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Journal Articles

Erythroid Ferritin Chains In Vivo Are Dispensable for Hemoglobinization but Play a Critical Non-Canonical Role in Erythropoietin Signaling

Ranjit Sahu, Kurt Langberg, Lorrie Delehanty, Kamaleldin E Elagib, Deepika Kotay, James Zimring, Angelo D'Alessandro, Adam Goldfarb
Journal: Blood
Blood (2024) 144 (Supplement 1): 7.
https://doi.org/10.1182/blood-2024-205194
Published: 2024
Journal Articles

Molecular Delineation and Targeting of a Megakaryocyte Ontogenic Switch for Therapeutic Applications

Kamaleldin E Elagib, Sijie Liu, Valentin Burguener, Ranjit Sahu, Deepika Kotay, Gerhard Wolber, Ciorsdaidh Watts, Adam Goldfarb
Journal: Blood
Blood (2024) 144 (Supplement 1): 1172.
https://doi.org/10.1182/blood-2024-203846
Published: 2024
Journal Articles

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming"

Kamaleldin E Elagib, PhDMBBS, Ashton Brock, PhD, Goar Mosoyan, Cara Clementelli, Lorrie L Delehanty, BS, Alexandra Pacheco-Benichou, Corinne Fruit, Thierry Besson, PhD, Stephen Morris, MD, Koji Eto, MD, Camelia Iancu-Rubin, PhD, Adam N Goldfarb, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3250.
https://doi.org/10.1182/blood-2019-129049
Published: 2019
Journal Articles

An IGF2BP3-Cdk9 Pathway Governs the Human Fetal-Adult Megakaryocyte Transition

Kamaleldin E Elagib, MBBS, PhD, Chih-Huan Lu, BS, Goar Mosoyan, Ewelina Zasadzińska, MS, Daniel R Foltz, PhD, Peter Balogh, Els Verhoeyen, Miriam Sansó, PhD, Robert P Fisher, MD PhD, Camelia Iancu-Rubin, PhD, Adam N Goldfarb, MD
Journal: Blood
Blood (2016) 128 (22): 886.
https://doi.org/10.1182/blood.V128.22.886.886
Published: 2016
Journal Articles

The Distinctive Morphogenesis of Infantile Megakaryopoiesis Is Associated with Altered P-TEFb Regulation By the Oncofetal Factor IGF2BP3

Kamaleldin E Elagib, MBBS, PhD, Chih-Huan Lu, Ewelina Zasadzińska, MSc, Daniel R Foltz, PhD, Peter Balogh, MSc, Adam N Goldfarb, MD
Journal: Blood
Blood (2014) 124 (21): 2911.
https://doi.org/10.1182/blood.V124.21.2911.2911
Published: 2014
Journal Articles

Synergy Between Specific Inflammatory Cytokines, IFNγ and TNFα, and Iron Restriction in Erythroid Blockade: A New Model for Anemia of Chronic Disease.

Chante Richardson, Grant C. Bullock, MD, PhD, Lorrie L Delehanty, Anne-Laure Talbot, Kamaleldin E Elagib, Jeremy Rubinstein, Adam Goldfarb, MD
Journal: Blood
Blood (2009) 114 (22): 159.
https://doi.org/10.1182/blood.V114.22.159.159
Published: 2009
Journal Articles

Calpain Regulation of Megakaryopoiesis through a Positive Regulatory Loop Involving P-TEFb, GATA-1, and RUNX1.

Kamaleldin E Elagib, Lorrie L Delehanty, Ivailo Mihaylov, Adam Goldfarb
Journal: Blood
Blood (2009) 114 (22): 566.
https://doi.org/10.1182/blood.V114.22.566.566
Published: 2009
Journal Articles

Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation

Kamaleldin E. Elagib, Ivailo S. Mihaylov, Lorrie L. Delehanty, Grant C. Bullock, Kevin D. Ouma, Jill F. Caronia, Sara L. Gonias, Adam N. Goldfarb
Journal: Blood
Blood (2008) 112 (13): 4884–4894.
https://doi.org/10.1182/blood-2008-03-145722
Published: 2008
Includes: Supplemental data
Journal Articles

In Vitro and in Vivo Abrogation of An Erythroid Iron Restriction Developmental Checkpoint by Isocitrate through a Novel Erythropoietin- Coupled Signaling Mechanism

Grant C. Bullock, Lorrie L Delehanty, Anne-Laure Talbot, Chante Richardson, Kamaleldin E Elagib, Adam Goldfarb
Journal: Blood
Blood (2008) 112 (11): 417.
https://doi.org/10.1182/blood.V112.11.417.417
Published: 2008
Journal Articles

A Murine Model for the Transient Myeloproliferative Disorder of Down Syndrome: Phenotypic Influence of p53 on Reversible Megakaryoblastic Disorder

Kamaleldin E Elagib, Lorrie L Delehanty, Adam Goldfarb
Journal: Blood
Blood (2008) 112 (11): 688.
https://doi.org/10.1182/blood.V112.11.688.688
Published: 2008
Journal Articles

Involvement of P-TEFb/CDK9 in Cooperative Transcriptional Activation of Megakaryocytic Genes by GATA-1 and RUNX1 and in Programming of Megakaryocytic Development In Vivo.

Kamaleldin E. Elagib, MD, PhD, Ivailo S. Mihaylov, Ph.D., Lorrie L. Delehanty, B.S., Grant C. Bullock, M.D., Ph.D., Kevin D. Ouma, Jill F. Caronia, B.S., Sara L. Gonias, B.S., Adam N. Goldfarb, M.D.
Journal: Blood
Blood (2007) 110 (11): 1227.
https://doi.org/10.1182/blood.V110.11.1227.1227
Published: 2007
Journal Articles

Regulation of RUNX1 Transcriptional Function by GATA-1 Kinase Recruitment: A Novel Pathway for Megakaryocytic Gene Regulation.

Kamaleldin E. Elagib, MD, PhD, Ivailo S. Mihaylov, Ph.D., Lorrie L. Delehanty, B.S., Sara L. Gonias, B.S., Jill F. Caronia, B.S., Adam N. Goldfarb, M.D.
Journal: Blood
Blood (2006) 108 (11): 1183.
https://doi.org/10.1182/blood.V108.11.1183.1183
Published: 2006
Journal Articles

Orientation-Dependent Regulation of RUNX1 and GATA-1 Transcriptional Function by the p300/CBP Coactivators.

Ivailo S. Mihaylov, PhD, Kamaleldin E. Elagib, M.D., Ph.D., Lorrie L. Delehanty, B.S., Sara L. Gonias, B.S., Jill F. Caronia, B.S., Adam N. Goldfarb, M.D.
Journal: Blood
Blood (2006) 108 (11): 1184.
https://doi.org/10.1182/blood.V108.11.1184.1184
Published: 2006
Journal Articles

Erythroid Inhibition by AML1-ETO: Repression of GATA-1 Function by a Novel Non-Transcriptional Mechanism Involving Targeted Protein Degradation.

Youngjin Choi, Ph.D., Kamaleldin E. Elagib, M.B.B.S., Ph.D., Adam N. Goldfarb, M.D.
Journal: Blood
Blood (2004) 104 (11): 388.
https://doi.org/10.1182/blood.V104.11.388.388
Published: 2004
Journal Articles

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation

Kamaleldin E. Elagib, Frederick K. Racke, Michael Mogass, Rina Khetawat, Lorrie L. Delehanty, Adam N. Goldfarb
Journal: Blood
Blood (2003) 101 (11): 4333–4341.
https://doi.org/10.1182/blood-2002-09-2708
Published: 2003