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Lorenzo Melchor, PhD
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Journal Articles

The Impact of Maintenance Lenalidomide on the Mutational Status of the Myeloma Clone at Relapse in the NCRI Myeloma XI Trial for Newly Diagnosed Multiple Myeloma Patients (NDMM)

John R Jones, MD, Niels Weinhold, PhD, Shweta S. Chavan, PhD, Charlotte Pawlyn, MB BChir, Lorenzo Melchor, PhD, David A Cairns, MSc, PhD, Dil B Begum, Charlotte Smith, Sidra Ellis, Amy Price, Amy L Sherborne, Brian A Walker, PhD, Christopher P Wardell, PhD, Gordon Cook, MD PhD, Matthew W Jenner, MD, Nigel H Russell, MD, Mark T Drayson, MD PhD, Roger G Owen, MD PhD, Faith E Davies, MD, Martin F Kaiser, MD, Graham H Jackson, MD PhD, Walter M Gregory, PhD, Mel Greaves, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4412.
https://doi.org/10.1182/blood.V128.22.4412.4412
Published: 2016
Journal Articles

Spatiotemporal Analysis of Intraclonal Heterogeneity in Multiple Myeloma: Unravelling the Impact of Treatment and the Propagating Capacity of Subclones Using Whole Exome Sequencing

Lorenzo Melchor, PhD, John R Jones, MD, Oleg Lenive, Erich Allen Peterson, PhD BS, MS, Annamaria Brioli, MD PhD, Alex Murison, PhD, Christopher P Wardell, PhD, Martin F Kaiser, Paula Proszek, Eileen Mary Boyle, MD PhD, Dil B Begum, Charlotte Pawlyn, MB BChir, David C Johnson, PhD, Inmaculada Rapado, David A Cairns, Walter M Gregory, Roger G Owen, Graham H Jackson, MD PhD, Mark T Drayson, MD PhD, Faith E Davies, MD, Joaquín Martínez-López, MD PhD, Richard S Houlston, MDPhDFRCP, Mel Greaves, FRS, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 371.
https://doi.org/10.1182/blood.V126.23.371.371
Published: 2015
Journal Articles

Myeloma XI Trial for Newly Diagnosed Multiple Myeloma (NDMM); A Report of Second Primary Malignancy (SPM) Rates and the Importance of Review of Reported Cases

John R Jones, MD, David A Cairns, Rachel Sigsworth, Corinne Collett, Charlotte Pawlyn, MB BChir, Alina Striha, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Mark T Drayson, MD PhD, Faith E Davies, MD, Walter M Gregory, Kevin Boyd, MD, Roger G Owen, Graham H Jackson, MD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1847.
https://doi.org/10.1182/blood.V126.23.1847.1847
Published: 2015
Journal Articles

Apobec Family Mutational Signatures Are Associated with Poor Prognosis Translocations in Multiple Myeloma

Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Lorenzo Melchor, PhD, Charlotte Pawlyn, MD, Martin F Kaiser, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David C Johnson, PhD, Ya-Wei Qiang, MD PhD, John Jones, MD, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 723.
https://doi.org/10.1182/blood.V124.21.723.723
Published: 2014
Journal Articles

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

Eileen M Boyle, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David C Johnson, PhD, Charlotte Pawlyn, MBBChir, John Jones, MD, Fabio Mirabella, PhD, Annamaria Brioli, Aneta Mikulasova, M.Sc., David A Cairns, PhD, Walter Gregory, PhD, Ana Quartilho, PhD, Mark T Drayson, MDPhD, Nigel Russell, Gordon Cook, MD PhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 637.
https://doi.org/10.1182/blood.V124.21.637.637
Published: 2014
Journal Articles

The Extent of Intra-Clonal Genetic Diversity within the Myeloma Clone Is a Predictive Biomarker of Progression and Outcome after Treatment

Lorenzo Melchor, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Christopher P Wardell, PhD, John Jones, MD, Martin F Kaiser, MD, Charlotte Pawlyn, MBBChir, David C Johnson, PhD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 640.
https://doi.org/10.1182/blood.V124.21.640.640
Published: 2014
Journal Articles

The Spectrum of Epigenetic Mutations in Myeloma and Their Clinical Impact

Charlotte Pawlyn, MBBChir, Martin F Kaiser, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, David C Johnson, PhD, Lorenzo Melchor, PhD, Eileen M Boyle, MD, John Jones, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Gordon Cook, MD, Roger G Owen, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2194.
https://doi.org/10.1182/blood.V124.21.2194.2194
Published: 2014
Journal Articles

Single-Cell Genetic Analysis Reveals The Genetic Composition Of Founder Clones, Phylogenetic Patterns Of Branching and Parallel Evolution, and Clonal Fluctuations Following Patient Treatment In Multiple Myeloma

Lorenzo Melchor, PhD, Annamaria Brioli, MD, Christopher P Wardell, PhD, Alexander Murison, PhD, Nicola E Potter, PhD, Martin F Kaiser, MD, Rosemary A Fryer, PhD, David C Johnson, PhD, Dil Begum, BSc, Sanna Hulkki, Gowri Vijayaraghavan, Ian Titley, PhD, Michele Cavo, MD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 398.
https://doi.org/10.1182/blood.V122.21.398.398
Published: 2013
Journal Articles

Discovery Of Genome Wide Epigenetic Programming In t(4;14) Multiple Myeloma and In The Progression From Myeloma To Plasma Cell Leukemia Via Methyl Binding Domain Protein Capture and Sequencing

Martin F Kaiser, MD, Alexander Murison, PhD, Christopher P Wardell, PhD, David C Johnson, PhD, Charlotte Pawlyn, MD, Fabio Mirabella, PhD, Lorenzo Melchor, PhD, Kerry Fenwick, Iwanka Kozarewa, PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 599.
https://doi.org/10.1182/blood.V122.21.599.599
Published: 2013
Journal Articles

Co-Existent Hyperdiploidy Does Not Abrogate The Poor Prognosis Associated With Adverse Cytogenetics In Myeloma

Charlotte Pawlyn, MD, Lorenzo Melchor, PhD, Eileen M Boyle, MD, Annamaria Brioli, MD, Martin F Kaiser, MD, Walter Gregory, PhD, Mark T Drayson, MD PhD, Graham Jackson, MD, Fiona M Ross, DPhil, J. Anthony Child, MD, Gareth J Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2013) 122 (21): 529.
https://doi.org/10.1182/blood.V122.21.529.529
Published: 2013
Journal Articles

Intra-Clonal Heterogeneity Is a Critical Early Event in the Preclinical Stages of Multiple Myeloma and Is Subject to Darwinian Fluctuation throughout the Disease

Lorenzo Melchor, PhD, Brian A Walker, BSc, PhD, Christopher P Wardell, PhD, Annamaria Brioli, MD, Martin F Kaiser, MD, Lucía López-Corral, MD, Sean Humphray, Lisa Murray, Mark Ross, David Bentley, Ramón García-Sanz, Jesús F San Miguel, MD, PhD, Faith E. Davies, MD, David Gonzalez, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2012) 120 (21): 3941.
https://doi.org/10.1182/blood.V120.21.3941.3941
Published: 2012