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Leland Mayne
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Journal Articles

Mechanisms of inhibition of human monoclonal antibodies in immune thrombotic thrombocytopenic purpura

Konstantine Halkidis, Chan Meng, Szumam Liu, Leland Mayne, Don L. Siegel, X. Long Zheng
Journal: Blood
Blood (2023) 141 (24): 2993–3005.
https://doi.org/10.1182/blood.2022019252
Published: 2023
Includes: Supplemental data
Journal Articles

Hydrogen-Deuterium Exchange Plus Mass Spectrometry (HX-MS) Reveals a Novel Mechanism Underlying the pH-Dependent Regulation of ADAMTS13 Activity

Catherine B. Zander, PhD, Vikram G. Pillai, PhD, Leland Mayne, PhD, S. Walter Englander, PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 238.
https://doi.org/10.1182/blood.V130.Suppl_1.238.238
Published: 2017
Journal Articles

Hydrogen Exchange Mass Spectrometry Reveals Allosteric Interactions Between the Distal and the Proximal Domains of Human ADAMTS13

Catherine B. Zander, PhD, Leland Mayne, PhD, S. Walter Englander, PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 2535.
https://doi.org/10.1182/blood.V128.22.2535.2535
Published: 2016
Journal Articles

Autoantibody Epitope Mapping By Hydrogen-Deuterium Exchange Mass Spectrometry at Nearly Single Amino Acid Residue Resolution Reveals Novel Exosites on ADAMTS13 Critical for Substrate Recognition and Mechanism of Autoimmune Thrombotic Thrombocytopenic Purpura

Veronica C. Casina, PhD, Wenbing Hu, PhD, Hayley A. Hanby, B.S., Brandy Pickens, PhD, Leland Mayne, PhD, Eric Ostertag, MD, PhD, Stephen Kacir, PhD, Don L. Siegel, MD, PhD, S. Walter Englander, PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2014) 124 (21): 108.
https://doi.org/10.1182/blood.V124.21.108.108
Published: 2014
Journal Articles

Deuterium-Hydrogen Exchange Coupled With Mass Spectrometry Revealed A Novel Autoantibody Binding Epitope and Substrate Recognition Site In ADAMTS13 Protease,

Veronica C. Casina, Ph.D, Wenbing Hu, Ph.D., Hayley A. Hanby, B.S., Don L. Siegel, M.D., Ph.D, Leland Mayne, Ph.D., S. Walter Englander, Ph.D., X. Long Zheng, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 455.
https://doi.org/10.1182/blood.V122.21.455.455
Published: 2013