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Marcel Spaargaren, PhD
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Journal Articles

Combined Inhibition of Phosphatidylinositol 3-Kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic Lymphocytic Leukemia Cells Blocks Survival, Adhesion and Proliferation

Rachel Thijssen, Gregor van Bochove, Martin FM de Rooij, Johanna ter Burg, Marcel Spaargaren, PhD, Coumaran Egile, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4691.
https://doi.org/10.1182/blood.V124.21.4691.4691
Published: 2014
Journal Articles

Combined Inhibition of mTOR and DNA-PK Blocks Survival, Adhesion, Proliferation and Chemoresistance in Primary Chronic Lymphocytic Leukemia (CLL) Cells

Rachel Thijssen, Gregor van Bochove, Ingrid AM Derks, Johanna ter Burg, Martin FM de Rooij, Marcel Spaargaren, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1981.
https://doi.org/10.1182/blood.V124.21.1981.1981
Published: 2014
Journal Articles

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Rachel Thijssen, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Katinka Weller, Hermen S Overkleeft, Marinus H.J. Van Oers, MD, PhD, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD
Journal: Blood
Blood (2013) 122 (21): 4188.
https://doi.org/10.1182/blood.V122.21.4188.4188
Published: 2013
Journal Articles

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

Eric Eldering, PhD, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Marinus H.J. Van Oers, MD, PhD, Hermen S Overkleeft, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD
Journal: Blood
Blood (2012) 120 (21): 3900.
https://doi.org/10.1182/blood.V120.21.3900.3900
Published: 2012
Journal Articles

Egress of CD19 + CD5 + Cells Into Peripheral Blood Following Treatment with the Bruton Tyrosine Kinase Inhibitor, PCI-32765, in Mantle Cell Lymphoma Patients

Betty Y Chang, PhD, Michelle Francesco, Padmaja Magadala, Min Mei Huang, PhD, Marcel Spaargaren, PhD, Joseph J. Buggy, PhD, Laurence Elias, MD
Journal: Blood
Blood (2011) 118 (21): 954.
https://doi.org/10.1182/blood.V118.21.954.954
Published: 2011
Journal Articles

Transcriptional Silencing of the Wnt-Antagonist Dickkopf-1 (DKK1) by Promoter Methylation Unleashes Aberrant Wnt Signaling In Advanced Multiple Myeloma

Kinga A Kocemba, MSc, Richard W Groen, PhD, Harmen van Andel, BSc, Karene Mahtouk, PhD, Marie Jose Kersten, MD, PhD, Marcel Spaargaren, PhD, Steven T Pals, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1919.
https://doi.org/10.1182/blood.V116.21.1919.1919
Published: 2010