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Sebastien Malinge, PhD
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Journal Articles

STAT3 Is Activated By DYRK1A and Is a Potential Therapeutic Target in B-ALL

Malini Rammohan, MS, Rahul S. Bhansali, Yi-Chien Tsai, Alexander Dong, Sebastien Malinge, PhD, Jean-Pierre Bourquin, MD PhD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 3898.
https://doi.org/10.1182/blood-2018-99-115429
Published: 2018
Journal Articles

The Chromosome 21 Kinase DYRK1A and Its Substrate FOXO1 Constitute a Novel Therapeutic Pathway in B-ALL

Rahul S. Bhansali, Malini Rammohan, MS, Ji Heon Paul Lee, MD PhD, Sebastien Malinge, PhD, Yi-Chien Tsai, Nobuko Hijiya, MD, Beat Bornhauser, PhD, Jean-Pierre Bourquin, MD PhD, Corinne Fruit, Thierry Besson, PhD, John D. Crispino, PhD MBA
Journal: Blood
Blood (2018) 132 (Supplement 1): 548.
https://doi.org/10.1182/blood-2018-99-119854
Published: 2018
Journal Articles

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemic Pathogenesis

Andrew Volk, PhD, Kaiwei Liang, PhD, Jianyun Zhao, Xinyu Li, Marinka Bulic, Stacy Marshall, Jeffrey W. Taub, MD, Yubin Ge, PhD, Sebastien Malinge, PhD, Elizabeth Bartom, PhD, Ali Shilatifard, PhD, John D. Crispino, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 245.
https://doi.org/10.1182/blood.V130.Suppl_1.245.245
Published: 2017
Journal Articles

DYRK1A Is a Therapeutic Target in B-ALL in Children with Down Syndrome

Paul Lee, MD PhD, Rahul Bhansali, BA, Malini Rammohan, BS, MS, Nobuko Hijiya, MD, Shai Izraeli, MD Prof, Jean-Pierre Bourquin, MD PhD, Sebastien Malinge, PhD, John Crispino, PhD MBA
Journal: Blood
Blood (2016) 128 (22): 2721.
https://doi.org/10.1182/blood.V128.22.2721.2721
Published: 2016
Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Cecile Thirant, PhD, Cecile K Lopez, Cathy Ignacimouttou, M'Boyba Diop, Lou Le Mouël, MD, Clarisse Thiollier, MD PhD, Aurelie Siret, Philippe Dessen, Zakia Aid, Julie Riviere, PhD, Philippe Rameau, Celine Lefebvre, Mehdi Khaled, PhD, Guy Leverger, MD, Paola Fabiola Ballerini, MDPhD, Arnaud Petit, MD PhD, Hana Raslova, PhD, Catherine Carmichael, Benjamin T. Kile, PhD, Eric Soler, PhD, John Crispino, PhD, Christian Wichmann, MD, Camille Lobry, PhD, Francoise Pfumio, PhD, Juerg Schwaller, MD, Nathalie M. Droin, PhD, William Vainchenker, MD PhD, Olivier A. Bernard, PhD, Sebastien Malinge, PhD, Thomas Mercher, PhD
Journal: Blood
Blood (2016) 128 (22): 572.
https://doi.org/10.1182/blood.V128.22.572.572
Published: 2016
Journal Articles

Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms

Qiang Jeremy Wen, PhD, MD, Benjamin Goldenson, Sebastien Malinge, PhD, Brady L Stein, MD MHS, Terra L Lasho, MT, (ASCP), Lawrence Breyfogle, Rachael Schultz, Qiong Yang, Laure gilles-Gendre, Priya Koppikar, Omar Abdel-Wahab, MD, Benjamin L. Ebert, MD, PhD, Animesh Pardanani, MBBS, PhD, Sandeep Gurbuxani, MBBS, PhD, Ross L. Levine, MD, Ann Mullally, MD, Ayalew Tefferi, MD, John D Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 109.
https://doi.org/10.1182/blood.V122.21.109.109
Published: 2013
Journal Articles

The Chromosome 21 Kinase DYRK1A Controls Cell Cycle Exit and Survival During Lymphoid Development and Is a Novel Therapeutic Target In Acute Lymphoblastic Leukemia

Benjamin J. Thompson, MD, PhD, Lauren Diebold, Sebastien Malinge, PhD, Bertrand Leblond, Anne-Sophie Casagrande, Laurent Désiré, Alicia Foucourt, Thierry Besson, Nobuko Hijiya, MD, John D. Crispino, PhD
Journal: Blood
Blood (2013) 122 (21): 814.
https://doi.org/10.1182/blood.V122.21.814.814
Published: 2013
Journal Articles

Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms

Qiang Jeremy Wen, MD, PhD, Benjamin Goldenson, Sebastien Malinge, PhD, Priya Koppikar, Ross L Levine, MD, Ayalew Tefferi, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 64.
https://doi.org/10.1182/blood.V118.21.64.64
Published: 2011
Journal Articles

Development of Acute Megakaryoblastic Leukemia in Down Syndrome Is Associated with Sequential Epigenetic Changes That Target the Down Syndrome Critical Region on Chromosome 21,

Maria E Figueroa, MD, Sebastien Malinge, PhD, Timothy M Chlon, Yushan Li, Elisabeth Paietta, PhD, Hugo F. Fernandez, MD, Martin S. Tallman, MD, Mitchell J Weiss, MD, Stella T Chou, MD, Ari Melnick, MD, John Crispino, PhD
Journal: Blood
Blood (2011) 118 (21): 3451.
https://doi.org/10.1182/blood.V118.21.3451.3451
Published: 2011
Journal Articles

Ikaros Is a GATA Switch Target Gene That Restrains Megakaryopoiesis In Part by Blocking Notch Signaling.

Sebastien Malinge, PhD, Clarisse Thiollier, Timothy M Chlon, Louis C Dore, Lauren Diebold, Susan Winandy, PhD, Thomas Mercher, PhD, John Crispino, PhD
Journal: Blood
Blood (2010) 116 (21): 1602.
https://doi.org/10.1182/blood.V116.21.1602.1602
Published: 2010
Journal Articles

Development of a Mouse Model of DS Megakaryoblastic Leukemia and Identification of the Hsa21 Gene DYRK1A as a Prominent Contributor to DS-AMKL

Sebastien Malinge, PhD, Gina Kirsammer, PhD, Meghan Bliss-Moreau, Timothy M Chlon, Lauren Diebold, Stella T Chou, MD, Mitchell Weiss, MD, Sandeep Gurbuxani, MBBS, PhD, John Crispino, PhD
Journal: Blood
Blood (2010) 116 (21): 469.
https://doi.org/10.1182/blood.V116.21.469.469
Published: 2010