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Tirtha Chakraborty
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Journal Articles

CD33-Deleted Hematopoietic Cells (Trem-Cel) Are Protected from CD33xCD3 Bispecific Antibody Treatment and Produce Significantly Reduced Levels of Inflammatory Cytokines in Preclinical Studies

Jessica Lisle, Sushma Krishnamurthy, Amanda Halfond, Lisa Pechilis, Nate Manalo, Melissa Chng, Brikena Gjeci, Gabriella Angelini, Fulton Norman, Caitlin Lourenco, Hannah Mager, Julia Etchin, Yonina Keschner, Mariana Silva, Bethany Mattson, Laura Barreyro, Christina Guttke, John Lydeard, Julian Scherer, Michelle I Lin, Tirtha Chakraborty
Journal: Blood
Blood (2023) 142 (Supplement 1): 3425.
https://doi.org/10.1182/blood-2023-180216
Published: 2023
Journal Articles

Multimodal Atlas of Paired Diagnosis and Relapse AML Samples Enables Novel Therapeutic Targeting of Surface Antigens

Amanda Halfond, Matthew Ung, Julia Etchin, Yonina Keschner, Julia DiFazio, Alyssa Pyclik, Guy Mundelboim, Gary Ge, John Lydeard, Tirtha Chakraborty
Journal: Blood
Blood (2023) 142 (Supplement 1): 164.
https://doi.org/10.1182/blood-2023-187045
Published: 2023
Journal Articles

Longitudinal Multimodal Atlas of AML Surface Antigens Enables Adaptive and Combinatorial Targeting

Julia Etchin, Matthew Ung, Amanda Halfond, Yonina Keschner, Julia DiFazio, Guy Mundelboim, Gary Ge, John Lydeard, Tirtha Chakraborty
Journal: Blood
Blood (2022) 140 (Supplement 1): 11804–11805.
https://doi.org/10.1182/blood-2022-170080
Published: 2022
Journal Articles

Efficient Multiplex Gene Editing of CD33 and CLL-1 in Human Hematopoietic Stem Cells Enables the Potential of Next-Generation Transplants for AML Treatment

Juliana Xavier-Ferrucio, Gabriella Angelini, Sushma Krishnamurthy, Nipul Patel, Michael Pettiglio, Timothy Collingsworth, Amanda Halfond, Julia Etchin, Yonina Keschner, Guy Mundelboim, Huan Qiu, Ruijia Wang, Gary Ge, John Lydeard, Michelle I Lin, Tirtha Chakraborty
Journal: Blood
Blood (2022) 140 (Supplement 1): 10217–10218.
https://doi.org/10.1182/blood-2022-167513
Published: 2022
Journal Articles

Multiplex Engineering of Human CD34+ HSPCs Enables Dual Gene Knock-out While Maintaining High Engraftment Potential and Safety

Nipul Patel, Michael Pettiglio, Christopher Cummins, Jeff Pimentel, Anjali Kapuria, Azita Ghodssi, Meltem Isik, Alejandra Falla, Ravindra Amunugama, Jessica Lisle, Shu Wang, Michelle Lin, John Lydeard, Gary Ge, Dane Hazelbaker, Elizabeth Paik, Tirtha Chakraborty
Journal: Blood
Blood (2021) 138 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2021-148007
Published: 2021
Journal Articles

G-CSF/Plerixafor Dual-Mobilized Donor Derived CD33CAR T-Cells As Potent and Effective AML Therapy in Pre-Clinical Models

Giacomo Canesin, Hillary Hoyt, Reid Williams, Mariana Silva, Melissa Chng, Christopher Cummins, Matthew Ung, Huan Qiu, John Shin, Jianxin Hu, Gary Ge, Julian Scherer, Tirtha Chakraborty, Sadik Kassim
Journal: Blood
Blood (2021) 138 (Supplement 1): 1716.
https://doi.org/10.1182/blood-2021-153868
Published: 2021
Journal Articles

Knock out of CD123 or CLL-1 By CRISPR-Cas9 Editing from Human Hematopoietic Stem Cell Transplants Provide New Possibilities for Increasing Therapeutic Index and Safety for AML Treatment

Chong Luo, Gabriella Angelini, Sushma Krishnamurthy, Jessica Lisle, Meltem Isik, Azita Ghdossi, Christopher Cummins, Michael Pettiglio, Dane Hazelbaker, Gary Ge, Patrick Tavares, Mugdha Nikam, Elizabeth Paik, John Lydeard, Michelle Lin, Tirtha Chakraborty
Journal: Blood
Blood (2021) 138 (Supplement 1): 3818.
https://doi.org/10.1182/blood-2021-146235
Published: 2021
Journal Articles

CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable.

Michelle I. Lin, PhD, Elizabeth Paik, PhD, Bibhu Mishra, PhD, David Burkhardt, Andrew Kernytsky, PhD, Michael Pettiglio, Yi-Shan Chen, Kaleigh Tomkinson, Amanda Woo, Mauricio Cortes, PhD, Siyuan Tan, PhD, Todd D Borland, BS, Lawrence Klein, PhD, Angela Yen, PhD, Sudipta Mahajan, Eric Chan, PhD, Brenda Eustace, PhD, Matthew Porteus, MD PhD, Tirtha Chakraborty, PhD, Chad Cowan, Rodger Novak, MD, Ante Lundberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 284.
https://doi.org/10.1182/blood.V130.Suppl_1.284.284
Published: 2017
Journal Articles

Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) to Treat Sickle Cell Disease (SCD) and β-Thalassemia

Michelle I Lin, PhD, Elizabeth J Paik, PhD, Bibhu P Mishra, PhD, Song Chou, PhD, Ying Zhang, PhD, Kaleigh Tomkinson, MS, Michael A Pettiglio, BS, Andrew Sanginario, BS, Amanda Woo, BS, Min Jin Lee, BS, Melanie Allen, MS, Thomas J Cradick, PhD, Tirtha Chakraborty, PhD, Matthew Porteus, MD PhD, Ciaran M Lee, PhD, Gang Bao, PhD, Annarita Miccio, PhD, Annalisa Lattanzi, PhD, Fulvio Mavilio, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 4708.
https://doi.org/10.1182/blood.V128.22.4708.4708
Published: 2016
Journal Articles

Crispr/Cas9- Mediated Genome Editing of Human CD34 + Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies

Bibhu Mishra, PhD, Song Chou, PhD, Michelle I Lin, PhD, Elizabeth J Paik, PhD, Ying Zhang, PhD, Ruibin Liang, MS, Kaleigh Tomkinson, MS, Michael Pettiglio, MS, Andrew Sanginario, BS, Melanie Allen, MS, Thomas Cradick, PhD, Matthias John, PhD, Tirtha Chakraborty, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 3623.
https://doi.org/10.1182/blood.V128.22.3623.3623
Published: 2016