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Journal Articles

Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia

Chiara F. Magnani, PhD, Claudia Mezzanotte, Claudia Cappuzzello, PhD, Fabrizio Benedicenti, Michela Bardini, PhD, Sarah Tettamanti, PhD, Grazia Fazio, PhD, Gianni Cazzaniga, PhD, Laurence J.N. Cooper, MD PhD, Eugenio Montini, PhD, Andrea Biondi, MD, Ettore Biagi, MD PhD

Blood (2016) 128 (22): 4022.

https://doi.org/10.1182/blood.V128.22.4022.4022

Published: 2016

Journal Articles

Chimeric Antigen Receptor-Modified T Cells for the Treatment of Acute Myeloid Leukemia Expressing CD33

Degang Song, PhD, Michael H. Swartz, Steve G. Biesecker, Fernando Borda, Rutul R. Shah, Peter Emtage, PhD, William G. Wierda, MD PhD, Laurence J.N. Cooper, MD PhD, Tim Chan, PhD

Blood (2016) 128 (22): 4058.

https://doi.org/10.1182/blood.V128.22.4058.4058

Published: 2016

Journal Articles

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Lenka V. Hurton, PhD, Harjeet Singh, PhD, Kirsten C. Switzer, PhD, Tiejuan Mi, MS, Leo G. Flores, Aaron Orozco, Sourindra N. Maiti, PhD, Shihuang Su, MS, Amer Najjar, PhD, Mary Helen Huls, BS, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD

Blood (2016) 128 (22): 2807.

https://doi.org/10.1182/blood.V128.22.2807.2807

Published: 2016

Journal Articles

Personalization of T-Cell Therapy Using a High-Throughput Platform to Identify Tumor-Specific T-Cell Receptors

Shan Zong, PhD, Laurence J.N. Cooper, MD PhD, George T McNamara, PhD, Hiroki Torikai, MD

Blood (2016) 128 (22): 3359.

https://doi.org/10.1182/blood.V128.22.3359.3359

Published: 2016

Journal Articles

Combination Immunotherapy with NY-ESO-1-Specific CAR + T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect

Krina Patel, MD, Simon Olivares, BS, Harjeet Singh, PhD, Lenka V. Hurton, PhD, Mary Helen Huls, BS, Muzaffar H. Qazilbash, MD, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD

Blood (2016) 128 (22): 3366.

https://doi.org/10.1182/blood.V128.22.3366.3366

Published: 2016

Journal Articles

Infusion of Ex Vivo Expanded Allogeneic Cord Blood-Derived Natural Killer Cells in Combination with Autologous Stem Cell Transplantation for Multiple Myeloma: Results of a Phase I Study

Blood (2015) 126 (23): 929.

https://doi.org/10.1182/blood.V126.23.929.929

Published: 2015

Journal Articles

Antigen Presenting Cell-Mediated Ex Vivo Expansion of Human Umbilical Cord Blood Cells Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

Nina Shah, MD, Dongxia Xing, Dean A. Lee, MD, PhD, Laurence J.N. Cooper, MD, PhD, William Decker, Sufang Li, Simon Robinson, PhD, Hong Yang, PHD, Simrit Parmar, M.D., Shawndeep Tung, MD, Michael Wang, MD, Richard Champlin, Catherine M Bollard, MD, Elizabeth J. Shpall

Blood (2010) 116 (21): 2100.

https://doi.org/10.1182/blood.V116.21.2100.2100

Published: 2010

Journal Articles

Combination of Gene Therapy and Nanoparticle Imaging for Improving T-Cell Therapy.

Yoonsu Choi, PhD, Zheng Li, PhD, Xukui Wang, MD, Hui Li, PhD, Feng Li, PhD, Daniel Y Lee, MD, PhD, Parijat Bhatnagar, PhD, Ching H Tung, PhD, Sibani L Biswal, PhD, Dean A. Lee, MD, PhD, King C Li, MD, MBA, Laurence J.N. Cooper, MD, PhD

Blood (2010) 116 (21): 1479.

https://doi.org/10.1182/blood.V116.21.1479.1479

Published: 2010

Journal Articles

NK-Cell Acquisition of Chemokine Receptors From Engineered Antigen Presenting Cells

Srinivas S. Somanchi, PhD, Anitha Gururajan, Laurence J.N. Cooper, MD, PhD, Dean A. Lee, MD, PhD

Blood (2010) 116 (21): 1744.

https://doi.org/10.1182/blood.V116.21.1744.1744

Published: 2010

Journal Articles

STAT3 Activation Promotes NK Cell Proliferation, NKG2D Expression, and NK Cell Antitumor Activity

Prasad Phatarpekar, Shiguo Zhu, MD, PhD, Cecele J. Denman, Nam Nguyen-Jackson, Stephanie S. Watowich, PhD, Laurence J.N. Cooper, MD, PhD, Dean A. Lee, MD, PhD

Blood (2010) 116 (21): 105.

https://doi.org/10.1182/blood.V116.21.105.105

Published: 2010

Journal Articles

NK Cell Proliferation and Cytolytic Function Are Compromised In the Hypoxic Tumor Microenvironment

Sonny Ang, PhD, Maria Lima Da Silva, PhD, Margaret Dawson, PhD, Matthew Figliola, PhD, Sourindra Maiti, PhD, Helen Huls, PhD, Elizabeth J. Shpall, PhD, Richard Champlin, Dean A. Lee, MD, PhD, Lucia Silla, MD, PhD, Laurence J.N. Cooper, MD, PhD

Blood (2010) 116 (21): 4291.

https://doi.org/10.1182/blood.V116.21.4291.4291

Published: 2010

Journal Articles

The Contribution of Signaling Endodomains to CD33-Mediated Killing of Acute Myeloid Leukemia by Natural Killer Cells Transiently Modified with Chimeric Antigen Receptor.

Jeffrey Friesen, Vladimir Senyukov, PhD, Cecele J Denman, Srinivas S. Somanchi, PhD, Simon Olivares, BS, Laurence J.N. Cooper, MD PhD, Dean A. Lee, MD, PhD

Blood (2009) 114 (22): 2463.

https://doi.org/10.1182/blood.V114.22.2463.2463

Published: 2009

Journal Articles

Gene Modification of Human Primary Natural Killer Cells by Electroporation with mRNA or DNA Coding for An Anti-GD2 Chimeric Antigen Receptor.

Srinivas S. Somanchi, Ph.D, Cecele J Denman, MS, Atharva Amritkar, Vladimir Senyukov, Ph.D, Simon Olivares, BS, Laurence J.N Cooper, MD, Ph.D, Dean A. Lee, MD, Ph.D

Blood (2009) 114 (22): 2467.

https://doi.org/10.1182/blood.V114.22.2467.2467

Published: 2009

Journal Articles

IL-7 as a Membrane-Bound Molecule for the Costimulation of Tumor-Specific T Cells.

Lenka V. Hurton, MS, Harjeet Singh, PhD, Simon Olivares, BS, Sonny O. Ang, PhD, Susan Staba Kelly, MD, Partow Kebriaei, MD, Dean A. Lee, MD, PhD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD

Blood (2009) 114 (22): 3035.

https://doi.org/10.1182/blood.V114.22.3035.3035

Published: 2009

Journal Articles

Sustained Ex Vivo Expansion of Human Peripheral Blood NK Cells Using Artificial APCs Bearing Membrane-Bound IL-21.

Cecele J Denman, MS, Lisa M. Kopp, DO, Vladimir Senyukov, PhD, Sarah Hagemeister, Jennifer Johnson, Maria A Lima Da Silva, Harjeet Singh, PhD, Lenka Hurton, Simon Olivares, BS, Mary Helen Huls, BS, Richard E Champlin, MD, Laurence J.N. Cooper, MD, PhD, Dean A. Lee, MD, PhD

Blood (2009) 114 (22): 3030.

https://doi.org/10.1182/blood.V114.22.3030.3030

Published: 2009

Journal Articles

Third Generation Chimeric Antigen Receptors Containing CD137 or CD134 Signaling Endodomains Augment CD19-Specific T-Cell Effector Function.

Harjeet Singh, PhD, Hillary N Gibbons, BS, Simon Olivares, BS, Matthew J. Figliola, BS, Margaret J. Dawson, BS, Mary Helen Huls, BS, Dean A Lee, MD, Ph.D, Partow Kebriaei, MD, Richard E Champlin, MD, Laurence J.N. Cooper, MD, PhD

Blood (2009) 114 (22): 4097.

https://doi.org/10.1182/blood.V114.22.4097.4097

Published: 2009

Journal Articles

Second Allogeneic Transplants for Relapsed Acute Lymphoblastic Leukemia Result in High Response Rates of Short Duration: Further Intervention Is Required to Maintain Response.

Partow Kebriaei, MD, Rima Saliba, PhD, Gabriela Rondon, MD, Laura Worth, MD, PhD, Laurence J.N. Cooper, MD, PhD, Deborah A. Thomas, MD, Hagop Kantarjian, MD, Marcos de Lima, MD, Richard E Champlin, MD, Sergio Giralt, MD

Blood (2009) 114 (22): 4293.

https://doi.org/10.1182/blood.V114.22.4293.4293

Published: 2009

Journal Articles

T Cells Demonstrate Enhanced Specificity for CD19 + Malignancies When Stimulated with IL-21.

Harjeet Singh, MS, PhD, Mary Helen Huls, BS, Margaret J. Dawson, BS, Tiejuan Mi, MS, Gianpietro Dotti, MD, Dean A. Lee, MD, PhD, Partow Kebriaei, MD, Elizabeth J. Shpall, MD, Perry B. Hackett, PhD, Carl H. June, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD, PhD

Blood (2008) 112 (11): 1539.

https://doi.org/10.1182/blood.V112.11.1539.1539

Published: 2008

Journal Articles

Cord Blood NK Cytotoxic Activity Can Be Selelctively Modulated by Accessory.

Dongxia Xing, PhD, Sufang Li, Robinson N. Simon, PhD, Decker William, PhD, Yang Hong, MD PhD, Steiner David, PhD, Thomas Michael, Richard E. Champlin, MD, John D. McMannis, PhD, Marcelo F. Vina, PhD, Laurence J.N. Cooper, MD PhD, Paul J. Simmons, PhD, Patrick A. Zweidler-Mckay, MD PhD, Elizabeth J. Shpall, MD

Blood (2007) 110 (11): 3272.

https://doi.org/10.1182/blood.V110.11.3272.3272

Published: 2007

Journal Articles

A Small Animal In Vivo Imaging Model of Expanded vs. Unexpanded UCB Stem Cells Reveals Differential Patterns of Engraftment.

David Steiner, PhD, Simon N. Robinson, PhD, William K. Decker, PhD, Frank C. Marini, PhD, Elizabeth J. Shpall, MD, Catherine M. Bollard, MD, Richard E. Champlin, MD, Dongxia Xing, PhD, Hong Yang, MD, PhD, Laurence J.N. Cooper, MD, PhD, Juri G. Gelovani, MD, Amer M. Najjar, PhD, Antonio Di Stasi, MD, PhD, Concetta Quintarelli, PhD, Patrick A. Zweidler-McKay, MD, PhD, Gianpietro Dotti, MD, PhD

Blood (2007) 110 (11): 1191.

https://doi.org/10.1182/blood.V110.11.1191.1191

Published: 2007

NARROW

Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia

Chimeric Antigen Receptor-Modified T Cells for the Treatment of Acute Myeloid Leukemia Expressing CD33

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Personalization of T-Cell Therapy Using a High-Throughput Platform to Identify Tumor-Specific T-Cell Receptors

Combination Immunotherapy with NY-ESO-1-Specific CAR + T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect

Infusion of Ex Vivo Expanded Allogeneic Cord Blood-Derived Natural Killer Cells in Combination with Autologous Stem Cell Transplantation for Multiple Myeloma: Results of a Phase I Study

Antigen Presenting Cell-Mediated Ex Vivo Expansion of Human Umbilical Cord Blood Cells Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

Combination of Gene Therapy and Nanoparticle Imaging for Improving T-Cell Therapy.

NK-Cell Acquisition of Chemokine Receptors From Engineered Antigen Presenting Cells

STAT3 Activation Promotes NK Cell Proliferation, NKG2D Expression, and NK Cell Antitumor Activity

NK Cell Proliferation and Cytolytic Function Are Compromised In the Hypoxic Tumor Microenvironment

The Contribution of Signaling Endodomains to CD33-Mediated Killing of Acute Myeloid Leukemia by Natural Killer Cells Transiently Modified with Chimeric Antigen Receptor.

Gene Modification of Human Primary Natural Killer Cells by Electroporation with mRNA or DNA Coding for An Anti-GD2 Chimeric Antigen Receptor.

IL-7 as a Membrane-Bound Molecule for the Costimulation of Tumor-Specific T Cells.

Sustained Ex Vivo Expansion of Human Peripheral Blood NK Cells Using Artificial APCs Bearing Membrane-Bound IL-21.

Third Generation Chimeric Antigen Receptors Containing CD137 or CD134 Signaling Endodomains Augment CD19-Specific T-Cell Effector Function.

Second Allogeneic Transplants for Relapsed Acute Lymphoblastic Leukemia Result in High Response Rates of Short Duration: Further Intervention Is Required to Maintain Response.

T Cells Demonstrate Enhanced Specificity for CD19 + Malignancies When Stimulated with IL-21.

Cord Blood NK Cytotoxic Activity Can Be Selelctively Modulated by Accessory.

A Small Animal In Vivo Imaging Model of Expanded vs. Unexpanded UCB Stem Cells Reveals Differential Patterns of Engraftment.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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