Combined with Idarubicin Represents a Potential Therapeutic Approach for PDE3A High Expressed Acute Myeloid Leukemia through Pyroptosis By Triggering Cleavage of Gasdermin E

The Influence of Methotrexate-Related Transporter and Metabolizing Enzyme Gene Polymorphisms on Peri-Engraftment Syndrome and Graft-Versus-Host Disease after Haplo-Hematopoietic Stem Cell Transplantation in Pediatric Patients with Malignant Hematological Diseases

Dysregulation of Immune Regulators in AML Bone Marrow Promotes Dysfunction of CD8 + T Cells

A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis

Improved Grfs Observed in a Multicenter Prospective Study of Tcrαβ- and CD45RA-Depleted Haploidentical Transplant in Children with Acute Leukemia

The Association of pDC Dose in Graft with CMV and EBV Infection after Allo-HSCT in Pediatric Patients: A Single-Center Experience

Association between Haploidentical Hematopoietic Stem Cell Transplantation Combined with an Umbilical Cord Blood Unit and Graft-Versus-Host Disease in Pediatric Patients with Acquired Severe Aplastic Anemia

Anagrelide Represents a Potential Therapeutic Therapy for Acute Myeloid Leukemia Cells Based on Phosphodiesterase 3A Expression

Graft-Versus-Host Disease Causes the Failure of Donor Hematopoietic Progenitor Cells to Reconstitute Plasmacytoid Dendritic Cells That Promote Tolerance of Donor T Cells Against the Host

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

Stim1 Deletion Synthetically Rescues Ezh2-Null Effector T Cells and Alloimmunity

Graft-Versus-Host Disease Impairs the Histone Methyltransferase Dot1l-Regulated Reconstitution of Plasmacytoid Dendritic Cells in Mice Undergoing Allo-HSCT

Id3 Is Essential for Mediating Ezh2-Regulated Persistence of Alloreactive T Cells in Gvhd Target Tissues in Mice

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American Society of Hematology

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ASH Publications

American Society of Hematology

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