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Journal Articles

Modulation of Thrombin-Induced Platelet Activation By Defibrotide

Kristin N. Maher, MD PhD, Xu Han, BS, MS, Keith B. Neeves, PhD, Marvin T. Nieman, PhD, Jorge Di Paola, MD

Blood (2019) 134 (Supplement_1): 3614.

https://doi.org/10.1182/blood-2019-125945

Published: 2019

Journal Articles

Analysis of a Naturally Occurring PAR4 Variant By Hydrogen/Deuterium Exchange Reveals Its Structural Rearrangement upon Activation By Thrombin and the Molecular Basis for Altered Reactivity

Xu Han, BS, MS, Lukas Hofmann, PhD, Maria de la Fuente, BS, Tivadar Orban, PhD, Nathan Alexander, PhD, Krzysztof Palczewski, PhD, Marvin T Nieman, PhD

Blood (2017) 130 (Supplement 1): 453.

https://doi.org/10.1182/blood.V130.Suppl_1.453.453

Published: 2017

Journal Articles

Thrombin Induces Protease Activated Receptor (PAR)-3/-4 Interaction in Human Podocytes

Sharma Ruchika, MD, Amanda P Waller, PhD, Shipra Agrawal, PhD, Berend H Isermann, MD, William E Smoyer, MD, Marvin T Nieman, PhD, Bryce A. Kerlin, MD

Blood (2015) 126 (23): 3488.

https://doi.org/10.1182/blood.V126.23.3488.3488

Published: 2015

Journal Articles

Cadherin-6 Forms a Functional Adhesion Complex with Alpha-Catenin and Beta-Catenin in Platelets and Is Required for Platelet Aggregation and Thrombus Formation

Michele Mumaw, PhD, Maria de la Fuente, BS, Carolyn Aldana, BS, BA, Wei Li, MD, Marvin T Nieman, PhD

Blood (2015) 126 (23): 2232.

https://doi.org/10.1182/blood.V126.23.2232.2232

Published: 2015

Journal Articles

Endogenous Thrombin Potential is Directly Correlated with Proteinuria Severity in Both Nephrotic Syndrome Patients and an Animal Model of Nephrotic Syndrome

Amanda P Waller, PhD, Marvin T. Nieman, PhD, William E. Smoyer, MD, Bryce A. Kerlin, MD

Blood (2014) 124 (21): 4243.

https://doi.org/10.1182/blood.V124.21.4243.4243

Published: 2014

Journal Articles

Thrombin Induces Apoptosis in Human and Rat Podocytes in a Protease Activated Receptor (PAR)-Dependent Manner

Ruchika Sharma, MD, Amanda P Waller, PhD, Adam Guess, Shipra Agrawal, PhD, Berend Isermann, William E. Smoyer, MD, Marvin T. Nieman, PhD, Bryce A. Kerlin, MD

Blood (2014) 124 (21): 2808.

https://doi.org/10.1182/blood.V124.21.2808.2808

Published: 2014

Journal Articles

Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

Leonard C. Edelstein, PhD, Lukas M Simon, Cory R Lindsay, PhD, Xiango Kong, MD, Raul Teruel Montoya, PhD, Benjamin E Tourdot, PhD, Edward Chen, PhD, Lin Ma, Shaun R Coughlin, PhD, Marvin T. Nieman, PhD, Michael Holinstat, PhD, Chad Shaw, PhD, Paul F Bray, MD

Blood (2014) 124 (21): 1434.

https://doi.org/10.1182/blood.V124.21.1434.1434

Published: 2014

Journal Articles

Analysis of Protease Activated Receptor 4 (PAR4) By Histidine Hydrogen Deuterium Exchange

Marvin T. Nieman, PhD, Maria de la Fuente, Masaru Miyagi, PhD

Blood (2014) 124 (21): 4166.

https://doi.org/10.1182/blood.V124.21.4166.4166

Published: 2014

Journal Articles

An Antibody Targeted To The Anionic Region Of Human Protease Activated Receptor 4 Inhibits Thrombosis Without Influencing Bleeding

Michele M. Mumaw, Maria de la Fuente, Amal Arachiche, PhD, Daniel N. Nobel, Marvin T. Nieman, PhD

Blood (2013) 122 (21): 2376.

https://doi.org/10.1182/blood.V122.21.2376.2376

Published: 2013

Journal Articles

Thrombin Generation Is Directly Correlated To Proteinuria Severity In An Experimental Model Of Nephrotic Syndrome

Amanda P. Waller, PhD, William E. Smoyer, MD, Melinda A. Chanley, RVT/LAT, Marvin T. Nieman, PhD, Bryce A. Kerlin, MD

Blood (2013) 122 (21): 3615.

https://doi.org/10.1182/blood.V122.21.3615.3615

Published: 2013

Journal Articles

Thrombin Induces Specific Signaling Pathways Distinct From Simultaneous Stimulation With PAR1 and PAR4 Agonist Peptides In Human Platelets

Amal Arachiche, PhD, Marvin T. Nieman, PhD

Blood (2013) 122 (21): 3516.

https://doi.org/10.1182/blood.V122.21.3516.3516

Published: 2013

Journal Articles

Thrombin Modulates PAR1-PAR4 Heterodimers

Maria de la Fuente, Amal Arachiche, PhD, Marvin T. Nieman, PhD

Blood (2011) 118 (21): 2203.

https://doi.org/10.1182/blood.V118.21.2203.2203

Published: 2011

Journal Articles

Over-Expression of the Mas Receptor Decreases Arterial Thrombosis Risk in B2R KO Mice by Elevating NO and Prostacyclin and Reducing GPVI Activation

Chao Fang, Evi Stavrou, MD, Alec A Schmaier, PhD, Gregory N Adams, Marvin T. Nieman, PhD, Gretchen LaRusch, Matthew Bilodeau, MD, PhD, Fakhri Mahdi, Mark Warnock, Alvin H. Schmaier, MD

Blood (2011) 118 (21): 700.

https://doi.org/10.1182/blood.V118.21.700.700

Published: 2011

Journal Articles

Prolylcarboxypeptidase Deficiency Is a Risk Factor for Arterial Thrombosis and Hypertension

Gregory Adams, Gretchen LaRusch, Evi Stavrou, MD, Yihua Zhou, Marvin T. Nieman, PhD, Gretta Jacobs, Yingjie Cui, Yuan Lu, Mukesh K Jain, M.D., Fakhri Mahdi, MD, Zia Shariat-Madar, Louis G D'Alecy, Alvin H. Schmaier, MD

Blood (2010) 116 (21): 651.

https://doi.org/10.1182/blood.V116.21.651.651

Published: 2010

Journal Articles

Mapping the Interface Between Protease Activated Receptor 1 (PAR1) and PAR4 Heterodimers

Daniel N. Noble, Maria de la Fuente, Marvin T. Nieman, PhD

Blood (2010) 116 (21): 3195.

https://doi.org/10.1182/blood.V116.21.3195.3195

Published: 2010

Journal Articles

Bradykinin B2 Receptor KO Mice Are Protected From Thrombosis by A Platelet Spreading Defect

Chao Fang, Alec Schmaier, PhD, Evi Stavrou, MD, Gregory Adams, Marvin T. Nieman, PhD, Gretchen LaRusch, Andrew Chen, MD, Yihua Zhou, Matthew Bilodeau, MD, PhD, Fakhri Mahdi, MD, Mark Warnock, Alvin H. Schmaier, MD

Blood (2010) 116 (21): 3198.

https://doi.org/10.1182/blood.V116.21.3198.3198

Published: 2010

Journal Articles

Mapping the Protease Activated Receptor 4 (PAR4) Homodimer Interface.

Marvin T Nieman, PhD

Blood (2009) 114 (22): 773.

https://doi.org/10.1182/blood.V114.22.773.773

Published: 2009

Journal Articles

Prolylcarboxypeptidase Murine Hypomorphs Are Hypertensive and Prothrombotic

Gregory N Adams, Yihua Zhou, Gretchen Larusch, Marvin T Nieman, PhD, Brian Hoit, PhD, Gretta Jacobs, MD, Xin Yu, Sc.D., Fakhri Mahdi, Zia Shariat-Madar, PhD, Louis D’Alecy, PhD, Yoshio Okada, Alvin H. Schmaier, MD

Blood (2008) 112 (11): 3915.

https://doi.org/10.1182/blood.V112.11.3915.3915

Published: 2008

Journal Articles

Protease Activated Receptor-4 (PAR4) Uses Anionic Residues to Interact with α-Thrombin in the Absence or Presence of PAR1.

Marvin T Nieman, PhD

Blood (2008) 112 (11): 2019.

https://doi.org/10.1182/blood.V112.11.2019.2019

Published: 2008

Journal Articles

The Contributions of the P4-P2 Positions in PAR1 and 4 for Thrombin Recognition and Cleavage.

Marvin T. Nieman, PhD, Alvin H. Schmaier, MD

Blood (2005) 106 (11): 3574.

https://doi.org/10.1182/blood.V106.11.3574.3574

Published: 2005

NARROW

Modulation of Thrombin-Induced Platelet Activation By Defibrotide

Analysis of a Naturally Occurring PAR4 Variant By Hydrogen/Deuterium Exchange Reveals Its Structural Rearrangement upon Activation By Thrombin and the Molecular Basis for Altered Reactivity

Thrombin Induces Protease Activated Receptor (PAR)-3/-4 Interaction in Human Podocytes

Cadherin-6 Forms a Functional Adhesion Complex with Alpha-Catenin and Beta-Catenin in Platelets and Is Required for Platelet Aggregation and Thrombus Formation

Endogenous Thrombin Potential is Directly Correlated with Proteinuria Severity in Both Nephrotic Syndrome Patients and an Animal Model of Nephrotic Syndrome

Thrombin Induces Apoptosis in Human and Rat Podocytes in a Protease Activated Receptor (PAR)-Dependent Manner

Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

Analysis of Protease Activated Receptor 4 (PAR4) By Histidine Hydrogen Deuterium Exchange

An Antibody Targeted To The Anionic Region Of Human Protease Activated Receptor 4 Inhibits Thrombosis Without Influencing Bleeding

Thrombin Generation Is Directly Correlated To Proteinuria Severity In An Experimental Model Of Nephrotic Syndrome

Thrombin Induces Specific Signaling Pathways Distinct From Simultaneous Stimulation With PAR1 and PAR4 Agonist Peptides In Human Platelets

Thrombin Modulates PAR1-PAR4 Heterodimers

Over-Expression of the Mas Receptor Decreases Arterial Thrombosis Risk in B2R KO Mice by Elevating NO and Prostacyclin and Reducing GPVI Activation

Prolylcarboxypeptidase Deficiency Is a Risk Factor for Arterial Thrombosis and Hypertension

Mapping the Interface Between Protease Activated Receptor 1 (PAR1) and PAR4 Heterodimers

Bradykinin B2 Receptor KO Mice Are Protected From Thrombosis by A Platelet Spreading Defect

Mapping the Protease Activated Receptor 4 (PAR4) Homodimer Interface.

Prolylcarboxypeptidase Murine Hypomorphs Are Hypertensive and Prothrombotic

Protease Activated Receptor-4 (PAR4) Uses Anionic Residues to Interact with α-Thrombin in the Absence or Presence of PAR1.

The Contributions of the P4-P2 Positions in PAR1 and 4 for Thrombin Recognition and Cleavage.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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