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Stephen V Frye
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Journal Articles

Therapeutic Targeting of Mertk and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison Stout, James Kelvin, Xiaodong Wang, Stephen V Frye, H. Shelton Earp, Jeffrey W. Tyner, Erik Dreaden, Deborah DeRyckere, Douglas K Graham
Journal: Blood
Blood (2021) 138 (Supplement 1): 1184.
https://doi.org/10.1182/blood-2021-151726
Published: 2021
Journal Articles

Mertk Inhibition Promotes Anti-Leukemia Immunity By Reversing T Cell Suppression Via the PD-1 Axis

Alisa Lee-Sherick, MD, Kristen Jacobsen, PhD, Curtis J. Henry, PhD, Rebecca Parker, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4019.
https://doi.org/10.1182/blood-2018-99-119818
Published: 2018
Journal Articles

Bone Marrow Stromal Cell Mediated Resistance to Mertk Inhibition in Acute Myeloid Leukemia

Katherine A Minson, MD, Madeline G Huey, BA, Annie Qiu, Xiaodong Wang, PhD, Stephen V Frye, PhD, H. Shelton Earp, MD, Deborah DeRyckere, PhD, Douglas K Graham, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3823.
https://doi.org/10.1182/blood.V130.Suppl_1.3823.3823
Published: 2017
Journal Articles

Mertk Is a Therapeutic Target in Early T-Precursor Acute Lymphoblastic Leukemia

Ryan J Summers, MD, Katherine A Minson, MD, Stephen V Frye, PhD, Xiaodong Wang, PhD, H. Shelton Earp, III, MD, Deborah DeRyckere, PhD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2536.
https://doi.org/10.1182/blood.V130.Suppl_1.2536.2536
Published: 2017
Journal Articles

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL- rearranged leukemia

Bowen Xu, Doan M. On, Anqi Ma, Trevor Parton, Kyle D. Konze, Samantha G. Pattenden, David F. Allison, Ling Cai, Shira Rockowitz, Shichong Liu, Ying Liu, Fengling Li, Masoud Vedadi, Stephen V. Frye, Benjamin A. Garcia, Deyou Zheng, Jian Jin, Gang Greg Wang
Journal: Blood
Blood (2015) 125 (2): 346–357.
https://doi.org/10.1182/blood-2014-06-581082
Published: 2015
Includes: Supplemental data
Journal Articles

MRX2843, a Novel Dual MerTK-FLT3 Inhibitor with Activity Against Resistance-Conferring FLT3 Mutations in Acute Myeloid Leukemia

Katherine A Minson, MD, Catherine C Smith, MD, Alisa B. Lee-Sherick, MD, Deborah DeRyckere, PhD, Elisabeth Lasater, PhD, Amanda A. Hill, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Neil P. Shah, MD PhD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3757.
https://doi.org/10.1182/blood.V124.21.3757.3757
Published: 2014
Journal Articles

UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia

Deborah DeRyckere, PhD, Alisa B. Lee-Sherick, MD, Amanda A. Hill, Lauren Page, BS, Xiaodong Wang, PhD, Stephen V. Frye, PhD, H. Shelton Earp, MD, Douglas K. Graham, MD PhD
Journal: Blood
Blood (2014) 124 (21): 998.
https://doi.org/10.1182/blood.V124.21.998.998
Published: 2014
Journal Articles

Development Of a Novel Small Molecule Inhibitor Of The Mer Tyrosine Kinase For Treatment Of Acute Lymphoblastic Leukemia

Deborah DeRyckere, Xiaodong Wang, Amanda A Hill, Weihe Zhang, Michael A Stashko, Susan Sather, Christopher E Cummings, William P Janzen, Stephen V Frye, H. Shelton Earp, III, Douglas K. Graham, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2666.
https://doi.org/10.1182/blood.V122.21.2666.2666
Published: 2013
Journal Articles

Mer Receptor Tyrosine Kinase Is a Novel Therapeutic Target In Multiple Myeloma

Sandra Christoph, Silke Maag, Deborah DeRyckere, Douglas K. Graham, MD, PhD, Stephen V Frye, H. Shelton Earp, III, Jing Liu, Chao Yang, Weihe Zhang, Xiaodong Wang, Ahmet H. Elmaagacli, Dietrich Beelen, MD
Journal: Blood
Blood (2013) 122 (21): 1957.
https://doi.org/10.1182/blood.V122.21.1957.1957
Published: 2013
Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Mediate Synergistic Inhibition Of Platelet Aggregation In Combination With ADP/P2Y Antagonists

Gilbert Acevedo, BS, Brian R. Branchford, MD, Luke Law, BS, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, H. Shelton Earp, III, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD
Journal: Blood
Blood (2013) 122 (21): 3507.
https://doi.org/10.1182/blood.V122.21.3507.3507
Published: 2013
Journal Articles

Novel Small Molecule Inhibitors Of The Gas6/TAM Signaling Pathway Inhibit Platelet Aggregation In Vitro and Protect Mice From Arterial and Venous Thrombosis In Vivo

Gilbert Acevedo, BS, Brian R. Branchford, MD, Christine Brzezinski, Susan Sather, Gary Brodsky, PhD, Deborah DeRyckere, Ph.D., Weihe Zhang, Jing Liu, H. Shelton Earp, III, Xiaodong Wang, Stephen V Frye, Douglas K. Graham, MD, PhD, Jorge Di Paola, MD
Journal: Blood
Blood (2013) 122 (21): 2296.
https://doi.org/10.1182/blood.V122.21.2296.2296
Published: 2013
Journal Articles

UNC1666, a Dual Mer and Flt-3 Tyrosine Kinase Small Molecule Inhibitor In Acute Myeloid Leukemia

Alisa B. Lee-Sherick, MD, Kelly Menachof, Amanda A Hill, Sean Rinella, MPH, Jing Liu, Deborah DeRyckere, Xiaodong Wang, Stephen V Frye, H. Shelton Earp, III, Douglas K. Graham, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3849.
https://doi.org/10.1182/blood.V122.21.3849.3849
Published: 2013