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Journal Articles

Analyzing the Transcriptome Discovers up-Regulation of HOXA Genes in Patients with Myeloid Neoplasms and Isochromosome 17q and Mutations in ASXL1 , SETBP1 and SRSF2

Manja Meggendorfer, PhD, Niroshan Nadarajah, M.Sc., Claudia Haferlach, MD, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2016) 128 (22): 2703.

https://doi.org/10.1182/blood.V128.22.2703.2703

Published: 2016

Journal Articles

Phenotype/Genotype Associations in TET2-Driven Myeloid Neoplasms

Cassandra M. Hirsch, BSc, Aziz Nazha, MD, Kassy E Kneen, Bartlomiej P Przychodzen, MSc, Niroshan Nadarajah, M.Sc., Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Tomas Radivoyevitch, PhD, Jaroslaw P. Maciejewski, MD, PhD, FACP, Manja Meggendorfer, PhD

Blood (2016) 128 (22): 4313.

https://doi.org/10.1182/blood.V128.22.4313.4313

Published: 2016

Journal Articles

Comprehensive Biologic Characterization of 99 Multiple Myeloma Patients Using Cytomorphology, FISH, Gene Expression Profiling and Mutation Screening Leads to Important Clinical and Therapeutic Insights

Simone Weber, Marietta Truger, Wolfgang Kern, MD, Martin H van Vliet, PhD, Erik H van Beers, Niroshan Nadarajah, M.Sc., Manja Meggendorfer, PhD, Dennis Haupt, Claudia Haferlach, MD, Torsten Haferlach, MD

Blood (2016) 128 (22): 4424.

https://doi.org/10.1182/blood.V128.22.4424.4424

Published: 2016

Journal Articles

Targeted RNA Sequencing Is Capable of Identifying Thus Far Unknown Partner Genes in Leukemias with Rare Translocations and Provides Important Clinical and Therapeutical Information

Claudia Haferlach, MD, Niroshan Nadarajah, M.Sc., Manja Meggendorfer, PhD, Nadine Dicht, Anna Stengel, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2016) 128 (22): 2857.

https://doi.org/10.1182/blood.V128.22.2857.2857

Published: 2016

Journal Articles

The Use of NGS for Molecular Investigations in Leukemia Adds Important Biological, Clinical and Prognostic Information Due to Its Higher Sensitivity in Comparison to the Gold Standard Sanger Sequencing

Torsten Haferlach, MD, Niroshan Nadarajah, M.Sc., Wolfgang Kern, MD, Claudia Haferlach, MD, Manja Meggendorfer, PhD

Blood (2016) 128 (22): 1557.

https://doi.org/10.1182/blood.V128.22.1557.1557

Published: 2016

Journal Articles

The Use of Unique Molecular Identifiers (UMIs) Strongly Improves Sequencing Detection Limits Allowing Earlier Detection of Small TP53 Mutated Clones in Leukemias

Constance Regina Baer, PhD, Niroshan Nadarajah, M.Sc., Claudia Haferlach, MD, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2016) 128 (22): 2027.

https://doi.org/10.1182/blood.V128.22.2027.2027

Published: 2016

Journal Articles

A Study on Paired Tissue Sequencing in Hematologic Diseases to Distinguish Somatic from Germline Sequence Variants in Routine Diagnostics

Constance Regina Baer, PhD, Niroshan Nadarajah, M.Sc., Claudia Haferlach, MD, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2016) 128 (22): 5511.

https://doi.org/10.1182/blood.V128.22.5511.5511

Published: 2016

Journal Articles

In CLL with Normal Karyotype By Conventional and Genomic Array Karyotyping the Prognostic Impact of an Unmutated IGHV Status Is Stronger Than the Impact of Gene Mutations

Calogero Vetro, MD, Torsten Haferlach, MD, Manja Meggendorfer, PhD, Sabine Jeromin, PhD, Constance Regina Baer, PhD, Niroshan Nadarajah, M.Sc., Wolfgang Kern, MD, Claudia Haferlach, MD

Blood (2016) 128 (22): 4357.

https://doi.org/10.1182/blood.V128.22.4357.4357

Published: 2016

Journal Articles

Pathogenic Relevance of Germ Line TET2 Alterations

Cassandra M. Hirsch, BSc, Aziz Nazha, MD, Kassy E Kneen, Manja Meggendorfer, PhD, Bartlomiej P Przychodzen, MSc, Niroshan Nadarajah, M.Sc., Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Thomas LaFramboise, PhD, Tomas Radivoyevitch, PhD, Jaroslaw P. Maciejewski, MD, PhD, FACP

Blood (2016) 128 (22): 3160.

https://doi.org/10.1182/blood.V128.22.3160.3160

Published: 2016

Journal Articles

Cytogenetic and Molecular Genetic Clonal Evolution in CLL Is Associated with an Unmutated IGHV Status and Frequently Leads to a Combination of Loss of 17p and TP53 mutation

Claudia Haferlach, MD, Sabine Jeromin, PhD, Niroshan Nadarajah, M.Sc., Melanie Zenger, Wolfgang Kern, MD, Torsten Haferlach, MD

Blood (2016) 128 (22): 3213.

https://doi.org/10.1182/blood.V128.22.3213.3213

Published: 2016

Journal Articles

Three Steps to the Diagnosis of Adult Ph-like ALL

Annette Fasan, PhD, Wolfgang Kern, MD, Niroshan Nadarajah, M.Sc., Simone Weber, Sonja Schindela, Nicole Schlenther, Susanne Schnittger, PhD, Torsten Haferlach, Claudia Haferlach, MD

Blood (2015) 126 (23): 2610.

https://doi.org/10.1182/blood.V126.23.2610.2610

Published: 2015

Journal Articles

A New Entity of Acute Myeloid Leukemia Driven By Epigenetic and Somatic Dis-Regulation of Uncx , a Novel Homeobox Transcription Factor Gene

Blood (2015) 126 (23): 1356.

https://doi.org/10.1182/blood.V126.23.1356.1356

Published: 2015

Journal Articles

AML with RUNX1 Mutations and Loss of RUNX1 Wild-Type - a Distinct Subset?

Claudia Haferlach, MD, Niroshan Nadarajah, M.Sc., Annette Fasan, PhD, Karolína Perglerová, Wolfgang Kern, MD, Susanne Schnittger, PhD, Torsten Haferlach

Blood (2015) 126 (23): 2578.

https://doi.org/10.1182/blood.V126.23.2578.2578

Published: 2015

Journal Articles

Significance Assessment of Mutations in MDS Patients Using Publicly Available Databases: A Study with 944 Samples and 6 Most Significantly Mutated Genes

Niroshan Nadarajah, M.Sc., Manja Meggendorfer, PhD, Wolfgang Kern, MD, Claudia Haferlach, MD, Torsten Haferlach

Blood (2015) 126 (23): 2849.

https://doi.org/10.1182/blood.V126.23.2849.2849

Published: 2015

Journal Articles

TET 2 Alterations in Myeloid Malignancies, Impact on Clinical Characteristics, Outcome, and Disease Predisposition

Aziz Nazha, MD, Manja Meggendorfer, PhD, Niroshan Nadarajah, M.Sc., Kassy E Kneen, Tomas Radivoyevitch, PhD, Bartlomiej Przychodzen, MSc, Hideki Makishima, MD PhD, Bhumika J. Patel, Srinivasa R. Sanikommu, MBBS, Sean Hobson, Mridul Mukherji, PhD, Mikkael A. Sekeres, MD MS, Torsten Haferlach, Jaroslaw P. Maciejewski, MD PhD

Blood (2015) 126 (23): 1645.

https://doi.org/10.1182/blood.V126.23.1645.1645

Published: 2015

Journal Articles

Myelodysplastic Syndrome Patients Show Mutation-Specific DNA Methylation Patterns

Constance Regina Baer, PhD, Niroshan Nadarajah, M.Sc., Yasunobu Nagata, MD, Tamara Alpermann, Genta Nagae, MD PhD, Yusuke Okuno, MD PhD, Yuichi Shiraishi, MD PhD, Satoru Miyano, MD PhD, Claudia Haferlach, MD, Wolfgang Kern, MD, Hiroyuki Aburatani, MD PhD, Seishi Ogawa, MD PhD, Torsten Haferlach

Blood (2015) 126 (23): 1646.

https://doi.org/10.1182/blood.V126.23.1646.1646

Published: 2015

Journal Articles

Landscape of DNA Methylation and Genetic Profiles in 291 Patients with Myelodysplastic Syndromes

Blood (2015) 126 (23): 5205.

https://doi.org/10.1182/blood.V126.23.5205.5205

Published: 2015

Journal Articles

Molecular Characterization of Philadelphia Chromosome Positive Acute Myeloid Leukemia - New Provisional Entity?

Simone Weber, Manja Meggendorfer, PhD, Niroshan Nadarajah, M.Sc., Karolína Perglerová, Susanne Schnittger, PhD, Claudia Haferlach, MD, Wolfgang Kern, MD, Torsten Haferlach

Blood (2015) 126 (23): 3846.

https://doi.org/10.1182/blood.V126.23.3846.3846

Published: 2015

Journal Articles

Accumulation of Somatic Mutations As a Function of Aging: A Study on 4843 TET2 Mutated Patients in Comparison to Their Respective SNP Pattern

Niroshan Nadarajah, M.Sc., Manja Meggendorfer, PhD, Wolfgang Kern, MD, Claudia Haferlach, MD, Torsten Haferlach

Blood (2015) 126 (23): 4111.

https://doi.org/10.1182/blood.V126.23.4111.4111

Published: 2015

Journal Articles

Modulation of the Clonal Composition in Relapsed CLL: A Study Based on Targeted Deep-Sequencing of ATM, BIRC3, NOTCH1, POT1, SF3B1, SAMHD1 and TP53

Sabine Jeromin, PhD, Wolfgang Kern, MD, Richard Schabath, Tamara Alpermann, Niroshan Nadarajah, M.Sc., Manja Meggendorfer, PhD, Susanne Schnittger, PhD, Torsten Haferlach, Claudia Haferlach, MD

Blood (2015) 126 (23): 1721.

https://doi.org/10.1182/blood.V126.23.1721.1721

Published: 2015

NARROW

Analyzing the Transcriptome Discovers up-Regulation of HOXA Genes in Patients with Myeloid Neoplasms and Isochromosome 17q and Mutations in ASXL1 , SETBP1 and SRSF2

Phenotype/Genotype Associations in TET2-Driven Myeloid Neoplasms

Comprehensive Biologic Characterization of 99 Multiple Myeloma Patients Using Cytomorphology, FISH, Gene Expression Profiling and Mutation Screening Leads to Important Clinical and Therapeutic Insights

Targeted RNA Sequencing Is Capable of Identifying Thus Far Unknown Partner Genes in Leukemias with Rare Translocations and Provides Important Clinical and Therapeutical Information

The Use of NGS for Molecular Investigations in Leukemia Adds Important Biological, Clinical and Prognostic Information Due to Its Higher Sensitivity in Comparison to the Gold Standard Sanger Sequencing

The Use of Unique Molecular Identifiers (UMIs) Strongly Improves Sequencing Detection Limits Allowing Earlier Detection of Small TP53 Mutated Clones in Leukemias

A Study on Paired Tissue Sequencing in Hematologic Diseases to Distinguish Somatic from Germline Sequence Variants in Routine Diagnostics

In CLL with Normal Karyotype By Conventional and Genomic Array Karyotyping the Prognostic Impact of an Unmutated IGHV Status Is Stronger Than the Impact of Gene Mutations

Pathogenic Relevance of Germ Line TET2 Alterations

Cytogenetic and Molecular Genetic Clonal Evolution in CLL Is Associated with an Unmutated IGHV Status and Frequently Leads to a Combination of Loss of 17p and TP53 mutation

Three Steps to the Diagnosis of Adult Ph-like ALL

A New Entity of Acute Myeloid Leukemia Driven By Epigenetic and Somatic Dis-Regulation of Uncx , a Novel Homeobox Transcription Factor Gene

AML with RUNX1 Mutations and Loss of RUNX1 Wild-Type - a Distinct Subset?

Significance Assessment of Mutations in MDS Patients Using Publicly Available Databases: A Study with 944 Samples and 6 Most Significantly Mutated Genes

TET 2 Alterations in Myeloid Malignancies, Impact on Clinical Characteristics, Outcome, and Disease Predisposition

Myelodysplastic Syndrome Patients Show Mutation-Specific DNA Methylation Patterns

Landscape of DNA Methylation and Genetic Profiles in 291 Patients with Myelodysplastic Syndromes

Molecular Characterization of Philadelphia Chromosome Positive Acute Myeloid Leukemia - New Provisional Entity?

Accumulation of Somatic Mutations As a Function of Aging: A Study on 4843 TET2 Mutated Patients in Comparison to Their Respective SNP Pattern

Modulation of the Clonal Composition in Relapsed CLL: A Study Based on Targeted Deep-Sequencing of ATM, BIRC3, NOTCH1, POT1, SF3B1, SAMHD1 and TP53

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American Society of Hematology

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ASH Publications

American Society of Hematology

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