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Shinji Hagiwara
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Journal Articles

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

Satoshi Kitazawa, PhD, Yukiko Ishii, PhD, Keiko Makita-Suzuki, Koichi Saito, PhD, Kensuke Takayanagi, Hiromi Sugihara, Shun Matsuda, PhD, Takayuki Yamakawa, PhD, Yasuhiro Tsutsui, Tadashi Tanaka, Tomohisa Hatta, PhD, Tohru Natsume, PhD, Toru Kondo, PhD, Yuichi Ishikawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2663.
https://doi.org/10.1182/blood-2019-121869
Published: 2019
Journal Articles

FF-10101 Retains Potent Inhibitory Activities Against Resistant Mutations to FLT3 Inhibitors, Newly Identified in Random Mutagenesis Screens

Yuichi Ishikawa, MD PhD, Koichi Saito, PhD, Naomi Kawashima, MD PhD, Michie Morimoto, Hidetoshi Murao, PhD, Daisuke Terada, Takeshi Yamaura, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2672.
https://doi.org/10.1182/blood-2019-124632
Published: 2019
Journal Articles

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations

Takeshi Yamaura, Toshiyuki Nakatani, Ken Uda, Hayato Ogura, Wigyon Shin, Naoya Kurokawa, Koichi Saito, Norie Fujikawa, Tomomi Date, Masaru Takasaki, Daisuke Terada, Atsushi Hirai, Akimi Akashi, Fangli Chen, Yoshiya Adachi, Yuichi Ishikawa, Fumihiko Hayakawa, Shinji Hagiwara, Tomoki Naoe, Hitoshi Kiyoi
Journal: Blood
Blood (2018) 131 (4): 426–438.
https://doi.org/10.1182/blood-2017-05-786657
Published: 2018
Includes: Supplemental data
Journal Articles

FF-10102-01: A Novel, Highly Selective Spleen Tyrosine Kinase Inhibitor, to Be in Clinical Application for Treatment of Autoimmune Diseases and B-Cell Malignancies

Chieko Kinouchi, Kazuya Taguchi, Susumu Shimoyama, Tadaaki Ioroi, DPhil, Hayato Ogura, Mari Yamamoto, Akiko Iino, Yoshimasa Maeda, DPhil, Hiroshi Kato, Hideyasu Fujiwara, DPhil, Shinji Hagiwara, DPhil, Hiroyuki Iwamura, Dphil, David J Kuter, MD DPhil, Takaaki Nakamura, DPhil, Yasuhiro Shimada
Journal: Blood
Blood (2016) 128 (22): 3745.
https://doi.org/10.1182/blood.V128.22.3745.3745
Published: 2016
Journal Articles

Development of FF-10101, a Novel Irreversible FLT3 Inhibitor, Which Overcomes Drug Resistance Mutations

Toshiyuki Nakatani, PhD, Ken Uda, Takeshi Yamaura, Masaru Takasaki, Akimi Akashi, Fangli Chen, MD, Yuichi Ishikawa, MDPhD, Fumihiko Hayakawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD, Tomoki Naoe, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1353.
https://doi.org/10.1182/blood.V126.23.1353.1353
Published: 2015