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Paula Cramer
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Journal Articles

Biallelic Deletion 13q in Chronic Lymphocytic Leukemia Treated with Targeted Agents

Malte Knöll, Rashmi Priyadharshini Dheenadayalan, Deyan Y. Yosifov, Jialei Qi, Christof Schneider, Felix Seyfried, Lueder Hinrich Meyer, Paula Cramer, Julia Von Tresckow, Michael Hallek, Barbara F. Eichhorst, Eugen Tausch, Stephan Stilgenbauer, Billy Jebaraj
Journal: Blood
Blood (2024) 144 (Supplement 1): 4608.
https://doi.org/10.1182/blood-2024-204910
Published: 2024
Journal Articles

Informative Censoring in Randomized First-Line Trials of Chronic Lymphocytic Leukemia

Florian Simon, Rudy Ligtvoet, Moritz Fürstenau, Petra Langerbeins, Anna Maria Fink, Julia Von Tresckow, Paula Cramer, Christian Bjørn Poulsen, Thomas Illmer, Lothar Müller, Ursula Vehling-Kaiser, Michael J. Eckart, Liliya Sivcheva, Javier Loscertales, Kathleen Jentsch-Ullrich, Holger F. Hebart, Mark-David Levin, Caspar Da Cunha-Bang, Nadine Kutsch, Eugen Tausch, Christof Schneider, Stephan Stilgenbauer, Sandra Robrecht, Arnon P. Kater, Carsten Utoft Niemann, Kirsten Fischer, Michael Hallek, Barbara F. Eichhorst, Othman Al-Sawaf
Journal: Blood
Blood (2024) 144 (Supplement 1): 6799.
https://doi.org/10.1182/blood-2024-203673
Published: 2024
Journal Articles

Impact of Ibrutinib on Quality of Life in Patients with Early-Stage, Asymptomatic Chronic Lymphocytic Leukemia: Results from the Phase III CLL12 Trial

Ellinor Goergen, Sandra Robrecht, Adam Giza, Can Zhang, Pascal Nieper, Florian Simon, Paula Cramer, Moritz Fürstenau, Othman Al-Sawaf, Nadine Kutsch, Anna Maria Fink, Ursula Vehling-Kaiser, Lothar Müller, Michael J. Eckart, Rudolf Schlag, Werner Freier, Tobias Gaska, Christina Balser, Marcel Reiser, Martina Beate Stauch, Clemens-Martin Wendtner, Eugen Tausch, Christof Schneider, Kirsten Fischer, Stephan Stilgenbauer, Barbara F. Eichhorst, Michael Hallek, Petra Langerbeins
Journal: Blood
Blood (2024) 144 (Supplement 1): 1859.
https://doi.org/10.1182/blood-2024-200903
Published: 2024
Journal Articles

Acalabrutinib, venetoclax, and obinutuzumab in relapsed/refractory CLL: final efficacy and ctDNA analysis of the CLL2-BAAG trial

Clinical Trials & Observations
Moritz Fürstenau, Adam Giza, Jonathan Weiss, Fanni Kleinert, Sandra Robrecht, Fabian Franzen, Janina Stumpf, Petra Langerbeins, Othman Al-Sawaf, Florian Simon, Anna-Maria Fink, Christof Schneider, Eugen Tausch, Johannes Schetelig, Peter Dreger, Sebastian Böttcher, Kirsten Fischer, Karl-Anton Kreuzer, Matthias Ritgen, Anke Schilhabel, Monika Brüggemann, Stephan Stilgenbauer, Barbara Eichhorst, Michael Hallek, Paula Cramer
Journal: Blood
Blood (2024) 144 (3): 272–282.
https://doi.org/10.1182/blood.2023022730
Published: 2024
Includes: Supplemental data
Journal Articles

Reassessing the chronic lymphocytic leukemia International Prognostic Index in the era of targeted therapies

Clinical Trials & Observations
Petra Langerbeins, Adam Giza, Sandra Robrecht, Paula Cramer, Julia von Tresckow, Othman Al-Sawaf, Anna Maria Fink, Moritz Fürstenau, Nadine Kutsch, Florian Simon, Valentin Goede, Manuela Hoechstetter, Carsten Utoft Niemann, Caspar da Cunha-Bang, Arnon Kater, Julie Dubois, Michael Gregor, Philipp Bernhard Staber, Eugen Tausch, Christof Schneider, Stephan Stilgenbauer, Barbara Eichhorst, Kirsten Fischer, Michael Hallek
Journal: Blood
Blood (2024) 143 (25): 2588–2598.
https://doi.org/10.1182/blood.2023022564
Published: 2024
Includes: Supplemental data
Journal Articles

Outcomes and Treatment Sequences of Therapies with BCL2- and BTK Inhibitors in Chronic Lymphocytic Leukemia (CLL): An Analysis of Patient Data within the German CLL Study Group (GCLLSG) Registry

Nadine Kutsch, Rudy Ligtvoet, Sandra Robrecht, Hartmut Linde, Thomas Illmer, Steffen Doerfel, Joerg Lipke, Ali Aldaoud, Rudolf Schlag, Jolanta Dengler, Othman Al-Sawaf, Petra Langerbeins, Paula Cramer, Barbara F. Eichhorst, Michael Hallek, Kirsten Fischer, Anna Maria Fink
Journal: Blood
Blood (2023) 142 (Supplement 1): 4644.
https://doi.org/10.1182/blood-2023-185741
Published: 2023
Journal Articles

Endpoint Surrogacy in Chronic Lymphocytic Leukemia: A Pooled Analysis of the German CLL Study Group

Florian Simon, Rudy Ligtvoet, Sandra Robrecht, Paula Cramer, Nadine Kutsch, Moritz Furstenau, Valentin Goede, Julia Von Tresckow, Petra Langerbeins, Anna-Maria Fink, Henriette Huber, Eugen Tausch, Christof Schneider, Clemens-Martin Wendtner, Matthias Ritgen, Martin Dreyling, Lothar Müller, Lutz Jacobasch, Werner Heinz, Ursula Vehling-Kaiser, Liliya Sivcheva, Sebastian Böttcher, Peter Dreger, Thomas Illmer, Michael Gregor, Philipp Bernhard Staber, Stephan Stilgenbauer, Carsten Utoft Niemann, Arnon P. Kater, Kirsten Fischer, Barbara F. Eichhorst, Michael Hallek, Othman Al-Sawaf
Journal: Blood
Blood (2023) 142 (Supplement 1): 1901.
https://doi.org/10.1182/blood-2023-178597
Published: 2023
Journal Articles

Long-Term Remissions with MRD-Guided Acalabrutinib, Venetoclax and Obinutuzumab in Relapsed/Refractory CLL: Follow-up Efficacy and Circulating Tumor DNA Analysis of the CLL2-Baag Trial

Moritz Furstenau, Adam Giza, Anna-Maria Fink, Sandra Robrecht, Jonathan Weiss, Fanni Kleinert, Christof Schneider, Eugen Tausch, Kirsten Fischer, Petra Langerbeins, Othman Al-Sawaf, Johannes Schetelig, Peter Dreger, Sebastian Böttcher, Karl-Anton Kreuzer, Matthias Ritgen, Anke Schilhabel, Monika Brüggemann, Stephan Stilgenbauer, Barbara F. Eichhorst, Michael Hallek, Paula Cramer
Journal: Blood
Blood (2023) 142 (Supplement 1): 203.
https://doi.org/10.1182/blood-2023-173708
Published: 2023
Journal Articles

MRD-Guided Zanubrutinib, Venetoclax and Obinutuzumab after an Optional Debulking with Bendamustine in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: Primary Endpoint Analysis of the Phase 2 CLL2-Bzag Study

Moritz Furstenau, Adam Giza, Christof Schneider, Eugen Tausch, Sandra Robrecht, Matthias Ritgen, Jörg Bittenbring, Holger F. Hebart, Björn Schöttker, Anna Lena Illert, Ullrich Graeven, Andrea Stoltefuss, Bernhard Heinrich, Robert Eckert, Anna-Maria Fink, Janina Stumpf, Florian Simon, Kirsten Fischer, Othman Al-Sawaf, Petra Langerbeins, Fanni Kleinert, Jonathan Weiss, Karl-Anton Kreuzer, Anke Schilhabel, Monika Brüggemann, Barbara F. Eichhorst, Stephan Stilgenbauer, Michael Hallek, Paula Cramer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1897.
https://doi.org/10.1182/blood-2023-173707
Published: 2023
Journal Articles

The CLL12 trial: ibrutinib vs placebo in treatment-naïve, early-stage chronic lymphocytic leukemia

Clinical Trials & Observations
Petra Langerbeins, Can Zhang, Sandra Robrecht, Paula Cramer, Moritz Fürstenau, Othman Al-Sawaf, Julia von Tresckow, Anna-Maria Fink, Karl-Anton Kreuzer, Ursula Vehling-Kaiser, Eugen Tausch, Lothar Müller, Michael Josef Eckart, Rudolf Schlag, Werner Freier, Tobias Gaska, Christina Balser, Marcel Reiser, Martina Stauch, Clemens-Martin Wendtner, Kirsten Fischer, Stephan Stilgenbauer, Barbara Eichhorst, Michael Hallek
Journal: Blood
Blood (2022) 139 (2): 177–187.
https://doi.org/10.1182/blood.2021010845
Published: 2022
Includes: Supplemental data
Journal Articles

Durable remissions following combined targeted therapy in patients with CLL harboring TP53 deletions and/or mutations

Clinical Trials & Observations
Paula Cramer, Eugen Tausch, Julia von Tresckow, Adam Giza, Sandra Robrecht, Christof Schneider, Moritz Fürstenau, Petra Langerbeins, Othman Al-Sawaf, Benedikt W. Pelzer, Anna Maria Fink, Kirsten Fischer, Clemens-Martin Wendtner, Barbara Eichhorst, Michael Kneba, Stephan Stilgenbauer, Michael Hallek
Journal: Blood
Blood (2021) 138 (19): 1805–1816.
https://doi.org/10.1182/blood.2020010484
Published: 2021
Includes: Supplemental data
Journal Articles

Pooled Analysis of First-Line Treatment with Targeted Agents in Patients with Chronic Lymphocytic Leukemia (CLL) Aged 80 Years and Older

Florian Simon, Adam Giza, Sandra Robrecht, Anna-Maria Fink, Paula Cramer, Julia Von Tresckow, Moritz Fürstenau, Valentin Goede, Eugen Tausch, Christof Schneider, Stephan Stilgenbauer, Clemens-Martin Wendtner, Barbara Eichhorst, Kirsten Fischer, Michael Hallek, Othman Al-Sawaf
Journal: Blood
Blood (2021) 138 (Supplement 1): 1552.
https://doi.org/10.1182/blood-2021-150698
Published: 2021
Journal Articles

Severe Infections in Patients with Chronic Lymphocytic Leukemia Treated with (Immuno-)Chemotherapy: A Pooled Analysis of Gcllsg Trials

Othman Al-Sawaf, MD, Can Zhang, PhD, Sandra Robrecht, PhD, Anna-Maria Fink, MD, Paula Cramer, Carmen D. Herling, MD PhD, Julia Von Tresckow, MD, Elisabeth Lange, MD, Sebastian Böttcher, MD PhD, Michael G. Kiehl, MD PhD, Martin Dreyling, MD, Ulrich Jaeger, Michael Gregor, MD, Ursula Vehling-Kaiser, MD, Matthias Ritgen, MD, Jan Dürig, MD, Eugen Tausch, MD, Stephan Stilgenbauer, MD, Clemens-Martin Wendtner, MD, Kirsten Fischer, MD, Valentin Goede, MD, Michael Hallek, MD, Barbara Eichhorst, MD, Petra Langerbeins, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-139242
Published: 2020
Journal Articles

Bendamustine Followed By Obinutuzumab and Idelalisib in Patients with Chronic Lymphocytic Leukemia (CLL): CLL2-BCG Trial of the German CLL Study Group (GCLLSG)

Paula Cramer, Julia Von Tresckow, MD, Anna-Maria Fink, MD, Gracia Braun, Sandra Robrecht, PhD, Can Zhang, PhD, Eugen Tausch, MD, Lothar Müller, MD, Wolfgang Knauf, MD, Othman Al-Sawaf, MD, Benedikt Pelzer, MD, Petra Langerbeins, MD, Kirsten Fischer, MD, Karl-Anton Kreuzer, MD, Matthias Ritgen, MD, Michael Kneba, MDPhD, Clemens-Martin Wendtner, MD, Stephan Stilgenbauer, MD, Barbara Eichhorst, MD, Michael Hallek, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–23.
https://doi.org/10.1182/blood-2020-134827
Published: 2020
Journal Articles

Sequential Treatment with Bendamustine, Obinutuzumab (GA101) and Ibrutinib in Chronic Lymphocytic Leukemia (CLL): Final Results of the CLL2-BIG Trial of the German CLL Study Group (GCLLSG)

Julia Von Tresckow, Paula Cramer, Nisha De Silva, MBBS, MRCP, FRCPath, Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Petra Langerbeins, MD, Anna- Maria Fink, MD, Othman Al-Sawaf, MD, Moritz Fürstenau, MD, Thomas Illmer, MD, Holger Klaproth, Eugen Tausch, Matthias Ritgen, Kirsten Fischer, MD, Clemens-Martin Wendtner, Karl-Anton Kreuzer, MD, Stephan Stilgenbauer, MD, Sebastian Böttcher, MD, Barbara F. Eichhorst, MD, Michael Hallek, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3046.
https://doi.org/10.1182/blood-2019-125895
Published: 2019
Journal Articles

Analysis of Outcomes of Younger (≤ 55 Years) Compared with Older (> 55 Years) Patients with Chronic Lymphocytic Leukaemia (CLL) in Seven Studies Conducted By the German CLL Study Group (GCLLSG)

Nisha De Silva, MBBS, MRCP, FRCPath, Sandra Robrecht, PhD, Can Zhang, PhD, Paula Cramer, Anna- Maria Fink, MD, Kirsten Fischer, MD, Valentin Goede, MD, Carmen D. Herling, MD PhD, Manuela Hoechstetter, MD, Clemens-Martin Wendtner, MD, Michael Hallek, MD, Barbara F. Eichhorst, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4293.
https://doi.org/10.1182/blood-2019-126528
Published: 2019
Journal Articles

Durable Remissions after Discontinuation of Combined Targeted Treatment in Patients with Chronic Lymphocytic Leukemia (CLL) Harbouring a High-Risk Genetic Lesion (del(17p)/TP53 Mutation)

Paula Cramer, Julia von Tresckow, MD, Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Eugen Tausch, MD, Moritz Fürstenau, MD, Petra Langerbeins, MD, Othman Al-Sawaf, MD, Anna-Maria Fink, MD, Kirsten Fischer, MD, Clemens-Martin Wendtner, Barbara Eichhorst, Michael Kneba, Stephan Stilgenbauer, MD PhD, Michael Hallek
Journal: Blood
Blood (2018) 132 (Supplement 1): 694.
https://doi.org/10.1182/blood-2018-99-113155
Published: 2018
Journal Articles

Obesity Negatively Impacts Outcome in Female Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Fludarabine, Cyclophosphamide and Rituximab (FCR): An Analysis of Three Phase III Studies of the German CLL Study Group (GCLLSG)

Moritz Fürstenau, MD, Georg Hopfinger, MD, Sandra Robrecht, PhD, Anna-Maria Fink, MD, Othman Al-Sawaf, MD, Petra Langerbeins, MD, Paula Cramer, Julia Von Tresckow, MD, Christian Maurer, MD, Nadine Kutsch, MD, Manuela Hoechstetter, MD, Martin Dreyling, MD PhD, Elisabeth Lange, Michael Kneba, Stephan Stilgenbauer, MD PhD, Hartmut Döhner, MD, Manfred Hensel, MD, Michael G. Kiehl, MD PhD, Ulrich Jaeger, MD, Clemens-Martin Wendtner, Valentin Goede, MD, Kirsten Fischer, MD, Michael Hallek, Barbara Eichhorst, Sebastian Theurich, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4429.
https://doi.org/10.1182/blood-2018-99-113257
Published: 2018
Journal Articles

Mode of Progression after First Line Treatment Correlates with Outcome of Chronic Lymphocytic Leukemia (CLL)

Othman Al-Sawaf, MD, Alexandra Bazeos, Sandra Robrecht, PhD, Jasmin Bahlo, PhD, Anna Maria Fink, MD, Julia Von Tresckow, Paula Cramer, MD, Petra Langerbeins, MD, Nadine Kutsch, MD, Kathryn Humphrey, PhD, Günter Fingerle-Rowson, MD PhD, Stephan Stilgenbauer, MD PhD, Clemens-Martin Wendtner, MD, Kirsten Fischer, MD, Barbara F. Eichhorst, MD, Michael Hallek, MD, Valentin Goede, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1740.
https://doi.org/10.1182/blood.V130.Suppl_1.1740.1740
Published: 2017
Journal Articles

Incidence of and Risk Factors for Major Hemorrhage in Patients Treated with Ibrutinib: Results from an Integrated Analysis

Jennifer R. Brown, MD PhD, Javid Moslehi, MD, Michael S. Ewer, MD MPH, JD, Susan M. O'Brien, MD, Paolo Ghia, MD PhD, Florence Cymbalista, MD, Tait D. Shanafelt, MD, Graeme Fraser, MD, Simon Rule, MD, Steven E. Coutre, MD, Marie-Sarah Dilhuydy, MD, Paula Cramer, MD, Ulrich Jaeger, MD, Martin Dreyling, MD, John C. Byrd, MD, Steven Treon, MD PhD, Emily Liu, Stephen Chang, PhD, Amulya Bista, Rama Vempati, Lisa Boornazian, BSN, Rudolph Valentino, PharmD, Vijay Reddy, MD PhD, Michelle Mahler, MD, Huiying Yang, MD PhD, Jan A. Burger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1743.
https://doi.org/10.1182/blood.V130.Suppl_1.1743.1743
Published: 2017