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Michael Pettiglio
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Journal Articles

Efficient Multiplex Gene Editing of CD33 and CLL-1 in Human Hematopoietic Stem Cells Enables the Potential of Next-Generation Transplants for AML Treatment

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Juliana Xavier-Ferrucio, Gabriella Angelini, Sushma Krishnamurthy, Nipul Patel, Michael Pettiglio, Timothy Collingsworth, Amanda Halfond, Julia Etchin, Yonina Keschner, Guy Mundelboim, Huan Qiu, Ruijia Wang, Gary Ge, John Lydeard, Michelle I Lin, Tirtha Chakraborty
Journal: Blood
Blood (2022) 140 (Supplement 1): 10217–10218.
https://doi.org/10.1182/blood-2022-167513
Published: 2022
Journal Articles

Knock out of CD123 or CLL-1 By CRISPR-Cas9 Editing from Human Hematopoietic Stem Cell Transplants Provide New Possibilities for Increasing Therapeutic Index and Safety for AML Treatment

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Chong Luo, Gabriella Angelini, Sushma Krishnamurthy, Jessica Lisle, Meltem Isik, Azita Ghdossi, Christopher Cummins, Michael Pettiglio, Dane Hazelbaker, Gary Ge, Patrick Tavares, Mugdha Nikam, Elizabeth Paik, John Lydeard, Michelle Lin, Tirtha Chakraborty
Journal: Blood
Blood (2021) 138 (Supplement 1): 3818.
https://doi.org/10.1182/blood-2021-146235
Published: 2021
Journal Articles

Multiplex Engineering of Human CD34+ HSPCs Enables Dual Gene Knock-out While Maintaining High Engraftment Potential and Safety

Free
Nipul Patel, Michael Pettiglio, Christopher Cummins, Jeff Pimentel, Anjali Kapuria, Azita Ghodssi, Meltem Isik, Alejandra Falla, Ravindra Amunugama, Jessica Lisle, Shu Wang, Michelle Lin, John Lydeard, Gary Ge, Dane Hazelbaker, Elizabeth Paik, Tirtha Chakraborty
Journal: Blood
Blood (2021) 138 (Supplement 1): 2939.
https://doi.org/10.1182/blood-2021-148007
Published: 2021
Journal Articles

CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable.

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Michelle I. Lin, PhD, Elizabeth Paik, PhD, Bibhu Mishra, PhD, David Burkhardt, Andrew Kernytsky, PhD, Michael Pettiglio, Yi-Shan Chen, Kaleigh Tomkinson, Amanda Woo, Mauricio Cortes, PhD, Siyuan Tan, PhD, Todd D Borland, BS, Lawrence Klein, PhD, Angela Yen, PhD, Sudipta Mahajan, Eric Chan, PhD, Brenda Eustace, PhD, Matthew Porteus, MD PhD, Tirtha Chakraborty, PhD, Chad Cowan, Rodger Novak, MD, Ante Lundberg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 284.
https://doi.org/10.1182/blood.V130.Suppl_1.284.284
Published: 2017
Journal Articles

Crispr/Cas9- Mediated Genome Editing of Human CD34 + Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies

Free
Bibhu Mishra, PhD, Song Chou, PhD, Michelle I Lin, PhD, Elizabeth J Paik, PhD, Ying Zhang, PhD, Ruibin Liang, MS, Kaleigh Tomkinson, MS, Michael Pettiglio, MS, Andrew Sanginario, BS, Melanie Allen, MS, Thomas Cradick, PhD, Matthias John, PhD, Tirtha Chakraborty, PhD, Chad A Cowan, PhD, Rodger Novak, MD, Ante S Lundberg, MD
Journal: Blood
Blood (2016) 128 (22): 3623.
https://doi.org/10.1182/blood.V128.22.3623.3623
Published: 2016