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Journal Articles

Targeting Cholesterol Homeostasis Enhances Phagocytosis of Acute Myeloid Leukemia Cells

Somadri Ghosh, Katrin Reinbach, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Oscar André, Maria Rodriguez Zabala, Pontus Nordenfelt, Marcus Järås

Blood (2024) 144 (Supplement 1): 4298.

https://doi.org/10.1182/blood-2024-206994

Published: 2024

Journal Articles

The 3D Chromatin Landscape of B-Cell Precursor Childhood Acute Lymphoblastic Leukemia

Larissa Helena Moura-Castro, Minjun Yang, Eleanor Woodward, Anders Castor, Thoas Fioretos, Bertil Johansson, Marcus Järås, Anna Hagström, Kajsa Paulsson

Blood (2023) 142 (Supplement 1): 4151.

https://doi.org/10.1182/blood-2023-178491

Published: 2023

Journal Articles

H2-K1 on MLL-AF9 Leukemia Cells Facilitates the Escape of NK Cell-Mediated Immune Surveillance

Somadri Ghosh, Maria Rodriguez Zabala, Gladys Telliam Dushime, Katrin Reinbach, Ramprasad Ramakrishnan, Ewa Sitnicka, Marcus Järås

Blood (2023) 142 (Supplement 1): 1579.

https://doi.org/10.1182/blood-2023-186382

Published: 2023

Journal Articles

Targeting SLC3A2 Sensitizes AML Cells Towards NK Cell-Mediated Killing

Kishan Bellamkonda, Ramprasad Ramakrishnan, Somadri Ghosh, Katrin Reinbach, Marcus Järås

Blood (2023) 142 (Supplement 1): 167.

https://doi.org/10.1182/blood-2023-188374

Published: 2023

Journal Articles

In Vivo crispr Screening Identifies GLUT1 As a Key Metabolic Regulator of MLL-AF9 -Driven Acute Myeloid Leukemia

Maria Rodriguez Zabala, Ramprasad Ramakrishnan, Katrin Reinbach, Leal Oburoglu, Somadri Ghosh, Ton Falqués, Pablo Peña-Martínez, Noelia Puente-Moncada, Thoas Fioretos, Anna Hagstroem-Andersson, Niels-Bjarne Woods, Marcus Järås

Blood (2021) 138 (Supplement 1): 3439.

https://doi.org/10.1182/blood-2021-152371

Published: 2021

Journal Articles

Preclinical and Clinical Signs of Efficacy of RVU120 (SEL120), a Specific CDK8/19 Inhibitor in DNMT3A-Mutated AML

Blood (2021) 138 (Supplement 1): 2371.

https://doi.org/10.1182/blood-2021-152273

Published: 2021

Journal Articles

RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

Blood (2021) 138 (Supplement 1): 1518.

https://doi.org/10.1182/blood-2021-150662

Published: 2021

Journal Articles

CDK8 Inhibitors Induce Transcriptional Reprogramming of AML Cells Associated with Differentiation

Milena Mazan, PhD, Marion Chapellier, PhD, Marcus Järås, PhD, Michal Mikula, MD PhD, Eliza Majewska, PhD, Katarzyna Wiklik, PhD, Michal Combik, PhD, Aniela Golas, PhD, Magdalena Masiejczyk, MSc, Elzbieta Fiedor, MSc, Federico Malusa, MSc, Przemyslaw Juszczynski, Prof., MD PhD, Magdalena Cybulska, DVM, Maciej Mikulski, PhD, Jerzy Ostrowski, Prof., MD PhD, Pawel Chrom, MD PhD, Krzysztof Brzózka, PhD, Tomasz Rzymski, PhD

Blood (2019) 134 (Supplement_1): 3774.

https://doi.org/10.1182/blood-2019-128073

Published: 2019

Journal Articles

Hepatic Leukemia Factor Is Critical for Hematopoietic Stem Cells and Promotes MLL-AF9 Acute Myeloid Leukemia

Aurelie Baudet, PhD, Karolina Paulina Komorowska, PhD, Hultmark Simon, MS, Marcus Järås, PhD, Marion Chapellier, PhD, Gunnar Juliusson, MD PhD, Mattias Magnusson, PhD

Blood (2019) 134 (Supplement_1): 2466.

https://doi.org/10.1182/blood-2019-122661

Published: 2019

Journal Articles

SEL120 - a First-in-Class CDK8/19 Inhibitor As a Novel Option for the Treatment of Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome - Data from Preclinical Studies and Introduction to a Phase Ib Clinical Trial

Blood (2019) 134 (Supplement_1): 2651.

https://doi.org/10.1182/blood-2019-127835

Published: 2019

Journal Articles

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

Blood (2018) 132 (Supplement 1): 1520.

https://doi.org/10.1182/blood-2018-99-111859

Published: 2018

Journal Articles

CXCR4 Has a CXCL12-Independent Essential Role in MLL-AF9 Driven Acute Myeloid Leukemia

Ramprasad Ramakrishnan, Pablo Peña-Martínez, Puneet Agarwal, PhD, Carl Högberg, PhD, Marion Chapellier, PhD, Mansi Shah, PhD, Björn Nilsson, MD PhD, Benjamin L. Ebert, MDPhD, Ravi Bhatia, MD, Marcus Järås, PhD

Blood (2018) 132 (Supplement 1): 774.

https://doi.org/10.1182/blood-2018-99-116137

Published: 2018

Journal Articles

Interleukin 4 Induces Macrophage-Mediated Phagocytosis of Leukemia Cells

Pablo Peña-Martínez, Mia Eriksson, PhD, Ramprasad Ramakrishnan, Marion Chapellier, PhD, Carl Högberg, PhD, Caroline Jansson, David Gisselsson Nord, MD PhD, Marcus Järås, PhD

Blood (2018) 132 (Supplement 1): 2730.

https://doi.org/10.1182/blood-2018-99-110606

Published: 2018

Journal Articles

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

Helena Ågerstam, Nils Hansen, Sofia von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (23): 2683–2693.

https://doi.org/10.1182/blood-2015-11-679985

Published: 2016

Includes: Supplemental data

Journal Articles

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

Helena Ågerstam, Nils Hansen, Sofia Von Palffy, Carl Sandén, Kristian Reckzeh, Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Maria Askmyr, Carl Högberg, Marianne Rissler, Kimmo Porkka, Hans Wadenvik, Satu Mustjoki, Johan Richter, MD, Marcus Järås, Thoas Fioretos

Blood (2016) 128 (22): 1118.

https://doi.org/10.1182/blood.V128.22.1118.1118

Published: 2016

Journal Articles

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Blood (2016) 128 (22): 739.

https://doi.org/10.1182/blood.V128.22.739.739

Published: 2016

Journal Articles

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Maria Askmyr, PhD, Helena Agerstam, PhD, Henrik Lilljebjörn, PhD, Nils Hansen, PhD, Christine Karlsson, PhD, Niklas Landberg, Carl Hogberg, PhD, Carin Lassen, Msc, Marianne Rissler, Johan Richter, MD PhD, Mats Ehinger, MD PhD, Marcus Jaras, PhD, Thoas Fioretos, MD PhD

Blood (2014) 124 (21): 3132.

https://doi.org/10.1182/blood.V124.21.3132.3132

Published: 2014

Journal Articles

Toll-like Receptor 1 Is a Candidate Therapeutic Target in Acute Myeloid Leukemia

Mia Eriksson, Pablo Peña, Marion Chapellier, PhD, Carl Högberg, PhD, Thoas Fioretos, MD PhD, Benjamin L Ebert, MD PhD, Marcus Järås, PhD

Blood (2014) 124 (21): 5782.

https://doi.org/10.1182/blood.V124.21.5782.5782

Published: 2014

Journal Articles

Interleukin-4 Is a Negative Regulator of Acute Myeloid Leukemia Cells

Pablo Enrique Peña Martínez, MSc, Marion Chapellier, PhD, Mia Eriksson, Ramprasad Ramakrishnan, MSc, Carl Högberg, PhD, Marcus Järås, PhD

Blood (2014) 124 (21): 2146.

https://doi.org/10.1182/blood.V124.21.2146.2146

Published: 2014

Journal Articles

Lenalidomide Induces Ubiquitination and Degradation of CSNK1A1 in MDS with Del(5q)

Emma C. Fink, Jan Krönke, MD, Slater N. Hurst, Namrata D. Udeshi, PhD, Tanya Svinkina, Rebekka K. Schneider, MD, Marie E. McConkey, PhD, Marcus Järås, PhD, Lars Bullinger, MD PhD, Steven A. Carr, PhD, Benjamin L. Ebert, MD DPhil

Blood (2014) 124 (21): 4.

https://doi.org/10.1182/blood.V124.21.4.4

Published: 2014

NARROW

Targeting Cholesterol Homeostasis Enhances Phagocytosis of Acute Myeloid Leukemia Cells

The 3D Chromatin Landscape of B-Cell Precursor Childhood Acute Lymphoblastic Leukemia

H2-K1 on MLL-AF9 Leukemia Cells Facilitates the Escape of NK Cell-Mediated Immune Surveillance

Targeting SLC3A2 Sensitizes AML Cells Towards NK Cell-Mediated Killing

In Vivo crispr Screening Identifies GLUT1 As a Key Metabolic Regulator of MLL-AF9 -Driven Acute Myeloid Leukemia

Preclinical and Clinical Signs of Efficacy of RVU120 (SEL120), a Specific CDK8/19 Inhibitor in DNMT3A-Mutated AML

RVU120 (SEL120) CDK8/19 Inhibitor - a Drug Candidate for the Treatment of MDS Can Induce Erythroid Differentiation

CDK8 Inhibitors Induce Transcriptional Reprogramming of AML Cells Associated with Differentiation

Hepatic Leukemia Factor Is Critical for Hematopoietic Stem Cells and Promotes MLL-AF9 Acute Myeloid Leukemia

SEL120 - a First-in-Class CDK8/19 Inhibitor As a Novel Option for the Treatment of Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome - Data from Preclinical Studies and Introduction to a Phase Ib Clinical Trial

CDK8 Inhibitor SEL120-34A Has Therapeutic Efficacy in Murine and Human Acute Myeloid Leukemia Models

CXCR4 Has a CXCL12-Independent Essential Role in MLL-AF9 Driven Acute Myeloid Leukemia

Interleukin 4 Induces Macrophage-Mediated Phagocytosis of Leukemia Cells

IL1RAP antibodies block IL-1–induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

IL1RAP Antibodies Block IL1-Induced Expansion of Primitive CML Cells and Display Therapeutic Effects in Xenograft Models

RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program

Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells

Toll-like Receptor 1 Is a Candidate Therapeutic Target in Acute Myeloid Leukemia

Interleukin-4 Is a Negative Regulator of Acute Myeloid Leukemia Cells

Lenalidomide Induces Ubiquitination and Degradation of CSNK1A1 in MDS with Del(5q)

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American Society of Hematology

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American Society of Hematology

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