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Peggy Scherle, PhD
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Journal Articles

PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

PRMT5 Inhibition Drives Therapeutic Vulnerability to BCL-2 Inhibition with Venetoclax and Provides Rationale for Combination Therapy in Mantle Cell Lymphoma

Fiona Brown, BS, Yang Zhang, PhD, Claire Hinterschied, Alexander Prouty, BS, Shelby Sloan, BS, JoBeth Helmig-Mason, Msc, Ji Hyun Chung, PhD, Kris Vaddi, PhD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Lapo Alinari, MD PhD, Peggy Scherle, PhD, Rosa Lapalombella, PhD, Jihye Paik, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 302.
https://doi.org/10.1182/blood-2019-130797
Published: 2019
Journal Articles

Targeting PRMT5 to Circumvent Acquired Ibrutinib Resistance in Mantle Cell Lymphoma

Shelby Sloan, BS, Fiona Brown, BS, JI Hyun Chung, PhD, Alexander Prouty, BS, Esther Wheeler, BS, Bonnie K Harrington, DVM, PhD, Eric Brooks, BS, Ayse S Yilmaz, MS, Hatice G Ozer, PhD, John C. Byrd, MD, Selina Chen-Kiang, PhD, Maurizio Di Liberto, PhD, Rosa Lapalombella, PhD, Kris Vaddi, PhD, Peggy Scherle, PhD, Youssef Youssef, MD, Robert A Baiocchi, MD PhD, Lapo Alinari, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4065.
https://doi.org/10.1182/blood-2019-128998
Published: 2019
Journal Articles

PRMT5 Is a Key Epigenetic Regulator That Promotes Transcriptional Activation in Mantle Cell Lymphoma By Regulating the Lysine Methyltransferase SETD7 and MLL1 Activity

JI Hyun Chung, PhD, Shelby Sloan, BS, Peggy Scherle, PhD, Kris Vaddi, PhD, Said Sif, PhD, Rosa Lapalombella, PhD, Robert A Baiocchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2777.
https://doi.org/10.1182/blood-2019-131020
Published: 2019
Journal Articles

LSD1 Inhibition Induces Fetal Hemoglobin Expression and Provides a Novel Therapeutic Approach to Sickle Cell Disease

Sang Hyun Lee, PhD, Maxim Soloviev, MDPhD, Yan Zhang, PhD, Valerie Roman, Gengjie Yang, Kevin Bowman, Krista Burke, Alexander Margulis, Sybil O'Connor, Yan-ou Yang, PhD, Liangxing Wu, PhD, Richard Wynn, PhD, Timothy Burn, PhD, Dana Shuey, PhD, Sharon Diamond, PhD, Wenqing Yao, PhD, Gregory Hollis, PhD, Swamy Yeleswaram, PhD, Alan Roberts, PhD, Reid Huber, PhD, Peggy Scherle, PhD, Bruce Ruggeri, PhD
Journal: Blood
Blood (2016) 128 (22): 2472.
https://doi.org/10.1182/blood.V128.22.2472.2472
Published: 2016
Journal Articles

High Resolution Mapping of Active RNA Polymerases Identifies KIT As a Target of BET Inhibitors in t(8;21) AML

Yue Zhao, PhD, Phillip Liu, PhD, Peggy Scherle, PhD, Reid Huber, PhD, Michael R. Savona, MD, Scott Hiebert, PhD
Journal: Blood
Blood (2015) 126 (23): 1225.
https://doi.org/10.1182/blood.V126.23.1225.1225
Published: 2015
Journal Articles

Discovery and Preclinical Characterization of INCB018424, a Selective JAK2 Inhibitor for the Treatment of Myeloproliferative Disorders.

Jordan Fridman, PhD, Roberto Nussenzveig, PhD, Phillip Liu, PhD, James Rodgers, PhD, Timothy Burn, PhD, Patrick Haley, DVM, Peggy Scherle, PhD, Robert Newton, PhD, Gregory Hollis, PhD, Steven Friedman, MD, Srdan Verstovsek, MD, PhD, Kris Vaddi, PhD
Journal: Blood
Blood (2007) 110 (11): 3538.
https://doi.org/10.1182/blood.V110.11.3538.3538
Published: 2007