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Journal Articles

The Phase 2 CARTITUDE-2 Trial: Updated Efficacy and Safety of Ciltacabtagene Autoleucel in Patients with Multiple Myeloma and 1-3 Prior Lines of Therapy (Cohort A) and with Early Relapse after First Line Treatment (Cohort B)

Jens Hillengass, Adam D. Cohen, Mounzer E Agha, Michel Delforge, Tessa Kerre, Wilfried Roeloffzen, Hermann Einsele, Hartmut Goldschmidt, Katja Weisel, Marc S. Raab, Christof Scheid, Sebastien Anguille, Pieter Sonneveld, Sonja Zweegman, Jordan M. Schecter, Kevin C De Braganca, Carolyn Chang Jackson, Philip Vlummens, Helen Varsos, Christina Corsale, Deepu Madduri, Tzu-min Yeh, Pankaj Mistry, Tito Roccia, Qingxuan Song, Muhammad Akram, Octavio Costa Filho, Dong Geng, Yael C. Cohen, Niels W.C.J. Van De Donk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1021.
https://doi.org/10.1182/blood-2023-178882
Published: 2023
Journal Articles

Clinical Experience with Cranial Nerve Impairment in the CARTITUDE-1, CARTITUDE-2 Cohorts A, B, and C, and Cartitude-4 Studies of Ciltacabtagene Autoleucel (Cilta-cel)

Niels W.C.J. Van De Donk, Surbhi Sidana, Jordan M. Schecter, Carolyn Chang Jackson, Nikoletta Lendvai, Kevin C De Braganca, Ana Slaughter, Carolina Lonardi, Philip Vlummens, Helen Varsos, Christina Corsale, Deepu Madduri, Shirin Jadidi, Junchen Gu, Hao Zhao, Katherine Li, Erin Lee, Loreta Marquez, Man Zhao, Tzu-min Yeh, Diana Chen, Erika Florendo, Nitin Patel, Muhammad Akram, Jaime Gellego Perez-Larraya, Paula Rodriguez Otero
Journal: Blood
Blood (2023) 142 (Supplement 1): 3501.
https://doi.org/10.1182/blood-2023-178743
Published: 2023
Journal Articles

Efficacy and safety of cilta-cel in patients with progressive multiple myeloma after exposure to other BCMA-targeting agents

Clinical Trials & Observations
Adam D. Cohen, María-Victoria Mateos, Yael C. Cohen, Paula Rodriguez-Otero, Bruno Paiva, Niels W. C. J. van de Donk, Thomas Martin, Attaya Suvannasankha, Kevin C. De Braganca, Christina Corsale, Jordan M. Schecter, Helen Varsos, William Deraedt, Liwei Wang, Martin Vogel, Tito Roccia, Xiaoying Xu, Pankaj Mistry, Enrique Zudaire, Muhammad Akram, Tonia Nesheiwat, Lida Pacaud, Irit Avivi, Jesus San-Miguel
Journal: Blood
Blood (2023) 141 (3): 219–230.
https://doi.org/10.1182/blood.2022015526
Published: 2023
Includes: Supplemental data
Journal Articles

Ciltacabtagene Autoleucel (Cilta-cel), a BCMA-Directed CAR-T Cell Therapy, in Patients with Multiple Myeloma (MM) and Early Relapse after Initial Therapy: CARTITUDE-2 Cohort B 18-Month Follow-up

Niels WCJ Van De Donk, Mounzer Agha, Adam D Cohen, Yael C Cohen, Sébastien Anguille, Tessa Kerre, Wilfried W.H. Roeloffzen, Jordan M Schecter, Kevin C De Braganca, Carolyn C Jackson, Helen Varsos, Pankaj Mistry, Tito Roccia, Xiaoying Xu, Katherine Li, Enrique Zudaire, Christina Corsale, Muhammad Akram, Dong Geng, Lida Pacaud, Pieter Sonneveld, Sonja Zweegman
Journal: Blood
Blood (2022) 140 (Supplement 1): 7536–7537.
https://doi.org/10.1182/blood-2022-159169
Published: 2022
Journal Articles

Efficacy and Safety of Cilta-Cel in Patients with Progressive Multiple Myeloma after Exposure to Non-Cellular Anti-BCMA Immunotherapy

Adam D. Cohen, María-Victoria Mateos, Yael C. Cohen, Paula Rodriguez Otero, Bruno Paiva, Niels W.C.J. Van De Donk, Thomas Martin, Attaya Suvannasankha, Christina Corsale, Jordan M. Schecter, Kevin C. De Braganca, Carolyn C. Jackson, Helen Varsos, William Deraedt, Tito Roccia, Pankaj Mistry, Xiaoying Xu, Katherine Li, Enrique Zudaire, Muhammad Akram, Lida Pacaud, Irit Avivi, Jesús San-Miguel
Journal: Blood
Blood (2022) 140 (Supplement 1): 4646–4648.
https://doi.org/10.1182/blood-2022-158563
Published: 2022
Journal Articles

Efficacy Outcomes and Characteristics of Patients with Multiple Myeloma (MM) Who Achieved Sustained Minimal Residual Disease Negativity after Treatment with Ciltacabtagene Autoleucel (cilta-cel) in CARTITUDE-1

Nikhil C. Munshi, Bruno Paiva, Thomas Martin, Saad Usmani, Yi Lin, Jordan M. Schecter, Carolyn C. Jackson, Deepu Madduri, Enrique Zudaire, Tzu-min Yeh, J. Blake Bartlett, Lida Pacaud, Muhammad Akram, Dong Geng, Sundar Jagannath, Adam D. Cohen, Jesús San-Miguel
Journal: Blood
Blood (2022) 140 (Supplement 1): 4652–4654.
https://doi.org/10.1182/blood-2022-159141
Published: 2022
Journal Articles

Efficacy and Safety of Ciltacabtagene Autoleucel (Cilta-cel), a B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Lenalidomide-Refractory Patients with Progressive Multiple Myeloma after 1-3 Prior Lines of Therapy: Updated Results from CARTITUDE-2

Yael C. Cohen, Adam D Cohen, Michel Delforge, Jens Hillengass, Hartmut Goldschmidt, Katja Weisel, Marc-Steffen Raab, Christof Scheid, Jordan M. Schecter, Kevin C. De Braganca, Helen Varsos, Tzu-min Yeh, Liwei Wang, Martin Vogel, Christina Corsale, Muhammad Akram, Lida Pacaud, Tonia Nesheiwat, Mounzer Agha, Hermann Einsele
Journal: Blood
Blood (2021) 138 (Supplement 1): 3866.
https://doi.org/10.1182/blood-2021-146072
Published: 2021
Journal Articles

CARTITUDE-2: Efficacy and Safety of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen (BCMA)-Directed Chimeric Antigen Receptor T-Cell Therapy, in Patients with Multiple Myeloma and Early Relapse after Initial Therapy

Niels W.C.J. Van de Donk, Michel Delforge, Mounzer Agha, Adam D Cohen, Yael C Cohen, Jens Hillengass, Sebastien Anguille, Tessa Kerre, Wilfried Roeloffzen, Jordan M. Schecter, Kevin C. De Braganca, Helen Varsos, Liwei Wang, Martin Vogel, Enrique Zudaire, Christina Corsale, Muhammad Akram, Dong Geng, Tonia Nesheiwat, Lida Pacaud, Pieter Sonneveld, Sonja Zweegman
Journal: Blood
Blood (2021) 138 (Supplement 1): 2910.
https://doi.org/10.1182/blood-2021-146074
Published: 2021
Journal Articles

CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Relapsed/Refractory Multiple Myeloma

Deepu Madduri, MD, Jesus G. Berdeja, MD, Saad Z. Usmani, MDMBBS,MBA, Andrzej Jakubowiak, MD PhD, Mounzer Agha, MD, Adam D. Cohen, MD, A. Keith Stewart, MBChB, Parameswaran Hari, MD MRCP, Myo Htut, MD, Elizabeth O'Donnell, MD, Nikhil C. Munshi, MD, David E. Avigan, MD, Abhinav Deol, MD, Alexander M. Lesokhin, MD, Indrajeet Singh, PhD, Enrique Zudaire, PhD, Tzu-Min Yeh, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, William Deraedt, MSc, Sen Hong Zhuang, MD PhD, Jeffrey R. Infante, MD, Dong Geng, PhD, Xiaoling Wu, PhD, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Syed Rizvi, MD, Frank Fan, MD PhD, Sundar Jagannath, MD, Yi Lin, MD PhD, Thomas Martin, III, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–25.
https://doi.org/10.1182/blood-2020-136307
Published: 2020
Journal Articles

Health-Related Quality of Life in the Cartitude-1 Study of Ciltacabtagene Autoleucel for Relapsed/Refractory Multiple Myeloma

Thomas Martin, III, MD, Yi Lin, MD PhD, Mounzer Agha, MD, Adam D. Cohen, MD, Myo Htut, MD, A. Keith Stewart, MBChB, Parameswaran Hari, MD MRCP, Jesus G. Berdeja, MD, Deepu Madduri, MD, Saad Z. Usmani, MDMBBS,MBA, Tzu-Min Yeh, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, William Deraedt, MSc, Katharine S. Gries, PhD PharmD, John Fastenau, RPh, MPH, PhD, Xiaoling Wu, PhD, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Andrzej Jakubowiak, MD PhD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-136368
Published: 2020
Journal Articles

Cytokine Release Syndrome in Patients with Relapsed/Refractory Multiple Myeloma Treated with Ciltacabtagene Autoleucel in the Phase 1b/2 CARTITUDE-1 Study

Yi Lin, MD PhD, Thomas Martin, III, MD, Adam D. Cohen, MD, Andrzej Jakubowiak, MD PhD, Jagoda Jasielec, MD, Saad Z. Usmani, MDMBBS,MBA, Deepu Madduri, MD, Mounzer Agha, MD, A. Keith Stewart, MBChB, Indrajeet Singh, PhD, Enrique Zudaire, PhD, Tzu-Min Yeh, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, William Deraedt, MSc, Dong Geng, PhD, Xiaoling Wu, PhD, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Vickie Wang, PhD, Jesus G. Berdeja, MD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-136360
Published: 2020
Journal Articles

Patient Expectations and Perceptions of Treatment in CARTITUDE-1: Phase 1b/2 Study of Ciltacabtagene Autoleucel in Relapsed/Refractory Multiple Myeloma

Adam D. Cohen, MD, Parameswaran Hari, MD MRCP, Myo Htut, MD, Jesus G. Berdeja, MD, Deepu Madduri, MD, Saad Z. Usmani, MDMBBS,MBA, Alicia J. Allred, PhD, Yunsi Olyslager, MSc, Arnob Banerjee, MD, Jenna D. Goldberg, MD, Jordan M. Schecter, MD, Carolyn C. Jackson, MD MPH, Katharine S. Gries, PhD PharmD, John Fastenau, RPh, MPH, PhD, William Deraedt, MSc, Marlene J. Carrasco, MD PhD MPH, Muhammad Akram, MD, Farah Hossain, PharmD, Sigrid Crawford, MA, Ross Morrison, MPH, Lynda Doward, MRes, Andrzej Jakubowiak, MD PhD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-136383
Published: 2020
Journal Articles

BCR-ABL Kinase Domain Mutations Exist in Few Imatinib Treated Chronic Myeloid Leukemia (CML) Patients Exhibiting Stable Cytogenetic and Hematologic Responses

Afia Muhammad Akram, PhD, Tanveer Akhtar, PhD, Asma Chaudhary, Muhammad Mudassar Shahzad, Ahmad Mukhtar Khalid, PhD, Nadia Sajid, MBBS, FCPS, Muhammad Farooq Sabar, PhD, Zafar Iqbal, BSc, MSc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5427.
https://doi.org/10.1182/blood-2018-99-111757
Published: 2018
Journal Articles

Brief Research Report: Novel Compound BCR-ABL Mutations in Late Chronic Phase Imatinib Sensitive CML Patients Are Associated with Progression to Advance Disease Phase

Zafar Iqbal, MPhil PhDPost-doc., Afia Muhammad Akram, Tanveer Akhtar, PhD, Aamer Aleem, MBBS FRCP, Muhammad Farooq Sabar, PhD, Zeba Aziz, MD MBBS, Nadia Sajid, Mahmood Rasool, PhD, Muhammad Asif, Mehmood Husssain Qazi, PhD, Saleh Oraibi, PhD, Ammara T Gill, MBBS ABIM, Khalid Al Jamaan, MDFRCPC, Mudassar Iqbal, MDMS, Ahmad Mukhtar Khalid
Journal: Blood
Blood (2016) 128 (22): 3089.
https://doi.org/10.1182/blood.V128.22.3089.3089
Published: 2016
Journal Articles

High Frequencies of Compound BCR-ABL Mutations and Their Association with Imatinib Resistant, Disease Progression and Late Chronic Phase Disease in Pakistani Chronic Myeloid Leukemia Patients Necessitate the Inclusion of Molecular Testing in Routine Clinical Settings

Zafar Iqbal, PhD, Afia Muhammad Akram, Tanveer Akhtar, PhD, Muhammad Khalid, MPhil PhD, Zeba Aziz, MD MBBS, Aamer Aleem, MBBS FRCP, Ammara T Gill, MBBS ABIM, Ahmad M Khalid, PhD, Abdullah Alanazi, MBBS, Ijaz H Shah, MD, Muhammad Khalid, MBBS, MPhil, Muhammad Farooq Sabar, PhD, Mudassar Iqbal
Journal: Blood
Blood (2015) 126 (23): 5167.
https://doi.org/10.1182/blood.V126.23.5167.5167
Published: 2015
Journal Articles

Detection of Five Common Fusion Oncogenes in Pakistani Children with Acute Lymphoblastic Leukemia and Their Association with Clinical Pattern and Treatment Outcome

Zafar Iqbal, MPhil PhD Post-doctorate, Sabir Noreen, MSc PhD, Aleem Aamer, MBBS MRCP FRCPath, Awan Tashfeen, MSc PhD, Tahir Naeem, MBBS MS DABMM, Asad Sultan, MSc, Ammara H Tahir, MBBS DABIM, Muhammad Absar, MSc, Muhammad Azhar Chishti, DVM PhD, Muhammad Faiyaz-ul-Haque, MPhil PhD FRCPath, Ahmed Mukhtar Khalid, MSc PhD, Muhammad Farooq Sabar, MSc PhD, Mahmood Rasool, MSc PhD, Agha Shabbir Ali, Amer Mahmood, PhD, Muhammad Akram, MBBS BCPS, Tariq Saeed, MBBS, Saleem Arsalan, MSc, Danish Mohsin, MSc, Ijaz Husssain Shah, MBBS FCPS, Muhammad Khalid, MBBS FCPS, Muhammad Asif, PhD, Mudassar Iqbal, MD MS, Tanveer Akhtar, MSc PhD Postdoctorate
Journal: Blood
Blood (2012) 120 (21): 5124.
https://doi.org/10.1182/blood.V120.21.5124.5124
Published: 2012
Journal Articles

Characterization of Common Fusion Oncogenes As Prognostic Molecular Identities in Adult Acute Lymphoblastic Leukemia Identifies the Need for Genetic Testing At Presentation, Molecular Prognostication and Differential Treatment

Zafar Iqbal, MPhil PhD Post-doctorate, Sabir Noreen, MSc PhD, Aleem Aamer, MBBS MRCP FRCPath, Awan Tashfeen, MSc PhD, Tahir Naeem, MBBS MS DABMM, Asad Sultan, MSc, Ammara H Tahir, MBBS DABIM, Muhammad Absar, MSc, Muhammad Azhar Chishti, DVM PhD, Muhammad Faiyaz -ul-Haque, MPhil PhD FRCPath, Ahmed Mukhtar Khalid, MSc PhD, Muhammad Farooq Sabar, MSc PhD, Mahmood Rasool, MSc PhD, Agha Shabbir Ali, Amer Mahmood, PhD, Muhammad Akram, MBBS BCPS, Tariq Saeed, MBBS, Saleem Arsalan, MSc, Danish Mohsin, MSc, Ijaz Husssain Shah, MBBS FCPS, Muhammad Khalid, MBBS FCPS, Muhammad Asif, PhD, Mudassar Iqbal, MD MS, Tanveer Akhtar, MSc PhD Postdoctorate
Journal: Blood
Blood (2012) 120 (21): 5115.
https://doi.org/10.1182/blood.V120.21.5115.5115
Published: 2012