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Journal Articles

Spatial Transcriptomic Profiling of Bone Marrow Vascular Niches Unveils an Endothelial Stress Signature in Myeloproliferative Neoplasms

Jimena Castorena, Christophe Desterke, Barbara Burroni, Lise Willems, Marie-Caroline Le Bousse-Kerdilès, Laurence Legros, Laura Velazquez

Blood (2024) 144 (Supplement 1): 4516.

https://doi.org/10.1182/blood-2024-210924

Published: 2024

Journal Articles

Pathological Heterotopic Ossifications in Brain or Spinal Cord Injured Patients: From Ectopic Bone to Hematopoietic Stem Cell Niche Development

Frédéric Torossian, PhD, Bernadette Guerton, Adrienne Anginot, PhD, Nassim Arouche, Laetitia Boutin, Denis Clay, Nathalie Rochet, PhD MD, Christophe Desterke, PhD, Erica Vlachos, Guillaume Genet, Philippe Denormandie, PhD MD, François Genet, PhD MD, Jean-Pierre Levesque, PhD, Jean-Jacques Lataillade, PhD MD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2016) 128 (22): 3889.

https://doi.org/10.1182/blood.V128.22.3889.3889

Published: 2016

Journal Articles

Accessible Chromatin Landscape Reveals a Proliferative Osteoprogenitor Transcriptional Program in Bone Marrow Mesenchymal Stromal Cells from Patients with Primary Myelofibrosis

Christophe Desterke, PhD, Nadira Ruzehaji, PhD, Bernadette Guerton, Johanna Konopacki, MD, Solene-Florence Kammerer-Jacquet, MD, Alessandro M. Vannucchi, MD PhD, Lisa Pieri, MD PhD, Christophe Martinaud, MD PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2016) 128 (22): 3135.

https://doi.org/10.1182/blood.V128.22.3135.3135

Published: 2016

Journal Articles

Assessment of Sites of Marrow and Extramedullary Hematopoieis By Hybrid Imaging in Patients with Primary Myelofibrosis

Mario Ojeda-Uribe, MD, Constantin Ungureanu, MD, Olivier Morel, MD, Christophe Desterke, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD, Hatem Boulahdour, MD PhD

Blood (2015) 126 (23): 2823.

https://doi.org/10.1182/blood.V126.23.2823.2823

Published: 2015

Journal Articles

Blood Traffic of Endothelial, Mesenchymal, Hematopoietic and Lin-/CD45-CD34+AC133+CXCR4+ Progenitor Cell Subsets Show Different Patterns in Pre-Fibrotic and Fibrotic Primary Myelofibrosis

Mario Ojeda-Uribe, MD, Christophe Desterke, PhD, Laura Jung, PhD, Pierre Bories, MD, Hanna Sovalat, PhD, Laurent Mauvieux, MD PhD, Jean Claude Eisenmann, Bruno Lioure, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2014) 124 (21): 3230.

https://doi.org/10.1182/blood.V124.21.3230.3230

Published: 2014

Journal Articles

Endogenous TGF-beta1 Mediated Osteogenic Impairment of Medullar Mesenchymal Stromal Cells in Primary Myelofibrosis

Christophe Martinaud, MD, Christophe Desterke, PhD, Johanna Konopacki, MD, Lisa Pieri, MDPhD, Rachel Golub, PhD, Sandrine Schmutz, PhD, Adrienne Anginot, PhD, Bernadette Guerton, Nathalie Rochet, MD PhD, Patricia Albanese, PhD, Emilie Henault, Thierry De Revel, Marie-Françoise Bourgeade, PhD, Vanucchi Alessandro, MD, Jean-Jacques Lataillade, MD PhD, Marie-Caroline Le Bousse-Kerdilès, PhD

Blood (2014) 124 (21): 1873.

https://doi.org/10.1182/blood.V124.21.1873.1873

Published: 2014

Journal Articles

CXCR7 participates in CXCL12-induced CD34 + cell cycling through β-arrestin–dependent Akt activation

Frédéric Torossian, Adrienne Anginot, Aurélie Chabanon, Denis Clay, Bernadette Guerton, Christophe Desterke, Laetitia Boutin, Stefano Marullo, Mark G. H. Scott, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdilès

Blood (2014) 123 (2): 191–202.

https://doi.org/10.1182/blood-2013-05-500496

Published: 2014

Includes: Supplemental data

Journal Articles

Bloodstream Progenitor-Cell Traffic In Primary Myelofibrosis Reveals Cell Subsets Showing Some Features Of Very-Small Embryonnic-Like Stem Cells (VSELs), Along With Endothelial (PEC), Mesenchymal (MPC) and Hematopoietic (HPC) Progenitor Cells

Mario Ojeda-Uribe, MD, Hanna Sovalat, PhD, Laura Jung, PhD, Christophe Desterke, PhD, Sylvie Thiebault, MD, Pierre Bories, MD, Laurent Mauvieux, MD, PhD, Philippe Tropel, PhD, Jean-Claude Eisenmann, MD, Bruno Lioure, MD, Anne-Claire Voegeli, PhD, Eric Jeandidier, MD, Stephane Viville, PharmD, PhD, Valerie Rimelen, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2013) 122 (21): 5265.

https://doi.org/10.1182/blood.V122.21.5265.5265

Published: 2013

Journal Articles

CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34 + Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation

Frederic Torossian, PhD, Aurélie Chabanon, PhD, Denis Clay, Bernadette Guerton, Adrienne Anginot, PhD, Richard Proust, Jean-Francois Ottavi, Emmanuel Dornier, Laetitia Boutin, Christophe Desterke, PhD, Mark Scott, PhD, Jean-Jacques Lataillade, MD, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2012) 120 (21): 3448.

https://doi.org/10.1182/blood.V120.21.3448.3448

Published: 2012

Journal Articles

Impairment of Myeloid Dendritic Differentiation and Role in the Support of Splenic Dysmegakaryopoiesis in Patients with Primary Myelofibrosis

Christophe Desterke, PhD, Bernadette Guerton, Sophie Amsellem, PhD, Agnes Charpentier, MD, Brigitte Dupriez, MD, Jean-Loup Demory, MD, Christophe Martinaud, MD, Jean-Jacques Lataillade, Julien Giron-Michel, Bruno Azzarone, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2012) 120 (21): 1762.

https://doi.org/10.1182/blood.V120.21.1762.1762

Published: 2012

Journal Articles

The Tetraspanin CD9 Is Involved in Primary Myelofibrosis Dysmegakaryopoiesis Through c-Myb Regulation and Stroma Interactions,

Christophe Desterke, PhD, Costanza Bogani, PhD, Lisa Pieri, MD, Alessandro M. Vannucchi, MD, PhD, Bernadette Guerton, Christophe Martinaud, MD, Denis Clay, Jean-Jacques Lataillade, MD, PhD, Hans Hasselbalch, MD, PhD, Heinz Gisslinger, MD, PhD, Sophie Amsellem, PhD, Jean-Loup Demory, MD, Agnès Charpentier, MD, Brigitte Dupriez, Claude Boucheix, MD, PhD, Eric Rubinstein, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2011) 118 (21): 3834.

https://doi.org/10.1182/blood.V118.21.3834.3834

Published: 2011

Journal Articles

Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

Fanny Baran-Marszak, Hajer Magdoud, Christophe Desterke, Anabell Alvarado, Claudine Roger, Stéphanie Harel, Elizabeth Mazoyer, Bruno Cassinat, Sylvie Chevret, Carole Tonetti, Stéphane Giraudier, Pierre Fenaux, Florence Cymbalista, Nadine Varin-Blank, Marie-Caroline Le Bousse-Kerdilès, Jean-Jacques Kiladjian, Laura Velazquez

Blood (2010) 116 (26): 5961–5971.

https://doi.org/10.1182/blood-2009-12-256768

Published: 2010

Includes: Supplemental data

Journal Articles

Abnormal Expression and Function of the Lnk Adaptor Protein in Myeloproliferative Neoplasms (MPN).

Jean-Jacques Kiladjian, MD, PhD, Fanny Baran-Marszak, MD, PhD, Christophe Desterke, PhD, Bruno Cassinat, Pharm.D, Hajer Magdoud, Elisabeth Mazoyer, MD, Pierre Fenaux, MD, PhD, Claude Gardin, Florence Cymbalista, MD, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD, Nadine Varin-Blank, PhD, Laura Velazquez, PhD

Blood (2009) 114 (22): 2897.

https://doi.org/10.1182/blood.V114.22.2897.2897

Published: 2009

Journal Articles

Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence

Jean-Jacques Lataillade, Olivier Pierre-Louis, Hans Carl Hasselbalch, Georges Uzan, Claude Jasmin, Marie-Claire Martyré, Marie-Caroline Le Bousse-Kerdilès

Blood (2008) 112 (8): 3026–3035.

https://doi.org/10.1182/blood-2008-06-158386

Published: 2008

Journal Articles

A New Multiparametric Flow Cytometry Technique Based on Combined Side Population (SP) and Aldehyde Deshydrogenase (ALDH) Functionalities Identifies a Hierarchy within the Human Hematopoietic Stem/Progenitor Compartment.

Olivier Pierre-Louis, Denis Clay, Bernadette Guerton, Christophe Desterke, Aurelie Chabanon, Jean-Valer Malfuson, Jean-Jacques Lataillade, Marie-Caroline Le Bousse-Kerdiles

Blood (2007) 110 (11): 2226.

https://doi.org/10.1182/blood.V110.11.2226.2226

Published: 2007

Journal Articles

FLT3 Mediated MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis

Christophe Desterke, Hans Hasselbalch, MD, PHD, Dominique Bordessoule, MD, PhD, Heinz Gisslinger, MD, PhD, Alessandro Vannucchi, MD, PhD, Olivier Pierre-Louis, Carole Tonetti, Philippe Dessen, PhD, Vladimir Lazar, MD, PhD, Bernadette Guerton, Denis Clay, William Vainchenker, MD, PhD, Stephane Giraudier, MD, PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2007) 110 (11): 1532.

https://doi.org/10.1182/blood.V110.11.1532.1532

Published: 2007

Journal Articles

Hypermethylation of CXCR4 Promoter, and Its Reactivation by Hypomethylating Agent, in CD34 + Cells from Primary Myelofibrosis Patients

Paola Guglielmelli, MD, Costanza Bogani, BiSc, Vanessa Ponziani, BiSc, Giada Poli, BiSc, Vittorio Rosti, MD, Cristophe Desterke, Alberto Bosi, MD, Marie Caroline Le Bousse-Kerdiles, PhD, Giovanni Barosi, MD, Alessandro M. Vannucchi, MD

Blood (2007) 110 (11): 1545.

https://doi.org/10.1182/blood.V110.11.1545.1545

Published: 2007

Journal Articles

Pivotal Role of FoxO3 and mTORC1 in the Opposite Effects of SDF-1 and TGF-β on Cell Cycle Progression in CD34 + Stem/Progenitor Cells.

Aurelie Chabanon, Christophe Desterke, Emilie Rodenburger, Denis Clay, Bernadette Guerton, Laetitia Boutin, Olivier Pierre-Louis, Claude Capron, PhD, Annelise Bennaceur-Griscelli, MD; PhD, Georges Uzan, PhD, Lucile Abecassis, PhD, Marie-Francoise Bourgeade, PhD, Jean-Jacques Lataillade, MD; PhD, Marie-Caroline Le Bousse-Kerdiles, PhD

Blood (2007) 110 (11): 3363.

https://doi.org/10.1182/blood.V110.11.3363.3363

Published: 2007

Journal Articles

Microarray Functional Comparison of CD34 + and Megakaryocytic Cell Transcriptomes in Myeloid Metaplasia with Myelofibrosis.

Marie-Caroline Le Bousse-Kerdiles, PhD, Christophe Desterke, Carole Tonetti, Philippe Dessen, PhD, Hugues Ripoche, Vladimir Lazar, PhD, MD, Bernadette Guerton, Denis Clay, William Vainchenker, PhD, MD, Stephane Giraudier, PhD, MD, Members of the French Inserm GEM European EUMNET Networks

Blood (2005) 106 (11): 3505.

https://doi.org/10.1182/blood.V106.11.3505.3505

Published: 2005

Journal Articles

Glivec/STI571 Treatment Stimulates Megakaryopoiesis and Normalizes PDGF Receptor beta Kinase Expression in Thrombocytopenic Patients with Myeloid Metaplasia with Myelofibrosis.

Marie Caroline le Bousse-Kerdiles, Christophe Desterke, Bernadette Guerton, Denis Clay, Hans Hasselbalch, Heinz Gisslinger, Jurgen Thiele, Hans Kvasnicka, Giovanni Barosi

Blood (2005) 106 (11): 2599.

https://doi.org/10.1182/blood.V106.11.2599.2599

Published: 2005

NARROW

Spatial Transcriptomic Profiling of Bone Marrow Vascular Niches Unveils an Endothelial Stress Signature in Myeloproliferative Neoplasms

Pathological Heterotopic Ossifications in Brain or Spinal Cord Injured Patients: From Ectopic Bone to Hematopoietic Stem Cell Niche Development

Accessible Chromatin Landscape Reveals a Proliferative Osteoprogenitor Transcriptional Program in Bone Marrow Mesenchymal Stromal Cells from Patients with Primary Myelofibrosis

Assessment of Sites of Marrow and Extramedullary Hematopoieis By Hybrid Imaging in Patients with Primary Myelofibrosis

Blood Traffic of Endothelial, Mesenchymal, Hematopoietic and Lin-/CD45-CD34+AC133+CXCR4+ Progenitor Cell Subsets Show Different Patterns in Pre-Fibrotic and Fibrotic Primary Myelofibrosis

Endogenous TGF-beta1 Mediated Osteogenic Impairment of Medullar Mesenchymal Stromal Cells in Primary Myelofibrosis

CXCR7 participates in CXCL12-induced CD34 + cell cycling through β-arrestin–dependent Akt activation

Bloodstream Progenitor-Cell Traffic In Primary Myelofibrosis Reveals Cell Subsets Showing Some Features Of Very-Small Embryonnic-Like Stem Cells (VSELs), Along With Endothelial (PEC), Mesenchymal (MPC) and Hematopoietic (HPC) Progenitor Cells

CXCR7 Functions Together with CXCR4 in SDF-1/CXCL12 Induced CD34 + Hematopoietic Progenitor Cell Cycling Through β-Arrestin 2-Dependent Akt Activation

Impairment of Myeloid Dendritic Differentiation and Role in the Support of Splenic Dysmegakaryopoiesis in Patients with Primary Myelofibrosis

The Tetraspanin CD9 Is Involved in Primary Myelofibrosis Dysmegakaryopoiesis Through c-Myb Regulation and Stroma Interactions,

Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms

Abnormal Expression and Function of the Lnk Adaptor Protein in Myeloproliferative Neoplasms (MPN).

Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence

A New Multiparametric Flow Cytometry Technique Based on Combined Side Population (SP) and Aldehyde Deshydrogenase (ALDH) Functionalities Identifies a Hierarchy within the Human Hematopoietic Stem/Progenitor Compartment.

FLT3 Mediated MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis

Hypermethylation of CXCR4 Promoter, and Its Reactivation by Hypomethylating Agent, in CD34 + Cells from Primary Myelofibrosis Patients

Pivotal Role of FoxO3 and mTORC1 in the Opposite Effects of SDF-1 and TGF-β on Cell Cycle Progression in CD34 + Stem/Progenitor Cells.

Microarray Functional Comparison of CD34 + and Megakaryocytic Cell Transcriptomes in Myeloid Metaplasia with Myelofibrosis.

Glivec/STI571 Treatment Stimulates Megakaryopoiesis and Normalizes PDGF Receptor beta Kinase Expression in Thrombocytopenic Patients with Myeloid Metaplasia with Myelofibrosis.

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American Society of Hematology

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American Society of Hematology

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