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Laurens T. van der Meer, PhD
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Journal Articles

Cathepsin B Mediated Lysosomal Degradation in Macrophages Controls the Pharmacokinetics of the Therapeutic Protein Asparaginase

Laurens T Van Der Meer, PhD, Samantha YA Terry, PhD, Dorette van Ingen Schenau, MSc, Kiki Andree, MSc, Gerben M Franssen, BSc, Debbie Roeleveld, MSc, Bart Metselaar, PhD, Thomas Reinheckel, PhD, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 3768.
https://doi.org/10.1182/blood.V126.23.3768.3768
Published: 2015
Journal Articles

Crispr/Cas9 Based Kinome Screen Identifies Novel Targets That Determine Sensitivity for Asparaginase Therapy in Acute Lymphoblastic Leukemia

Laurens T Van Der Meer, PhD, Jiangyan Yu, MSc, Miriam Butler, MSc, Jolien M R van der Meer, MSc, Roland P Kuiper, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 2629.
https://doi.org/10.1182/blood.V126.23.2629.2629
Published: 2015
Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 905.
https://doi.org/10.1182/blood.V126.23.905.905
Published: 2015
Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 3587.
https://doi.org/10.1182/blood.V124.21.3587.3587
Published: 2014
Journal Articles

The Therapeutic Protein Asparaginase Is Efficiently Cleared By Bone Barrow and Spleen Resident Macrophages

Laurens T van der Meer, PhD, Samantha YA Terry, PhD, Dorette S van IngenSchenau, MSc, Kiki C Andree, MSc, Peter M Hoogerbrugge, MD PhD, Otto C Boerman, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 3630.
https://doi.org/10.1182/blood.V124.21.3630.3630
Published: 2014
Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 5193.
https://doi.org/10.1182/blood.V124.21.5193.5193
Published: 2014
Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 2545.
https://doi.org/10.1182/blood.V122.21.2545.2545
Published: 2013
Journal Articles

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Laurens T. van der Meer, PhD, Laurensia Yuniati, MSc, Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Manon Alkema, Caroline Rodenbach, Blanca Scheijen, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 3796.
https://doi.org/10.1182/blood.V122.21.3796.3796
Published: 2013
Journal Articles

A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Laurens T. van der Meer, PhD, Esmé Waanders, PhD, Marloes Levers, BSc, Hanka Venselaar, MSc, Debbie Roeleveld, BSc, Joachim Boos, MD, PhD, Claudia Lanvers-Kaminsky, PhD, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD, D. Maroeska W.M. te Loo, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2458.
https://doi.org/10.1182/blood.V120.21.2458.2458
Published: 2012
Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2011) 118 (21): 399.
https://doi.org/10.1182/blood.V118.21.399.399
Published: 2011