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Journal Articles

Upregulation of Bcl-2 Confers Resistance to FLT3 Inhibition in FLT3 -ITD AML with Secondary Acquired Mutations

Kotoko Yamatani, MD, Yoko Tabe, MD PhD, Kaori Saito, Haeun Yang, Yuko Murakami-Tonami, MD PhD, Koya Suzuki, PhD, Weiguo Zhang, MD PhD, Sonoko Kinjo, PhD, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, PhD, Shigeo Yamaguchi, MD PhD, Hironori Harada, MD PhD, Takashi Miida, MD PhD, Neil P. Shah, MD PhD, Marina Y. Konopleva, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 3944.

https://doi.org/10.1182/blood-2018-99-109957

Published: 2018

Journal Articles

Combined Targeting of Bcl-2 and XPO1 Overcomes Acquired Resistance to Tyrosine Kinase Inhibitors in the FLT3-ITD/TKD Double Mutant AML

Yoko Tabe, MD PhD, Kotoko Yamatani, MD, Haeun Yang, Kaori Saito, Yuko Murakami-Tonami, MD, Koya Suzuki, PhD, Weiguo Zhang, MD PhD, Sonoko Kinjo, PhD, Kazuho Ikeo, PhD, Masaki Hosoya, PhD, Kaoru Mogushi, PhD, Shigeo Yamaguchi, Hironori Harada, MD PhD, Takashi Miida, MD PhD, Neil Shah, MD, Marina Y. Konopleva, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 2640.

https://doi.org/10.1182/blood-2018-99-113195

Published: 2018

Journal Articles

Mitochondrial Transfer Confers Microenvironment-Mediated Resistance to Oxphos Inhibition in AML

Haeun Yang, Yoko Tabe, MD PhD, Kaori Saito, Rodrigo Jacamo, PhD, Helen Ma, MS, Vivian Ruvolo, MS, Junichi Imoto, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, PhD, Shigeo Yamaguchi, Kotoko Yamatani, MD, Yuko Murakami-Tonami, MD, Koya Suzuki, PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Marina Y. Konopleva, MD PhD

Blood (2018) 132 (Supplement 1): 430.

https://doi.org/10.1182/blood-2018-99-112933

Published: 2018

Journal Articles

XPO1 Inhibition Targets Transcriptional Vulnerability of FLT3-ITD+D835 Double Mutant AML through p53 Accumulation and Inhibition of Oncogenic Transcription Factors: Lesson Learned from Cage Sequencing of Primary AML Cells

Kotoko Yamatani, MD PhD, Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Haeun Yang, Kaori Saito, Weiguo Zhang, MD PhD, Kazuho Ikeo, PhD, Sonoko Kinjo, Kaoru Mogushi, PhD, Masaki Hosoya, Yoshihide Hayashizaki, MD PhD, Yasunari Yamanaka, MD PhD, Hironori Harada, Takashi Miida, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 1244.

https://doi.org/10.1182/blood.V130.Suppl_1.1244.1244

Published: 2017

Journal Articles

Novel Oxidative Phosphorylation Inhibitor IACS-010759 Induces AMPK-Dependent Apoptosis of AML Cells

Haeun Yang, Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Kaori Saito, Helen Ma, MS, Vivian Ruvolo, PhD, Junichi Imoto, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, Yoshihide Hayashizaki, MD PhD, Yasunari Yamanaka, MD PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD

Blood (2017) 130 (Supplement 1): 1245.

https://doi.org/10.1182/blood.V130.Suppl_1.1245.1245

Published: 2017

Journal Articles

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia

Jo Ishizawa, Eiji Sugihara, Shinji Kuninaka, Kaoru Mogushi, Kensuke Kojima, Christopher B. Benton, Ran Zhao, Dhruv Chachad, Norisato Hashimoto, Rodrigo O. Jacamo, Yihua Qiu, Suk Young Yoo, Shinichiro Okamoto, Michael Andreeff, Steven M. Kornblau, Hideyuki Saya

Blood (2017) 129 (14): 1958–1968.

https://doi.org/10.1182/blood-2016-07-726216

Published: 2017

Includes: Supplemental data

Journal Articles

Novel FAO Inhibitor Avocatin B Induces Apoptosis of Acute Monocytic Leukemia Cells in Adipocyte Co-Culture System Via ER Stress and ATF4 Activation

Yoko Tabe, MD PhD, Shinichi Yamamoto, PhD, Mika Kikkawa, PhD, Hikari Taka, PhD, Kaoru Mogushi, PhD, Hiromichi Mastushita, MD PhD, Takashi Miida, MDPhD, Michael Andreeff, MD PhD, Paul A Spagnuolo, PhD, Marina Konopleva, MD PhD

Blood (2015) 126 (23): 3692.

https://doi.org/10.1182/blood.V126.23.3692.3692

Published: 2015

Journal Articles

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcript Signatures in Acute Monocytic Leukemia Cells By Fatty Acid Oxidation Inhibition

Yoko Tabe, MD PhD, Marina Konopleva, MD PhD, Norikazu Monma, PhD, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Yasunari Yamanaka, MD PhD, Hiromichi Matsushita, MD PhD, Takashi Miida, MD PhD, Yoshihide Hayashizaki, MD PhD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 3631.

https://doi.org/10.1182/blood.V126.23.3631.3631

Published: 2015

Journal Articles

Bone Marrow Adipocyte-Derived Free Fatty Acids Induce Gene Signature Linking Transcription with Metabolic Changes That Contribute to Survival of Acute Monocytic Leukemia Cells

Yoko Tabe, MD PhD, Masako Harada, PhD, Yuka Miyamae, Kaoru Mogushi, Saiko Kazuno, Tsutomu Fujimura, Hiromichi Matsushita, MD PhD, Takashi Ueno, Takehiko Yokomizo, MD PhD, Takashi Miida, MD PhD, Ismael Samudio, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 1013.

https://doi.org/10.1182/blood.V124.21.1013.1013

Published: 2014

NARROW

Upregulation of Bcl-2 Confers Resistance to FLT3 Inhibition in FLT3 -ITD AML with Secondary Acquired Mutations

Combined Targeting of Bcl-2 and XPO1 Overcomes Acquired Resistance to Tyrosine Kinase Inhibitors in the FLT3-ITD/TKD Double Mutant AML

Mitochondrial Transfer Confers Microenvironment-Mediated Resistance to Oxphos Inhibition in AML

XPO1 Inhibition Targets Transcriptional Vulnerability of FLT3-ITD+D835 Double Mutant AML through p53 Accumulation and Inhibition of Oncogenic Transcription Factors: Lesson Learned from Cage Sequencing of Primary AML Cells

Novel Oxidative Phosphorylation Inhibitor IACS-010759 Induces AMPK-Dependent Apoptosis of AML Cells

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia

Novel FAO Inhibitor Avocatin B Induces Apoptosis of Acute Monocytic Leukemia Cells in Adipocyte Co-Culture System Via ER Stress and ATF4 Activation

Cap Analysis of Gene Expression (CAGE) Sequencing Reveals Alterations of the Transcript Signatures in Acute Monocytic Leukemia Cells By Fatty Acid Oxidation Inhibition

Bone Marrow Adipocyte-Derived Free Fatty Acids Induce Gene Signature Linking Transcription with Metabolic Changes That Contribute to Survival of Acute Monocytic Leukemia Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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