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Journal Articles

Robust Discovery of Candidate DNA Methylation Cancer Drivers

Heng Pan, PhD, Loïc Renaud, MD MSc, Ronan Chaligne, PhD, Johannes Bloehdorn, MD, Eugen Tausch, MD, Daniel Mertens, PhD, Anna-Maria Fink, MD, Kirsten Fischer, MD, Chao Zhang, PhD, Doron Betel, PhD, Andreas Gnirke, Marcin Imielinski, Jerome Moreaux, PhD, Michael Hallek, Alexander Meissner, PhD, Stephan Stilgenbauer, MD, Catherine J. Wu, MD, Olivier Elemento, PhD, Dan A. Landau, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-136830

Published: 2020

Journal Articles

An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells

Johannes C Hellmuth, MD, Chi-Shuen Chu, PhD, Rajat Singh, PhD, Lucy A Skrabanek, PhD, Ashley Doane, Olivier Elemento, PhD, Robert G. Roeder, PhD, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 24.

https://doi.org/10.1182/blood-2019-130692

Published: 2019

Journal Articles

Disrupting GRINL1A Association with Cereblon Accelerates IKZF1/3 Degradation and IMiD Killing of Mantle Cell Lymphoma Cells By CDK4/6 Inhibition

Nicole Zhao, Maurizio Di Liberto, PhD, Olivier Elemento, PhD, Selina Chen-Kiang, PhD, Xiangao Huang, PhD

Blood (2019) 134 (Supplement_1): 299.

https://doi.org/10.1182/blood-2019-128927

Published: 2019

Journal Articles

Immune Sculpting of Clonal Hematopoiesis in Advanced and Metastatic Solid Tumors

Eti Sinha, Bhavneet Binder, Olivier Elemento, PhD, Duane C. Hassane, PhD

Blood (2019) 134 (Supplement_1): 3721.

https://doi.org/10.1182/blood-2019-132222

Published: 2019

Journal Articles

T-Cell Clonal Expansion and Activation Associated with Durable Clinical Response to Dual BTK and CDK4/6 Inhibitor Therapy in Mantle Cell Lymphoma

Christina Y. Lee, MD, Maurizio Di Liberto, PhD, Yang Hu, PhD, Xiangao Huang, PhD, Nancy L Bartlett, MD, Kami J. Maddocks, MD, John P. Leonard, MD, Nils-Petter Rudqvist, PhD, Lorenzo Galluzzi, PhD, Peter Martin, FRCPC, MD MS, Olivier Elemento, PhD, Selina Chen-Kiang, PhD

Blood (2019) 134 (Supplement_1): 3973.

https://doi.org/10.1182/blood-2019-122322

Published: 2019

Journal Articles

Heterogeneous Genetic Alterations and Novel Pathogenic Pathways in Relapsed DLBCL Revealed By Whole Exome Sequencing

Jiao Ma, PhD, Kui Nie, PhD, Giorgio Inghirami, MD, Kenneth Eng, B.S., Olivier Elemento, PhD, Rex Au-Yeung, Yajie Shen, BSA, Gopesh Srivastava, Jerald Gong, MD, Mina L Xu, MD, Leonard H.C. Tan, Wayne Tam, MD PhD

Blood (2019) 134 (Supplement_1): 2770.

https://doi.org/10.1182/blood-2019-125448

Published: 2019

Journal Articles

Composite Copy Number Variation in CDK4 , CDKN2A and RB1 Predisposes Mantle Cell Lymphoma to Expansion of PD1+ Tumor Cells and Resistance to CDK4/6 Inhibitor Therapy as Revealed by Integrative Longitudinal scRNA-seq

Maurizio Di Liberto, PhD, Yang Hu, PhD, Xiangao Huang, PhD, Christina Y. Lee, MD, Kevin Wang, B.S., Nancy L. Bartlett, MD, LeAnn Ridling, Kristie A. Blum, MD, Kami J. Maddocks, MD, Steven I Park, MD, Jia Ruan, MD PhD, Kenneth Eng, B.S., Lorenzo Galluzzi, PhD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS, Olivier Elemento, PhD, Selina Chen-Kiang, PhD

Blood (2019) 134 (Supplement_1): 1492.

https://doi.org/10.1182/blood-2019-130944

Published: 2019

Journal Articles

The DNA Helicase Hells Is a New Unconventional Player in ALK - Anaplastic Large Cell Lymphoma Biology

Valentina Fragliasso, PhD, Annalisa Tameni, Akanksha Verma, Rohan Bareja, Tayla Heavican, Javeed Iqbal, PhD, Gloria Manzotti, PhD, Danilo Fiore, PhD, Valentina Mularoni, PhD, Wing C. Chan, MD, Francesco Merli, MD, Olivier Elemento, PhD, Alessia Ciarrocchi, PhD, Giorgio Inghirami, MD

Blood (2019) 134 (Supplement_1): 1477.

https://doi.org/10.1182/blood-2019-122701

Published: 2019

Journal Articles

Cooperative Repression of IRF4 and Induction of IRF7 By CDK4/6 Inhibition Sensitizes Mantle Cell Lymphoma Cells to IMiD-Mediated Apoptosis Independent of p16 Deletion or c-Myc Overexpression

Basel A Humos, Maurizio Di Liberto, PhD, Xiangao Huang, PhD, Olivier Elemento, PhD, Selina Chen-Kiang, PhD

Blood (2018) 132 (Supplement 1): 2864.

https://doi.org/10.1182/blood-2018-99-117487

Published: 2018

Journal Articles

Targeting the Epichaperome As an Effective Precision Medicine Approach in a Novel PML-SYK Fusion Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 1435.

https://doi.org/10.1182/blood-2018-99-118764

Published: 2018

Journal Articles

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Blood (2017) 130 (Supplement 1): 109.

https://doi.org/10.1182/blood.V130.Suppl_1.109.109

Published: 2017

Journal Articles

Targeting DNA Repair Mechanisms to Overcome Drug Resistance in Diffuse Large B Cell Lymphoma

Julie Devin, Yea-Lih Lin, PhD, Alboukadel Kassambara, PhD, Guillaume Cartron, Olivier Elemento, PhD, Angelos Constantinou, PhD, Philippe Pasero, PhD, Caroline Bret, PhD PharmD, Jerome Moreaux, PhD

Blood (2017) 130 (Supplement 1): 1479.

https://doi.org/10.1182/blood.V130.Suppl_1.1479.1479

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Takenobu Nii, PhD, Jo Ishizawa, MD PhD, Varun Vijay Prabhu, BPharm, MS, PhD, Vivian Ruvolo, PhD, Neel Madhukar, Ran Zhao, Hong Mu, MD PhD, Lauren Heese, Kensuke Kojima, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Neil Charter, Sean Deacon, Olivier Elemento, PhD, Joshua E. Allen, PhD, Wolfgang Oster, MD, Martin Stogniew, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2616.

https://doi.org/10.1182/blood.V130.Suppl_1.2616.2616

Published: 2017

Journal Articles

Exploring the Tumor Clonal Dynamics between Diffuse Large B-Cell Lymphomas and Bone Marrow Involvement By Deep Immunoglobulin Heavy Chain VDJ Sequencing

Anna S Nam, MD, Jiao Ma, PhD, Ayako Miyaguchi, PhD, David Redmond, Kui Nie, PhD, Olivier Elemento, PhD, Wayne Tam, MD PhD

Blood (2017) 130 (Supplement 1): 2737.

https://doi.org/10.1182/blood.V130.Suppl_1.2737.2737

Published: 2017

Journal Articles

RNA Sequencing Data-Driven Dissection of Human Plasma Cell Differentiation Reveals New Potential Transcription Regulators

Alboukadel Kassambara, PhD, Laurie Herviou, Michel Jourdan, Coraline Thibaut, Veronika Vikova, Olivier Elemento, PhD, Jerome Moreaux, PhD

Blood (2017) 130 (Supplement 1): 4382.

https://doi.org/10.1182/blood.V130.Suppl_1.4382.4382

Published: 2017

Journal Articles

The Pro-Tumorigenic Vascular Niche Sustains the T-Cell Acute Lymphoblastic Leukemia Phenotype and Fosters Resistance to Therapy

Blood (2016) 128 (22): 279.

https://doi.org/10.1182/blood.V128.22.279.279

Published: 2016

Journal Articles

PRMT5 Targets Tumor Suppressor Micro RNAs to Regulate Cyclin D1 and c-MYC in Mantle Cell Lymphoma

Vrajesh Karkhanis, PhD, Lapo Alinari, MD PhD, Bethany Mundy, MD, Michael Caliguri, MD, Selina Chen-Kiang, PhD, Olivier Elemento, PhD, Sif Said, PhD, Robert A Baiocchi, MD PhD

Blood (2016) 128 (22): 2937.

https://doi.org/10.1182/blood.V128.22.2937.2937

Published: 2016

Journal Articles

AICDA Introduces Epigenetic Plasticity in Germinal Center-Derived Lymphomas and Accelerates Lymphomagenesis

Maria Del Pilar Dominguez, PhD, Matt Teater, M.S., David Redmond, Zhengming Cheng, PhD, Jayanta Chaudhuri, PhD, Olivier Elemento, PhD, Ari Melnick, MD, Rita Shaknovich, MD PhD

Blood (2016) 128 (22): 1045.

https://doi.org/10.1182/blood.V128.22.1045.1045

Published: 2016

Journal Articles

PIK3IP1 Inhibition of PI3K in G1 Arrest Induced By CDK4 Inhibition Reprograms MCL for Ibrutinib Therapy

Maurizio Di Liberto, PhD, Xiangao Huang, PhD, Olivier Elemento, PhD, Ken Eng, Kristie A. Blum, MD, Nancy L. Bartlett, MD, Steven I. Park, MD, Jia Ruan, MD PhD, Kami J. Maddocks, MD, Giorgio Inghirami, MD, Lewis Cantley, MD, John P. Leonard, MD, Peter Martin, MD, Selina Chen-Kiang, PhD

Blood (2016) 128 (22): 610.

https://doi.org/10.1182/blood.V128.22.610.610

Published: 2016

NARROW

Robust Discovery of Candidate DNA Methylation Cancer Drivers

An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells

Disrupting GRINL1A Association with Cereblon Accelerates IKZF1/3 Degradation and IMiD Killing of Mantle Cell Lymphoma Cells By CDK4/6 Inhibition

Immune Sculpting of Clonal Hematopoiesis in Advanced and Metastatic Solid Tumors

T-Cell Clonal Expansion and Activation Associated with Durable Clinical Response to Dual BTK and CDK4/6 Inhibitor Therapy in Mantle Cell Lymphoma

Heterogeneous Genetic Alterations and Novel Pathogenic Pathways in Relapsed DLBCL Revealed By Whole Exome Sequencing

Composite Copy Number Variation in CDK4 , CDKN2A and RB1 Predisposes Mantle Cell Lymphoma to Expansion of PD1+ Tumor Cells and Resistance to CDK4/6 Inhibitor Therapy as Revealed by Integrative Longitudinal scRNA-seq

The DNA Helicase Hells Is a New Unconventional Player in ALK - Anaplastic Large Cell Lymphoma Biology

Cooperative Repression of IRF4 and Induction of IRF7 By CDK4/6 Inhibition Sensitizes Mantle Cell Lymphoma Cells to IMiD-Mediated Apoptosis Independent of p16 Deletion or c-Myc Overexpression

Targeting the Epichaperome As an Effective Precision Medicine Approach in a Novel PML-SYK Fusion Acute Myeloid Leukemia

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Targeting DNA Repair Mechanisms to Overcome Drug Resistance in Diffuse Large B Cell Lymphoma

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Exploring the Tumor Clonal Dynamics between Diffuse Large B-Cell Lymphomas and Bone Marrow Involvement By Deep Immunoglobulin Heavy Chain VDJ Sequencing

RNA Sequencing Data-Driven Dissection of Human Plasma Cell Differentiation Reveals New Potential Transcription Regulators

The Pro-Tumorigenic Vascular Niche Sustains the T-Cell Acute Lymphoblastic Leukemia Phenotype and Fosters Resistance to Therapy

PRMT5 Targets Tumor Suppressor Micro RNAs to Regulate Cyclin D1 and c-MYC in Mantle Cell Lymphoma

AICDA Introduces Epigenetic Plasticity in Germinal Center-Derived Lymphomas and Accelerates Lymphomagenesis

PIK3IP1 Inhibition of PI3K in G1 Arrest Induced By CDK4 Inhibition Reprograms MCL for Ibrutinib Therapy

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American Society of Hematology

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American Society of Hematology

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