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Journal Articles

OPEC/Mpec for Adult T-Cell Leukemia/Lymphoma: A Single-Institution Study

Daisuke Nakamura, MD, PhD, Makoto Yoshimitsu, MD, PhD, Tomohisa Tabuchi, MD, Naosuke Arima, MD, Maiko Hayashida, MD, Hirosaka Inoue, MD, Kakushi Matsushita, MD, PhD, Tadashi Matsumoto, MD, PhD, Naomichi Arima, MD, PhD, Kenji Ishitsuka, MD, PhD

Blood (2016) 128 (22): 1828.

https://doi.org/10.1182/blood.V128.22.1828.1828

Published: 2016

Journal Articles

Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, PhD, Naomichi Arima, MD PhD, Keisuke Sato, MS, Moe Toyoshima, Shin-ichiro Honda, PhD, Shinji Soeda, PhD

Blood (2016) 128 (22): 2327.

https://doi.org/10.1182/blood.V128.22.2327.2327

Published: 2016

Journal Articles

Telmisartan, Angiotensin II Receptor Blocker, Induces Apoptosis and Autophagy in Adult T-Cell Leukemia Cells from Patients and Leukemia Cell Lines

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD PhD, Naomichi Arima, MD PhD, Shuhei Soeda, PhD, Shinya Hirata, MD PhD, Hiroaki Tanaka, PhD, Shin-ichiro Honda, PhD, Shinji Soeda, PhD

Blood (2015) 126 (23): 2055.

https://doi.org/10.1182/blood.V126.23.2055.2055

Published: 2015

Journal Articles

Profound Immune Exhaustion and Downregulation Of Interleukin-7 Alpha Receptor (CD127) In CD8 and CD4 T-Cell Subsets In Jamaican Patients Co-Infected With Human T-Cell Lymphotropic Virus Type-1 and Human Immunodeficiency Virus Type-1 Despite Normal Or Above Normal CD4 Counts

Yohann White, BMedSc, MBBS, DU, PhD, DTM&H, Geoffrey Barrow, MBBS, MPH, David Gilbert, BSc, MBBS, DM, FACP, FRCP (Ed.), Tanya Clarke, MBBS, DM, ABIM, Adedamola Soyibo, BSc, MBBS, DM, FACP, Andre McGregor, BSc, Dewayne Stennett, BSc, PhD, Gilian Wharfe, MBBS, DM, Dwight Lowe, MBBS, DM, Michelle Hamilton, MBBS, PhD, Monica Smikle, PhD, Naomichi Arima, MD, PhD, Everard Barton, BSc, MBBS, DM, FACP, FRCP (Ed.)

Blood (2013) 122 (21): 3498.

https://doi.org/10.1182/blood.V122.21.3498.3498

Published: 2013

Journal Articles

B and T Lymphocyte Attenuator (BTLA)/Herpes Virus Entry Mediator (HVEM) Interaction: Attenuating Virus Specific CD8+T Cell Function In HTLV-1 Infection

Ezinne Chioma Chibueze, MD, Makoto Yoshimitsu, MD, Naomichi Arima, MD, PhD

Blood (2013) 122 (21): 4727.

https://doi.org/10.1182/blood.V122.21.4727.4727

Published: 2013

Journal Articles

Immune Exhaustion and 2B4 Expression in Human T-Cell Lymphotropic Virus Type 1(HTLV-1) Infection

Ezinne Chioma Chibueze, MD, Yohann White, MD, PhD, Makoto Yoshimitsu, MD PhD, Tomohiro Kozako, PhD, Shinsuke Suzuki, MD, PhD, Kakushi Matsushita, MD, Kimiharu Uozumi, MD, PhD, Naomichi Arima, MD, PhD

Blood (2012) 120 (21): 4807.

https://doi.org/10.1182/blood.V120.21.4807.4807

Published: 2012

Journal Articles

CD70 Expression on HTLV-1 Infected T Cells of Carriers and ATL Patients and Its Clinical Significance

Izumi Masamoto, BSc, MSc, Sawako Horai, PhD, Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, Junko Niimoto, BSc, Yohann White, BMedSc, MBBS, Kimiharu Uozumi, MD, PhD, Shinsuke Suzuki, MD, PhD, Naomichi Arima, MD, PhD

Blood (2010) 116 (21): 1730.

https://doi.org/10.1182/blood.V116.21.1730.1730

Published: 2010

Journal Articles

Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells

Tomohiro Kozako, Makoto Yoshimitsu, MD, Yohann White, Akiyoshi Aikawa, Teruhisa Shoji, Shinichiro Honda, Hiroshi Shimeno, Shinji Soeda, Naomichi Arima

Blood (2010) 116 (21): 2768.

https://doi.org/10.1182/blood.V116.21.2768.2768

Published: 2010

Journal Articles

Target Epitopes of Human T Lymphotropic Virus 1 Recognized by Class I MHC-Restricted Cytotoxic T Lymphocytes in HAM/TSP Patients and Infected Patients with Autoimmune Disorders.

Tomohiro Kozako, PhD, Masaki Akimoto, MD, PhD, Yohann White, MD, Shingo Toji, Kakushi Matsushita, MD, PhD, Ryuji Kubota, MD, PhD, Shuji Izumo, MD, PhD, Shinsuke Suzuki, MD, PhD, Kimiharu Uozumi, MD, Hiroshi Shimeno, PhD, Shinji Soeda, PhD, Naomichi Arima, MD, PhD

Blood (2009) 114 (22): 2660.

https://doi.org/10.1182/blood.V114.22.2660.2660

Published: 2009

Journal Articles

SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.

Tomohiro Kozako, PhD, Teruhisa Shoji, Akiyoshi Aikawa, Satoru Hayashida, Yukako Kuramoto, PhD, Rie Mononagare, Shinichiro Honda, PhD, Hiroshi Shimeno, PhD, Shinji Soeda, PhD, Makoto Yoshimitsu, MD, Yohann White, MD, Naomichi Arima, MD, PhD

Blood (2009) 114 (22): 3684.

https://doi.org/10.1182/blood.V114.22.3684.3684

Published: 2009

Journal Articles

Increased Frequency of HTLV-1 Tax Specific CD8+ Regulatory T-Cells in HTLV-1 Infected Individuals.

Yohann White, MBBS, BMedSc, Makoto Yoshimitsu, MD, Tomohiro Kozako, PhD, Kakushi Matsushita, MD, PhD, Kimiharu Uozumi, MD, Shinsuke Suzuki, MD, PhD, Hiroki Kofune, BSc, Naomichi Arima, MD, PhD

Blood (2009) 114 (22): 3676.

https://doi.org/10.1182/blood.V114.22.3676.3676

Published: 2009

Journal Articles

Immunological Function against Human T-Lymphotrophic Virus Type I in Carriers with Collagen Diseases and HAM/TSP.

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, Masaki Akimoto, MD, PhD, Kakushi Matsushita, MD, PhD, Yohann White, MD, Shingo Toji, Shuji Izumo, MD, PhD, Shunro Sonoda, MD, PhD, Naomichi Arima, MD, PhD

Blood (2008) 112 (11): 1470.

https://doi.org/10.1182/blood.V112.11.1470.1470

Published: 2008

Journal Articles

Efficient Induction of HTLV-1-Specific CTL Response by HTLV-1/HBc Chimeric Particle without Adjuvant as a Prophylactic for HTLV-1- Associated T-Cell Leukemia

Tomohiro Kozako, PhD, Katsuhiko Fukada, PhD, Shinya Hirata, MD, PhD, Michiko Harao, MD, PhD, Yasuharu Nishimura, MD, PhD, Youichiro Kino, PhD, Yohann White, MD, Naomichi Arima, MD, PhD

Blood (2008) 112 (11): 84.

https://doi.org/10.1182/blood.V112.11.84.84

Published: 2008

Journal Articles

CTL Exhaustion in Persistent HTLV-1 Infection and ATLL Is Restored through PD-1/PD-L1 Pathway.

Tomohiro Kozako, PhD, Makoto Yoshimitsu, MD, Hiroshi Fujiwara, MD, PhD, Izumi Masamoto, MS, Sawako Horai, PhD, Masaki Akimoto, MD, PhD, Yukio Suruga, MD, PhD, Hideaki Kawada, MD, Heiichiro Hamada, MD, Noriko Aoki, MD, Shinsuke Suzuki, MD, PhD, Kakushi Matsushita, MD, PhD, Kimiharu Uozumi, MD, PhD, Chuwa Tei, MD, PhD, Naomichi Arima, MD, PhD

Blood (2007) 110 (11): 511.

https://doi.org/10.1182/blood.V110.11.511.511

Published: 2007

Journal Articles

A Pilot Study of Reduced-Intensity Conditioning Stem Cell Transplantation with T-Cell Replete HLA-Mismatched Allograft from Child to Parent Patient for the Treatment of Refractory Adult T-Cell Leukemia.

Hiroshi Fujiwara, MD, PhD, Atsuo Ozaki, MD, Makoto Yoshimitsu, MD, Heiichiro Hamada, MD, Hideaki Kawada, MD, Kakushi Matsushita, MD.Ph.D, Naomichi Arima, MD.Ph.D, Chuwa Tei, MD.Ph.D

Blood (2006) 108 (11): 5406.

https://doi.org/10.1182/blood.V108.11.5406.5406

Published: 2006

Journal Articles

The Frequency, Diversity, and Function of Human T-Cell Leukemia Virus Type 1-Specific CD8+ T-Cell Is Reduced in Adult T-Cell Leukemia Patients.

Tomohiro Kozako, PhD, Masaki Akimoto, MD, Izumi Masamoto, Makoto Yoshimitsu, MD, Kakushi Matsushita, MD, PhD, Shinsuke Suzuki, MD, PhD, Kimiharu Uozumi, MD, PhD, Naomichi Arima, MD, PhD

Blood (2006) 108 (11): 1264.

https://doi.org/10.1182/blood.V108.11.1264.1264

Published: 2006

Journal Articles

Soluble CD30 Can Distinguish Disease Progression from Acute GVHD in Patients with Adult T Cell Leukemia/Lymphoma Who Received Allogeneic Hematopoietic Stem Cell Transplantation.

Makoto Yoshimitsu, MD, Hiroshi Fujiwara, MD, PhD, Noriko Aoki, MD, Atsuo Ozaki, MD, Heiichiro Hamada, MD, Kakushi Matsushita, MD, Naomichi Arima, MD, Chuwa Tei, MD

Blood (2006) 108 (11): 4423.

https://doi.org/10.1182/blood.V108.11.4423.4423

Published: 2006

Journal Articles

The Clinical Significance of Programmed Death1 Ligand-1 Expression on Leukemia Cells in Adult T Cell Leukemia Patients.

Makoto Yoshimitsu, MD, Tomohiro Kozako, PhD, Hiroshi Fujiwara, MD, PhD, Naomichi Arima, MD, Chuwa Tei, MD

Blood (2006) 108 (11): 4425.

https://doi.org/10.1182/blood.V108.11.4425.4425

Published: 2006

Journal Articles

Graft vs. HTLV-I Virus Effect Can Be Induced Independently of Graft vs. Leukemia Effect in Patients with Adult T-Cell Leukemia Who Received Allogeneic Hematopoietic Stem Cell Transplantation.

Hiroshi Fujiwara, MD, PhD, Makoto Yoshimitsu, MD, Atsuo Ozaki, MD, Tomohiro Kozako, Ph.D, Naomichi Arima, MD.Ph.D, Chuwa Tei, MD.Ph.D

Blood (2006) 108 (11): 2903.

https://doi.org/10.1182/blood.V108.11.2903.2903

Published: 2006

Journal Articles

Characterization of T-Cell Lymphoma Cell Lines with a Novel t(9;14)(q34;q11.2) Rearrangement: Does gamma-Secretase Inhibitor Sensitivity Depend on Intragenic NOTCH1 Breakpoint?.

Shinsuke Suzuki, MD, PhD, Stefan Nagel, PhD, Bjoern Schneider, Maren Kaufmann, Dorothea Anders, Hirohito Tsubouchi, MD, Kimiharu Uozumi, MD, Naomichi Arima, MD, Hans G. Drexler, MD, Roderick A.F. MacLeod, PhD

Blood (2006) 108 (11): 2332.

https://doi.org/10.1182/blood.V108.11.2332.2332

Published: 2006

NARROW

OPEC/Mpec for Adult T-Cell Leukemia/Lymphoma: A Single-Institution Study

Induction of Apoptosis and Autophagy By Nampt Inhibition in Adult T-Cell Leukemia/Lymphoma and Leukemic Cell Lines

Telmisartan, Angiotensin II Receptor Blocker, Induces Apoptosis and Autophagy in Adult T-Cell Leukemia Cells from Patients and Leukemia Cell Lines

Profound Immune Exhaustion and Downregulation Of Interleukin-7 Alpha Receptor (CD127) In CD8 and CD4 T-Cell Subsets In Jamaican Patients Co-Infected With Human T-Cell Lymphotropic Virus Type-1 and Human Immunodeficiency Virus Type-1 Despite Normal Or Above Normal CD4 Counts

B and T Lymphocyte Attenuator (BTLA)/Herpes Virus Entry Mediator (HVEM) Interaction: Attenuating Virus Specific CD8+T Cell Function In HTLV-1 Infection

Immune Exhaustion and 2B4 Expression in Human T-Cell Lymphotropic Virus Type 1(HTLV-1) Infection

CD70 Expression on HTLV-1 Infected T Cells of Carriers and ATL Patients and Its Clinical Significance

Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells

Target Epitopes of Human T Lymphotropic Virus 1 Recognized by Class I MHC-Restricted Cytotoxic T Lymphocytes in HAM/TSP Patients and Infected Patients with Autoimmune Disorders.

SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.

Increased Frequency of HTLV-1 Tax Specific CD8+ Regulatory T-Cells in HTLV-1 Infected Individuals.

Immunological Function against Human T-Lymphotrophic Virus Type I in Carriers with Collagen Diseases and HAM/TSP.

Efficient Induction of HTLV-1-Specific CTL Response by HTLV-1/HBc Chimeric Particle without Adjuvant as a Prophylactic for HTLV-1- Associated T-Cell Leukemia

CTL Exhaustion in Persistent HTLV-1 Infection and ATLL Is Restored through PD-1/PD-L1 Pathway.

A Pilot Study of Reduced-Intensity Conditioning Stem Cell Transplantation with T-Cell Replete HLA-Mismatched Allograft from Child to Parent Patient for the Treatment of Refractory Adult T-Cell Leukemia.

The Frequency, Diversity, and Function of Human T-Cell Leukemia Virus Type 1-Specific CD8+ T-Cell Is Reduced in Adult T-Cell Leukemia Patients.

Soluble CD30 Can Distinguish Disease Progression from Acute GVHD in Patients with Adult T Cell Leukemia/Lymphoma Who Received Allogeneic Hematopoietic Stem Cell Transplantation.

The Clinical Significance of Programmed Death1 Ligand-1 Expression on Leukemia Cells in Adult T Cell Leukemia Patients.

Graft vs. HTLV-I Virus Effect Can Be Induced Independently of Graft vs. Leukemia Effect in Patients with Adult T-Cell Leukemia Who Received Allogeneic Hematopoietic Stem Cell Transplantation.

Characterization of T-Cell Lymphoma Cell Lines with a Novel t(9;14)(q34;q11.2) Rearrangement: Does gamma-Secretase Inhibitor Sensitivity Depend on Intragenic NOTCH1 Breakpoint?.

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American Society of Hematology

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American Society of Hematology

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