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Journal Articles

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

Manit Munshi, MS, Jiaji Chen, BS, Xia Liu, MD, Lian Xu, MS, Nickolas Tsakmaklis, BA, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Christopher Patterson, MAcc, Kirsten Meid, MPH, Joshua Gustine, MPH, Jorge J. Castillo, MD, Zachary R Hunter, PhD, Jinhua Wang, PhD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP, Guang Yang, PhD

Blood (2018) 132 (Supplement 1): 4116.

https://doi.org/10.1182/blood-2018-99-117372

Published: 2018

Journal Articles

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Guang Yang, PhD, Jinhua Wang, PhD, Li Tan, PhD, Xia Liu, MD, Manit Munshi, MS, Jiaji G Chen, Lian Xu, MS, Nickolas Tsakmaklis, Maria Demos, Amanda Kofides, Maria Luisa Guerrera, MD, Gloria G Chan, MS, Zachary R Hunter, PhD, Christopher Patterson, MAcc, Jorge J. Castillo, MD, Sara J Buhrlage, PhD, Nathanael S. Gray, PhD, Steven P Treon, MD PhD FRCP

Blood (2018) 132 (Supplement 1): 40.

https://doi.org/10.1182/blood-2018-99-119171

Published: 2018

Journal Articles

Triple Degradation of BTK, IKZF1 and IKZF3 in B-Cell Malignancies

Sara Morrow, BA, Dennis Dobrovolsky, PhD, Eric Wang, PhD, Radosław P. Nowak, PhD, Katherine Donovan, PhD, Tyler Faust, PhD, Guang Yang, PhD, Zhengnian Li, PhD, Eric Fischer, Steven P Treon, MD PhD FRCP, David M Weinstock, MD, Nathanael S. Gray, PhD

Blood (2018) 132 (Supplement 1): 263.

https://doi.org/10.1182/blood-2018-99-116895

Published: 2018

Journal Articles

Identification of Wee1 and IGF-1R As Novel Therapeutic Targets for Mutant RAS-Driven Acute Leukemia By Combinatory Chemical Screens

Atsushi Nonami, MDPhD, Chen Zhao, PhD, Liu Qingsong, PhD, Kristen Cowens, Amanda L. Christie, Yongfei Chen, Martin Sattler, PhD, Kwok-Kin Wang, MDPhD, Nathanael S. Gray, PhD, James D. Griffin, MD, Ellen L. Weisberg, PhD

Blood (2014) 124 (21): 3502.

https://doi.org/10.1182/blood.V124.21.3502.3502

Published: 2014

Journal Articles

Citron Rho-Interacting Serine/Threonine kinase (CIT) Is a Novel Therapeutic Target in Multiple Myeloma Cells

Yawara Kawano, MDPhD, Ilyas Sahin, MD, Michele Moschetta, MD, Jinhua Wang, Salomon Manier, MD, Siobhan Glavey, MD, Yuji Mishima, PhD, Katsutoshi Kokubun, PhD, Shokichi Tsukamoto, MD PhD, Antonio Sacco, BS, Kenneth C. Anderson, MD, Aldo M Roccaro, MD PhD, Nathanael S. Gray, PhD, Irene M. Ghobrial, MD

Blood (2014) 124 (21): 3430.

https://doi.org/10.1182/blood.V124.21.3430.3430

Published: 2014

Journal Articles

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Julia Elizabeth Maxson, PhD, Abel L Melissa, BS, Jinhua Wang, PhD, Xianming Deng, PhD, Samuel B Luty, BS, Huahang Sun, MA, Julie Gorenstein, MS, Richard Middleton, PhD, Nathanael S. Gray, PhD, Brian J. Druker, Jeffrey W. Tyner, PhD

Blood (2014) 124 (21): 435.

https://doi.org/10.1182/blood.V124.21.435.435

Published: 2014

Journal Articles

Serine/Threonine Kinase STK4 Is a Novel Target in Myeloma

Francesca Cottini, Teru Hideshima, MDPhD, Sara Buhrlage, PhD, Nathanael S. Gray, PhD, Paul G. Richardson, Giovanni Tonon, MDPhD, Kenneth C Anderson, MD

Blood (2014) 124 (21): 645.

https://doi.org/10.1182/blood.V124.21.645.645

Published: 2014

Journal Articles

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

Helena Mistry, Ph.D., Grace Hsieh, M.D., Sara Buhrlage, Ph.D, Min Huang, Ph.D., Eunmi Park, Ph.D., Gregory Cuny, Ph.D., Ilene Galinsky, ANP, Richard M. Stone, MD, Nathanael S Gray, PhD, Kalindi Parmar, PhD, Alan D. D'Andrea, MD

Blood (2013) 122 (21): 2906.

https://doi.org/10.1182/blood.V122.21.2906.2906

Published: 2013

Journal Articles

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Guang Yang, PhD, Xia Liu, MD, Yangsheng Zhou, MD, Lian Xu, Yang Cao, MD, Robert Manning, Christopher Patterson, Christina K Tripsas, MA, Zachary Hunter, Sara Buhrlage, Ph.D, Nathanael S Gray, PhD, Steven Peter Treon, MD, MA, PhD

Blood (2013) 122 (21): 4255.

https://doi.org/10.1182/blood.V122.21.4255.4255

Published: 2013

Journal Articles

Germinal Center Kinase Regulates The Proliferation and Survival Of Diffuse Large B-Cell Lymphoma

Blood (2013) 122 (21): 643.

https://doi.org/10.1182/blood.V122.21.643.643

Published: 2013

Journal Articles

Using Small Molecules To Identify Critical Signaling Pathways Of Mutant N-RAS In Acute Leukemia Cells

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Jianming Zhang, PhD, Qingsong Liu, PhD, Matthew Patricell, PhD, Hojong Yoon, Amanda L. Christie, B.S., Amy M. Sauer, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S. Gray, PhD, James D. Griffin, MD

Blood (2013) 122 (21): 169.

https://doi.org/10.1182/blood.V122.21.169.169

Published: 2013

Journal Articles

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Blood (2012) 120 (21): 1470.

https://doi.org/10.1182/blood.V120.21.1470.1470

Published: 2012

Journal Articles

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

Atsushi Nonami, MD, PhD, Martin Sattler, PhD, Ellen L. Weisberg, PhD, Liu Qingsong, PhD, Jianming Zhang, PhD, Guillaume Adelmant, PhD, Jarrod A Marto, PhD, Nancy Kohl, PhD, Andrew L. Kung, MD, PhD, Taebo Sim, PhD, Nathanael S Gray, PhD, James D. Griffin, MD

Blood (2012) 120 (21): 2455.

https://doi.org/10.1182/blood.V120.21.2455.2455

Published: 2012

Journal Articles

A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue.

Mohammad Azam, PhD, Markus Seeliger, PhD, Nathanael S. Gray, PhD, John Kuriyan, PhD, George Q. Daley, MD, PhD

Blood (2007) 110 (11): 223.

https://doi.org/10.1182/blood.V110.11.223.223

Published: 2007

Journal Articles

Dissection of Bcr-abl Structural Domains Relating to Kinase Auto-Inhibition Using a Forward Mutational Screen with the Non-ATP Competitive Inhibitor GNF-2.

John T. Powers, PhD, Mohammad Azam, PhD, Nathanael S. Gray, PhD, George Q. Daley, MD, PhD

Blood (2007) 110 (11): 1021.

https://doi.org/10.1182/blood.V110.11.1021.1021

Published: 2007

NARROW

MYD88 Triggered SYK Activation Promotes BCR Cross-Talk, and Identifies SYK As a Novel Therapeutic Target of Mutated MYD88 Signaling

A Novel HCK Inhibitor Kin-8193 Blocks BTK Activity in BTK Cys481 Mutated Ibrutinib Resistant B-Cell Lymphomas Driven By Mutated MYD88

Triple Degradation of BTK, IKZF1 and IKZF3 in B-Cell Malignancies

Identification of Wee1 and IGF-1R As Novel Therapeutic Targets for Mutant RAS-Driven Acute Leukemia By Combinatory Chemical Screens

Citron Rho-Interacting Serine/Threonine kinase (CIT) Is a Novel Therapeutic Target in Multiple Myeloma Cells

Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations

Serine/Threonine Kinase STK4 Is a Novel Target in Myeloma

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

PI3K/AKT Pathway Is Activated By MYD88 L265P and Use Of PI3K-Delta Inhibitors Induces Robust Tumor Cell Killing In Waldenstrom’s Macroglobulinemia

Germinal Center Kinase Regulates The Proliferation and Survival Of Diffuse Large B-Cell Lymphoma

Using Small Molecules To Identify Critical Signaling Pathways Of Mutant N-RAS In Acute Leukemia Cells

TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

Deciphering the Critical Pathways of Mutant N-RAS in AML Using Small Molecule Inhibitors.

A Unified Mechanism of Tyrosine Kinase Regulation by the Gatekeeper Residue.

Dissection of Bcr-abl Structural Domains Relating to Kinase Auto-Inhibition Using a Forward Mutational Screen with the Non-ATP Competitive Inhibitor GNF-2.

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American Society of Hematology

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American Society of Hematology

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