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Journal Articles

Small Angle X-Ray Scattering Reveals the Conformation of Î² 2 glycoprotein I and the Conformational Binding Epitopes of Autoantibodies

Seung J. Kim, PhD, Jacob H. Rand, MD PhD, Philip G. de Groot, PhD, Rolf T. Urbanus, PhD, Dina Schneidman, PhD, Man K. Chan, PhD, Hilde Kelchtermans, PhD, Bas De Laat, MD PhD

Blood (2017) 130 (Supplement 1): 2378.

https://doi.org/10.1182/blood.V130.Suppl_1.2378.2378

Published: 2017

Journal Articles

Applying Neural Networking Identifies Antiphospholipid Syndrome Patients with an Accuracy of 98.7%

Romy Kremers, PhD, Stéphane Zuily, MDPhD, Hilde Kelchtermans, PhD, Philip G. de Groot, PhD, Tessa Peters, Saartje Bloemen, PhD, Coenraad Hemker, MD PhD, Denis Wahl, MD PhD, Bas De Laat, MD PhD

Blood (2017) 130 (Supplement 1): 460.

https://doi.org/10.1182/blood.V130.Suppl_1.460.460

Published: 2017

Journal Articles

Binding of Erythrocyte ICAM–4 to the Platelet Activated Integrin α IIb β 3 leads to a Direct Erythrocyte-Platelet Adhesion Under Venous Flow Shear Rate

Vivian Xiaoyan Du, Philip G de Groot, PhD, Richard van Wijk, PhD, Zaverio M. Ruggeri, MD, PhD, Bas De Laat, PhD

Blood (2012) 120 (21): 105.

https://doi.org/10.1182/blood.V120.21.105.105

Published: 2012

Journal Articles

Variability in Exposure of Epitope G40-R43 of Domain I in Commercial Anti-β 2 -Glycoprotein I IgG Elisas Influences the Diagnosis of the Antiphospholipid Syndrome

Leonie Pelkmans, Hilde Kelchtermans, PhD, Marisa Ninivaggi, Theo Lindhout, PhD, Philip G de Groot, PhD, Vittorio Pengo, Bas De Laat, PhD

Blood (2012) 120 (21): 632.

https://doi.org/10.1182/blood.V120.21.632.632

Published: 2012

Journal Articles

Characterization of the Binding Between the Polymeric Platelet Adhesive Proteins, Multimerin 1 and Von Willebrand Factor

D'Andra Parker, BSc (Hon), Subia Tasneem, PhD, Nola Fuller, MSc, J. Evan Sadler, MD, PhD, Philip G de Groot, PhD, Catherine PM Hayward, MD, PhD

Blood (2011) 118 (21): 1144.

https://doi.org/10.1182/blood.V118.21.1144.1144

Published: 2011

Journal Articles

Protected by Nature: Effects of Exercise In Non-Severe Haemophilia Patients

Ingrid E.M. den Uijl, DVM, MSc, Wim G Groen, Msc, Jan Jaap van der Net, PhD, Diederick E Grobbee, PhD, Philip G de Groot, PhD, Kathelijn Fischer, MD, PhD

Blood (2010) 116 (21): 545.

https://doi.org/10.1182/blood.V116.21.545.545

Published: 2010

Journal Articles

Active Von Willebrand Factor (VWF) in Plasma of Sickle Cell Patients Is An Indicator of Disease Severity.

Junmei Chen, PhD, William Hobbs, MD, PhD, Jennie Le, Peter J Lenting, PhD, Philip G De Groot, PhD, Jose A. Lopez, MD

Blood (2009) 114 (22): 2552.

https://doi.org/10.1182/blood.V114.22.2552.2552

Published: 2009

Journal Articles

Apolipoprotein E Receptor 2′ Mediates Pathogenic Effects of Dimeric β 2 glycoprotein I and of Anti- β 2 glycoprotein I Antibodies in Vivo

Zurina Romay-Penabad, Ph.D., Rolf T Urbanus, MD, Elizabeth Pappalardo, B.S., Yong Hwang, M.D., Ronald H.W.M. Derksen, MD., Tuya Shilagard, Ph.D., Gracie Vargas, Ph.D., Maarten TT Pennings, Ph.D., Philip G De Groot, PhD, Silvia S Pierangeli, Ph.D.

Blood (2008) 112 (11): 408.

https://doi.org/10.1182/blood.V112.11.408.408

Published: 2008

Journal Articles

Identification of a Role for Apolipoprotein E Receptor 2 as a Platelet Receptor for Factor XI

Tara C White, Michelle A Berny, Erik I Tucker, Jiaqing Pang, David Gailani, MD, Rolf T Urbanus, MD, Philip G de Groot, PhD, András Gruber, MD, Owen JT McCarty, PhD

Blood (2008) 112 (11): 3914.

https://doi.org/10.1182/blood.V112.11.3914.3914

Published: 2008

Journal Articles

Transition from Non-Platelet-Binding to Platelet-Binding Conformation of Von Willebrand Factor Occurs upon Exocytosis

Evelyn Groot, Rob Fynheer, MD, PhD, Silvie AE Sebastian, Peter J Lenting, PhD, Philip G De Groot, PhD

Blood (2008) 112 (11): 3917.

https://doi.org/10.1182/blood.V112.11.3917.3917

Published: 2008

Journal Articles

Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.

Bas De Laat, PhD, Philip G. de Groot, PhD, Ronald H.W.M. Derksen, MD., Rolf T. Urbanus, Koen Mertens, PhD, Frits Rosendaal, MD, PhD, Carine J.M. Doggen, PhD

Blood (2008) 112 (11): 1813.

https://doi.org/10.1182/blood.V112.11.1813.1813

Published: 2008

Journal Articles

Beta2-Glycoprotein I: Implications for a Regulatory Role in Thrombotic Thrombocytopenic Purpura.

Bas de Laat, PhD, Johanna A. Kremer Hovinga, MD, PhD, Wouter Pos, Evelyn Groot, Jing-Fei Dong, MD, PhD, Bernard Lammle, MD, PhD, Jan Voorberg, PhD, Philip G. de Groot, PhD

Blood (2007) 110 (11): 278.

https://doi.org/10.1182/blood.V110.11.278.278

Published: 2007

Journal Articles

Hypofibrinolysis as a Risk Factor for Venous Thrombosis.

Mirjam E. Meltzer, MSc, Carine J.M. Doggen, PhD, Philip G. de Groot, PhD, Frits R. Rosendaal, MD, PhD, Ton Lisman, PhD

Blood (2006) 108 (11): 272.

https://doi.org/10.1182/blood.V108.11.272.272

Published: 2006

Journal Articles

O -Linked Glycosylation with Sialylated T-Antigen: A Novel Carbohydrate Determinant of von Willebrand Factor Antigen Levels.

Peter J. Lenting, PhD, Carina J.M. van Schooten, MSc, Ton Lisman, PhD, Marijke van den Berg, MD, PhD, Jeroen C.J. Eikenboom, MD, PhD, Frank W.G. Leebeek, MD, PhD, Jenny Goudemand, MD, PhD, Edith Fressinaud, MD, PhD, Philip G. de Groot, PhD, Cécile V. Denis, PhD

Blood (2006) 108 (11): 178.

https://doi.org/10.1182/blood.V108.11.178.178

Published: 2006

Journal Articles

Beta2-Glycoprotein I Interferes with von Willebrand Factor-Dependent Platelet Adhesion.

Peter J. Lenting, PhD, Janine J. Hulstein, PhD, Bas de Laat, PhD, Ronald H. Derksen, MD,PhD, Rob Fijnheer, MD,PhD, Philip G. de Groot, PhD

Blood (2006) 108 (11): 415.

https://doi.org/10.1182/blood.V108.11.415.415

Published: 2006

Journal Articles

Studies with the Nanobody That Detects the Gain-of-Function of von Willebrand Factor in a Cohort of Patients with Type 2B von Willebrand Disease: Correlation with Platelet Count, VWF Multimers and Molecular Defects.

Augusto B. Federici, MD, Luciano Baronciani, PhD, Maria T. Canciani, PhD, Barbara Moroni, PhD, Carlo Balduini, MD, Pier M. Mannucci, MD, Peter J. Lenting, PhD, Philip G. de Groot, PhD

Blood (2006) 108 (11): 1011.

https://doi.org/10.1182/blood.V108.11.1011.1011

Published: 2006

Journal Articles

Identification of the von Willebrand Factor Binding Site in Collagen Using Triple Helical Peptides.

Ton Lisman, PhD, Nicholas Raynal, PhD, Dafna Groeneveld, BSci, Ben Maddox, BA, Tony Peachey, BA, Eric G. Huizinga, PhD, Philip G. de Groot, PhD, Richard W. Farndale, PhD

Blood (2005) 106 (11): 413.

https://doi.org/10.1182/blood.V106.11.413.413

Published: 2005

Journal Articles

Pathological Anti-β 2 -Glycoprotein I Antibodies Disrupt the Anticoagulant Activity of Annexin A5: A Possible Explanation for the Lupus Anticoagulant Paradox.

Bas de Laat, PhD, Xiao-Xuan Wu, PhD, Menno van Lummel, Ronald H.W.M. Derksen, PhD, MD, Philip G. de Groot, PhD, Jacob H. Rand, PhD

Blood (2005) 106 (11): 135.

https://doi.org/10.1182/blood.V106.11.135.135

Published: 2005

Journal Articles

Interaction of beta2-Glycoprotein I with Members of the Low Density Lipoprotein Receptor Family.

Menno van Lummel, Maarten T.T. Pennings, Ronald H.W.M. Derksen, MD, PhD, Erik Westein, Peter J. Lenting, PhD, Philip G. de Groot, PhD

Blood (2005) 106 (11): 2646.

https://doi.org/10.1182/blood.V106.11.2646.2646

Published: 2005

Journal Articles

Recombinant Factor VIIa Enhances Platelet Adhesion and Aggregation under Flow Conditions at Normal and Reduced Platelet Count.

Ton Lisman, PhD, Jelle Adelmeijer, Bsci, Sandra Cauwenberghs, MSci, Elisabeth C.M. van Pampus, MD, Johan W.M. Heemskerk, PhD, Philip G. de Groot, PhD

Blood (2004) 104 (11): 2618.

https://doi.org/10.1182/blood.V104.11.2618.2618

Published: 2004

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Small Angle X-Ray Scattering Reveals the Conformation of Î² 2 glycoprotein I and the Conformational Binding Epitopes of Autoantibodies

Applying Neural Networking Identifies Antiphospholipid Syndrome Patients with an Accuracy of 98.7%

Binding of Erythrocyte ICAM–4 to the Platelet Activated Integrin α IIb β 3 leads to a Direct Erythrocyte-Platelet Adhesion Under Venous Flow Shear Rate

Variability in Exposure of Epitope G40-R43 of Domain I in Commercial Anti-β 2 -Glycoprotein I IgG Elisas Influences the Diagnosis of the Antiphospholipid Syndrome

Characterization of the Binding Between the Polymeric Platelet Adhesive Proteins, Multimerin 1 and Von Willebrand Factor

Protected by Nature: Effects of Exercise In Non-Severe Haemophilia Patients

Active Von Willebrand Factor (VWF) in Plasma of Sickle Cell Patients Is An Indicator of Disease Severity.

Apolipoprotein E Receptor 2′ Mediates Pathogenic Effects of Dimeric β 2 glycoprotein I and of Anti- β 2 glycoprotein I Antibodies in Vivo

Identification of a Role for Apolipoprotein E Receptor 2 as a Platelet Receptor for Factor XI

Transition from Non-Platelet-Binding to Platelet-Binding Conformation of Von Willebrand Factor Occurs upon Exocytosis

Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.

Beta2-Glycoprotein I: Implications for a Regulatory Role in Thrombotic Thrombocytopenic Purpura.

Hypofibrinolysis as a Risk Factor for Venous Thrombosis.

O -Linked Glycosylation with Sialylated T-Antigen: A Novel Carbohydrate Determinant of von Willebrand Factor Antigen Levels.

Beta2-Glycoprotein I Interferes with von Willebrand Factor-Dependent Platelet Adhesion.

Studies with the Nanobody That Detects the Gain-of-Function of von Willebrand Factor in a Cohort of Patients with Type 2B von Willebrand Disease: Correlation with Platelet Count, VWF Multimers and Molecular Defects.

Identification of the von Willebrand Factor Binding Site in Collagen Using Triple Helical Peptides.

Pathological Anti-β 2 -Glycoprotein I Antibodies Disrupt the Anticoagulant Activity of Annexin A5: A Possible Explanation for the Lupus Anticoagulant Paradox.

Interaction of beta2-Glycoprotein I with Members of the Low Density Lipoprotein Receptor Family.

Recombinant Factor VIIa Enhances Platelet Adhesion and Aggregation under Flow Conditions at Normal and Reduced Platelet Count.

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