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Journal Articles

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Pedro Ramos, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Laura Breda, Ph.D, Bart J Crielaard, PhD, Ritama Gupta, Undergraduate student, Ella Guy, Maria F Mariongiu, PhD, Ross L. Levine, Omar Abdel-Wahab, PhD, Benjamin L. Ebert, Nico van Rooijen, PhD, Saghi Ghaffari, MD, PhD, Robert W Grady, PhD, Patricia Giardina, MD, Stefano Rivella, PhD

Blood (2012) 120 (21): 81.

https://doi.org/10.1182/blood.V120.21.81.81

Published: 2012

Journal Articles

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

Carla Casu, PhD, Pedro Ramos, PhD, Luca Melchiori, PhD, Ella Guy, Eliezer A. Rachmilewitz, Patricia Giardina, MD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 3187.

https://doi.org/10.1182/blood.V118.21.3187.3187

Published: 2011

Journal Articles

The Regulation of Hepcidin in β-Thalassemia

Nermi Parrow, PhD, Sara Gardenghi, PhD, Pedro Ramos, PhD, Yatrik Shah, PhD, Robert Fleming, MD, Carla Casu, PhD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 901.

https://doi.org/10.1182/blood.V118.21.901.901

Published: 2011

Journal Articles

Macrophages Impair Erythroid Development in β-Thalassemia Intermedia

Carla Casu, PhD, Pedro Ramos, PhD, Ella Guy, Nico van Rooijen, PhD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 1035.

https://doi.org/10.1182/blood.V118.21.1035.1035

Published: 2011

Journal Articles

Investigating the Role of Cytokines and Hepcidin in Anemia of Inflammation

Sara Gardenghi, PhD, Thomas M. Renaud, MD, Alessandra Meloni, PhD, Pedro Ramos, PhD, Carla Casu, PhD, Keegan S Cooke, Barbra J Sasu, PhD, Patricia Giardina, MD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2011) 118 (21): 1046.

https://doi.org/10.1182/blood.V118.21.1046.1046

Published: 2011

Journal Articles

ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload

Pedro Ramos, Sara Gardenghi, PhD, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 2063.

https://doi.org/10.1182/blood.V116.21.2063.2063

Published: 2010

Journal Articles

Optimizing the Use of Deferasirox: Evidence of Synergy When Combined with Deferoxamine

Robert W Grady, PhD, Renzo Galanello, MD, Dorothy A Kleinert, NP, MPH, Carole S. Paley, MD, Patricia J. Giardina, MD

Blood (2010) 116 (21): 5163.

https://doi.org/10.1182/blood.V116.21.5163.5163

Published: 2010

Journal Articles

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Pedro Ramos, PhD, Ella Guy, Robert W Grady, PhD, Maria de Sousa, MD, PhD, Stefano Rivella, PhD

Blood (2010) 116 (21): 4251.

https://doi.org/10.1182/blood.V116.21.4251.4251

Published: 2010

Journal Articles

Iron Chelation with Deferasirox in Thalassemia Major Patients with Low Iron Burdens and Moderate to High Transfusion Regimens.

Elizabeth Evans, Dorothy A. Kleinert, NP, Kevin Mennitt, MD, Robert W. Grady, PhD, Patricia J. Giardina, MD

Blood (2009) 114 (22): 4070.

https://doi.org/10.1182/blood.V114.22.4070.4070

Published: 2009

Journal Articles

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

Pedro Ramos, Ella Guy, Nan Chen, Sara Gardenghi, Robert W. Grady, PhD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 4044.

https://doi.org/10.1182/blood.V114.22.4044.4044

Published: 2009

Journal Articles

Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Iron Absorption in Mice Affected by β-Thalassemia and Other Disorders of Red Cell Production.

Luca Melchiori, Sara Gardenghi, PhD, Ella C. Guy, Eliezer Rachmilewitz, M.D, Patricia J Giardina, MD, Robert W. Grady, PhD, Mohandas Narla, DSc, Xiuli An, MD, PhD, Stefano Rivella, PhD

Blood (2009) 114 (22): 2020.

https://doi.org/10.1182/blood.V114.22.2020.2020

Published: 2009

Journal Articles

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Pedro Ramos, Ella Guy, Nan Chen, Robert W. Grady, PhD, Barry S. Coller, MD, Maria De Sousa, MD, Stefano Rivella, PhD

Blood (2009) 114 (22): 2023.

https://doi.org/10.1182/blood.V114.22.2023.2023

Published: 2009

Journal Articles

Increased Hepcidin Expression in Mice Affected by β-Thalassemia Reduces Iron Overload with No Effect on Anemia

Sara Gardenghi, PhD, Maria Franca Marongiu, Kristen Muirhead, Pedro Ramos, Cindy N. Roy, PhD, Nancy C. Andrews, MD, PhD, Elizabeta Nemeth, PhD, Antonia Follenzi, Eliezer Rachmilewitz, M.D, Patricia Giardina, MD, Robert W Grady, PhD, Stefano Rivella, PhD

Blood (2008) 112 (11): 128.

https://doi.org/10.1182/blood.V112.11.128.128

Published: 2008

Journal Articles

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Ella Guy, Ilaria Libani, PhD, Luca Melchiori, Thomas Scholzen, PhD, Raffaella Schiro, MD, Pedro Ramos, Margrit Kernbach, Bettina Baron-Luehr, Laura Breda, PhD, Matteo Porotto, PhD, Maria de Sousa, MD, Maria Domenica Cappellini, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Johannes Gerdes, PhD, Stefano Rivella, PhD

Blood (2007) 110 (11): 275.

https://doi.org/10.1182/blood.V110.11.275.275

Published: 2007

Journal Articles

Leukocyte Apoptosis and Mitochondrial Dysfunction in β-Thalassemia Patients Treated with Deferasirox or Deferoxamine.

Patrick B. Walter, PhD, John Porter, MD, Patricia Evans, PhD, Janet L. Kwiatkowski, MD, Ellis J. Neufeld, MD, Thomas Coates, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Elliott Vichinsky, MD, Nancy F. Olivieri, MD, Felicia Trachtenberg, PhD, Daniele Alberti, MD, Jaymes Holland, PhD, Ellen Fung, PhD, Bruce Ames, PhD, Annie Lui, BS, Paul Harmatz, MD

Blood (2007) 110 (11): 2773.

https://doi.org/10.1182/blood.V110.11.2773.2773

Published: 2007

Journal Articles

Efficacy of the Novel Oral Iron Chelator Deferitrin in Metabolic Iron Balance Studies.

Robert W. Grady, PhD, Maria Sitarou, MD, Renzo Galanello, MD, Hannah Tamary, MD, Eliana Lai, MD, Aurelio Maggio, MD, Farrukh Shah, MD, Patricia J. Giardina, MD, Joanne M. Donovan, MD, PhD

Blood (2007) 110 (11): 2775.

https://doi.org/10.1182/blood.V110.11.2775.2775

Published: 2007

Journal Articles

Pharmacokinetic and Toxicological Results of a 28-Day Multiple Dose Study of Starch-Conjugated Deferoxamine (S-DFO, 40SD02) in Iron-Loaded Dogs.

Robert W. Grady, PhD, James Bakke, BS, Karen Steinmetz, PhD, Terry R. Bishop, PhD, Bo E. Hedlund, PhD

Blood (2007) 110 (11): 2780.

https://doi.org/10.1182/blood.V110.11.2780.2780

Published: 2007

Journal Articles

Long-Term Outcome of Iron-Induced Cardiac Disease in Patients with Thalassemia Major Treated with Combined DFP/DFO or DFO Alone.

Maria Eliana Lai, MD, Stefania Vacquer, MD, Alessia Pepe, MD, Aurelio Maggio, MD, Maria P. Carta, MD, Paolo Cianciulli, MD, Patrizio Bina, MD, Franco Sau, MD, Robert W. Grady, PhD

Blood (2006) 108 (11): 1764.

https://doi.org/10.1182/blood.V108.11.1764.1764

Published: 2006

Journal Articles

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Sara Gardenghi, PhD, Maria Marongiu, Pedro Ramos, Ella Guy, Laura Breda, PhD, Amy Chadburn, MD, Yifang Liu, Gideon Rechavi, MD, Ninette Amariglio, PhD, E.A. Rachmilewitz, MD, Diedra Wrighting, PhD, Nancy C. Andrews, MD, Maria de Sousa, MD, Patricia Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2006) 108 (11): 1543.

https://doi.org/10.1182/blood.V108.11.1543.1543

Published: 2006

Journal Articles

Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.

Laura Breda, PhD, Sara Gardenghi, PhD, Ella Guy, Ninette Amariglio, PhD, Konstantin Adamsky, PhD, Orly Weizer-Stern, PhD, Eliezer Rachmilewitz, MD, Gideon Rechavi, MD, Patricia J. Giardina, MD, Robert W. Grady, PhD, Stefano Rivella, PhD

Blood (2005) 106 (11): 3846.

https://doi.org/10.1182/blood.V106.11.3846.3846

Published: 2005

NARROW

Removal of Macrophages From the Erythroid Niche Impairs Stress Erythropoiesis but Improves Pathophysiology of Polycythemia Vera and Beta-Thalassemia

Potential Therapeutic Applications of Jak2 Inhibitors in Beta-Thalassemia and Sickle Cell Disease,

The Regulation of Hepcidin in β-Thalassemia

Macrophages Impair Erythroid Development in β-Thalassemia Intermedia

Investigating the Role of Cytokines and Hepcidin in Anemia of Inflammation

ß-Thalassemic Mice Require Functional Hfe to Modulate Hepcidin Expression In Response to Iron Overload

Optimizing the Use of Deferasirox: Evidence of Synergy When Combined with Deferoxamine

Hfe Modulates the Response to Erythopoietic Stress In Wt Mice by Two Distinct Mechanisms

Iron Chelation with Deferasirox in Thalassemia Major Patients with Low Iron Burdens and Moderate to High Transfusion Regimens.

Absence of the Hemochromatosis Gene Hfe Confers Protection Under Conditions of Stress Erythropoiesis.

Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Iron Absorption in Mice Affected by β-Thalassemia and Other Disorders of Red Cell Production.

Macrophage Depletion Leads to Modification of Thalassemic Phenotype.

Increased Hepcidin Expression in Mice Affected by β-Thalassemia Reduces Iron Overload with No Effect on Anemia

Accelerated Proliferation and Limited Differentiation, Mediated through Jak2, Exacerbate Ineffective Erythropoiesis in β-Thalassemia.

Leukocyte Apoptosis and Mitochondrial Dysfunction in β-Thalassemia Patients Treated with Deferasirox or Deferoxamine.

Efficacy of the Novel Oral Iron Chelator Deferitrin in Metabolic Iron Balance Studies.

Pharmacokinetic and Toxicological Results of a 28-Day Multiple Dose Study of Starch-Conjugated Deferoxamine (S-DFO, 40SD02) in Iron-Loaded Dogs.

Long-Term Outcome of Iron-Induced Cardiac Disease in Patients with Thalassemia Major Treated with Combined DFP/DFO or DFO Alone.

Ineffective Erythropoiesis in β-Thalassemia Is Characterized by Increased Iron Absorption Mediated by down Regulation of Hepcidin and up Regulation of Ferroportin.

Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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