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Journal Articles

Small Activating RNA-Mediated Induction of HBG Via Liposome Delivery for In Vivo Treatment of Sickle Cell Disease and Beta-Thalassemia

Laura Sinigaglia, Marcella O'Reilly, Rhea Bhalla, Khoa Chung, Pardis Piri Dizaji, Victoria Begley, Rose Hodgson, Gabriela Lin, Konstantinos Vanezis, Julieta Tesone, Helen Paterson, Shreyasi Swamy, Henrik Hansen, Natalia Izotova, Bruno Doreste, Yulia Lomonosova, Luke Haslett, Robert Habib, Robert F Place, Jon Voutila, Vikash Reebye, Troels Koch, Brid M Ryan
Journal: Blood
Blood (2024) 144 (Supplement 1): 1104.
https://doi.org/10.1182/blood-2024-206236
Published: 2024
Journal Articles

Chromatin Accessibility Analysis Reveals Epigenetic Evolution Is a Common Mechanism of Relapse in Acute Myeloid Leukemia

Kevin A. Nuno, Armon Azizi, Thomas Koehnke, Asiri Ediriwickrema, M. Ryan Corces, Ravi Majeti
Journal: Blood
Blood (2021) 138 (Supplement 1): 677.
https://doi.org/10.1182/blood-2021-148928
Published: 2021
Journal Articles

Multi-Omic Analysis Identifies Epigenetic Evolution in Relapsed Acute Myeloid Leukemia

Kevin Nuno, BS, Armon Azizi, BS, Thomas Koehnke, MD, M. Ryan Corces, PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-143141
Published: 2020
Journal Articles

Single-Cell Mutational Profiling of Clonal Evolution in De Novo AML during Therapy and Relapse

Alexey Aleshin, MD MBA, Robert Durruthy-Durruthy, PhD, M. Ryan Corces, PhD, Melissa Stafford, Michaela Liedtke, MD, Bruno C. Medeiros, MD, Dennis J. Eastburn, PhD, Ravindra Majeti, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1469.
https://doi.org/10.1182/blood-2018-99-118089
Published: 2018
Journal Articles

Azacitidine and Ascorbate Inhibit the Competitive Outgrowth of Human TET2 Mutant HSPCs in a Xenograft Model of Pre-Leukemia

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Rajiv Sharma, PhD, M. Ryan Corces, PhD, Andreas Reinisch, MD PhD, David Cruz, MS, Thomas Koehnke, MD PhD, Daiki Karigane, MDPhD, Amy Fan, BS, Ravindra Majeti, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 887.
https://doi.org/10.1182/blood-2018-99-113907
Published: 2018
Journal Articles

Characterization and Targeting TET2-Mutant HSPCs and AML

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Andreas Reinisch, MD PhD, Rajiv Sharma, PhD, David Cruz, BS, M. Ryan Corces, PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2509.
https://doi.org/10.1182/blood.V130.Suppl_1.2509.2509
Published: 2017
Journal Articles

Pluripotent Reprogramming of Human AML Resets Leukemic Behavior and Models Therapeutic Targeting of Subclones

Mark Ping Chao, MD PhD, Gentles Andrew, PhD, Chatterjee Susmita, MS, Andreas Reinisch, MDPhD, M. Ryan Corces, PhD, Jinfeng Shen, PhD, Morganti Rachel, Rahul Singha, PhD, Daniel Haag, PhD, Marius Wernig, PhD, Joseph Wu, MD PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2016) 128 (22): 575.
https://doi.org/10.1182/blood.V128.22.575.575
Published: 2016
Journal Articles

An HPFH Mutation in the γ-Globin Gene Promoter of Humanized Cooley's Anemia Mice Rescues Them from Perinatal Lethality and Renders Them Transfusion Independent

Suean Daimia Fontenard, BS, Yongliang Huo, PhD, Shanrun Liu, MD PhD, Jonathan Lockhart, BS, Michael Berlett, BS, Thomas M Ryan, PhD
Journal: Blood
Blood (2016) 128 (22): 1290.
https://doi.org/10.1182/blood.V128.22.1290.1290
Published: 2016
Journal Articles

In Vivo Efficacy of Bcl11a Erythroid-Enhancer Deletion in Humanized Mouse Models of Anemia

Thomas M Ryan, PhD, Suean Daimia Fontenard, BS, Shanrun Liu, MD PhD, Jonathan Lockhart, BS, Michael Berlett, BS
Journal: Blood
Blood (2016) 128 (22): 2465.
https://doi.org/10.1182/blood.V128.22.2465.2465
Published: 2016
Journal Articles

Rescue of a Humanized Mouse Model of β-Thalassemia Major By Allogeneic Bone Marrow Transplantation in the Absence of Cytoreductive Conditioning

Jonathan Lockhart, BS, Yongliang Huo, PhD, Shanrun Liu, MD PhD, Suean Daimia Fontenard, BS, Michael Berlett, BS, Thomas M Ryan, PhD
Journal: Blood
Blood (2016) 128 (22): 2155.
https://doi.org/10.1182/blood.V128.22.2155.2155
Published: 2016
Journal Articles

Novel Insights into the Clinical Phenotype and Pathophysiology Underlying Low VWF Levels: The Low Von Willebrand Factor in Ireland Cohort (LoVIC) Study

Michelle Lavin, MB FRCPath, Sonia Aguila, PhD, Sonja Schneppenheim, MD, Niall Dalton, BSc, Jamie M O'Sullivan, PhD, Niamh M O'Connell, MB, FRCPath, PhD, Kevin M. Ryan, MB, Mary Byrne, MSc, Margaret Nolan, BSc, Roger Preston, PhD, Ulrich Budde, MD, Paula D. James, MD, Jorge Di Paola, MD, James S O'Donnell, MD PhD
Journal: Blood
Blood (2016) 128 (22): 873.
https://doi.org/10.1182/blood.V128.22.873.873
Published: 2016
Journal Articles

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition

Subarna Sinha, Daniel Thomas, Linda Yu, Andrew J. Gentles, Namyoung Jung, M. Ryan Corces-Zimmerman, Steven M. Chan, Andreas Reinisch, Andrew P. Feinberg, David L. Dill, Ravindra Majeti
Journal: Blood
Blood (2015) 125 (2): 316–326.
https://doi.org/10.1182/blood-2014-03-566018
Published: 2015
Includes: Supplemental data
Journal Articles

Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Max Jan, PhD, Thomas M. Snyder, PhD, M. Ryan Corces-Zimmerman, Irving L. Weissman, Stephen R. Quake, PhD, Ravindra Majeti, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4.
https://doi.org/10.1182/blood.V118.21.4.4
Published: 2011
Journal Articles

Preclinical transfusion-dependent humanized mouse model of β thalassemia major

Yongliang Huo, Sean C. McConnell, Thomas M. Ryan
Journal: Blood
Blood (2009) 113 (19): 4763–4770.
https://doi.org/10.1182/blood-2008-12-197012
Published: 2009
Includes: Supplemental data
Journal Articles

Lentiviral Insertion Site Analysis of Corrected Mouse Model of β Thalassemia Following Lentiviral Transduction of Embryonic Stem Cells.

Rui Yang, Sean C. McConnell, Yongliang Huo, Clayton Ulrey, Shan-Run Liu, Ting-Ting Zhang, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 2592.
https://doi.org/10.1182/blood.V110.11.2592.2592
Published: 2007
Journal Articles

Human Gamma Globin Gene Regulation in Knock-In Mouse Models of Anemia.

Sean C. McConnell, Yongliang Huo, Shan-Run Liu, Ting-Ting Zhang, Clayton L. Ulrey, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 1779.
https://doi.org/10.1182/blood.V110.11.1779.1779
Published: 2007
Journal Articles

A Humanized Cooley’s Anemia Mouse Model.

Yongliang Huo, Sean C. McConnell, Clayton L. Ulrey, Ting-Ting Zhang, Rui Yang, Shan-Run Liu, Thomas M. Ryan, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 1784.
https://doi.org/10.1182/blood.V110.11.1784.1784
Published: 2007
Journal Articles

Efficient Clonal Gene Delivery into Human Embryonic Stem Cells Via Active Transgenesis Using PiggyBac Transposition.

Ting-Ting Zhang, Clayton L. Ulrey, Shan-Run Liu, Rui Yang, Sean C. McConnell, Yongliang Huo, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 5149.
https://doi.org/10.1182/blood.V110.11.5149.5149
Published: 2007
Journal Articles

Erythroid Development in the Absence of Hemoglobin.

Shan-Run Liu, Sean C. McConnell, Yongliang Huo, Ting-Ting Zhang, Rui Yang, Clayton L. Ulrey, Thomas M. Ryan
Journal: Blood
Blood (2007) 110 (11): 1262.
https://doi.org/10.1182/blood.V110.11.1262.1262
Published: 2007
Journal Articles

Correction of sickle cell disease by homologous recombination in embryonic stem cells

Li-Chen Wu, Chiao-Wang Sun, Thomas M. Ryan, Kevin M. Pawlik, Jinxiang Ren, Tim M. Townes
Journal: Blood
Blood (2006) 108 (4): 1183–1188.
https://doi.org/10.1182/blood-2006-02-004812
Published: 2006