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Journal Articles

Inhibition of Translation Initiation and Heat Shock Factor 1 (HSF1): A Novel Strategy Targeting FLT3 Double Mutant and Non-FLT3 Mutant AML Progenitor/Stem Cells

Jo Ishizawa, MD PhD, Ran Zhao, Lauren Heese, Alex Jaeger, PhD, Yuki Nishida, Rodrigo Jacamo, PhD, Kensuke Kojima, MD PhD, Man Chun John MA, PhD, Vivian Ruvolo, PhD, Dhruv Chachad, R. Eric Davis, MD, William Devine, PhD, John A Porco, Jr., PhD, Luke Whitesell, MD, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2637.

https://doi.org/10.1182/blood.V130.Suppl_1.2637.2637

Published: 2017

Journal Articles

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia

Jo Ishizawa, Eiji Sugihara, Shinji Kuninaka, Kaoru Mogushi, Kensuke Kojima, Christopher B. Benton, Ran Zhao, Dhruv Chachad, Norisato Hashimoto, Rodrigo O. Jacamo, Yihua Qiu, Suk Young Yoo, Shinichiro Okamoto, Michael Andreeff, Steven M. Kornblau, Hideyuki Saya

Blood (2017) 129 (14): 1958–1968.

https://doi.org/10.1182/blood-2016-07-726216

Published: 2017

Includes: Supplemental data

Journal Articles

Discovery of Predictive Gene Signatures for Tumor Sensitivity to MDM2 Inhibition in Development of a Novel MDM2 Inhibitor DS-3032b

Jo Ishizawa, MD PhD, Kenji Nakamaru, Takahiko Seki, Koichi Tazaki, Kensuke Kojima, MD PhD, Dhruv Chachad, Courtney D DiNardo, MD, Sherry Pierce, BSN, BA, Keyur P. Patel, MD PhD, Archie Tse, R Eric Davis, MD, Arvind Rao, PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 2893.

https://doi.org/10.1182/blood.V128.22.2893.2893

Published: 2016

Journal Articles

ONC212 Is a Potent Member of the Imipridone Class of Anti-Cancer Compounds That Induces p53-Independent Apoptosis in Hematological Malignancies

Takenobu Nii, PhD, Jo Ishizawa, MD PhD, Ran Zhao, Jianfang Zeng, MD PhD, Dhruv Chachad, Kensuke Kojima, MD PhD, Marina Konopleva, MD PhD, Richard Eric Davis, MD, Joshua E Allen, PhD, Martin Stogniew, PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 4059.

https://doi.org/10.1182/blood.V128.22.4059.4059

Published: 2016

Journal Articles

The Novel Thiosemicarbazone Derivative Coti-2 Induces Mitochondrial Apoptosis in Acute Myeloid Leukemia Cells Via a p53-Independent Mechanism

Dhruv Chachad, Jo Ishizawa, MD PhD, Wayne R Danter, MD, Gordon Mills, MD PhD, Michael Andreeff, MD PhD, Kensuke Kojima, MD, PhD

Blood (2016) 128 (22): 2757.

https://doi.org/10.1182/blood.V128.22.2757.2757

Published: 2016

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Blood (2015) 126 (23): 2051.

https://doi.org/10.1182/blood.V126.23.2051.2051

Published: 2015

Journal Articles

Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach

Jo Ishizawa, MD PhD, Rodrigo Omar Jacamo, PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Vivian Ruvolo, MS, Peter Ruvolo, PhD, Weiguo Zang, PhD, Yoko Tabe, MD PhD, Marina Konopleva, MD PhD, William Devine, PhD, Susan Lindquist, PhD, John A Porco, Jr., Luke Whitesell, MD PhD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 2548.

https://doi.org/10.1182/blood.V126.23.2548.2548

Published: 2015

Journal Articles

Prognostic Impact and Targeting of BMI-1 in Acute Myeloid Leukemia

Yuki Nishida, MD, Kensuke Kojima, MD PhD, Aya Maeda, Dhruv Chachad, MS, Hiroaki Kitamura, MD, Jo Ishizawa, MD PhD, Michael Andreef, MD PhD, Steven M. Kornblau, MD, Shinya Kimura, MD

Blood (2014) 124 (21): 3617.

https://doi.org/10.1182/blood.V124.21.3617.3617

Published: 2014

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

Jo Ishizawa, MD PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Peter P. Ruvolo, PhD, Vivian R Ruvolo, MA, Rodrigo Jacamo, PhD, Archana Dilip, MS, Hong Mu, MD PhD, Zhihong Zeng, MD, Polina Matre, PhD, Joshua E. Allen, PhD, Sattva S Neelapu, MD, Timothy J. McDonnell, MD PhD, Roberto N. Miranda, MD, Larry W. Kwak, MD PhD, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD, R Eric Davis, MD, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 3122.

https://doi.org/10.1182/blood.V124.21.3122.3122

Published: 2014

NARROW

Inhibition of Translation Initiation and Heat Shock Factor 1 (HSF1): A Novel Strategy Targeting FLT3 Double Mutant and Non-FLT3 Mutant AML Progenitor/Stem Cells

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia

Discovery of Predictive Gene Signatures for Tumor Sensitivity to MDM2 Inhibition in Development of a Novel MDM2 Inhibitor DS-3032b

ONC212 Is a Potent Member of the Imipridone Class of Anti-Cancer Compounds That Induces p53-Independent Apoptosis in Hematological Malignancies

The Novel Thiosemicarbazone Derivative Coti-2 Induces Mitochondrial Apoptosis in Acute Myeloid Leukemia Cells Via a p53-Independent Mechanism

Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach

Prognostic Impact and Targeting of BMI-1 in Acute Myeloid Leukemia

ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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