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Journal Articles

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Hisashi Kato, MD PhD, Shigenori Honda, MD, Hirokazu Kashiwagi, Nobuko Nishiura, Keigo Akuta, Koichi Kokame, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2019) 134 (Supplement_1): 1062.

https://doi.org/10.1182/blood-2019-129668

Published: 2019

Journal Articles

Physicians' and Patients' Perspectives on Treatments in ITP - a Multi-Country Perspective: Results from the ITP World Impact Survey (I-WISh)

James B. Bussel, MD, Waleed Ghanima, MD PhD, Yoshiaki Tomiyama, MD, Donald M. Arnold, MD, Drew Provan, MD, Ming Hou, MD PhD, Cristina Santoro, MD PhD, Serge Laborde, Alexandra Kruse, Caroline Kruse, Mervyn Morgan, Barbara Lovrencic, John Waller, PhD, Jens Haenig, Nichola Cooper, MD MRCP

Blood (2019) 134 (Supplement_1): 1097.

https://doi.org/10.1182/blood-2019-130591

Published: 2019

Journal Articles

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Keigo Akuta, Kazunobu Kiyomizu, MD, Hirokazu Kashiwagi, Shinji Kunishima, PhD, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, MD PhD, Shigenori Honda, MD, Yuzuru Kanakura, MD PhD, Toshiyuki Miyata, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 3743.

https://doi.org/10.1182/blood-2018-99-115953

Published: 2018

Journal Articles

Efficacy and Safety of Romiplostim in Patients with Acquired Aplastic Anemia Ineligible or Refractory to Immunosuppressive Therapy: Interim Analysis of Phase 2/3 Clinical Trial

Blood (2018) 132 (Supplement 1): 1306.

https://doi.org/10.1182/blood-2018-99-112478

Published: 2018

Journal Articles

Results from the ITP World IMPACT Survey (I-WISh): Patients with Immune Thrombocytopenia (ITP) Experience Impaired Quality of Life (QoL) Regarding Daily Activities, Social Interactions, Emotional Well-Being and Working Lives

Nichola Cooper, MRCP, Alexandra Kruse, Caroline Kruse, Shirley Watson, Mervyn Morgan, James B. Bussel, MD, Waleed Ghanima, Donald M. Arnold, MD MSc, FRCPC, Cristina Santoro, Ming Hou, MD, Yoshiaki Tomiyama, MD, Serge Laborde, Barbara Lovrencic, John Waller, PhD BSc, Tom Bailey, Gavin Taylor-Stokes, Miona Stankovic, Andrew Provan

Blood (2018) 132 (Supplement 1): 4804.

https://doi.org/10.1182/blood-2018-99-112858

Published: 2018

Journal Articles

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Hisashi Kato, MDPhD, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD

Blood (2018) 132 (Supplement 1): 1136.

https://doi.org/10.1182/blood-2018-99-112852

Published: 2018

Journal Articles

Patients with Immune Thrombocytopenia (ITP) Frequently Experience Severe Fatigue but Is It Under-Recognized By Physicians: Results from the ITP World Impact Survey (I-WISh)

Caroline Kruse, Alexandra Kruse, Shirley Watson, Mervyn Morgan, Nichola Cooper, MRCP, Waleed Ghanima, Andrew Provan, Donald M. Arnold, MD MSc, FRCPC, Cristina Santoro, Ming Hou, MD, Yoshiaki Tomiyama, MD, Serge Laborde, Barbara Lovrencic, John Waller, PhD BSc, Gavin Taylor-Stokes, Tom Bailey, Miona Stankovic, James B. Bussel, MD

Blood (2018) 132 (Supplement 1): 2273.

https://doi.org/10.1182/blood-2018-99-112378

Published: 2018

Journal Articles

Addition of Melphalan to Fludarabine/Busulfan (FLU/BU4/MEL) Provides Survival Benefit for Patients with Myeloid Malignancy Following Allogeneic Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation

Tomoaki Ueda, Tetsuo Maeda, MD, Kentaro Fukushima, MD PhD, Jiro Fujita, MD PhD, Shinsuke Kusakabe, MD, Takafumi Yokota, MD PhD, Hirohiko Shibayama, MD PhD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 2099.

https://doi.org/10.1182/blood-2018-99-112328

Published: 2018

Journal Articles

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Yoichiro Morikawa, MD, Hisashi Kato, MD PhD, Keigo Akuta, MD, Hirokazu Kashiwagi, MD PhD, Shigenori Honda, MD PhD, Yuzuru Kanakura, MD PhD, Yoshiaki Tomiyama, MD PhD

Blood (2016) 128 (22): 4908.

https://doi.org/10.1182/blood.V128.22.4908.4908

Published: 2016

Journal Articles

Rituximab As Second-Line Treatment For Chronic Immune Thrombocytopenia: Investigator-Initiated Clinical Trial In Japan

Yoshitaka Miyakawa, MD, PhD, Shinya Katsutani, MD, PhD, Takahiro Yano, MD, PhD, Shosaku Nomura, MD, PhD, Kaichi Nishiwaki, MD, Yoshiaki Tomiyama, MD, PhD, Masaaki Higashihara, MD, PhD, Yukari Shirasugi, MD, PhD, Masakatsu Nishikawa, MD, PhD, Katsutoshi Ozaki, MD, PhD, Kayoko Kikuchi, Takayuki Abe, PhD, Yuji Sato, MD, PhD, Yuzuru Kanakura, Kingo Fujimura, MD, PhD, Yasuo Ikeda, MD, PhD, Shinichiro Okamoto, MD, PhD

Blood (2013) 122 (21): 3554.

https://doi.org/10.1182/blood.V122.21.3554.3554

Published: 2013

Journal Articles

Evaluation of Romiplostim In a Randomized Placebo-Controlled Phase 3 Study of a Japanese Population with Chronic Immune Thrombocytopenia (ITP).

Koji Miyazaki, MD, Yukari Shirasugi, MD, Kiyoshi Ando, MD, PhD, Yoshiaki Tomiyama, MD, Shinichiro Okamoto, MD, PhD, Mineo Kurokawa, MD, Keita Kirito, MD, Yuji Yonemura, MD, PhD, Shinichiro Mori, MD, Kensuke Usuki, MD, PhD, Koji Iwato, MD, PhD, Satoshi Hashino, MD, PhD, Helen Wei, PhD, Richard Lizambri, MD

Blood (2010) 116 (21): 3704.

https://doi.org/10.1182/blood.V116.21.3704.3704

Published: 2010

Journal Articles

Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor

Tsuyoshi Kamae, MD, Kazunobu Kiyomizu, MD, Tsuyoshi Nakazawa, MD, Seiji Tadokoro, MD, Shigenori Honda, MD, Hirokazu Kashiwagi, MD, Yuzuru Kanakura, MD, PhD, Yoshiaki Tomiyama, MD

Blood (2010) 116 (21): 2524.

https://doi.org/10.1182/blood.V116.21.2524.2524

Published: 2010

Journal Articles

Six Month Treatment of Low Dose Eltrombopag Is Efficacious in Japanese Patients with Refractory Chronic Immune Thrombocytopenic Purpura (ITP).

Yoshiaki Tomiyama, MD, Yoshitaka Miyakawa, MD, PhD, Shinichiro Okamoto, MD, PhD, Shinya Katsutani, MD, Akiro Kimura, MD, Yasushi Okoshi, MD, PhD, Haruhiko Ninomiya, MD, PhD, Hiroshi Kosugi, MD, PhD, Shosaku Nomura, MD, Katsutoshi Ozaki, MD, Yasuo Ikeda, MD, Nobuyuki Koh, Koichi Katsura, MD, PhD, Yuzuru Kanakura, MD, PhD

Blood (2009) 114 (22): 1324.

https://doi.org/10.1182/blood.V114.22.1324.1324

Published: 2009

Journal Articles

Antagonism of P2y12 Receptor Results in Severe Impairment of Serum Thromboxane Levels. Can We Manage Patients without Combination Therapy with Aspirin?

Kamala Bhavaraju, MS, Alexander Georgakis, Jianguo Jin, MD, Yoshiaki Tomiyama, MD, Alan T. Nurden, Paquita Nurden, Satya P. Kunapuli, Ph.D.

Blood (2009) 114 (22): 4013.

https://doi.org/10.1182/blood.V114.22.4013.4013

Published: 2009

Journal Articles

P2Y 12 -Independent Transient Activation and P2Y 12 -Dependent Prolonged Activation of Platelet Integrin α IIb β 3 .

Masamichi Shiraga, MD, Tsuyoshi Kamae, MD, Masao Akiyama, MD, Seiji Tadokoro, MD, Hirokazu Kashiwagi, MD, Kenji Oritani, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2006) 108 (11): 1509.

https://doi.org/10.1182/blood.V108.11.1509.1509

Published: 2006

Journal Articles

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Tsuyoshi Kamae, MD, Masamichi Shiraga, MD, Hirokazu Kashiwagi, MD, Hisashi Kato, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2005) 106 (11): 1655.

https://doi.org/10.1182/blood.V106.11.1655.1655

Published: 2005

Journal Articles

Hematopoietic Stem Cells Fail to Trans-Differentiate into Smooth Muscle-Lineage Cells In Vivo.

Takafumi Yokota, MD, PhD, Sanai Sato, MD, PhD, Yutaka Kawakami, MD, PhD, Yoshinori Nagai, MD, PhD, Jian-xing Ma, PhD, Jen-Yue Tsai, PhD, Kenji Oritani, MD, PhD, Yoshiaki Tomiyama, MD, PhD, Itaru Matsumura, MD, PhD, Paul W. Kincade, PhD, Yuzuru Kanakura, MD, PhD

Blood (2005) 106 (11): 1703.

https://doi.org/10.1182/blood.V106.11.1703.1703

Published: 2005

Journal Articles

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Hisashi Kato, Graduate Student, Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Shigenori Honda, MD, Shigeki Miyata, MD, Junichiro Yamamoto, PhD, Yoshiyuki Kurata, MD, Tohru Funahashi, MD, Iichiro Shimomura, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 800.

https://doi.org/10.1182/blood.V104.11.800.800

Published: 2004

Journal Articles

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Masamichi Shiraga, MD, Shigeki Miyata, MD, Tsuyoshi Kamae, MD, Hisashi Kato, MD, Teruo Kiyoi, MD, Hirokazu Kashiwagi, MD, Shigenori Honda, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD

Blood (2004) 104 (11): 742.

https://doi.org/10.1182/blood.V104.11.742.742

Published: 2004

Journal Articles

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

Hirokazu Kashiwagi, MD, Masamichi Shiraga, MD, Hisashi Kato, MD, Tsuyoshi Kamae, MD, Naoko Yamamoto, MD, Seiji Tadokoro, MD, Yoshiyuki Kurata, MD, Yoshiaki Tomiyama, MD, Yuzuru Kanakura, MD, PhD

Blood (2004) 104 (11): 1546.

https://doi.org/10.1182/blood.V104.11.1546.1546

Published: 2004

NARROW

The Critical Role of Kindlin-3 in Intiation of Physiological Thrombus Formation ~ Analysis of Kindlin-3 Deficient Patient

Physicians' and Patients' Perspectives on Treatments in ITP - a Multi-Country Perspective: Results from the ITP World Impact Survey (I-WISh)

αIIb(R990W), a Gain-of Function Mutation of αIIbβ3, Knock-in Mice Show Moderately Impaired Thrombopoiesis

Efficacy and Safety of Romiplostim in Patients with Acquired Aplastic Anemia Ineligible or Refractory to Immunosuppressive Therapy: Interim Analysis of Phase 2/3 Clinical Trial

Results from the ITP World IMPACT Survey (I-WISh): Patients with Immune Thrombocytopenia (ITP) Experience Impaired Quality of Life (QoL) Regarding Daily Activities, Social Interactions, Emotional Well-Being and Working Lives

Platelet Integrin αIIbβ3 Activation Kinetics in Inherited Platelet Functional Disorders ∼ the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 αIIbβ3 Activation By inside-out Signaling

Patients with Immune Thrombocytopenia (ITP) Frequently Experience Severe Fatigue but Is It Under-Recognized By Physicians: Results from the ITP World Impact Survey (I-WISh)

Addition of Melphalan to Fludarabine/Busulfan (FLU/BU4/MEL) Provides Survival Benefit for Patients with Myeloid Malignancy Following Allogeneic Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation

The Association of PAR4 Polymorphism with Human Platelet Reactivity in Japanese

Rituximab As Second-Line Treatment For Chronic Immune Thrombocytopenia: Investigator-Initiated Clinical Trial In Japan

Evaluation of Romiplostim In a Randomized Placebo-Controlled Phase 3 Study of a Japanese Population with Chronic Immune Thrombocytopenia (ITP).

Bleeding Tendency and Impaired Platelet Function In a Patient Carrying a Heterozygous Mutation In Thromboxane A2 Receptor

Six Month Treatment of Low Dose Eltrombopag Is Efficacious in Japanese Patients with Refractory Chronic Immune Thrombocytopenic Purpura (ITP).

Antagonism of P2y12 Receptor Results in Severe Impairment of Serum Thromboxane Levels. Can We Manage Patients without Combination Therapy with Aspirin?

P2Y 12 -Independent Transient Activation and P2Y 12 -Dependent Prolonged Activation of Platelet Integrin α IIb β 3 .

Critical Role of Endogenous ADP Via P2Y12 Receptor in Maintenance of α Iib β 3 Activation.

Hematopoietic Stem Cells Fail to Trans-Differentiate into Smooth Muscle-Lineage Cells In Vivo.

Enhanced Platelet Aggregation and Thrombogenic Tendency in Adiponectin-Deficient Mice.

Impaired Platelet Function in a P2Y 12 -Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

Negative Regulation of Platelet Function by a Secreted Cell Repulsive Protein, Semaphorin 3A.

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American Society of Hematology

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American Society of Hematology

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