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Journal Articles

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Metis Hasipek, PhD, Yihong Guan, PhD, Dale Grabowski, BS, Xiaorong Gu, PhD, Yogenthiran Saunthararajah, MD, Robert Silverman, PhD, George R Stark, PhD, Jaroslaw Maciejewski, PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 29–30.

https://doi.org/10.1182/blood-2020-142457

Published: 2020

Journal Articles

Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive

Xiaorong Gu, PhD, Rita Tohme, PhD, Mendel Goldfinger, MD, Benjamin K. Tomlinson, MD, Nneha Sakre, PhD, Shannon Hanmer, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD, Amit Verma, MBBS, Yogenthiran Saunthararajah, MD

Blood (2020) 136 (Supplement 1): 26–27.

https://doi.org/10.1182/blood-2020-143200

Published: 2020

Journal Articles

A Novel Therapeutic Strategy for Preferential Elimination of Multiple Myeloma Cells By Targeting Protein Disulfide Isomerase

Metis Hasipek, PhD, Dale Grabowski, BS, Yihong Guan, PhD, Anand D. Tiwari, PhD, Xiaorong Gu, PhD, Jason Valent, MD, Jaroslaw Maciejewski, PhD, Frederic Joel Reu, James G Phillips, PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 32–33.

https://doi.org/10.1182/blood-2020-142847

Published: 2020

Journal Articles

Feedback Responses of the Pyrimidine Metabolism Network Mediate Resistance to Decitabine and 5-Azacytidine

Xiaorong Gu, PhD, Rita Tohme, PhD, Benjamin K. Tomlinson, MD, Lisa Durkin, Caroline Schuerger, Asmaa M Zidan, MB, BCh, Tomas Radivoyevitch, PhD, Hetty E. Carraway, MD MBA, Ronald Sobecks, MD, Betty K. Hamilton, MD, Alan Lichtin, MD, Jaroslaw P. Maciejewski, MD PhD, Yogenthiran Saunthararajah, MD

Blood (2019) 134 (Supplement_1): 537.

https://doi.org/10.1182/blood-2019-125823

Published: 2019

Journal Articles

TET2 Loss Accelerates Leukemogenesis By Disrupting Mismatch Repair Proteins

Blood (2019) 134 (Supplement_1): 1200.

https://doi.org/10.1182/blood-2019-132005

Published: 2019

Journal Articles

LUC7L2 Is a Novel RNA-Splicing Regulatory Factor Mutated in Myelodysplastic Syndromes

Courtney Hershberger, BS, James Hiznay, Rosemary Dietrich, Xiaorong Gu, PhD, Cassandra M. Hirsch, Amy Graham, BS, MS, Bartlomiej P. Przychodzen, Valeria Visconte, PhD, Vera Adema, PhD, Yvonne Parker, Hetty E. Carraway, MD MBA, Tomas Radivoyevitch, PhD, Mikkael A. Sekeres, MD MS, Yogenthiran Saunthararajah, MD, Jaroslaw P. Maciejewski, Richard A Padgett

Blood (2018) 132 (Supplement 1): 3073.

https://doi.org/10.1182/blood-2018-99-112838

Published: 2018

Journal Articles

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Xiaorong Gu, PhD, Quteba Ebrahem, MD, Reda Z. Mahfouz, MD PhD, Metis Hasipek, PhD, Francis Enane, PhD, Tomas Radivoyevitch, Nicolas Rapin, PhDMSc, Bartlomiej P. Przychodzen, MSc, Ramesh Balusu, PhD, Claudiu V Cotta, David Wald, MD PhD, Zhenbo Hu, MD PhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD, Yogenthiran Saunthararajah, MD

Blood (2017) 130 (Supplement 1): 878.

https://doi.org/10.1182/blood.V130.Suppl_1.878.878

Published: 2017

Journal Articles

PHF6 Somatic Mutations and Their Functional Role in the Pathophysiology of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

Bartlomiej P Przychodzen, MSc, Xiaorong Gu, PhD, Dewen You, PhD, Cassandra M. Hirsch, BSc, Michael J. Clemente, M.S., Mikkael A. Sekeres, MD MS, Aziz Nazha, MD, Hideki Makishima, MD PhD FACP., Jaroslaw P Maciejewski, MD PhD FACP

Blood (2016) 128 (22): 2736.

https://doi.org/10.1182/blood.V128.22.2736.2736

Published: 2016

Journal Articles

The Role of LUC7L2 in Splicing and MDS

Courtney Elizabeth Hershberger, BS, Naoko Hosono, MD, PhD, Jarnail Singh, PhD, Rosemary C Dietrich, M.S., Xiaorong Gu, PhD, Hideki Makishima, MD PhD FACP., Yogen Saunthararajah, MD, Jaroslaw P Maciejewski, MD PhD FACP, Richard A Padgett, PhD

Blood (2016) 128 (22): 5504.

https://doi.org/10.1182/blood.V128.22.5504.5504

Published: 2016

Journal Articles

The Mechanism By Which Mutant Nucleophosmin (NPM1) Creates Leukemic Self-Renewal Is Readily Reversed

Xiaorong Gu, PhD, Reda Z. Mahfouz, MD, PhD, Quteba Ebrahem, Francis Enane, Tomas Radivoyevitch, PhD, Michael J. Clemente, M.S., Bartlomiej P Przychodzen, MSc, Zhenbo Hu, MD PhD, Ramesh Balusu, PhD, Claudiu V. Cotta, MD, David N. Wald, MDPhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, Jaroslaw P Maciejewski, MD PhD FACP, Yogenthiran Saunthararajah, MD

Blood (2016) 128 (22): 444.

https://doi.org/10.1182/blood.V128.22.444.444

Published: 2016

Journal Articles

PHF6 - Somatic Mutations and Their Role in Pathophysiology of MDS and AML

Bartlomiej Przychodzen, MSc, Xiaorong Gu, PhD, Dewen You, PhD, Cassandra M. Hirsch, Michael J. Clemente, Aaron D. Viny, MD MS, Ross L. Levine, MD, Torsten Haferlach, Manja Maggendorfer, Mikkael A. Sekeres, MD MS, Hetty E. Carraway, MD MBA, Aziz Nazha, MD, Francis Enane, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1259.

https://doi.org/10.1182/blood.V126.23.1259.1259

Published: 2015

Journal Articles

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations

Blood (2014) 124 (21): 125.

https://doi.org/10.1182/blood.V124.21.125.125

Published: 2014

Journal Articles

A Specific Mechanism By Which NPM1 mutations Impede Myeloid Differentiation Also Explains The Link With DNMT3A Mutation

Xiaorong Gu, PhD, Reda Z Mahfouz, MD/PhD, Francis Enane, MS, Zhenbo Hu, MD, PhD, Michael J. Clemente, Bartlomiej P Przychodzen, PhD, Mikkael A. Sekeres, MD, MS, Anjali S. Advani, MD, Matt Kalaycio, MD, Jaroslaw P. Maciejewski, MD, PhD, Yogen Saunthararajah, M.D.

Blood (2013) 122 (21): 1254.

https://doi.org/10.1182/blood.V122.21.1254.1254

Published: 2013

Journal Articles

Extra-Nuclear Dislocation of PU.1 but Not CEBPA by Mutated NPM1 in AML Explains Lineage-Associations, ATRA Therapeutic Potential and DNMT3A Secondary Mutation.

Xiaorong Gu, PhD, Reda Z Mahfouz, MD/PhD, Zhenbo Hu, MD, PhD, Yogenthiran Saunthararajah, MD

Blood (2012) 120 (21): 2427.

https://doi.org/10.1182/blood.V120.21.2427.2427

Published: 2012

Journal Articles

Runx1 Regulates Pu.1 Coactivator/Corepressor Exchange

Xiaorong Gu, PhD, Zhenbo Hu, MD, Quteba Ebrahem, MD, Kwok Peng Ng, PhD, Jack S Crabb, MS, John W Crabb, PhD, Yogen Saunthararajah, MD

Blood (2011) 118 (21): 2372.

https://doi.org/10.1182/blood.V118.21.2372.2372

Published: 2011

Journal Articles

Effective and Non-Cytotoxic p53 Independent Epigenetic-Differentiation Therapy In Xeno-Transplant Models of Human Acute Myeloid Leukemia

Kwok Peng Ng, PhD, Quteba Ebrahem, MD, Soledad Negrotto, PhD, Reda Mahfouz, MD, Kevin Link, PhD, Zhenbo Hu, MD, Xiaorong Gu, PhD, Anjali Advani, MD, Matt Kalaycio, MD, Mikkael A. Sekeres, MD, MS, Edward A. Copelan, MD, Jaroslaw P Maciejewski, MD, PhD, FACP, James C. Mulloy, PhD, Yogenthiran Saunthararajah, MD

Blood (2010) 116 (21): 3309.

https://doi.org/10.1182/blood.V116.21.3309.3309

Published: 2010

NARROW

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive

A Novel Therapeutic Strategy for Preferential Elimination of Multiple Myeloma Cells By Targeting Protein Disulfide Isomerase

Feedback Responses of the Pyrimidine Metabolism Network Mediate Resistance to Decitabine and 5-Azacytidine

TET2 Loss Accelerates Leukemogenesis By Disrupting Mismatch Repair Proteins

LUC7L2 Is a Novel RNA-Splicing Regulatory Factor Mutated in Myelodysplastic Syndromes

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

PHF6 Somatic Mutations and Their Functional Role in the Pathophysiology of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)

The Role of LUC7L2 in Splicing and MDS

The Mechanism By Which Mutant Nucleophosmin (NPM1) Creates Leukemic Self-Renewal Is Readily Reversed

PHF6 - Somatic Mutations and Their Role in Pathophysiology of MDS and AML

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations

A Specific Mechanism By Which NPM1 mutations Impede Myeloid Differentiation Also Explains The Link With DNMT3A Mutation

Extra-Nuclear Dislocation of PU.1 but Not CEBPA by Mutated NPM1 in AML Explains Lineage-Associations, ATRA Therapeutic Potential and DNMT3A Secondary Mutation.

Runx1 Regulates Pu.1 Coactivator/Corepressor Exchange

Effective and Non-Cytotoxic p53 Independent Epigenetic-Differentiation Therapy In Xeno-Transplant Models of Human Acute Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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