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Michelle I. Lin
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Journal Articles

CD33-Deleted Hematopoietic Cells (Trem-Cel) Are Protected from CD33xCD3 Bispecific Antibody Treatment and Produce Significantly Reduced Levels of Inflammatory Cytokines in Preclinical Studies

Jessica Lisle, Sushma Krishnamurthy, Amanda Halfond, Lisa Pechilis, Nate Manalo, Melissa Chng, Brikena Gjeci, Gabriella Angelini, Fulton Norman, Caitlin Lourenco, Hannah Mager, Julia Etchin, Yonina Keschner, Mariana Silva, Bethany Mattson, Laura Barreyro, Christina Guttke, John Lydeard, Julian Scherer, Michelle I Lin, Tirtha Chakraborty
Journal: Blood
Blood (2023) 142 (Supplement 1): 3425.
https://doi.org/10.1182/blood-2023-180216
Published: 2023
Journal Articles

Efficient Multiplex Gene Editing of CD33 and CLL-1 in Human Hematopoietic Stem Cells Enables the Potential of Next-Generation Transplants for AML Treatment

Juliana Xavier-Ferrucio, Gabriella Angelini, Sushma Krishnamurthy, Nipul Patel, Michael Pettiglio, Timothy Collingsworth, Amanda Halfond, Julia Etchin, Yonina Keschner, Guy Mundelboim, Huan Qiu, Ruijia Wang, Gary Ge, John Lydeard, Michelle I Lin, Tirtha Chakraborty
Journal: Blood
Blood (2022) 140 (Supplement 1): 10217–10218.
https://doi.org/10.1182/blood-2022-167513
Published: 2022
Journal Articles

CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable.

Michelle I. Lin, PhD, Elizabeth Paik, PhD, Bibhu Mishra, PhD, David Burkhardt, Andrew Kernytsky, PhD, Michael Pettiglio, Yi-Shan Chen, Kaleigh Tomkinson, Amanda Woo, Mauricio Cortes, PhD, Siyuan Tan, PhD, Todd D Borland, BS, Lawrence Klein, PhD, Angela Yen, PhD, Sudipta Mahajan, Eric Chan, PhD, Brenda Eustace, PhD, Matthew Porteus, MD PhD, Tirtha Chakraborty, PhD, Chad Cowan, Rodger Novak, MD, Ante Lundberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 284.
https://doi.org/10.1182/blood.V130.Suppl_1.284.284
Published: 2017
Journal Articles

Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia

Michelle I Lin, PhD, Elizabeth J Paik, PhD, Bibhu P Mishra, PhD, Song Chou, PhD, Ying Zhang, PhD, Kaleigh Tomkinson, MS, Michael A Pettiglio, BS, Andrew Sanginario, BS, Amanda Woo, BS, Min Jin Lee, BS, Melanie Allen, MS, Thomas J Cradick, PhD, Tirtha Chakraborty, PhD, Matthew Porteus, MD PhD, Ciaran M Lee, PhD, Gang Bao, PhD, Annarita Miccio, PhD, Annalisa Lattanzi, PhD, Fulvio Mavilio, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 4708.
https://doi.org/10.1182/blood.V128.22.4708.4708
Published: 2016
Journal Articles

Crispr/Cas9- Mediated Genome Editing of Human CD34 + Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies

Bibhu Mishra, PhD, Song Chou, PhD, Michelle I Lin, PhD, Elizabeth J Paik, PhD, Ying Zhang, PhD, Ruibin Liang, MS, Kaleigh Tomkinson, MS, Michael Pettiglio, MS, Andrew Sanginario, BS, Melanie Allen, MS, Thomas Cradick, PhD, Matthias John, PhD, Tirtha Chakraborty, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 3623.
https://doi.org/10.1182/blood.V128.22.3623.3623
Published: 2016
Journal Articles

Angiopoietin-Like Proteins Stimulate HSC Development Through Direct Interaction With Notch

Michelle I Lin, PhD, Emily Price, Sonja Boatman, Eirini Trompouki, PhD, Sruthi Satishchandran, Charles W Carspecken, MD, Audrey Uong, Anthony DiBiase, Jon C. Aster, MD, PhD, Richard M. White, MD, PhD, Leonard I. Zon, M.D.
Journal: Blood
Blood (2013) 122 (21): 463.
https://doi.org/10.1182/blood.V122.21.463.463
Published: 2013
Journal Articles

Formation of a PKCζ/β-catenin complex in endothelial cells promotes angiopoietin-1–induced collective directional migration and angiogenic sprouting

Malika Oubaha, Michelle I. Lin, Yoran Margaron, Dominic Filion, Emily N. Price, Leonard I. Zon, Jean-François Côté, Jean-Philippe Gratton
Journal: Blood
Blood (2012) 120 (16): 3371–3381.
https://doi.org/10.1182/blood-2012-03-419721
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

Scl and Notch Act Downstream of Hedgehog Signaling to Promote Embryonic Hematopoiesis From Endothelial Cells

Peter G Kim, Colleen E Albacker, Il-ho Jang, PhD, Garrett C Heffner, PhD, Yoowon Lim, Teresa V. Bowman, PhD, Michelle I Lin, PhD, Leonard I. Zon, MD, Sabine Loewer, PhD, George Q. Daley, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1283.
https://doi.org/10.1182/blood.V118.21.1283.1283
Published: 2011
Journal Articles

Genetic Interaction Between Angiopoietin-Like Proteins 1 and 2 and Notch Signaling During HSC Development

Michelle I Lin, Charles W Carspecken, Audrey Uong, Emily Price, Leonard I. Zon, MD
Journal: Blood
Blood (2010) 116 (21): 573.
https://doi.org/10.1182/blood.V116.21.573.573
Published: 2010
Journal Articles

Genetic Analyses in Zebrafish Reveal That Angiopoietin-Like Proteins 1 and 2 Are Required for HSC Development during Embryogenesis

Michelle I Lin, PhD, Leonard I. Zon, MD
Journal: Blood
Blood (2008) 112 (11): 729.
https://doi.org/10.1182/blood.V112.11.729.729
Published: 2008