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Journal Articles

Pharmacological Inhibition of Luteinizing Hormone Signaling Promotes HSC Quiescence and Hematopoietic Regeneration

Enrico Velardi, PhD BS, Jennifer Tsai, MD PhD, Stefan Radtke, PhD, Kirsten Cooper, Kimon Argyropoulos, MD, Shieh Jae-Hung, PhD, Yusuke Shono, MD PhD, Robert R. Jenq, MD, Alan M. Hanash, Malcolm A.S. Moore, DPhil, Hans-Peter Kiem, MD PhD, Marcel R.M. van den Brink, MD PhD, Jarrod A Dudakov, PhD

Blood (2017) 130 (Supplement 1): 1139.

https://doi.org/10.1182/blood.V130.Suppl_1.1139.1139

Published: 2017

Journal Articles

Suppression of Luteinizing Hormone Enhances HSC Recovery after Hematopoietic Injuries

Enrico Velardi, PhD, Jennifer Jia-ying Tsai, PhD, Kimon V. Argyropoulos, MD, Shieh Jae-Hung, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, MD PhD, Lauren Young, Tobias Wertheimer, Robert R. Jenq, MD, Alan M Hanash, MD PhD, Malcolm A.S. Moore, PhD, Marcel Van Den Brink, MD PhD, Jarrod A Dudakov, PhD

Blood (2016) 128 (22): 370.

https://doi.org/10.1182/blood.V128.22.370.370

Published: 2016

Journal Articles

Novel Alkylating Agent, Ureidomustine Exhibit Pre-Clinical Efficacy in B-Cell Lymphoma with Minimal Dose-Limiting Myelotoxicity

Eloisi Caldas Lopes, Shieh Jae-Hung, Srikanth Ambati, Su Tsann-Long, Fabian Correa, Elizabeth Peguero, Malcolm A.S. Moore

Blood (2015) 126 (23): 1556.

https://doi.org/10.1182/blood.V126.23.1556.1556

Published: 2015

Journal Articles

Pre-Clinical Evaluation of a Novel DNA Crosslinking Agent, Bo-1055 in B-Cell Lymphoma

Eloisi Caldas Lopes, Fabian Correa, Elizabeth Peguero, Srikanth R. Ambati, MBBS, MD, Jae Hung Shieh, Tsann Long SU, Malcolm A.S. Moore

Blood (2014) 124 (21): 5483.

https://doi.org/10.1182/blood.V124.21.5483.5483

Published: 2014

Journal Articles

Ex Vivo expansion Of Umbilical Cord Blood CD34+ Cells Under Hypoxic Conditions Using Novel Compound#999 With Cytokines

Saadiya Khan, MD, Alison L. Stewart, PhD, Siddhartha Mukherjee, MD, PhD, Stuart L. Scheiber, Benjamin L. Ebert, MD, DPhil, Todd R. Golub, MD, David T. Scadden, M.D., Malcolm A.S. Moore, D.Phil

Blood (2013) 122 (21): 4508.

https://doi.org/10.1182/blood.V122.21.4508.4508

Published: 2013

Journal Articles

Anti-Neoplastic Effect Of High Affinity and Covalent-Binding Microtubule Stabilizing Agents In AML Cells Sensitive and Resistant By ABC-Transporter Overexpression

Benet Pera, PhD, Michel Jordi, MSc, Ruben Hoya-Arias, PhD, José Fernando Díaz, PhD, Weishuo Fang, PhD, Karl-Heinz Altmann, PhD, Malcolm A.S. Moore, D.Phil

Blood (2013) 122 (21): 4225.

https://doi.org/10.1182/blood.V122.21.4225.4225

Published: 2013

Journal Articles

Drug Screening of Primary Human Pediatric Pre-B Cell Acute Lymphoblastic Leukemia (pre-B ALL) Cells in Their Stromal Niche

Jae-Hung Shieh, PhD, Tsann-Long Su, Ph.D., Jason Shieh, undergraduate, Malcolm A.S. Moore, PhD

Blood (2012) 120 (21): 4295.

https://doi.org/10.1182/blood.V120.21.4295.4295

Published: 2012

Journal Articles

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

Blood (2012) 120 (21): 571.

https://doi.org/10.1182/blood.V120.21.571.571

Published: 2012

Journal Articles

Derivation and Drug Screening of Growth Factors- and Stroma-Dependent Human Multiple Myeloma Cells

Jae-Hung Shieh, PhD, Tsann-Long Su, Ph.D., Jason Shieh, undergraduate, Malcolm A.S. Moore, D. Phil

Blood (2012) 120 (21): 5020.

https://doi.org/10.1182/blood.V120.21.5020.5020

Published: 2012

Journal Articles

Anti-Apoptotic Bcl2 and Bcl-Xl Proteins Involved in Stroma-Induced Drug Tolerance to Hsp70 and Hsp90 Inhibitors in Leukemia and B-Cell Lymphoma

Eloisi Caldas Lopes, Fabian M Correa, Ling-Bo Shen, Jae-Hung Shieh, PhD, Tony Taldone, PhD, Gabriela Chiosis, PhD, Malcolm A.S. Moore, PhD

Blood (2012) 120 (21): 4900.

https://doi.org/10.1182/blood.V120.21.4900.4900

Published: 2012

Journal Articles

Monocytes Modulate Megakaryocyte-Mediated Fibrosis of Bone Marrow Stromal Cells in Vitro

Emil Tom Kuriakose, MD, Jason Shieh, undergraduate, Jae Hung Shieh, PhD, Richard T. Silver, MD, Malcolm A.S. Moore, PhD

Blood (2012) 120 (21): 1759.

https://doi.org/10.1182/blood.V120.21.1759.1759

Published: 2012

Journal Articles

Temporal Generation and Molecular Characterization of Functional Hematopoietic Cells From Human Embryonic Stem Cells.

Ruben Hoya-Arias, PhD, Ling-Bo Shen, Ullas Mony, PhD, Elizabeth Peguero, Benet Pera, PhD, Malcolm A.S. Moore, PhD

Blood (2012) 120 (21): 2352.

https://doi.org/10.1182/blood.V120.21.2352.2352

Published: 2012

Journal Articles

TIF1γ Knockdown Enhances Hematopoietic Stem Cell Self Renewal with Preferential Myeloid Differentiation and Delayed Erythropoiesis

David C Dorn, MD, Wei He, Joan Massague, Malcolm A.S. Moore, D.Phil

Blood (2011) 118 (21): 4829.

https://doi.org/10.1182/blood.V118.21.4829.4829

Published: 2011

Journal Articles

Selective Targeting of Leukemic Over Normal Stem Cells by the Serotonin Receptor Antagonist SB-216641

Alissa R. Kahn, MD, Kimberly A. Hartwell, PhD, Peter G. Miller, PhD, Benjamin L. Ebert, MD, D.Phil, Todd R. Golub, MD, Malcolm A.S. Moore, D.Phil

Blood (2011) 118 (21): 1884.

https://doi.org/10.1182/blood.V118.21.1884.1884

Published: 2011

Journal Articles

The Nup98-HoxA9 Leukemogenic Fusion Protein Blocks Xpo1 and Tap-Mediated Nuclear Export

Yildirim Dogan, PhD, Sutapa Sahay, PhD, David C Dorn, MD, Anna Franceschino, MD, Michael Xu, Malcolm A.S. Moore, D.Phil

Blood (2011) 118 (21): 5228.

https://doi.org/10.1182/blood.V118.21.5228.5228

Published: 2011

Journal Articles

In Vitro Culture Reveals Microenvironment-Dependent Growth, Heterogeneity and Hierarchical Structure of Primary Human Pediatric Pre-B Cell Acute Lymphoblastic Leukemia (pre-B ALL) Cells

Jae Hung Shieh, PhD, Peter G Steinherz, MD, Jason Shieh, Malcolm A.S. Moore, D.Phil

Blood (2011) 118 (21): 1483.

https://doi.org/10.1182/blood.V118.21.1483.1483

Published: 2011

Journal Articles

Identification and Characterization of Hematopoietic Stem (HSC)/Progenitor Cells in Human Solid Tumors

Roland C Leung, MD, David C Dorn, MD, PhD, Robert J Downey, MD, Douglas A Levine, MD, Malcolm A.S. Moore, PhD

Blood (2008) 112 (11): 4785.

https://doi.org/10.1182/blood.V112.11.4785.4785

Published: 2008

Journal Articles

Graft-Vs-Graft Immune Interaction Is the Likely Mechanism of Absolute Unit Dominance in Double Unit Cord Blood (DCB) Transplantation Using Patient DCB Grafts: An in Vivo but Not in Vitro Phenomenon

Lamis K Eldjerou, MD, Sonali Chaudhury, MD, Mai He, MD, Maria E Arcila, MD, Paulo A Salazar, Richard J O’Reilly, MD, Juliet N Barker, MBBS, Malcolm A.S. Moore, PhD

Blood (2008) 112 (11): 3486.

https://doi.org/10.1182/blood.V112.11.3486.3486

Published: 2008

Journal Articles

An Animal Model That Predicts Unit Engraftment in Double Unit Cord Blood Transplant Recipients.

S. Chaudhury, MD, J.N. Barker, MBBS, A. de Baisre, MD, R.J. O’Reilly, MD, Malcolm A.S. Moore, D.Phil

Blood (2007) 110 (11): 176.

https://doi.org/10.1182/blood.V110.11.176.176

Published: 2007

Journal Articles

Targeting Cdk4/6 in Combination Therapy Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma through Synergistic Mitochondria Depolarization.

Xiangao Huang, PhD, Tracey Louie, B.Sc., Maurizio Di Liberto, Ph.D., Jun Rice, Ph.D., David Jayabalan, B.Sc., Kang Zhang, B.Sc., Michael Palladino, Ph.D., Isan Chen, M.D., Peter Toogood, Ph.D, Ruben Niesvizky, M.D., Malcolm A.S. Moore, Ph.D., Selina Chen-Kiang, Ph.D.

Blood (2007) 110 (11): 667.

https://doi.org/10.1182/blood.V110.11.667.667

Published: 2007

NARROW

Pharmacological Inhibition of Luteinizing Hormone Signaling Promotes HSC Quiescence and Hematopoietic Regeneration

Suppression of Luteinizing Hormone Enhances HSC Recovery after Hematopoietic Injuries

Novel Alkylating Agent, Ureidomustine Exhibit Pre-Clinical Efficacy in B-Cell Lymphoma with Minimal Dose-Limiting Myelotoxicity

Pre-Clinical Evaluation of a Novel DNA Crosslinking Agent, Bo-1055 in B-Cell Lymphoma

Ex Vivo expansion Of Umbilical Cord Blood CD34+ Cells Under Hypoxic Conditions Using Novel Compound#999 With Cytokines

Anti-Neoplastic Effect Of High Affinity and Covalent-Binding Microtubule Stabilizing Agents In AML Cells Sensitive and Resistant By ABC-Transporter Overexpression

Drug Screening of Primary Human Pediatric Pre-B Cell Acute Lymphoblastic Leukemia (pre-B ALL) Cells in Their Stromal Niche

Niche-Based Screening Identifies Novel Small Molecules That Overcome Stromal Effects in Multiple Myeloma

Derivation and Drug Screening of Growth Factors- and Stroma-Dependent Human Multiple Myeloma Cells

Anti-Apoptotic Bcl2 and Bcl-Xl Proteins Involved in Stroma-Induced Drug Tolerance to Hsp70 and Hsp90 Inhibitors in Leukemia and B-Cell Lymphoma

Monocytes Modulate Megakaryocyte-Mediated Fibrosis of Bone Marrow Stromal Cells in Vitro

Temporal Generation and Molecular Characterization of Functional Hematopoietic Cells From Human Embryonic Stem Cells.

TIF1γ Knockdown Enhances Hematopoietic Stem Cell Self Renewal with Preferential Myeloid Differentiation and Delayed Erythropoiesis

Selective Targeting of Leukemic Over Normal Stem Cells by the Serotonin Receptor Antagonist SB-216641

The Nup98-HoxA9 Leukemogenic Fusion Protein Blocks Xpo1 and Tap-Mediated Nuclear Export

In Vitro Culture Reveals Microenvironment-Dependent Growth, Heterogeneity and Hierarchical Structure of Primary Human Pediatric Pre-B Cell Acute Lymphoblastic Leukemia (pre-B ALL) Cells

Identification and Characterization of Hematopoietic Stem (HSC)/Progenitor Cells in Human Solid Tumors

Graft-Vs-Graft Immune Interaction Is the Likely Mechanism of Absolute Unit Dominance in Double Unit Cord Blood (DCB) Transplantation Using Patient DCB Grafts: An in Vivo but Not in Vitro Phenomenon

An Animal Model That Predicts Unit Engraftment in Double Unit Cord Blood Transplant Recipients.

Targeting Cdk4/6 in Combination Therapy Overcomes Proteasome Inhibitor Resistance in Multiple Myeloma through Synergistic Mitochondria Depolarization.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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