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Journal Articles

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Benjamin Watkins, MD, Aneesah P. Garrett, Jingyang Chen, Scott N. Furlan, MD, Kelly Hamby, Bernard Vanhove, PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2425.

https://doi.org/10.1182/blood.V124.21.2425.2425

Published: 2014

Journal Articles

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Ryan P Flynn, Swetha Ramakrishnan, Karnail Singh, PhD, Cynthia R. Giver, PhD, Kelly Hanby, Linda Stempora, Aneesah P. Garrett, Carly GK Ziegler, Gregory Tharp, Steven Bosinger, Bruce R. Blazar, MD, Edmund K. Waller, MD PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2432.

https://doi.org/10.1182/blood.V124.21.2432.2432

Published: 2014

Journal Articles

Alterations In Specific Immune Cell Subsets In Children With Sickle Cell Disease

Robert S. Nickel, MD, Jeanne E. Hendrickson, MD, John T. Horan, MD, MPH, Aneesah P. Garrett, Jennifer M. Robertson, PhD, Ifeyinwa Osunkwo, MD, MPH, Leslie S. Kean, MD, PhD

Blood (2013) 122 (21): 2208.

https://doi.org/10.1182/blood.V122.21.2208.2208

Published: 2013

Journal Articles

Alloimmunization To HLA Class I Antigens But Not H-Y Antigens Is Associated With Transfusion In Children With Sickle Cell Disease

Robert S. Nickel, MD, Jeanne E. Hendrickson, MD, Leslie S. Kean, MD, PhD, Marianne E. McPherson Yee, MD, MSc, Robert A. Bray, PhD, Howard M. Gebel, PhD, David B. Miklos, MD, PhD, John T. Horan, MD, MPH

Blood (2013) 122 (21): 39.

https://doi.org/10.1182/blood.V122.21.39.39

Published: 2013

Journal Articles

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

Natalia Kozyr, Ph.D., Carly GK Ziegler, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Taylor Deane, Linda Stempora, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 1888.

https://doi.org/10.1182/blood.V120.21.1888.1888

Published: 2012

Journal Articles

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

Natalia Kozyr, Ph.D., Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Divya Tiwari, MD, Taylor Deane, Linda Stempora, Joe Jenkins, Elizabeth Strobert, Anapatricia Garcia, DVM, PhD, Prachi Sharma, Cynthia Courtney, Angela Panoskaltsis-Mortari, Cynthia R. Giver, PhD, Edmund K. Waller, MD, PhD, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 2998.

https://doi.org/10.1182/blood.V120.21.2998.2998

Published: 2012

Journal Articles

A First-in-Disease Trial of in Vivo Costimulation Blockade for Acute GvHD Prevention: The Addition of Abatacept to Standard GvHD Prophylaxis Controls Early CD4+ T Cell Proliferation and Is Associated with Low Rates of Severe Acute GvHD

Divya Tiwari, MD, John Horan, Amelia Langston, MD, Muna Qayed, M.D., M.Sc., Jennifer Carr, Heather Renfroe, Couture Cynthia, Hanna J. Khoury, MD, Robertson Jennifer, R. Donald Harvey, PharmD, Aneesh Mehta, Edmund K. Waller, MD, PhD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 741.

https://doi.org/10.1182/blood.V120.21.741.741

Published: 2012

Journal Articles

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

Karnail Singh, Ph.D., Natalia Kozyr, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2011) 118 (21): 1008.

https://doi.org/10.1182/blood.V118.21.1008.1008

Published: 2011

Journal Articles

CD28-Directed T Cell Costimulation Blockade with Abatacept to Prevent GvHD During High-Risk Unrelated HSCT: A First-in-Disease Feasibility Trial,

Leslie S. Kean, MD, PhD, Amelia Langston, MD, Muna Qayad, MD, H. Jean Khoury, MD, FACP, Divya Tiwari, MD, Cynthia Couture, Heather Renfroe, Sharon Sen, Jennifer Robertson, PhD, Edmund K Waller, MD PhD, John T. Horan

Blood (2011) 118 (21): 4078.

https://doi.org/10.1182/blood.V118.21.4078.4078

Published: 2011

Journal Articles

Prevention of Acute GvHD During MHC Haploidentical BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model.

Weston Miller, Caleb E. Wheeler, MD, Angela Panoskaltsis-Mortari, PhD, Allan D Kirk, MD, PhD, Christian P Larsen, MD, PhD, Bruce R. Blazar, MD, Leslie S Kean, MD, PhD

Blood (2009) 114 (22): 2455.

https://doi.org/10.1182/blood.V114.22.2455.2455

Published: 2009

Journal Articles

MHC-Matched Stem Cell Transplantation in Rhesus Macaques Using a Costimulation Blockade-Based Immunomodulation Platform.

Leslie S. Kean, MD, PhD, Kelly Hamby, Taylor Deane, Thomas C. Pearson, MD/PhD, Christian P. Larsen, MD/Phd

Blood (2007) 110 (11): 1189.

https://doi.org/10.1182/blood.V110.11.1189.1189

Published: 2007

Journal Articles

Berkeley Sickle Cell Disease Mice Exhibit Multifaceted Immune Hyper-Activation, and Avidly Reject Allogeneic Bone Marrow Transplantation.

Leslie S. Kean, MD, PhD, Kelly Hamby, Jennifer Perry, David R. Archer, PhD

Blood (2007) 110 (11): 2251.

https://doi.org/10.1182/blood.V110.11.2251.2251

Published: 2007

Journal Articles

Effects of Sickle Cell Disease on Hematopoietic Stem Cell Function and the Bone Marrow Microenvironment.

Elisabeth H. Javazon, PhD, Leslie S. Kean, MD, PhD, Jennifer Perry, BS, Jessica Butler, BS, David R. Archer, PhD

Blood (2006) 108 (11): 1227.

https://doi.org/10.1182/blood.V108.11.1227.1227

Published: 2006

NARROW

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

Alterations In Specific Immune Cell Subsets In Children With Sickle Cell Disease

Alloimmunization To HLA Class I Antigens But Not H-Y Antigens Is Associated With Transfusion In Children With Sickle Cell Disease

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

Synergistic Control of Acute GvHD: Effectively Down-Regulating T Cell Proliferation and Cytotoxicity with Combined mTOR Inhibition and CD28:CD80/86 Costimulation Blockade.

A First-in-Disease Trial of in Vivo Costimulation Blockade for Acute GvHD Prevention: The Addition of Abatacept to Standard GvHD Prophylaxis Controls Early CD4+ T Cell Proliferation and Is Associated with Low Rates of Severe Acute GvHD

Sirolimus Inhibits Proliferation but Enhances Suppressive Activity of Rhesus Macaque Natural CD4 Regulatory T Cells

CD28-Directed T Cell Costimulation Blockade with Abatacept to Prevent GvHD During High-Risk Unrelated HSCT: A First-in-Disease Feasibility Trial,

Prevention of Acute GvHD During MHC Haploidentical BMT: Evaluating the Efficacy of T-Cell Costimulation Blockade Using a Novel Rhesus Macaque Transplant Model.

MHC-Matched Stem Cell Transplantation in Rhesus Macaques Using a Costimulation Blockade-Based Immunomodulation Platform.

Berkeley Sickle Cell Disease Mice Exhibit Multifaceted Immune Hyper-Activation, and Avidly Reject Allogeneic Bone Marrow Transplantation.

Effects of Sickle Cell Disease on Hematopoietic Stem Cell Function and the Bone Marrow Microenvironment.

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American Society of Hematology

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American Society of Hematology

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