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Journal Articles

The PARP Inhibitor Olaparib Antagonizes Leukemic Growth Induced By TET1 Overexpression in AML1-ETO Positive Acute Myeloid Leukemia

Shiva Bamezai, PhD, Jing He, Dr., Deniz Sahin, M.Sc, Fabian Mohr, PhD, Fabio Ciccarone, PhD, Naidu M Vegi, PhD, Alex Pulikkottil Jose, M.Sc, Medhanie A. Mulaw, Jun.-Prof. Dr., Paola Caiafa, MD, Konstanze Döhner, Hartmut Döhner, MD, Michaela Feuring-Buske, PD Dr., Christian Buske, Vijay P.S. Rawat, PhD

Blood (2016) 128 (22): 4063.

https://doi.org/10.1182/blood.V128.22.4063.4063

Published: 2016

Journal Articles

The Methylcytosine Dioxygenase TET3 Is Aberrantly Expressed in Acute Myeloid Leukemia and Promotes AML Growth

Alex Pulikkottil Jose, M.Sc, Fabian Mohr, PhD, Shiva Bamezai, PhD, Holzmann Karlheinz, Dr., Ursula Kohlhofer, Dr. MD vet., Leticia Quintanilla-Martinez Fend, Prof. Dr., Tadafumi Iino, Dr., Koichi Akashi, MD PhD, Konstanze Döhner, Hartmut Döhner, MD, Michaela Feuring-Buske, PD Dr., Christian Buske, Vijay P.S. Rawat, PhD

Blood (2016) 128 (22): 771.

https://doi.org/10.1182/blood.V128.22.771.771

Published: 2016

Journal Articles

TET1 Promotes Leukemic Growth in T-ALL Via Maintenance of 5-Hydroxymethylation Marks and Can be Antagonized By the PARP Inhibitor Olaparib

Deniz Sahin, M.Sc, Shiva Bamezai, PhD, Fabio Ciccarone, PhD, Elena Fischbein, MSc, Fabian Mohr, PhD, Medhanie A. Mulaw, Jun.-Prof. Dr., Alex Pulikkottil Jose, M.Sc, Paola Caiafa, MD, Lüder-Hinrich Meyer, MD, Klaus-Michael Debatin, Prof. Dr., Geertruy te Kronnie, PhD, Konstanze Döhner, Hartmut Döhner, Prof. Dr., Michaela Feuring-Buske, PD Dr., Christian Buske, Vijay P.S. Rawat, PhD

Blood (2016) 128 (22): 737.

https://doi.org/10.1182/blood.V128.22.737.737

Published: 2016

Journal Articles

The Homeobox Gene VENTX Collaborates with AML1-ETO in Inducing an Acute Leukemia in Mice

Eva Gentner, BSc, MSc, Naidu Vegi, Dr., Medhanie A. Mulaw, Jun. Prof. Dr., Leticia Quintanilla-Fend, Prof. Dr., Hartmut Döhner, Prof. Dr., Konstanze Döhner, MD, Christian Buske, Vijay P.S. Rawat, Jun. Prof. Dr., Michaela Feuring-Buske, PD Dr.

Blood (2015) 126 (23): 3642.

https://doi.org/10.1182/blood.V126.23.3642.3642

Published: 2015

Journal Articles

Knockdown Of The Piwi - Like Protein 4 (PIWIL4) Delays Leukemic Growth and Is Associated With Gross Changes In The Global Histone Methylation Marks In Human MLL - Rearranged AML

Shiva Bamezai, Medhanie M Mulaw, PhD, Fengbiao Zhou, Christian Rohde, PhD, Carsten Muller-Tidow, MD, Konstanze Dohner, M.D., Hartmut Dohner, MD, Michaela Feuring Buske, MD, Christian Buske, MD, Vijay P.S Rawat, PhD

Blood (2013) 122 (21): 597.

https://doi.org/10.1182/blood.V122.21.597.597

Published: 2013

Journal Articles

AML1-ETO Collaborates with the TALE Homeobox Genes MEIS1 and MEIS2 in Inducing AML.

Naidu M Vegi, PhD, Josef Klappacher, MSc, Franz Oswald, PhD, Rainer Claus, MD, Medhanie M Mulaw, PhD, Verena Thiel, Msc, Vijay P.S Rawat, PhD, Leticia Quintanilla Fend, MD, Christoph Plass, PhD, Konstanze Döhner, MD, Hartmut Döhner, MD, Wolfgang Hiddemann, MD, Michaela Feuring Buske, MD, Christian Buske, MD

Blood (2012) 120 (21): 2387.

https://doi.org/10.1182/blood.V120.21.2387.2387

Published: 2012

Journal Articles

The Leukemogenic Potential of Cdx2 Is Dependent on Its N-Terminal Serine Sites and Can Be Counteracted by MAPK Inhibitors

Vijay P.S. Rawat, PhD, Vegi M. Naidu, MSc, Deepak Bararia, PhD, Silvia Thoene, MSc, Farid Ahmed, PhD, Leticia Quintanilla-Martinez, MD, Wolfgang Hiddemann, Stefan Bohlander, Michaela Feuring-Buske, MD, Christian Buske, MD

Blood (2008) 112 (11): 3784.

https://doi.org/10.1182/blood.V112.11.3784.3784

Published: 2008

Journal Articles

Cdx4 Differs from Cdx2 in Its Oncogenic Potential and Its Regulation of Hox Gene Expression in the Murine Bone Marrow Transplantation Model.

Silvia Thoene, MSc, Vijay P.S. Rawat, PhD, Vegi M. Naidu, MSc, Wolfgang Hiddemann, MD, Michaela Feuring-Buske, MD, Christian Buske, MD

Blood (2008) 112 (11): 1187.

https://doi.org/10.1182/blood.V112.11.1187.1187

Published: 2008

Journal Articles

AML1-ETO Collaborates with the Homeobox Gene Meis1 in Inducing Acute Leukemia in the Mouse Bone Marrow Transplantation Model.

Vegi M. Naidu, MSc, Vijay P.S. Rawat, PhD, Christina Schessl, PhD, Konstantin Petropoulus, PhD, Monica Cusan, Aniruddha J Deshpande, PhD, Leticia Quintanilla Martinez, MD, Wolfgang Hiddemann, Michaela Feuring Buske, MD, Christian Buske, MD

Blood (2008) 112 (11): 928.

https://doi.org/10.1182/blood.V112.11.928.928

Published: 2008

Journal Articles

Ectopic Expression of CDX2 Perturbs HOX Gene Expression in Murine Progenitors Depending on Its N-Terminal Transactivation Domain and Is Closely Correlated with Deregulated HOX Gene Expression in Human Acute Myeloid Leukemia.

Vijay P.S. Rawat, PhD, Silvia Thoene, M.Sc, Vegi M. Naidu, M.Sc, Natalia Arseni, Ph.D., Bernhard Heilmeier, M.D., Klaus Metzeler, M.D., Konstantin Petropoulos, M.Sc, Aniruddha Deshpande, Ph.D., Leticia Quintanilla-Martinez, M.D., Stefan Bohlander, M.D., Karsten Spiekermann, M.D., Wolfgang Hiddemann, M.D., Michaela Feuring-Buske, M.D., Christian Buske, M.D.

Blood (2007) 110 (11): 2125.

https://doi.org/10.1182/blood.V110.11.2125.2125

Published: 2007

Journal Articles

Constitutive Expression of Lef-1 in Murine Hematopoietic Progenitors Causes Myeloid and Lymphoid Leukemias Propagated by a Leukemic Stem Cell Population with Lymphoid Characteristics.

Konstantin Petropoulos, MSc, Christina Schessl, PhD, Natalia Arseni, PhD, Vijay P.S. Rawat, PhD, Aniruddha Deshpande, PhD, Christiane Stadler, PhD, Wolfgang Hiddemann, Leticia Quintanilla-Martinez, PhD, Stefan K. Bohlander, Michaela Feuring-Buske, MD, Christian Buske, MD

Blood (2007) 110 (11): 2645.

https://doi.org/10.1182/blood.V110.11.2645.2645

Published: 2007

Journal Articles

The Vent-Like Homeobox Gene VENTX2 Is Expressed in Human Hematopoietic Progenitor Cells and Promotes Human Myeloid Development In Vitro and In Vivo.

Natalia Arseni, PhD, Farid Ahmed, Ph.D., Vijay P.S. Rawat, Ph.D., Timothy J. Sadlon, M.D., Wolfgang Hiddemann, M.D., Christian Buske, M.D., Michaela Feuring-Buske, M.D.

Blood (2007) 110 (11): 1275.

https://doi.org/10.1182/blood.V110.11.1275.1275

Published: 2007

Journal Articles

The Transforming Potential of the Homeobox Gene Cdx2 Is Depending on Its N-Terminal Transactivation Domain In Vivo and Can Be Antagonized by the MEK1/2 Inhibitor in a Mouse Model of t(12;13) Positive AML.

Vijay P.S. Rawat, MSc, Natalia Arseni Arseni, Ph.D., Vegi M. Naidu, M.Sc, John P. Lynch, Ph.D, Wolfgang Hiddemann, MD, Michaela Feuring-Buske, MD, Christian Buske, MD

Blood (2006) 108 (11): 7.

https://doi.org/10.1182/blood.V108.11.7.7

Published: 2006

Journal Articles

The AML1-ETO Fusion Gene and the FLT3 Length Mutation Collaborate in Inducing Acute Leukemia in a Murine Bone Marrow Transplantation Model.

Christina Schessl, Vijay P.S. Rawat, Monica Cusan, Aniruddha Deshpande, Tobias M. Kohl, Patricia M. Rosten, Karsten Spiekermann, R.Keith Humphries, Susanne Schnittger, Wolfgang Kern, Wolfgang Hiddemann, Leticia Quintanilla-Martinez, Stefan K. Bohlander, Michaela Feuring-Buske, Christian Buske

Blood (2005) 106 (11): 100.

https://doi.org/10.1182/blood.V106.11.100.100

Published: 2005

Journal Articles

The Oncogenic Potential of the Homeobox Gene Cdx2 Is Depending on the MAPK Pathway and Can Be Antagonized by the MEK1/2 Inhibitor PD98059 in a Mouse Model of t(12;13)(p13;q12) Positive AML.

Vijay P.S. Rawat, Vegi M. Naidu, Christina Schessl, Monica Cusan, R.Keith Humphries, Ph.D, J. P. Lynch, Ph.D, W. Hiddemann, MD, Ph.D., Michaela Feuring-Buske, MD, Christian Buske, MD

Blood (2004) 104 (11): 1975.

https://doi.org/10.1182/blood.V104.11.1975.1975

Published: 2004

NARROW

The PARP Inhibitor Olaparib Antagonizes Leukemic Growth Induced By TET1 Overexpression in AML1-ETO Positive Acute Myeloid Leukemia

The Methylcytosine Dioxygenase TET3 Is Aberrantly Expressed in Acute Myeloid Leukemia and Promotes AML Growth

TET1 Promotes Leukemic Growth in T-ALL Via Maintenance of 5-Hydroxymethylation Marks and Can be Antagonized By the PARP Inhibitor Olaparib

The Homeobox Gene VENTX Collaborates with AML1-ETO in Inducing an Acute Leukemia in Mice

Knockdown Of The Piwi - Like Protein 4 (PIWIL4) Delays Leukemic Growth and Is Associated With Gross Changes In The Global Histone Methylation Marks In Human MLL - Rearranged AML

AML1-ETO Collaborates with the TALE Homeobox Genes MEIS1 and MEIS2 in Inducing AML.

The Leukemogenic Potential of Cdx2 Is Dependent on Its N-Terminal Serine Sites and Can Be Counteracted by MAPK Inhibitors

Cdx4 Differs from Cdx2 in Its Oncogenic Potential and Its Regulation of Hox Gene Expression in the Murine Bone Marrow Transplantation Model.

AML1-ETO Collaborates with the Homeobox Gene Meis1 in Inducing Acute Leukemia in the Mouse Bone Marrow Transplantation Model.

Ectopic Expression of CDX2 Perturbs HOX Gene Expression in Murine Progenitors Depending on Its N-Terminal Transactivation Domain and Is Closely Correlated with Deregulated HOX Gene Expression in Human Acute Myeloid Leukemia.

Constitutive Expression of Lef-1 in Murine Hematopoietic Progenitors Causes Myeloid and Lymphoid Leukemias Propagated by a Leukemic Stem Cell Population with Lymphoid Characteristics.

The Vent-Like Homeobox Gene VENTX2 Is Expressed in Human Hematopoietic Progenitor Cells and Promotes Human Myeloid Development In Vitro and In Vivo.

The Transforming Potential of the Homeobox Gene Cdx2 Is Depending on Its N-Terminal Transactivation Domain In Vivo and Can Be Antagonized by the MEK1/2 Inhibitor in a Mouse Model of t(12;13) Positive AML.

The AML1-ETO Fusion Gene and the FLT3 Length Mutation Collaborate in Inducing Acute Leukemia in a Murine Bone Marrow Transplantation Model.

The Oncogenic Potential of the Homeobox Gene Cdx2 Is Depending on the MAPK Pathway and Can Be Antagonized by the MEK1/2 Inhibitor PD98059 in a Mouse Model of t(12;13)(p13;q12) Positive AML.

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American Society of Hematology

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American Society of Hematology

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