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Yann Godfrin
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Journal Articles

Pharmacokinetic and Pharmacodynamic Characterization of Graspa Versus Native L-Asparaginase in Combination with Cooprall Chemotherapy in a Phase 3 Randomized Trial for the Treatment of Patients with Relapsed Acute Lymphoblastic Leukemia (NCT01518517)

Xavier Thomas, MD PhD, Yves Bertrand, MDPhD, Andre Baruchel, MD PhD, Nicolas Blin, MD, Emmanuelle Tavernier, MD, Stephane Ducassou, MD, Norbert Vey, Virginie Gandemer, MD PhD, Victoria Cacheux, MD, Francoise Mazingue, MD, Emmanuel Raffoux, Genevieve Plat, MD, Jose Fernandes, MD, Maryline Poiree, MD, Luc Fornecker, MD, Jean-Louis Stephan, MD, Mathilde Hunault, MD PhD, Anne Auvrignon, MD, Thibault Leguay, MD, Stephane Lepretre, MD, Alina Ferster, MD PhD, Isabelle Pellier, MD, Emmanuel Plouvier, MD, Claudine Schmitt, Cecile Bonin, Pharm D, Yann Godfrin, PhD, Iman El Hariry, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2492.
https://doi.org/10.1182/blood.V126.23.2492.2492
Published: 2015
Journal Articles

Expanded Access Program of Graspa for Treatment of Patients with Acute Lymphoblastic Leukemia Unable to Receive Other Form of L-Asparaginase - a Status Update (NCT02197650)

Yves Bertrand, MDPhD, Hervé Dombret, Bruno Quesnel, MD PhD, Jean-Louis Stephan, MD, Claudine Schmitt, MD, Severine Lissandre, MD, Maryline Poiree, MD, Christian Recher, MDPhD, Emmanuel Plouvier, MD, Cécile Dumesnil de Maricourt, MD, David Salako, MSc, Yann Godfrin, PhD, Iman El Hariry, MDPhD
Journal: Blood
Blood (2015) 126 (23): 4877.
https://doi.org/10.1182/blood.V126.23.4877.4877
Published: 2015
Journal Articles

Evaluation of the Impact of the Presence of Neutralizing L-Asparaginase Antibodies on the Efficacy and Safety of Graspa in Phase 3 Randomized Trial Versus Native L-Asparaginase in Patients with Relapsed Acute Lymphoblastic Leukemia (NCT01518517)

Yves Bertrand, MDPhD, Andre Baruchel, MD, Xavier Thomas, MD PhD, Nicolas Blin, MD, Emmanuelle Tavernier, MD, Stephane Ducassou, MD, Norbert Vey, Virginie Gandemer, MD PhD, Victoria Cacheux, MD, Francoise Mazingue, MD, Emmanuel Raffoux, Genevieve Plat, MD, Jose Fernandes, MD, Maryline Poiree, MD, Luc Fornecker, MD, Jean-Louis Stephan, MD, Mathilde Hunault, MD PhD, Anne Auvrignon, MD, Thibault Leguay, MD, Dominique Plantaz, MDPhD, Stephane Lepretre, MD, Alina Ferster, MD PhD, Isabelle Pellier, MD, Emmanuel Plouvier, MD, Claudine Schmitt, Cecile Bonin, Pharm D, Yann Godfrin, PhD, Iman El Hariry, MDPhD
Journal: Blood
Blood (2015) 126 (23): 3734.
https://doi.org/10.1182/blood.V126.23.3734.3734
Published: 2015
Journal Articles

L-Asparaginase Allergic Patients Treated with L-Asparaginase Loaded into Red Blood Cells in an Expanded Access Program. Report of Four Cases

Audrey Contet, MD, Severine Lissandre, MD, Céline Berthon, MD PhD, Yann Godfrin, PhD, Yves Bertrand, MD
Journal: Blood
Blood (2014) 124 (21): 937.
https://doi.org/10.1182/blood.V124.21.937.937
Published: 2014
Journal Articles

L-Asparaginase Ex Vivo Activity Distorts Plasmatic Asparagine Depletion Assessment

Willy Berlier, PhD, Yann Godfrin, PhD
Journal: Blood
Blood (2014) 124 (21): 5357.
https://doi.org/10.1182/blood.V124.21.5357.5357
Published: 2014
Journal Articles

Asparagine Synthetase Expression and L-Asparaginase Sensitivity in Aggressive Lymphomas

Willy Berlier, PhD, Karine Aguera, Anne-Marie Chevrier, Fanny Gallix, Alexandra Traverse-Glehen, MD PhD, Gilles Salles, MD PhD, Yann Godfrin, PhD
Journal: Blood
Blood (2014) 124 (21): 5494.
https://doi.org/10.1182/blood.V124.21.5494.5494
Published: 2014
Journal Articles

L-Asparaginase Sensitivity and Asparagine Synthetase Expression In Primary Tumor Cells From AML Patients

Willy Berlier, PhD, Karine Aguera, Mohamed El Hamri, PhD, Marie-Pierre Goutagny, Fanny Gallix, Yves Bertrand, MD, Xavier Thomas, MD, Yann Godfrin, PhD
Journal: Blood
Blood (2013) 122 (21): 1423.
https://doi.org/10.1182/blood.V122.21.1423.1423
Published: 2013
Journal Articles

L-Asparaginase Loaded Inside Red Cells Has An Acceptable Tolerability Profile On Bilirubin Value

Celine Plisson, MD, Mathilde Hunault, Xavier Thomas, MD, Thibault Legay, MD, Yves Bertrand, MD, Thierry Andre, MD, Yann Godfrin, PhD
Journal: Blood
Blood (2013) 122 (21): 2642.
https://doi.org/10.1182/blood.V122.21.2642.2642
Published: 2013
Journal Articles

Two Years Follow-up Results of Graspall/Graall-SA2–2008 Study: L-Asparaginase-Loaded Red Blood Cell Combined with Standard EWALL Chemotherapy in Older Patients with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (Ph-ALL)

Mathilde Hunault-Berger, MD, PhD, Thibaut Leguay, MD, Françoise Huguet, Stéphane Leprêtre, MD, Eric Deconinck, MD, PhD, Mario Ojeda Uribe, MD, Caroline Bonmati, MD, Pierre Bories, MD, Chantal Himberlin, MD, Patrice Chevallier, MD, Philippe Rousselot, MD, PhD, Oumedaly Reman, MD, Marie-Laure Boulland, MD, Severine Lissandre, MD, Pascal Turlure, MD, Didier Bouscary, Laurence Sanhes, MD, Ollivier Legrand, MD, PhD, Isabelle Plantier, MD, Frédérique Orsini Piocelle, MD, Véronique Lhéritier, Elodie Boucher, Yann Godfrin, PhD, Norbert Ifrah, Hervé Dombret, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1473.
https://doi.org/10.1182/blood.V120.21.1473.1473
Published: 2012
Journal Articles

Blast Asparagine Synthetase Deficiency in Acute Myeloid Leukemia

Willy Berlier, PhD, Mohamed El Hamri, PhD, Karine Aguera, Yannick Campion, Fabien Gay, PhD, Yann Godfrin, PhD, Xavier Thomas, MD
Journal: Blood
Blood (2012) 120 (21): 4333.
https://doi.org/10.1182/blood.V120.21.4333.4333
Published: 2012
Journal Articles

IHP-Loaded Red Blood Cells Efficacy in Sickle Transgenic Mice

Vanessa Bourgeaux, PhD, Emeline Aufradet, Yannick Campion, Anne-Marie Chevrier, Geneviève De Souza, Cyril Martin, PhD, Yann Godfrin, PhD
Journal: Blood
Blood (2011) 118 (21): 2119.
https://doi.org/10.1182/blood.V118.21.2119.2119
Published: 2011
Journal Articles

L-Asparaginase-Loaded Red Blood Cells Combined with Standard EWALL Chemotherapy in Older Patients with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (Ph- ALL): First Results of the GRASPALL/GRAALL-SA2-2008 Study

Mathilde Hunault, MD, PhD, Thibault Legay, MD, Françoise Huguet, MD, Stéphane Leprêtre, MD, Eric Deconinck, MD, PhD, Mario Ojeda Uribe, MD, Caroline Bonmati, MD, Bruno Lioure, Catherine Himberlin, MD, Patrice Chevallier, MD, Philippe Rousselot, MD, PhD, Oumedaly Reman, MD, Marie-Laure Boulland, MD, Véronique Lhéritier, Severine Lissandre, MD, Pascal Turlure, MD, Didier Bouscary, MD, PhD, Laurence Sanhes, MD, Ollivier Legrand, Isabelle Plantier, Frédérique Orsini Piocelle, MD, David Liens, MD, Yann Godfrin, PhD, Norbert Ifrah, Herve Dombret
Journal: Blood
Blood (2011) 118 (21): 2579.
https://doi.org/10.1182/blood.V118.21.2579.2579
Published: 2011
Journal Articles

L-Asparaginase Loaded Red Blood Cells: From Prescription to Injection

Jerome Bailly, Pharm.D, Veronique Sezanne, Pharm.D, Yann Godfrin, PhD
Journal: Blood
Blood (2011) 118 (21): 4252.
https://doi.org/10.1182/blood.V118.21.4252.4252
Published: 2011
Journal Articles

IHP-Loaded Red Blood Cells as Preventive Therapy In Sickle Cell Disease

Vanessa Bourgeaux, PhD, Yannick Campion, Emeline Aufradet, Cyril Martin, PhD, Yann Godfrin, PhD
Journal: Blood
Blood (2010) 116 (21): 1625.
https://doi.org/10.1182/blood.V116.21.1625.1625
Published: 2010
Journal Articles

GRASPALL 2005.01 Clinical Study: L-Asparaginase Loaded into Red Blood Cells Is Effective at Depleting Serum Asparagine in Children and Adults with Relapsed Acute Lymphoblastic Leukaemia (ALL)

Yves Bertrand, Xavier Thomas, Andre Baruchel, Françoise Mazingue, Anne Auvrignon, Selim Corm, Herve Dombret, Patrice Chevallier, Claire Galambrun, Françoise Huguet, Faezeh Legrand, Françoise Mechinaud, Norbert Vey, Sylvie Chabaud, Florence Noel Baron, Irène Philip, David Liens, Yann Godfrin
Journal: Blood
Blood (2008) 112 (11): 306.
https://doi.org/10.1182/blood.V112.11.306.306
Published: 2008
Journal Articles

Allosteric Hemoglobin Effector Loaded Erythrocytes Improve the Efficiency of Transfusion to Prevent Sickling.

Vanessa Bourgeaux, Olivier Hecquet, Dominique Rigal, Alain Francina, Yann Godfrin
Journal: Blood
Blood (2008) 112 (11): 1418.
https://doi.org/10.1182/blood.V112.11.1418.1418
Published: 2008
Journal Articles

An Assay to Predict L-Asparaginase Neutralization and Enzyme Loaded Red Blood Cells to Maintain in Vivo Efficacy.

Emmanuelle Dufour, Christine Saban-Vianey, Henri Coquelin, Yann Godfrin
Journal: Blood
Blood (2008) 112 (11): 907.
https://doi.org/10.1182/blood.V112.11.907.907
Published: 2008
Journal Articles

L-Asparaginase Loaded into Erythrocytes (GRASPA): Principle and Interests in Acute Lymphoblastic Leukemia.

Yann Godfrin, PhD, Xavier Thomas, M.D., Yves Bertrand, M.D., Corinne Duget, M.D.
Journal: Blood
Blood (2007) 110 (11): 4325.
https://doi.org/10.1182/blood.V110.11.4325.4325
Published: 2007