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Journal Articles

Venetoclax and Epigenetic Modifiers: Promising Novel Combinations for the Treatment of Multiple Myeloma

Lyndsey Flanagan, Michael E. O'Dwyer, Philip Murphy, John Quinn, Siobhan Glavey, Triona Ni Chonghaile
Journal: Blood
Blood (2021) 138 (Supplement 1): 4703.
https://doi.org/10.1182/blood-2021-147185
Published: 2021
Journal Articles

Metabolic Changes in Venetoclax Resistance Are Determined By Differentiation State in T-Cell Acute Lymphoblastic Leukemia

Alessandra Di Grande, Andrew Roe, Thomas Lefeivre, Theresa E. Leon, Marc R. Mansour, Jonathan Bond, Pieter Van Vlierberghe, Triona Ni Chonghaile
Journal: Blood
Blood (2021) 138 (Supplement 1): 3401.
https://doi.org/10.1182/blood-2021-152489
Published: 2021
Journal Articles

The Splenic Microenvironment Is a Novel Site of Relapse Following ABT-199 Treatment

Alessandra Di Grande, BSc, Sofie Piers, Pieter Van Vlierberghe, PhD, Triona Ni Chonghaile, PhD BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3800.
https://doi.org/10.1182/blood-2019-127970
Published: 2019
Journal Articles

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Kimberly Bodaar, MD, Ingrid M. Aries, PhD MSc, Salmaan Karim, Triona Ni Chonghaile, PhD BSc, Melissa A. Burns, MD, Laura Hinze, Maren Pfirrmann, James Degar, Jack Landrigan, Sebastian Balbach, Sofie Peirs, PhD, Bjorn Menten, PhD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Meenakshi Devidas, PhD, Mignon L. Loh, MD, Stephen P. Hunger, MD, David T Teachey, MD, Karen R. Rabin, MD PhD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent Wood, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Pieter Van Vlierberghe, PhD, Stuart H. Orkin, MD, Birgit Knoechel, MDPhD, Anthony Letai, MD PhD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 889.
https://doi.org/10.1182/blood-2018-99-113518
Published: 2018
Journal Articles

High-Throughput Screen Identification of Albendazole As a Novel Repurposed Drug in Acute Myeloid Leukaemia

Kyle B Matchett, PhD, Ivan V Grishagin, PhD, Laura Kettyle, PhD, Catriona Dowling, PhD, Triona Ni Chonghaile, PhD, Ken I Mills, BSc PhDFRCPath, Alexander Thompson, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5062.
https://doi.org/10.1182/blood.V130.Suppl_1.5062.5062
Published: 2017
Journal Articles

PRC2 Mutations Induce Resistance to Conventional Chemotherapy By Inhibiting Mitochondrial Apoptosis in T-Cell Acute Lymphoblastic Leukemia

Ingrid Ariës, PhD, Triona Ni Chonghaile, PhD, Salmaan Karim, Mina Jacob, Kristen E. Stevenson, MS, Donna S. Neuberg, ScD, Meenakshi Devidas, PhD, Mignon Loh, MD, Stephen Hunger, David T Teachey, MD, Karen R. Rabin, MD PhD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent L. Wood, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Birgit Knoechel, MD PhD, Pieter Van Vlierberghe, PhD, Anthony Letai, MD PhD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2016) 128 (22): 604.
https://doi.org/10.1182/blood.V128.22.604.604
Published: 2016
Journal Articles

BH3 Profiling Identifies Bcl-2 Dependency in Multiple Myeloma and Predicts Sensitivity to BH3 Mimetics

Cyrille Touzeau, MD, Jeremy Ryan, SM, Philippe Moreau, MD, Triona Ni Chonghaile, PhD, Steven Le Gouill, Paul G. Richardson, Kenneth C. Anderson, Martine Amiot, PhD, Anthony G. Letai, MD PhD
Journal: Blood
Blood (2014) 124 (21): 417.
https://doi.org/10.1182/blood.V124.21.417.417
Published: 2014
Journal Articles

Therapeutic Targeting of the Bcl2 Family

Anthony Letai, MD, PhD, Matthew S. Davids, MD, Triona Ni Chonghaile, PhD, Jing Deng, PhD, Luv Patel, B.S.
Journal: Blood
Blood (2013) 122 (21): SCI-42.
https://doi.org/10.1182/blood.V122.21.SCI-42.SCI-42
Published: 2013
Journal Articles

Mitochondrial Apoptotic Priming Measured by BH3 Profiling Regulates Clinical Response to Chemotherapy in Myeloma and Acute Lymphoblastic Leukemia and Explains Therapeutic Index

Triona Ni Chonghaile, PhD, Kristopher Sarosiek, PhD, Jeremy Ryan, Vicki Del Gaizo Moore, PhD, Yu-Tzu Tai, PhD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Richard M. Stone, MD, Daniel J DeAngelo, MD, PhD, Constantine S. Mitsiades, MD, PhD, Stephen E. Sallan, MD, Michelle Hirsch, MD PhD, Lewis B. Silverman, MD, Ruben Carrasco, MD, PhD, Anthony G. Letai, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1442.
https://doi.org/10.1182/blood.V118.21.1442.1442
Published: 2011